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Omics Studies and Systems Biology Perspective towards Abiotic Stress Response in Plants

American Journal of Plant Sciences 2020年第12期11卷 2172-2194页

作者： Jyoti Prakash Sahoo Laxmipreeya Behera Siddhartha Shankar Sharma Jannila Praveena Suman Kumari Nayak kailash Chandra Samal Department of Agricultural Biotechnology Odisha University of Agriculture and Technology Bhubaneswar India Department of Genetics and Plant Breeding Uttar Banga Krishi Viswavidyalaya Cooch Behar India Department of Fruit Science and Horticulture Technology Odisha University of Agriculture and Technology Bhubaneswar India Department of Plant Physiology Odisha University of Agriculture and Technology Bhubaneswar India

Plant abiotic stress responses are vital yield-restricting aspect in agriculture. Recent technology in plant biology allows research of such stress responses at a molecular scale in plants. Network analysis provides in-depth knowledge regarding omics information visualisation as it reduces the intrinsic intricacy of such data. The use of integrated functional genomics helps to understand the relationship between the genomic profile and the phenotypic profile in different environmental conditions of an organism. Plants’ responses to abiotic stress are often considered as a complex process. Systems biology approaches allow visualising and understanding how plant life works to overcome abiotic stress. The combination of integrated functional genomics along with bioinformatics will put a hand in additional in-depth research knowledge on stress tolerance to plants by exploiting available genetic information and continuously improving techniques and strategies. Most of the omics technologies are high throughput with very rapid data generation rates and humongous outputs. These technologies have made noticeable contributions to the modern-day improvements in our knowledge of plant biology. So, in this review, omics studies and the system biology approach towards abiotic stress tolerance in plants are highlighted.

关键词： Genomics Proteomics Transcriptomics System Biology Abiotic Stress Plants

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Chronic Dietary Administration of 2-Deoxy-D-Glucose Does Not Compromise Neurobehavioral Functions at Tumor Preventive Doses in Mice

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Journal of Behavioral and Brain Science 2015年第9期5卷 381-393页

作者： Saurabh Singh Mayank Kumar kailash Manda Seenu Haridas Anant Narayan Bhatt Daman Saluja Bilikere S. Dwarakanath Division of Radiation Biosciences Institute of Nuclear Medicine and Allied Sciences Delhi India Medical Biotechnology Laboratory Dr. B.R. Ambedkar Center for Biomedical Research University of Delhi Delhi India

Beneficial effects of dietary energy restriction (DER), including extension of life-span, reduction in cancer risk, anti-cancer effects and decrease in age related neurodegenerative diseases have been well established. Given that DER is difficult to implement in humans due to practical constraints, development of energy restriction mimetics (ERMs) is considered as a suitable alternative. Our recent studies have established the anti-tumor effects of the dietary administration of the glycolytic inhibitor 2-deoxy-D-glucose, a potential ERM, an alternative to DER;without any adverse effects on general physiology. Since functioning of the brain is critically dependent on glucose, we investigated the effects of chronic dietary 2-DG administration on the behavioural outcome in mice. Our findings based on a battery of neuro-behavioural tests clearly suggest that the chronic dietary administration of 2-DG that appreciably impairs the process of tumorigenesis has no adverse effect on the cognitive, affective and sensory-motor functions. Together with the maintenance of normal physiology reported by us earlier, these observations strengthen the potential of dietary 2-DG as a safe cancer preventive strategy.

关键词： Glycolysis Energy Restriction Mimetics (ERMs) 2-Deoxy-D-Glucose (2-DG) Tumor Prevention Neuro-Behaviour

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Mossbauer,X-ray and Magnetization studies of Mn1-xZnxFe2O4(0.1≤x≤0.5)

Mossbauer,X-ray and Magnetization studies of Mn1-xZnxFe2O4(0...

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8th International Symposium on the Industrial Applications of the Mossbauer Effect

作者： R.L.Dhiman S.P.Taneja kailash Chandra C.Wynter P.G.Department of Applied Physics S.D.CollegeAmbala Cantt.133 001India Department of Physics Maharashi Dayanand UniversityRohtak 124 001India I.I.C Indian Institute of TechnologyRoorkee 450012India Department of Chemistry Nassu Community CollegeGarden CityNYUSA

Zinc substituted manganese ferrite;Mn1- xnFeO for x = 0.1,0.2,0.3,0.4 & 0.5 were synthesized by conventional solid state reaction route and studied by means of X-ray diffraction, Mossbauer and magnetization *** unit cell parameter ’a’ decreases linearly with zinc concentration,due to smaller ionic radius of *** structural parameters such as theoretical lattice parameter,X-ray density,ionic radii,bond length,oxygen positional parameter,jump length

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Application of Artificial Intelligence for Efficient Development,Manufacturing and Implementation of Steel

Application of Artificial Intelligence for Efficient Develop...

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第十三届中国钢铁年会

作者： Hedstr?m Peter Mu Wangzhong Serrano Ismael García Kolli Satish Chowdary kailash Holmstr?m Claes KTH Royal Institute of Technology Department of Materials Science and Engineering

Data-driven methods,based on artificial intelligence(AI) or machine learning,contribute to a paradigmatic shift in materials science and engineering at present The conventional approach of materials development manufacturing and implementation,requires extensive experimental testing,and by replacing certain parts,or ultimately most parts,to AI-based methods this process can be made significantly more *** will present the underlying methodology which has been developed over the past years in collaboration between Materials Science at KTH Royal Institute of Technology and the company Ferritico *** will give application examples and an outlook on AI for *** work aims at supporting the implementation of the concept Steel Industry 4.0.

关键词： artificial intelligence machine learning manufacturing material design steels industry 4.0

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豚鼠脊髓损伤模型早期骨代谢指标的改变

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复旦学报（医学版） 2002年第5期29卷 352-353页

作者：凯拉什李泽兵复旦大学附属中山医院康复科上海200032

目的　观察豚鼠脊髓损伤 (SCI)模型的骨代谢生化指标 ,骨密度骨量和形态学变化。方法　将 2 3只豚鼠分为实验组 (A组 )及正常对照组 (B组 ) ,3～ 4月龄 ,体重 4 2 7～ 710 g。A组人工脊髓损伤后 2周测BMD、血清BALP和尿Pyd/Cr,Ca/Cr,并... 详细信息

目的　观察豚鼠脊髓损伤 (SCI)模型的骨代谢生化指标 ,骨密度骨量和形态学变化。方法　将 2 3只豚鼠分为实验组 (A组 )及正常对照组 (B组 ) ,3～ 4月龄 ,体重 4 2 7～ 710 g。A组人工脊髓损伤后 2周测BMD、血清BALP和尿Pyd/Cr,Ca/Cr,并制备胫骨骺病理切片及测胫骨干重、灰重 ,采用SPSS软件作秩和检验和t检验 (P 0 .0 5 )无明显变化。结论　脊髓损伤后早期骨吸收明显增加。

关键词：脊髓损伤骨代谢指标骨吸收废用性骨质疏松

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The Golden Spice Turmeric (<i>Curcuma longa</i>) and Its Feasible Benefits in Prospering Human Health—A Review

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American Journal of Plant Sciences 2021年第3期12卷 455-475页

作者： Jyoti Prakash Sahoo Laxmipreeya Behera Jannila Praveena Shraddha Sawant Ankita Mishra Siddhartha Shankar Sharma Lipi Ghosh Ambika Prasad Mishra Asit Ranjan Sahoo Pranay Pradhan Subhasmita Sahu Ankit Moharana kailash Chandra Samal Department of Agricultural Biotechnology Odisha University of Agriculture and Technology Bhubaneswar India Department of Fruit Science and Horticulture Technology Odisha University of Agriculture and Technology Bhubaneswar India Department of Plant Pathology Odisha University of Agriculture and Technology Bhubaneswar India Department of Plant Breeding and Genetics Odisha University of Agriculture and Technology Bhubaneswar India Department of Genetics and Plant Breeding and Seed Science & Technology Centurion University of Technology and Management Parlakhemundi India School of Development Studies Tata Institute of Social Sciences Mumbai India Department of Soil Science and Agricultural Chemistry Faculty of Agriculture Sri Sri University Cuttack India Department of Nematology Odisha University of Agriculture and Technology Bhubaneswar India Department of Floriculture and Landscaping Odisha University of Agriculture and Technology Bhubaneswar India Department of Seed Science and Technology Odisha University of Agriculture and Technology Bhubaneswar India

From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. Curcuma longa (Turmeric) is an Indian rhizomatous medicinal herb from the Zingiberaceae family that is common and widely available across the globe. The components of Turmeric are curcumin, demethoxycurcumin and bisdemethoxycurcumin and these are collectively known as curcuminoids. Curcumin, the active ingredient of Turmeric is generally investigated by the scientific community for its wide range of antioxidant activity, anti-Inflammatory properties and anti-cancer activity, anti-metabolic syndrome activities, neuroprotective activity, antimicrobial effects, anti-arthritis effects, anti-viral effects, anti-asthma and anti-diabetic effects, anti-obesity, cardio and liver toxicity protection activity, anti-depression and anxiety activities. Turmeric has been widely used as a typical household treatment for cough, sore throat, respiratory ailments and could be an effective immunity booster against SARS-CoV-2 therapy during the ongoing pandemic situation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, turmeric and its constituents have the potential for the development of modern medicine for the treatment of various diseases. So in this review, we describe the various metabolic roles of curcumin and activities for the benefit of human health.

关键词： Turmeric Plant Extracts Curcumin Medicinal Properties SARS-CoV-2 Immunity

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Gas Sensing Mechanism of Metal Oxide Doped PANi Composites

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材料科学与工程（中英文B版） 2013年第5期3卷 310-313页

作者： kailash R. Nemade Sandeep A. Waghuley Department of Physics Sant Gadge Baba Amravati University Amravati 444 602 India

Novel hybrid gas-sensitive materials were made-up by means of metal oxide (MOX) doped organopolymers. The hybrid gas-sensitive materials were prepared by varying molar concentration of Bi2O3 and Y2O3 MOX in conducting polymer PANi. The hybrid materials have tested upon exposure to LPG gas. The sensitivity of both composites materials was studied at room temperature. The gas sensing mechanism explained on the basis of chemisorbed/adsorbed oxygen. The materials were characterized by FTIR and SEM analysis.

关键词：聚苯胺复合材料氧化物掺杂金属氧化物机制混合气体气敏敏感材料导电聚合物

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Clinical approach to diarrheal disorders in allogeneic hematopoietic stem cell transplant recipients

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World Journal of Hematology 2016年第1期5卷 23-30页

作者： Shadi Hamdeh Abd Almonem M Abdelrahman Osama Elsallabi Ranjan Pathak Smith Giri kailash Mosalpuria Vijaya Raj Bhatt Department of Internal Medicine Creighton University School of Medicine Department of Medicine Reading Health System Reading Department of Medicine University of Tennessee Health Science Center Department of Internal Medicine Division of Hematology-Oncology University of Nebraska Medical Center

Diarrhea is a common complication of allogeneic hematopoietic stem cell transplant(HSCT), with an average incidence of approximately 40%-50%. A wide variety of etiologies can contribute to diarrhea in HSCT patients, including medication-induced mucosal inflammation, infections, graft-vs-host disease and cord colitis syndrome in umbilical cord blood transplant. Clinical manifestations can vary from isolated diarrheal episodes, to other organ involvement including pneumonia or myocarditis, and rarely multiorgan failure. The approach for diagnosis of diarrheal disorders in HSCT patients depends on the most likely cause. Given the risk of life-threatening conditions, the development of clinically significant diarrhea requires prompt evaluation, supportive care and specific therapy, as indicated. Serious metabolic and nutritional disturbances can happen in HSCT patients, and may even lead to mortality. In this review, we aim to provide a practical approach to diagnosis and management of diarrhea in the post-transplant period.

关键词： Diarrhea Medication-induced diarrhea Allogeneic hematopoietic stem cell transplant Enteric infection Graft-vs-host disease

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Efficacy and Safety of Tinefcon^® Tablets in Subjects with Plaque Psoriasis: An Open Label, Non-Comparative, Multicenter, Phase IV Trial

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Journal of Cosmetics, Dermatological Sciences and Applications 2016年第2期6卷 55-66页

作者： Somesh Sharma kailash Bhatia Meetesh Agarwal Sandesh Gupta Leelavathi Budamakuntla Sudhakar Grandhi Vinod Titarmare Sushil Pande Ranjan Rawal Aruna Samarth Rizwan Haq Vikrant Saoji D. V. S. Pratap L. M. Kansal D. G. Saple Shatrughan Sahay Parag Kalyani Puneet Goyal Sharmila Patil A. J. Kanwar Bhavesh Swarnakar Sujay Kulkarni Abhijeet Morde Hitesh Khandagale Yogesh Dound Nitin Jadhav Sanjeev Hegde Murlidhara Padigaru Ashish C. Suthar Piramal Enterprises Limited Mumbai India Bhatia Skin Center Bima Nagar Indore India Agrawal Path LAB Vijaynagar Indore India Skin & Laser Center Krishna Nagar New Delhi India Diabetes and Shirdi Skin Care Centre Karnataka India Medipoint Hospitals Pvt. Ltd. Pentagon Research Pvt. Ltd. Pune India Skin Care Clinic Nagpur India NKP Salve Institute and Lata Mangeshkar Hospital Nagpur India Department of Dermatology Sheth VS General Hospital Ahmedabad India Sai Skin Care Clinic Hyderabad India Radiance Skin Care Clinic Nagpur India Dr. Vikrant Saoji’s Clinic Ramdaspeth Nagpur India Durgabai Deshmukh Hospital & Research Center Hyderabad India Kansal Cosmetic & Skin Care Clinic Jaipur India Dr. Saple’s Clinic Dadar (East) Mumbai India Sri Skin Care & Laser Clinic Lucknow UP India Ruby Hall Clinic Pune India Renova Skin & Laser Clinic Sector-9 Mansarovar Jaipur India Dr. D. Y. Patil Medical College and Hospital Nerul Navi Mumbai India Department of Dermatology Venerology & Leprology Postgraduate Institute of Medical Education and Research Chandigarh India Swarnakar Superspeciality Centre Indore India Clinical Research and Development Piramal Enterprises Limited Mumbai India

Importance: This post-marketing surveillance study was conducted to evaluate real-world information about the efficacy and safety of oral Tinefcon? tablets (Sphaeranthus indicus based) in plaque psoriasis patients. Materials and Methods: Patients aged at least 18 years and older with clinical diagnosis of plaque psoriasis, were enrolled in this open label, non-comparative, multicenter trial. All eligible subjects received four 700 mg Tinefcon? tablets/day for 12 weeks. The primary outcome measure was percent change in Psoriasis Area Severity Index (PASI) score from baseline to week 12. The secondary outcome measures were Physician Global Assessment (PGA), Nail Psoriasis Severity Index (NAPSI), Psoriatic Arthritis Evaluation and Gene Expression Profiling and Immunohistochemistry. Results: After completion of Tinefcon? treatment at 12 weeks, more than half of subjects (52%) achieved PASI 50 response;PASI 75 response was attained in 68 (23%) subjects and PASI 90 response in 22 (7%) subjects. Five subjects with severe psoriasis achieved PASI 90 without receiving any concomitant medication. Reduction in severity as assessed by PGA was observed in more than half of patients with moderate disease. Histopathological evaluation revealed that epidermal thickness was considerably reduced in 66% of subjects. The expression of inflammatory marker S100A9 protein was(meaningfully reduced in 60% patients with non-significant reduction of Keratin 10 protein expression. Gene expression analysis showed increase down regulation of SERPINB4;PI3 and KRT16 genes after a 12-week treatment period in subjects with higher PASI scores. Conclusion: Oral Tinefcon? tablets showed good efficacy and had a favorable safety profile in plaque psoriasis patients.

关键词： Psoriasis Tinefcon® Tablet Sphaeranthus indicus

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