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Plasma Science and Technology 2020年第5期22卷 35-43页

作者： Xudong GAO Jixuan WANG Yanfeng GAO Hongyan YAN kaiqiang xue Xingnan DENG Xin YANG School of Water Conservancy and Hydroelectric power Hebei University of EngineeringHandan 056038People's Republic of China

Needle-to-plane geometry has been widely investigated and used in underwater pulsed *** position relationship between the needle tip and insulation layer significantly affects the discharge *** carried out experiments on underwater pulsed discharge with the needle tip protruding from,recessing into,and flushing with the insulating *** results are as ***,underwater pulsed discharge has a strong randomness under the experimental *** discharge patterns appeared under the same experimental ***,recession into the insulator surface led to a higher probability of occurrence but a lower strength of spark discharge than ***,between the needle tip protruding from and recessing into the insulation material,the average speed of propagation of underwater pulsed spark discharge decreased by an order of *** study shows that the optimum length of needle tip protruding from the insulation layer is 1 mm to obtain a strong underwater pulsed spark discharge.

关键词： discharge strength development speed of discharge channel plasma properties randomicity of spark discharge underwater pulsed spark discharge

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液电效应结合网过滤用于循环冷却水除垢研究

环境科学与技术 2016年第9期39卷 150-154,165页

作者：高旭东薛凯强邓星男河北工程大学河北邯郸056038

针对现有循环冷却水系统水处理技术存在的不足,将液电效应与网过滤技术相结合,设计了一种自清洁网过滤装置。对高浓缩倍率的电厂模拟和实际循环冷却水进行除垢试验,测试流注放电形式、携带比例、放电频率对除垢效果的影响。试验结果表明... 详细信息

针对现有循环冷却水系统水处理技术存在的不足,将液电效应与网过滤技术相结合,设计了一种自清洁网过滤装置。对高浓缩倍率的电厂模拟和实际循环冷却水进行除垢试验,测试流注放电形式、携带比例、放电频率对除垢效果的影响。试验结果表明:该装置能够有效地对模拟和实际循环冷却水进行处理;正流注放电产生的清洁效果更明显;高携带比例时过滤网被完全堵住所需时间较长,压差较小,低携带比例时第一次放电产生的效果更明显,最终压差维持在更低水平;在试验设定的2种频率下,最终压差维持在相当的水平,从节能角度考虑,建议采用每分钟电击1次。该装置运行费用极其低廉,仅节约用水省下总成本的1.3%,就足以支付其运行电费。

关键词：循环冷却水火花放电网过滤碳酸钙运行费用

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直接空冷单元夏季喷雾增湿过程的研究

电力系统装备 2023年第6期 55-58页

作者：薛凯强河北蔚州能源综合开发有限公司河北张家口075799

针对某电厂600 MW直接空冷机组的一个空冷单元为研究对象,运用CFD软件模拟了空冷单元内加装喷雾增湿系统的作用过程及效果。文章分析了喷水降温系统的结构与原理,为了保证喷出的水滴不会落到风机上面,运用理论和数值模拟相结合说明了液... 详细信息

针对某电厂600 MW直接空冷机组的一个空冷单元为研究对象,运用CFD软件模拟了空冷单元内加装喷雾增湿系统的作用过程及效果。文章分析了喷水降温系统的结构与原理,为了保证喷出的水滴不会落到风机上面,运用理论和数值模拟相结合说明了液滴的临界直径和悬浮风速的关系;对比分析了喷雾前后空冷单元内部的温度场和流场,发现喷雾增湿系统有利于降低凝汽器入口空气温度,提高机组的经济性。

关键词：直接空冷机组喷雾增湿系统喷雾效果空冷凝汽器

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中部地区传统乡村重构中的建筑改造思路

苏州科技学院学报（工程技术版） 2016年第3期29卷 41-47页

作者：薛恺强文剑钢苏州科技大学建筑与城市规划学院江苏苏州215011

传统乡村正面临空间重构、功能重组转型,这是激活乡村、寻求发展的重要机遇,但传统的城乡规划方法存在诸多问题,使得村庄规划和传统建筑保护与改造无法落地实施。总结中国乡村生活理念演化,站在城乡统筹规划的视野下解读我国中部地区乡... 详细信息

传统乡村正面临空间重构、功能重组转型,这是激活乡村、寻求发展的重要机遇,但传统的城乡规划方法存在诸多问题,使得村庄规划和传统建筑保护与改造无法落地实施。总结中国乡村生活理念演化,站在城乡统筹规划的视野下解读我国中部地区乡村重构难题和乡村建筑现状,结合"绿十字"在中部地区的乡村建设实践,提出传统乡村建筑改造"延续历史"、"保留生活"、"适应变化"、"开启民智"策略,为乡村建筑改造提供新思路。

关键词：乡村重构建筑危机 “绿十字”乡建改造思路

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-Jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-Lin Li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao Lin Tang Jun Zhan Yiyuan xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Mimicking aneurysm in a patient with chronic occlusion of the left middle cerebral artery

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World Journal of Clinical Cases 2025年第3期13卷 20-23页

作者： xue-Jian Wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina

The chronic occlusion of intracranial arteries generally has no or mild clinical symptoms,and the clinical symptoms of acute cerebral artery occlusion are mostly manifested as severe cerebral infarction symptoms,which often make early diagnosis difficult,thus losing the best treatment *** cerebral infarction occurs,the consequences are difficult to *** is also an important reason for the high misdiagnosis rate and mortality of this *** this paper,the characteristics of the disease were analyzed to provide clinical reference.

关键词： Chronic occlusion Misdiagnose Arterial occlusion Middle cerebral artery occlusion Aneurysm