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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu kaishun xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury

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Bioactive Materials 2021年第8期6卷 2523-2534页

作者： Chenggui Wang Min Wang kaishun xia Jingkai Wang Feng Cheng Kesi Shi Liwei Ying Chao Yu Haibin Xu Shining xiao Chengzhen Liang Fangcai Li Bo Lei Qixin Chen Department of Orthopedics Surgery 2nd Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009ZhejiangPR China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyFrontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an710054PR China

The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide *** inflammatory microenvironment is one of main obstacles on inhibiting the recovery of *** mesenchymal stem cells(MSCs)derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment ***,the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not ***,we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel(FE)with sustainable and long term extracellular vesicle release(FE@EVs)for improving motor functional recovery after *** orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord,thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation,reducing inflammatory reaction,promoting remyelination and axonal *** study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases.

关键词： Bioactive biomaterials Multifunctional hydrogel Extracellular vesicles release Spinal cord injury repair

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Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell

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Bioactive Materials 2021年第10期6卷 3568-3579页

作者： Chao Yu Dongdong Li Chenggui Wang kaishun xia Jingkai Wang xiaopeng Zhou Liwei Ying Jiawei Shu xianpeng Huang Haibin Xu Bin Han Qixin Chen Fangcai Li Jianbin Tang Chengzhen Liang Nigel Slater Department of Orthopedics Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou CityZhejiang ProvincePR China Orthopedics Research Institute of Zhejiang University Hangzhou CityZhejiang ProvincePR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou CityZhejiang ProvincePR China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand College of Chemical and Biological EngineeringZhejiang UniversityHangzhouZhejiang310027China Department of Chemical Engineering and Biotechnology University of CambridgeCambridgeUnited Kingdom

Cell transplantation has been proved the promising therapeutic effects on intervertebral disc degeneration(IVDD).However,the increased levels of reactive oxygen species(ROS)in the degenerated region will impede the efficiency of human adipose-derived stem cells(human ADSCs)transplantation *** inhibits human ADSCs proliferation,and increases human ADSCs ***,we firstly devised a novel amphiphilic copolymer PEG-PAPO,which could self-assemble into a nanosized micelle and load lipophilic kartogenin(KGN),as a single complex(PAKM).It was an injectable esterase-responsive micelle,and showed controlled release ability of KGN and apocynin(APO).Oxidative stimulation promoted the esterase activity in human ADSCs,which accelerate degradation of esterase-responsive *** its monomer,the PAKM micelle possessed better bioactivities,which were attributed to their synergistic *** enhanced the viability,autophagic activation(P62,LC3 II),ECM-related transcription factor(SOX9),and ECM(Collagen II,Aggrecan)maintenance in human ***,it is demonstrated that the injection of PAKM with human ADSCs yielded higher disc height and water content in ***,PAKM micelles perform promoting cell survival and differentiation effects,and may be a potential therapeutic agent for IVDD.

关键词： Intervertebral disc degeneration Polymer-drug conjugates Mesenchymal stem cell Reactive oxygen species Stem cell therapy

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A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair

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Bioactive Materials 2022年第9期7卷 103-119页

作者： Biao Yang Chengzhen Liang Di Chen Feng Cheng Yuang Zhang Shaoke Wang Jiawei Shu xianpeng Huang Jingkai Wang kaishun xia Liwei Ying Kesi Shi Chenggui Wang Xuhua Wang Fangcai Li Qian Zhao Qixin Chen Department of Orthopedics Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009ZhejiangChina Orthopedics Research Institute of Zhejiang University Hangzhou310009ZhejiangChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310009ZhejiangChina Ningbo Research Institute of Zhejiang University Ningbo315100ZhejiangChina State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027ZhejiangChina NHC and CAMS Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhou310003ZhejiangChina

The current effective method for treatment of spinal cord injury(SCI)is to reconstruct the biological microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells(NSCs)to repair ***,the method is characterized by several challenges including irregular wounds,and mechanical and electrical mismatch of the material-tissue *** the current study,a unique and facile agarose/gelatin/polypyrrole(Aga/Gel/PPy,AGP3)hydrogel with similar conductivity and modulus as the spinal cord was developed by altering the concentration of Aga and *** gelation occurred through non-covalent interactions,and the physically crosslinked features made the AGP3 hydrogels *** vitro cultures showed that AGP3 hydrogel exhibited excellent biocompatibility,and promoted differentiation of NSCs toward neurons whereas it inhibited over-proliferation of *** in vivo implanted AGP3 hydrogel completely covered the tissue defects and reduced injured cavity *** vivo studies further showed that the AGP3 hydrogel provided a biocompatible microenvironment for promoting endogenous neurogenesis rather than glial fibrosis formation,resulting in significant functional *** sequencing analysis further indicated that AGP3 hydrogel significantly modulated expression of neurogenesis-related genes through intracellular Ca2+signaling ***,this supramolecular strategy produces AGP3 hydrogel that can be used as favorable biomaterials for SCI repair by filling the cavity and imitating the physiological properties of the spinal cord.

关键词： Conducting polymer Supramolecular hydrogels Biomimetic scaffolds Nerve regeneration Spinal cord injury

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γδT细胞在肿瘤中的作用

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医学综述 2017年第11期23卷 2155-2159,2165页

作者：王君杰朱健俞巍夏楷顺王倚天陶惠民浙江大学医学院附属第二医院骨科杭州310009

γδT细胞因不具有主要组织相容性复合物限制性而被用于肿瘤的免疫治疗。γδT细胞在动物实验和临床试验中都有良好的抗肿瘤效果。目前,γδT细胞的动物模型研究主要通过过继免疫和体内直接激活两种手段。而绝大多数临床试验则聚焦在V... 详细信息

γδT细胞因不具有主要组织相容性复合物限制性而被用于肿瘤的免疫治疗。γδT细胞在动物实验和临床试验中都有良好的抗肿瘤效果。目前,γδT细胞的动物模型研究主要通过过继免疫和体内直接激活两种手段。而绝大多数临床试验则聚焦在Vγ9Vδ2^+T细胞亚群,通过体内或体外激活提升其外周血浓度而达到杀伤肿瘤的目的。然而,γδT细胞可能在某些时候起到促癌作用,并且这一促肿瘤生长作用与白细胞介素17密切相关。

关键词： γδT细胞肿瘤免疫疗法抗肿瘤

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基于ABAQUS的升主动脉置换术术后血流数值模拟

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中国医学物理学杂志 2021年第5期38卷 650-654页

作者：孙凯顺张洪明张桂敏夏健明孙毅昆明理工大学工程力学系云南昆明650500 云南省阜外心血管病医院云南昆明650032

目的:为研究人工升主动脉置换术治疗Stanford A型主动脉夹层后的血流动力学规律,采集临床CT图像,构建术后个性化主动脉流场几何模型。基于计算流体动力学对其进行数值模拟,得到术后流域壁面压力分布和流速分布两个力学指标,从而分析术... 详细信息

目的:为研究人工升主动脉置换术治疗Stanford A型主动脉夹层后的血流动力学规律,采集临床CT图像,构建术后个性化主动脉流场几何模型。基于计算流体动力学对其进行数值模拟,得到术后流域壁面压力分布和流速分布两个力学指标,从而分析术后流域规律。方法:采集术后CT图像DICOM文件并应用影像后处理软件MIMICS进行三维重构及优化获得几何模型,再将该流域模型导入网格划分软件进行CFD网格划分,最后将网格文件导入ABAQUS/CFD模块进行多周期瞬态模拟。结果:通过模拟计算,得到术后主动脉在心动周期不同时刻的血流动力学参数。结论:血流动力学参数与边界条件密切相关。主动脉内复杂流场环境与心血管疾病存在一定联系。数值模拟可为人工血管置换术后病情发展提供参考。

关键词：主动脉人工血管计算流体力学数值模拟 ABAQUS

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吴茱萸汤研究热点及趋势可视化分析

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中国中医药信息杂志 2024年第2期31卷 84-89页

作者：夏青青陈偶英曾勇王金星康焱红方芳陈燕李东雅朱海利湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007 湖南省中医药研究院湖南长沙410006 湖南省中医药研究院附属医院湖南长沙410006

目的了解吴茱萸汤的研究现状、热点和趋势,为相关研究提供参考。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)建库至2023年2月28日收录的吴茱萸汤相关研究文... 详细信息

目的了解吴茱萸汤的研究现状、热点和趋势,为相关研究提供参考。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)建库至2023年2月28日收录的吴茱萸汤相关研究文献。采用NoteExpress3.6合并去重,通过CiteSpace6.1.R6软件绘制作者、机构、关键词知识图谱并进行解读。结果共纳入822篇文献,发文量呈波动上升趋势;主要来源期刊有《新中医》《河南中医》《四川中医》等;主要研究机构有北京中医药大学、中国中医科学院、山东中医药大学等;涉及566位作者,发文较多的有王智民(12篇)、龚慕辛(9篇)、毕开顺(5篇)等;高频关键词有“头痛”“《伤寒论》”“中医药疗法”等。结论吴茱萸汤治疗慢性胃炎、高血压等原发病疗效确切,是本领域研究热点;通过高效液相色谱等方法探索其活性成分、在分子水平上阐释其作用机制和作用靶点是本领域的研究趋势。

关键词：吴茱萸汤可视化分析文献计量学 CiteSpace

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羔羊“醉酒症”的病原研究及防治

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中国草食动物科学 2022年第2期42卷 42-46页

作者：王玉茂李书光沈志强曲光刚王建军王金良张娜杨丽芳孟霞韩开顺山东省滨州畜牧兽医研究院滨州256600 山东绿都生物科技有限公司滨州256600 平原县畜牧业发展中心平原253100

近年来,山东省及周边省份多地羔羊出现整窝大面积不明病因的瘫痪症,行走摇摆似醉酒状,在临床上俗称“醉酒症”。为探究该病的病因,通过临床解剖、病料采集、病原的分离鉴定、动物回归试验,首次确定羔羊“醉酒症”的病原为A型产气荚膜梭... 详细信息

近年来,山东省及周边省份多地羔羊出现整窝大面积不明病因的瘫痪症,行走摇摆似醉酒状,在临床上俗称“醉酒症”。为探究该病的病因,通过临床解剖、病料采集、病原的分离鉴定、动物回归试验,首次确定羔羊“醉酒症”的病原为A型产气荚膜梭菌,并制定了快速治疗和预防该病的综合防控方案,能够在24 h内快速控制并彻底杜绝羔羊“醉酒症”的发生。

关键词：羔羊 “醉酒症” 病原 A型产气荚膜梭菌

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开顺饮加减治疗食管癌临床疗效观察

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中医学报 2011年第5期26卷 529-530页

作者：唐书生董瑞霞南京中医药大学江苏南京210046 磁县肿瘤医院河北磁县056500

目的:观察开顺饮治疗食管癌的近期疗效。方法:采用开顺饮治疗食管癌60例患者。结果:60例患者中完全缓解1例(1.7%),部分缓解5例(8.3%),微效6例(10%),稳定35例(58.3%),进展13例(21.7%)。结论:开顺饮治疗食管癌有一定近期疗效。

关键词：食管癌开顺饮噎膈

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