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The Chinese-German Journal of Clinical Oncology 2007年第5期6卷 442-443页

作者： kaijian lei hua luo yuming lia shengqun ying Department of Oncology The No. 2 People＇s Hospital of Yibin Yibin 644000 China

Objective: To evaluate the therapeutic efficacy of injecting recombinant mutant human tumor necrosis factor (rmhTNF) into pericardial cavity of carcinoma patients with malignant pericardial effusion. Methods: In 20 cases of malignant pericardial effusion, the intrapericardial catheter was inserted into pericardial cavity, and then rmhTNF of 1.5 × 107 U was infused. The infusion was repeated every 5-7 days with the total 4-6 times. If the effusion disappeared, rmhTNF was then used 2 more times and then the intrapericardial catheter was pulled out. Results: Of 20 patients, 14 were complete response (CR), 4 were partial response (PR) and 2 no change (NC). The disappearance of effusion in 6 cases lasted for more than 6 months. Conclusion: Injecting rmhTNF into pericardial cavity may be a better way to control malignant pericardial effusion and has mild side effects.

关键词： pericardial effusion recombinant mutant human tumor necrosis factor (rmhTNF) intrapericardial catheter

LncRNA CCRR maintains Ca^(2+)homeostasis against myocardial infarction through the FTO-SERCA2a pathway

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Science China(Life Sciences) 2024年第8期67卷 1601-1619页

作者： hua Yang Lina Xuan Shengjie Wang Huishan luo Xiaomeng Duan Jianjun Guo Shijia Cui Jieru Xin Junwei Hao Xiufang Li Jun Chen Feihan Sun Xiaolin Hu Siyun Li ying Zhang lei Jiao Baofeng Yang Lihua Sun Department of Pharmacology Harbin Medical University(State Key Laboratory of Frigid Zone Cardiovascular Diseasethe State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of EducationJoint International Research Laboratory of Cardiovascular Medicine ResearchMinistry of EducationChina)College of PharmacyHarbin Medical UniversityHarbin 150081China

Cardiac conduction regulatory RNA(CCRR)has been documented as an antiarrhythmic lncRNA in our earlier *** study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca^(2+)homeostasis in myocardial infarction(MI).Overexpression of CCRR via AAV9-mediated delivery not only partially reversed ischemia-induced contractile dysfunction but also alleviated abnormal Ca^(2+)homeostasis and reduced the heightened methylation level of SERCA2a following *** effects were also observed in CCRR overexpressing transgenic mice.A conserved sequence domain of CCRR mimicked the protective function observed with the full ***,silencing CCRR in healthy mice led to intracellular Ca^(2+)overloading of *** increased SERCA2a protein stability by upregulating FTO *** direct interaction between CCRR and FTO protein was characterized by RNA-binding protein immunoprecipitation(RIP)analysis and RNA pulldown *** of NFATc3 was identified as an upstream mechanism responsible for CCRR downregulation in *** study demonstrates that CCRR is a protective lncRNA that acts by maintaining the function of FTO,thereby reducing the m^(6)A RNA methylation level of SERCA2a,ultimately preserving calcium homeostasis for myocardial contractile function in ***,CCRR may be considered a promising therapeutic strategy with a beneficial role in cardiac pathology.

关键词： CCRR calcium homeostasis FTO myocardial infarction SERCA2a

低氮胁迫下不同皮燕麦品种早期的响应研究及耐低氮性综合评价

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草业学报 2024年第2期33卷 164-184页

作者：罗颖李聪王沛田莉华汪辉周青平雷映霞西南民族大学四川若尔盖高寒湿地生态系统国家野外科学观测研究站四川成都610041

为探讨在低氮胁迫下皮燕麦早期的形态、生理响应以及筛选出耐低氮皮燕麦品种,本研究以18种不同皮燕麦品种为材料,采用水培法,设置全氮(4 mmol·L^(-1),CK)和1/10 N(0.4 mmol·L^(-1),LN)两个氮浓度水平,在处理21 d后,对低氮胁迫下皮燕麦... 详细信息

为探讨在低氮胁迫下皮燕麦早期的形态、生理响应以及筛选出耐低氮皮燕麦品种,本研究以18种不同皮燕麦品种为材料,采用水培法,设置全氮(4 mmol·L^(-1),CK)和1/10 N(0.4 mmol·L^(-1),LN)两个氮浓度水平,在处理21 d后,对低氮胁迫下皮燕麦的7项形态指标和14项生理指标进行测定和分析;通过相关性分析、主成分降维分析提取影响因子,结合隶属函数分析和聚类分析进行综合评价。结果表明:1)低氮胁迫下不同皮燕麦品种早期的株高、地上部生物量、硝态氮含量、硝酸还原酶活性、谷氨酰胺合成酶活性、谷氨酸脱氢酶活性、可溶性糖含量与可溶性蛋白含量均呈下降趋势;谷氨酸合成酶活性、丙二醛含量、活性氧含量均呈上升趋势;根长、地下部生物量、根冠比变化趋势不尽相同;2)21项生理指标中有12对指标呈极显著相关性,根冠比(RSR)与地下部干重(RDW)呈极显著正相关关系,谷氨酰胺合成酶(GS)与可溶性蛋白(SP)呈极显著负相关;3)低氮胁迫下皮燕麦的生物量、氮代谢因子、光合因子、抗氧化因子、渗透调节因子可作为评价耐低氮性的重要指标;4)18份皮燕麦可划分为3大类,青海甜燕麦和青海444这两份品种耐低氮能力较强,为耐低氮型品种,甜燕2号和青燕2号这两份皮燕麦品种的耐低氮能力较弱,为氮敏感型品种,其余材料耐低氮性居中。

关键词：皮燕麦耐低氮性生理响应综合评价

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The Squeezing Effect in a Mesoscopic RLC Circuit

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Communications in Theoretical Physics 2002年第5期38卷 611-614页

作者： JI ying-hua luo Hai-Mei lei Min-Sheng Department of Physics Jiangxi Normal University Nanchang 330027 China Department of Physics Jiangxi Normal University Nanchang 330027 China Department of Physics Jiangxi Normal University Nanchang 330027 China

Using the path integral method we derive quantum wave function and quantum fluctuations of charge andcurrent in the mesoscopic RLC circuit. We find that the quantum fluctuation of charge decreases with time, oppositely,the quantum fluctuation of current increases with time monotonously. Therefore there is a squeezing effect in the *** some more charge devices are used in the mesoscopic-damped circuit, the quantum noise can be reduced. We also findthat uncertainty relation of charge and current periodically varies with the period π/2 in the under-damped case.

关键词： dissipative mesoscopic RLC circuit, quantum fluctuation, squeezing effect

硫酸化焙烧——水浸法从镍精矿中同步提取金属及矿相转化

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Transactions of Nonferrous Metals Society of China 2024年第3期34卷 1003-1015页

作者：杜守明牟文宁李丽莹石树正陈欢欢雷雪飞郭瑞罗绍华王乐东北大学材料科学与工程学院沈阳110819 东北大学秦皇岛分校资源与材料学院秦皇岛066004 东北大学秦皇岛分校资源与材料学院河北省电介质与电解质功能材料重点实验室秦皇岛066004 秦皇岛市资源清洁转化与高效利用重点实验室秦皇岛066004 华北理工大学冶金与能源学院唐山063210

提出低温NH_(4)HSO_(4)焙烧—水浸工艺从金川镍精矿中同步提取Ni、Cu和Co,并系统研究硫酸化焙烧和水浸出过程中一些因素对金属提取的影响。结果表明,在优化的焙烧和水浸条件下,95.7%Ni、98.9%Cu和96.8%Co被提取。利用TG-DTA、XRD、SEM和... 详细信息

提出低温NH_(4)HSO_(4)焙烧—水浸工艺从金川镍精矿中同步提取Ni、Cu和Co,并系统研究硫酸化焙烧和水浸出过程中一些因素对金属提取的影响。结果表明,在优化的焙烧和水浸条件下,95.7%Ni、98.9%Cu和96.8%Co被提取。利用TG-DTA、XRD、SEM和EDS等手段分析矿相的转化机理,在NH_(4)HSO_(4)及其分解的SO_(3)和NH3的硫酸化反应下,有价金属被转化为水溶性金属—铵配合物从而得到有效的提取。通过提高浸出温度使铁离子与铵离子结合形成NH_(4)[Fe_(3)(SO_(4))_(2)(OH)_(6)]沉淀可除去浸出液中的杂质铁。在焙烧过程中收集的挥发物为(NH_(4))_(2)SO_(4)和(NH_(4))_(2)SO_(3),可用作硫酸化焙烧的试剂。

关键词：镍精矿 NH_(4)HSO_(4)焙烧同步提取水浸出矿相转化

Predictive risk scales for development of pressure ulcers in pediatric patients admitted to general ward and intensive care unit

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World Journal of Clinical Cases 2021年第35期9卷 10956-10968页

作者： Wen-Jun luo Xue-Zhen Zhou Jia-ying lei ying Xu Rui-hua huang Sun Yat-sen Memorial Hospital Guangzhou 510235Guangdong ProvinceChina

BACKGROUND More than ten special scales are available to predict the risk of pressure ulcers in ***,the performances of those scales have not yet been compared in *** To compare the Waterlow,Braden Q,and Glamorgan scales,and identify more suitable pressure ulcer evaluation scale for the pediatric intensive care unit(PICU).METHODS Trained nurses used the Waterlow,Braden Q,and Glamorgan scales to assess pediatric patients at Sun Yat-sen Memorial Hospital(China)within 24 h of admission from May 2017 to December 2020 in two *** examination was carried out to identify pressure ulcers every 3 d for 3 *** The incidence of pressure ulcers was 3/28(10.7%)in the PICU and 5/314(1.6%)in the general pediatric *** children in the general ward,the Waterlow,Braden Q,and Glamorgan scales had comparable area under the operating characteristic curve(AUC)of 0.870,0.924,and 0.923,respectively,and optimal cut-off values of 14,14,and 29 *** PICU,the Waterlow,Braden Q,and Glamorgan scales had slightly lower AUC of 0.833,0.733,and 0.800,respectively,and optimal cut-off values of 13,16,and 27 *** Q demonstrated a satisfactory specificity,and during the second stage of the study for PICU patients,the AUC of the Braden Q scale was 0.810,with an optimal cut-off value of 18.35 *** The Waterlow,Braden Q,and Glamorgan scales have comparable performance while the Braden Q scale demonstrates a better specificity and can be successfully used by pediatric nurses to identify patients at high risk of pressure ulcers in PICU.

关键词： Pressure ulcer Risk assessment Children Intensive care unit

Re-epithelialization resulted from prostate basal cells in canine prostatic urethra may represent the ideal healing method after two-micron laser resection of the prostate

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Asian Journal of Andrology 2015年第5期17卷 831-838,I0010-I0011页

作者： ying Cao Guang-Heng luo lei luo Xiu-Shu Yang Jian-Xin Hu hua Shi Ping huang Zhao-Lin Sun Shu-Jie Xia Department of Urology Shanghai First People's Hospital Shanghai Jiaotong University Shanghai 200080 China Department of Urology Guizhou Provincial People's Hospital Guiyang 550002 China Department of Pathology Guizhou Provincial People's Hospital Guiyang 550002 China

The purpose of this study is to characterize the re-epithelialization of wound healing in canine prostatic urethra and to evaluate the effect of this re-epithelialization way after two-micron laser resection of the prostate （TmLRP）. TmLRP and partial bladder neck mucosa were performed in 15 healthy adult male crossbred canines. Wound specimens were harvested at 3 days, and 1, 2, 3, and 4 weeks after operation, respectively. The histopathologic characteristics were observed by hematoxylin and eosin staining. The expression of cytokeratin 14 （CK14）, CK5, CK18, synaptophysin （Syn）, chromogranin A （CgA）, uroplakin, transforming growth factor-β1 （TGF-β1）, and TGF-β type Ⅱ receptor in prostatic urethra wound were examined by immunohistochemistry and real-time polymerase chain reaction, respectively. Van Gieson staining was performed to determine the expression of collagen fibers in prostatic urethra and bladder neck would. The results showed that the re-epithelialization of the prostatic urethra resulted from the mobilization of proliferating epithelial cells from residual prostate tissue under the wound. The proliferating cells expressed CK14, CK5, but not CK18, Syn, and CgA and re-epithelialize expressed uroplakin since 3 weeks. There were enhanced TGF-β1 and TGF-β type Ⅱ receptor expression in proliferating cells and regenerated cells, which correlated with specific phases of re-epithelialization. Compared with the re-epithelialization of the bladder neck, re-epithelialization of canine prostatic urethra was faster, and the expression of collagen fibers was relatively low. In conclusion, re-epithelialization in canine prostatic urethra resulted from prostate basal cells after TmLRP and this re-epithelialization way may represent the ideal healing method from anatomic repair to functional recovery after injury.

关键词： basal cell benign prostate hyperplasia re-epithelialization two-micron laser wound healing

Twin pregnancy with triple parathyroid adenoma:A case report and review of literature

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World Journal of Clinical Cases 2018年第11期6卷 466-471页

作者： Yu Zhang Jin-Wang Ding Ling-ying Yu Ding-Cun luo Jian-liang Sun Zhi-Kai lei Zhi-hua Wang Department of Oncology Affiliated Hangzhou First People's HospitalZhejiang University School of Medicine Department of Endocrinology Affiliated Hangzhou First People's HospitalZhejiang University School of Medicine Department of Anesthesiology Affiliated Hangzhou First People's HospitalZhejiang University School of Medicine Department of Ultrasound Branch Affiliated Hangzhou First People's HospitalZhejiang University School of Medicine Department of Obstetrics and Gynecology Affiliated Hangzhou First People's HospitalZhejiang University School of Medicine

Primary hyperparathyroidism(PHPT) is rare during pregnancy. A case of twin pregnancy with three simultaneous parathyroid adenomas at the same time has not been reported. Multiple parathyroid lesions are difficult to diagnose, as pregnant women who insist upon continuing a pregnancy are not able to undergo 99mTc-sestamibi scintigraphy, so cases of PHPT are easily unobserved and often can have serious consequences for the patient and the fetus. Therefore, we reported a case of a 28-year-old woman mid-pregnancy with twins, who had hypercalcemia and was eventually diagnosed with twin pregnancy with PHPT due to a triple parathyroid adenoma, had good pregnancy outcomes after undergoing surgery in mid-pregnancy. Twin pregnancy with PHPT due to a triple parathyroid adenoma, as presented in this case, is very rare and surgery in mid-pregnancy is demonstrated here as safe. Intraoperative parathormone monitoring was and remains key to a successful operation.

关键词： Primary hyperparathyroidism Pregnancy Triple parathyroid adenoma Surgery

髓系抑制性细胞调节炎症性疾病中Th17应答的研究进展

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中南医学科学杂志 2024年第1期52卷 142-145页

作者：贺烈娜何依芳何花熊灵铃龙伟祥罗英雷爱华南华大学衡阳医学院南华大学衡阳医学院基础医学院病原生物学研究所湖南衡阳421001

髓系抑制性细胞(MDSC)是一群具有免疫抑制功能的调节性细胞。MDSC与炎症性疾病的发生密切相关。Th17细胞属于CD4+T细胞亚群,主要通过分泌白细胞介素(IL)-17、IL-22等细胞因子在炎症性疾病中发挥重要作用。MDSC可通过表达精氨酸酶-1、IL-... 详细信息

髓系抑制性细胞(MDSC)是一群具有免疫抑制功能的调节性细胞。MDSC与炎症性疾病的发生密切相关。Th17细胞属于CD4+T细胞亚群,主要通过分泌白细胞介素(IL)-17、IL-22等细胞因子在炎症性疾病中发挥重要作用。MDSC可通过表达精氨酸酶-1、IL-1β及分泌转化生长因子-β等调控Th17活化,进而影响炎症性疾病的过程。本文综述MDSC调控Th17细胞的作用方式及其在系统性红斑狼疮、类风湿关节炎及哮喘等炎症性疾病中的作用。

关键词：髓系抑制性细胞 Th17 炎症

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16410例针灸会诊患者病例特征分析

中国中西医结合杂志 2024年第3期44卷 303-308页

作者：樊同涛樊小农李改改罗禹珩莫礼华付宗英田婧梁欣侯珣瑞李丹茂雷衍东徐明天津中医药大学第一附属医院针灸研究所天津300381 国家中医针灸临床医学研究中心天津300381 贵州医科大学附属医院针灸科贵阳550004 国家中医药管理局针刺量效关系实验室(三级) 天津300381 天津市针灸学重点实验室天津300381 贵州中医药大学第二附属医院呼吸与危重症医学科贵阳550003

目的了解贵州医科大学附属医院针灸会诊患者病例特征,为综合医院针灸学科发展提供思路和方向。方法通过医院信息管理系统收集针灸科2016年1月1日—2021年12月31日会诊记录单及患者相关信息,对会诊患者一般情况、原发疾病及所属系统进行... 详细信息

目的了解贵州医科大学附属医院针灸会诊患者病例特征,为综合医院针灸学科发展提供思路和方向。方法通过医院信息管理系统收集针灸科2016年1月1日—2021年12月31日会诊记录单及患者相关信息,对会诊患者一般情况、原发疾病及所属系统进行统计分析。结果近6年针灸科共收到16410例患者25566次会诊申请,其中接受治疗者13716例,原发病涉及19个系统505种疾病,循环系统、消化系统和神经系统排在前3位,占比69.2%,每周>1次会诊的病种仅7个。年度前10位疾病以脑血管病和急腹症为主,神经和胃肠类症状为主要会诊原因。结论针灸会诊病例覆盖面广而不均,优势病种相对较少而集中。

关键词：综合医院针灸会诊国际疾病分类法