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Journal of Forensic Science and Medicine 2024年第1期10卷 42-46页

作者： Aishwarya Bhatnagar Sugandha Arya Jyothi S Kumar Aishwarya Arya kailash Chandra Morya Sudhir Baroopal Department of Oral Medicine and Radiology Vyas Dental College and HospitalJodhpurRajasthanIndia Department of Conservative and Endodontics Vyas Dental College and HospitalJodhpurRajasthanIndia

Background:Palatal rugae are asymmetrical elevations present on hard palate and are significant due to their uniqueness,stability and thus,aid in forensic ***:The objective is to determine palatal rugae morphology between parents and their offsprings and to determine their genetic *** and Methods:This randomized controlled cross-sectional single-blinded study was conducted on 50 families(randomly selected)who visited Vyas Dental College and Hospital.A total of 150 maxillary study models were examined and rugae were delineated and shape,size,and pattern of rugae were ***:Weak but significant correlation was seen in the nonspecific and angular type of palatal rugae between child and mother and child and father as P<*** with either or both of their parent was seen for curved,wavy,divergent,straight,horseshoe,angular,and nonspecific type of rugae with the higher%of wavy pattern matching(52%with mother and 54%with father).A considerable number of samples showed high heritability of primary and secondary rugae from both parents,but more predominantly to their mothers(branched,nonspecific,and straight).Conclusion:Both environmental and genetic factors can influence the rugae ***,studies should be conducted on a larger sample size to get more significant results.

关键词： Forensic identification heredity palatal rugae uniqueness

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Signal integration in the （m）TORC1 growth pathway

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Frontiers in Biology 2018年第4期13卷 237-262页

作者： kailash.ramlaul Christopher H. S. Aylett Section of Structural Biology Department of Medicine Imperial College London SW7 2AZ UK

BACKGROUND： The protein kinase Target Of Rapamycin （TOR） is a nexus for the regulation of eukaryotic cell growth. TOR assembles into one of two distinct signalling complexes, TOR complex 1 （TORC1） and TORC2 （mTORC1/2 in mammals）, with a set of largely non-overlapping protein partners. （m）TORC 1 activation occurs in response to a series of stimuli relevant to cell growth, including nutrient availability, growth factor signals and stress, and regulates much of the cell＇s biosynthetic activity, from proteins to lipids, and recycling through autophagy, mTORC1 regulation is of great therapeutic significance, since in humans many of these signalling complexes, alongside subunits of mTORC1 itself, are implicated in a wide variety of pathophysiologies, including multiple types of cancer, neurological disorders, neurodegenerative diseases and metabolic disorders including diabetes. METHODOLOGY： Recent years have seen numerous structures determined of （m）TOR, which have provided mechanistic insight into （m）TORC 1 activation in particular, however the integration of cellular signals occurs upstream of the kinase and remains incompletely understood. Here we have collected and analysed in detail as many as possible of the molecular and structural studies which have shed light on （m）TORC 1 repression, activation and signal integration. CONCLUSIONS： A molecular understanding of this signal integration pathway is required to understand how （m）TORC1 activation is reconciled with the many diverse and contradictory stimuli affecting cell growth. We discuss the current level of molecular understanding of the upstream components of the （m）TORC1 signalling pathway, recent progress on this key biochemical frontier, and the future studies necessary to establish a mechanistic understanding of this master-switch for eukaryotic cell growth.

关键词： mTORC 1 nutrient sensing GATOR complex TSC complex Rag GTPases Rheb

Fault Management Cyber-Physical Systems in Virtual Storage Model

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Computers, Materials & Continua 2022年第2期70卷 3781-3801页

作者： kailash Kumar Ahmad Abdullah Aljabr College of Computing and Informatics Saudi Electronic UniversityRiyadh11673Kingdom of Saudi Arabia

On average,every two years,the amount of data existing globally *** development will be affected and improved by Cyber-Physical Systems(CPS).The number of problems remained even though developments helped Information Technology experts extract better value from their storage *** of poor interoperability between different vendors and devices,countless numbers of Storage Area Networks were *** setup used for data storage includes a complex and rigid arrangement of routers,switch,hosts/servers,storage *** have evaluated the performance of routing protocol Transmission Control Protocol(TCP)and Fibre Channel Protocol(FCP)under different network scenario by Network Simulator(NS)-3 *** simulated the Node Failure and NetworkCongestion issuewithDoS attacks and a counter effect on the Packet Distribution Ratio and End-to-End Delay efficiency metrics with different nodes and speed of node *** study is performed for the Simple NetworkManagement Protocol(SNMP)on FCP *** results proved that the proposed method isolates the malicious and congested nodes and improves the Network’s performance.

关键词： CPS data storage virtualization TCP FCP

Fuzzy Control Based Resource Scheduling in IoT Edge Computing

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Computers, Materials & Continua 2022年第6期71卷 4855-4870页

作者： Samah Alhazmi kailash Kumar Soha Alhelaly College of Computing and Informatics Saudi Electronic UniversityRiyadhKingdom of Saudi Arabia

Edge Computing is a new technology in Internet of Things(IoT)paradigm that allows sensitive data to be sent to disperse devices quickly and without *** is identical to Fog,except its positioning in the end devices is much nearer to end-users,making it process and respond to clients in less ***,it aids sensor networks,real-time streaming apps,and the IoT,all of which require high-speed and dependable internet *** such an IoT system,Resource Scheduling Process(RSP)seems to be one of the most important *** paper presents a RSP for Edge Computing(EC).The resource characteristics are first standardized and ***,for task scheduling,a Fuzzy Control based Edge Resource Scheduling(FCERS)is *** results demonstrate that this technique enhances resource scheduling efficiency in EC and Quality of Service(QoS).The experimental study revealed that the suggested FCERS method in this work converges quicker than the other *** method reduces the total computing cost,execution time,and energy consumption on average compared to the *** ES allocates higher processing resources to each user in case of limited availability of MDs;this results in improved task execution time and a reduced total task computation ***,the proposed FCERS m 1m may more efficiently fetch user requests to suitable resource categories,increasing user requirements.

关键词： IoT edge computing resource scheduling task scheduling fuzzy control

Potential of plant growth-promoting rhizobacteria-plant interactions in mitigating salt stress for sustainable agriculture:A review

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Pedosphere 2022年第2期32卷 223-245页

作者： kailash Chand KUMAWAT Sharon NAGPAL Poonam SHARMA Department of Microbiology Punjab Agricultural UniversityLudhianaPunjab 141004India Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhianaPunjab 141004India

Soil salinization affecting different crops is one of the serious threats to global food *** salinity affects 20%and 33%of the total cultivated and irrigated agricultural lands,respectively,and has been reported to caused a global crop production loss of 27.3 billion *** conventional approaches,such as using salt-tolerant varieties,saline soil scrapping,flushing,leaching,and adding supplements (e.g.,gypsum and lime),often fail to alleviate *** this context,developing diverse arrays of microbes enhancing crop productivity under saline soil conditions without harming soil health is *** advanced omics approaches have enabled gaining new insights into the structure and metabolic functions of plant-associated beneficial *** genera of salt-tolerating rhizobacteria ameliorating biotic and abiotic stresses have been isolated from different legumes,cereals,vegetables,and oil seeds under extreme alkaline and saline soil *** progress in rhizosphere microbiome research has revived the belief that plants may be more benefited from their association with interacting diverse microbial communities as compared with individual members in a *** the last decade,several salt-tolerating plant growth-promoting rhizobacteria (PGPR) that improve crop production under salt stress have been exploited for the reclamation of saline *** review highlights that the interaction of salt-tolerating microbes with plants improves crop productivity under salinity stress along with potential salt tolerance mechanisms involved and will open new avenues for capitalizing on cultivable diverse microbial communities to strengthen plant salt tolerance and,thus,to refine agricultural practices and production under saline conditions.

关键词： antagonistic activities antioxidant enzymes benefical microbes osmotolerance rhizosphere microbiome salt tolerance sustainable agriculture

BERT for Conversational Question Answering Systems Using Semantic Similarity Estimation

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Computers, Materials & Continua 2022年第3期70卷 4763-4780页

作者： Abdulaziz Al-Besher kailash Kumar M.Sangeetha Tinashe Butsa College of Computing and Informatics Saudi Electronic UniversityRiyadh11673Kingdom of Saudi Arabia Department of Information Technology SRMInstitute of Science and TechnologyKattankulathurIndia Department of Information Technology Harare Institute of TechnologyBelvedereHarare

Most of the questions from users lack the context needed to thoroughly understand the problemat hand,thus making the questions impossible to *** Similarity Estimation is based on relating user’s questions to the context from previous Conversational Search Systems(CSS)to provide answers without requesting the user’s *** imposes constraints on the time needed to produce an answer for the *** proposed model enables the use of contextual data associated with previous Conversational Searches(CS).While receiving a question in a new conversational search,the model determines the question that refers tomore *** then infers past contextual data related to the given question and predicts an answer based on the context inferred without engaging in multi-turn interactions or requesting additional data from the user for *** model shows the ability to use the limited information in user queries for best context inferences based on Closed-Domain-based CS and Bidirectional Encoder Representations from Transformers for textual representations.

关键词： Semantic similarity estimation conversational search multi-turn interactions context inference BERT user intent

Co-inoculation of indigenous Pseudomonas oryzihabitans and Bradyrhizobium *** the growth,symbiotic efficacy,nutrient acquisition,and grain yield of soybean

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Pedosphere 2022年第3期32卷 438-451页

作者： kailash Chand KUMAWAT Inderjeet SINGH Sharon NAGPAL Poonam SHARMA Rajeev Kumar GUPTA Asmita SIRARI Department of Microbiology Punjab Agricultural UniversityLudhiana 141004(India) Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhiana 141004(India) Department of Soil Science Punjab Agricultural UniversityLudhiana 141004(India)

Soil microbes play a vital role in improving plant growth,crop productivity,and soil health through solubilization of essential *** investigation was conducted to access the efficacy of Bradyrhizobium ***-3 and the indigenous phosphate-solubilizing Pseudomonas oryzihabitans LSE-3 in improving the symbiosis,nutrient accumulation,and yield of *** isolate LSE-3,selected on the basis of phosphate solubilization,was screened for beneficial traits,antagonistic activities,and *** levels of indole acetic acid production(50.34±2.35μg mL^(-1)),phosphate solubilization(184.4±7.4 mg L^(-1)),biofilm formation(optical density at 560 mm,1.3896±0.04),siderophore production(121.46±1.61μg mL^(-1)),and 1-aminocyclopropane-1-carboxylate deaminase activity(0.51±0.07 mmolα-ketobutyrateμg^(-1) protein h^(-1))were significantly higher with the dual inoculants(LSBR-3 and LSE-3)than with the single inoculant *** plant growth-promoting traits of single and dual inoculants were evaluated for the synergistic effects on soybean under field *** plots treated with LSBR-3+LSE-3 exhibited improvement in seed germination,plant height,plant biomass,and chlorophyll content compared with the uninoculated *** inoculant treatments resulted in significantly higher symbiotic efficacy evidenced by increased nodulation(40.0±0.75 plant^(-1)),nodule biomass(188.52±6.29 mg plant^(-1)),and leghemoglobin content(11.02±0.83 mg g^(-1) fresh nodule),and significantly increased activities of phosphatase(75.16±3.17 and 58.77±6.08μg p-nitrophenol g^(-1) h^(-1) for alkaline and acid phosphatase,respectively)and dehydrogenase(32.66±1.92μg triphenylformazan g^(-1) h^(-1))compared with the *** inoculation with LSBR-3 and LSE-3 enhanced the uptake of macro-and micronutrients,reduced Na content in shoots,and resulted in 10.85%higher grain yield and ***$96.80 ha^(-1) higher profit compared with the *** is the first report on the effectiv

关键词： bacteria biofilm formation phosphate solubilization plant growth-promoting trait sustainable agriculture zinc solubilization

An Acoustic Analysis of Fluctuations for Inter-and Intra-Speaker Variability in Speech Sounds

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Journal of Forensic Science and Medicine 2023年第1期9卷 38-43页

作者： Jasdeep Kaur kailash Chandra Juglan Kush Sharma Vishal Sharma Department of Physics School of Chemical Engineering and Physical Sciences Lovely Professional UniversityPhagwaraPunjab Data Manager School of Community Medicine and Public HealthPostgraduate Institute of Medical Education and ResearchChandigarh Institute of Forensic Science and Criminology Panjab UniversityChandigarhIndia

Background:Variation in the speech of speakers is a crucial issue for the forensic *** main reason behind incorrect speaker identification is greater intra-speaker *** the forensic state of play,a lot of research has been carried out on speaker *** inter variations and intra fluctuations in speakers for the Punjabi language is still a grey *** and Objectives:Our aim is to study acoustic analysis of fluctuations for inter and intra speaker variability in speech *** our study,we will consider Punjabi vowel with *** Statistical methods will be applied to analyze the data;firstly,the Shapiro-Wilk test will be checked for normality and then Levene’s Test to assess the equality of *** and Method:Five vowels were selected with different *** were combined to make meaningful *** these meaningful words were embedded in *** speakers participated *** are students of A.S College at Khanna in *** individuals were aged between 20-22 years with no hearing or speech *** voice samples were recorded with help of good quality microphone and by Goldwave software in the sound proof *** were introduced directly into PRAAT software by the use of a Sony microphone and with sampling rate of 44100 Hz *** Analysis has been done with help of Goldwave software in form of *** and Conclusion:Each formant shows a different value for inter variations and inter speaker fluctuations.F1 and F2 shows lesser speaker variation than the high-frequency region in F3 and F4,so we can say that in comparison with the lower part,high-frequency regions are more *** assumptions for TWO-WAY ANOVA is violated and hence,we have used the non-parametric Friedman Test and performed its Post hoc *** Posthoc analysis,we can say that F1 and F2(p>0.05)and F2 and F3(p>0.05)gave the same type of ***,from the results of these st

关键词： Forensic voice identification Friedman test intervariations and intrafluctuations Punjabi

Silicon and plant nutrition—dynamics,mechanisms of transport and role of silicon solubilizer microbiomes in sustainable agriculture:A review

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Pedosphere 2023年第4期33卷 534-555页

作者： Barkha SHARMA kailash Chand KUMAWAT Shalini TIWARI Ajay KUMAR Rouf Ahmad DAR Ummed SINGH Massimiliano CARDINALE Department of Microbiology G.B.Pant University of Agriculture&TechnologyPantnagarUttarakhand 263145(India) Department of Industrial Microbiology Jacob Institute of Biotechnology and BioengineeringSam Higginbottom University of AgricultureTechnology and Sciences(SHUATS)PrayagrajUttar Pradesh 211007(India) College of Agriculture Agriculture UniversityJodhpurBaytuBarmerRajasthan 344034(India) Department of Biological and Environmental Sciences and Technologies-DiSTeBA University of SalentoSP6 Lecce-MonteroniLecce I-73100(Italy)

Silicon(Si)is the second most abundant element in the Earth’s crust and has numerous roles in both soils and plants,although it is inaccessible to plants in its native state(insoluble silicate minerals).This inaccessibility can lead to insufficiency,which induces anomalies in plant growth and ***,Si alleviates various biotic and abiotic stresses in plants by enhancing tolerance mechanisms at different stages of uptake/deposition as a monosilicic *** utilization of conventional Si fertilizers to boost agricultural productivity in an attempt to meet the world’s ever-increasing food demand may result in surface and groundwater pollution,waterway eutrophication,soil fertility depletion,and accumulation of hazardous elements such as arsenic in *** addressing the drawbacks of chemical fertilizers,this review emphasizes an environmentally friendly alternative,namely,Si-solubilizing microorganisms(SSMs),as bioinoculants to liberate soluble Si and thus making it available to plants.A deep understanding of recent advances in the functional diversity,colonization patterns,modes of action,role in biogeochemical cycling,and plant stress tolerance of SSMs and their implementation in Si-based agrowaste management through the fabrication of nanoparticles,could help to establish a reliable tool for economically and environmentally sustainable *** this perspective,in this review,we comprehensively summarize the latest methodologies for the isolation,screening,and characterization of SSMs and Si solubilization mechanisms,including ligands(divalent cations),acids(inorganic and organic),alkali(nucleophilic attack),extracellular polysaccharides,and factors affecting them,as well as Si-mediated regulation of gene expression involved in Si uptake,transportation,and *** have critically revised the role of SSMs according to the current *** contributions of SSMs to biofertilization are still being explored;hence,we also

关键词： agrowaste management biofertilizer bioinoculant monosilicic acid plant stress silicon-solubilizing microorganism