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Synthetic and Systems Biotechnology 2024年第1期9卷 127-133页

作者： Hu Li Wei Li kaihui song Yu Liu Guiyun Zhao Yi-Ling Du Polytechnic Institute Zhejiang UniversityHangzhou310022China Department of Microbiology Zhejiang University School of MedicineHangzhou310058China College of Life Sciences Zhejiang University310058HangzhouChina

The biological signaling molecule nitric oxide(NO)has recently emerged as a metabolic precursor for the creation of microbial natural products with diversified structures and biological *** the biosynthetic gene clusters(BGCs)of these compounds,genes associated with NO production pathways have been *** this study,we employ a nitric oxide synthase(NOS)-guided genome mining strategy for the targeted discovery of NO-derived bacterial natural products and NO-utilizing *** show that a conserved NOS-containing BGC,distributed across several actinobacterial genomes,is responsible for the biosynthesis of lajollamycin,a unique nitro-tetraene-containing antibiotic whose biosynthetic mechanism remains *** a combination of in vivo and in vitro studies,we unveil the first cytochrome P450 enzyme capable of catalyzing olefin nitration in natural product *** results not only expand the current knowledge about biosynthetic nitration processes but also offer an efficient way for targeted identification of NO-utilizing metabolic pathways and novel nitrating biocatalysts.

关键词： Nitric oxide Genome mining Biosynthesis Nitration Cytochrome P450

Targeted genome mining for microbial antitumor agents acting through DNA intercalation

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Synthetic and Systems Biotechnology 2023年第3期8卷 520-526页

作者： Zhijie Zhao Guiyun Zhao Yi Chai Wei Li kaihui song Wenbin Zhao Hairong Li Miaolian Wu Zhan Zhou Yi-Ling Du The Fourth Affiliated Hospital and Department of Microbiology School of MedicineZhejiang UniversityHangzhou310058China Yong Loo Lin School of Medicine National University of SingaporeSingapore Innovation Institute for Artificial Intelligence in Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China The Fourth Affiliated Hospital School of MedicineZhejiang UniversityYiwu322000China Zhejiang Provincial Key Laboratory for Microbial Biochemistry and Metabolic Engineering Hangzhou310058China

Microbial natural products have been one of the most important sources for drug *** the current postgenomic era,sequence-driven approaches for natural product discovery are becoming increasingly ***,we develop an effective genome mining strategy for the targeted discovery of microbial metabolites with antitumor *** method employs uvrA-like genes as genetic markers,which have been identified in the biosynthetic gene clusters(BGCs)of several chemotherapeutic drugs of microbial origin and confer self-resistance to the corresponding *** systematic genomic analysis of gifted actinobacteria genera,identification of uvrA-like gene-containing BGCs,and targeted isolation of products from a BGC prioritized for metabolic analysis,we identified a new tetracycline-type DNA intercalator *** results thus provide a new genome mining strategy for the efficient discovery of antitumor agents acting through DNA intercalation.

关键词： Genome mining Microbial natural product DNA intercalator UvrA-like protein Biosynthetic gene clusters Tetracycline

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水合肼在高岭石层间插层行为的量子化学研究

化学学报 2013年第11期71卷 1553-1562页

作者：张超王幸宋西亮宋开慧钱萍尹洪宗山东农业大学化学与材料科学学院泰安271018 山东省临沂市益民实验中学临沂276025

水合肼以其碱性及吸附性受到越来越多的关注,同时它在粘土中的污染问题也越来越受到重视.本工作构建了高岭石团簇模型为Al6Si6O42H42并在B3LYP/6-31G(d,p),MP2/6-31G(d,p)//B3LYP/6-31G(d,p)和MP2/6-31++G(d,p)//B3LYP/6-31G(d,p)水平下对一水合肼以及二水合肼在高岭石层间的插层性质(如:优化构型、结构参数、结合能、电荷分布、振动光谱、静电势等)进行探究.计算表明,当一水合肼进入层间后,水分子和肼分子之间的相互作用发生了改变.即水与肼分子分别以氢键的形式插层于高岭石层间,且肼与高岭石之间的相互作用要强于肼与水之间的相互作用,同时插层位点多位于高岭石四面体层和八面体层的重叠区域内,这些都是水合肼易进入高岭石层间而难以脱去的重要因素.当二水合肼进入层间后,随着层间距的不断扩大,肼分子与高岭石铝氧层之间的相互作用仍强于肼分子与水分子间的作用.但当层间距超过1.05 nm时,水分子与肼分子之间的作用则强于肼分子与高岭石的作用,这也印证了若要将肼脱附,需将层间距增大以减弱肼分子与高岭石的作用,再用溶剂将其脱附的可行性.

关键词：水合肼高岭石插层氢键

中国省域生物质发电潜力评价及规划目标配额分析

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中国科技论坛 2016年第1期 124-129页

作者：宋开慧周景月张培栋阚士亮青岛科技大学环境与安全工程学院山东青岛266042

利用2012年宏观数据,探究中国生物质资源的省域分布及发电潜力阈值,构建生物质发电潜力指数(BPGI)指标体系,评价各省(区、市)生物质发电的发展水平及潜力,并结合省级电网碳排放强度对各省规划装机目标配额进行优化。结果表明:2012年中... 详细信息

利用2012年宏观数据,探究中国生物质资源的省域分布及发电潜力阈值,构建生物质发电潜力指数(BPGI)指标体系,评价各省(区、市)生物质发电的发展水平及潜力,并结合省级电网碳排放强度对各省规划装机目标配额进行优化。结果表明:2012年中国生物质发电潜力阈值为1.612×105MW/年;河南、黑龙江、山东位列前三,可承担中国"十三五"期间24.10%的生物质发电目标装机量;上海、北京、浙江等地可通过资金输出间接承担。为促进中国生物质发电产业的布局优化、合理开发提供参考。

关键词：生物质发电潜力指数目标配额财税上网电价

三塘湖盆地马朗凹陷上石炭统沉积岩层地球化学特征及古环境意义

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岩性油气藏 2021年第4期33卷 63-75页

作者：陈亚军荆文波宋小勇何伯斌伍宏美王睿解士建宋凯辉马强北京中科联华石油科学研究院北京100101 中国石油吐哈油田分公司勘探开发研究院新疆哈密839009 中国石油玉门油田分公司勘探开发研究院甘肃酒泉735019

为判别三塘湖盆地马朗凹陷上石炭统火山喷发间歇期沉积岩夹层的古沉积环境,以上石炭统卡拉岗组和哈尔加乌组熔岩和火山碎屑岩中沉积岩夹层样品的微量元素测试结果为基础,通过微量元素地球化学研究,运用w(U)/w(Th),w(V)/w(Cr),w(V)/w(V+N... 详细信息

为判别三塘湖盆地马朗凹陷上石炭统火山喷发间歇期沉积岩夹层的古沉积环境,以上石炭统卡拉岗组和哈尔加乌组熔岩和火山碎屑岩中沉积岩夹层样品的微量元素测试结果为基础,通过微量元素地球化学研究,运用w(U)/w(Th),w(V)/w(Cr),w(V)/w(V+Ni),w(V)/w(Sc),w(Sr)/w(Ba),w(B)/w(Ga)等判别出的指标图版,结合因素筛选分析法,用多组组合指标来判别古沉积环境,以了解沉积岩夹层沉积介质的氧化还原状态。结果表明:卡拉岗组和哈尔加乌组熔岩和火山碎屑岩中沉积岩夹层w(V)/w(Cr),w(V)/w(Sc),w(V)/w(V+Ni),w(Sr)/w(Ba)和w(B)/w(Ga)这5类比值演化趋势较稳定,是古沉积环境判别较佳的组合指标;卡拉岗组沉积岩夹层形成于水、陆过渡相及陆上氧化环境介质中,哈尔加乌组沉积岩夹层主要形成于水下还原环境介质中,少量形成于水、陆过渡复杂环境介质中。该地球化学方法具有普适性,可用于不同地质时代、不同区域地质条件下火山喷发间歇期沉积岩层古沉积环境的研究中。

关键词：微量元素地球化学古沉积环境卡拉岗组哈尔加乌组马朗凹陷

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： song Jiang Congwen Zhu Ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao Yu Yuhang song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

Effect of Initial Oxide Film on the Formation and Performance of Plasma Electrolytic Oxidation Coating on 7075 Aluminum Alloy

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Acta Metallurgica Sinica(English Letters) 2022年第9期35卷 1559-1571页

作者： Mingyu Zhu Yingwei song kaihui Dong Dayong Shan En-Hou Han Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China

In the early stage of plasma electrolytic oxidation(PEO),the quick formation of the initial oxide film on the surface of the aluminum substrate is necessary for the subsequent discharge spark ***,the compactness of the initial oxide film greatly affects the quality of the PEO coating,but the related mechanisms are not investigated in *** this paper,the status of the initial oxide film was adjusted by adding the(NaPO)into the based electrolyte,and then the effect of initial oxide film on the formation of the PEO coating was *** and chemical composition were analyzed by scanning electron microscope,transmission electron microscopy and X-ray photoelectron *** compactness of the initial oxide film was characterized by Mott-Schottky *** corrosion resistance was measured by electrochemical impedance *** results show that the addition of(NaPO)can promote the co-deposition of phosphide compound into the initial oxide film and improve the film compactness,which is beneficial for the more uniform spark discharge in the later *** a result,the addition of(NaPO)is helpful to obtain PEO coating with better performance.

关键词： Aluminum alloys Plasma electrolytic oxidation Initial oxide film Growth process Spark discharge Compactness

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run song Shiyi Yin Jiannan Wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis