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Exploring the material basis and mechanism of Moringa oleifera in alleviating slow transit constipation based on network pharmacology and animal models

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Food Science and Human Wellness 2024年

作者： Sijin Li Xiaoyu Gao kaifeng guo Shuangfeng Liu Weiqian Yang Yan Zhao Jun Sheng Zhongbin Bai Yang Tian College of Food Science and Technology Yunnan Agricultural University Yunnan Key Laboratory of Precision Nutrition and Personalized Food Manufacturing Yunnan Agricultural University Department of Science and Technology Yunnan Agricultural University College of Veterinary Medicine Yunnan Agricultural University Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources Ministry of Education Yunnan Agricultural University

Moringa oleifera(M. oleifera) have laxative effects， but their active compositions and mechanisms are not very clear thus far. To this end， we systematically explored the active components and mechanism of M. oleifera leaves in relieving constipation by using the slow transit constipation (STC) mouse model and network pharmacology. The results of animal experiments showed that M. oleifera aqueous extract (MOA) had good laxative activity， and its 70% alcohol soluble part (ASP) also showed significant laxative activity(P < 0.01). Network pharmacological prediction results suggested that L-phenylalanine (Phe) was the key compound of ASP， and it might relieve constipation through tachykinin receptor 1 (TACR1) and three kinds of adrenergic receptors， including alpha-1a (ADRA1A)， alpha-2a (ADRA2A)， and alpha-2b (ADRA2B). Further animal experiment results showed that Phe significantly promoted gastrointestinal motility. Phe may relieve STC by enhancing the release of substance P (SP) and upregulating the mRNA expression of TACR1 in the ileum. Importantly， Phe may also promote intestinal movement by downregulating ADRA2A and ADRA2B and upregulating calmodulin and the mRNA and protein expression of myosin light chain 9 (MYL9) in the ileum， thereby activating the GPCR-MLC signaling pathway. These results lay a foundation for the application of M. oleifera and Phe in constipation.

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《云南省消防专项规划编制技术导则》编制探讨

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规划师 2024年第5期40卷 145-153页

作者：刘作燕曹洪华张林邹源飞郭凯峰云南师范大学地理学部云南省城乡规划设计研究院建筑设计分院云南师范大学泛亚商学院南昌市城市规划设计研究总院规划设计院昆明理工大学环境科学与工程学院云南省人民政府发展研究中心

《云南省消防专项规划编制技术导则》针对传统消防专项规划存在的时间协同问题、空间协同问题和数据协调问题,以加强规划协同、建立工作协调机制和强化规划实施监督为目标,从“省+州(市)+县(市、区)”3个层次提出技术指引,统筹考虑中心... 详细信息

《云南省消防专项规划编制技术导则》针对传统消防专项规划存在的时间协同问题、空间协同问题和数据协调问题,以加强规划协同、建立工作协调机制和强化规划实施监督为目标,从“省+州(市)+县(市、区)”3个层次提出技术指引,统筹考虑中心城区、乡村地区、“四名一文一传”、产业园区、重要河流和旅游景区等区域的消防规划布局,是全国首部全域消防专项规划编制技术导则,其编制技术路线可为其他地区消防专项规划的编制与修订提供借鉴。

关键词：消防专项规划编制技术导则云南省

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高炉铁水质量提升研究实践

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甘肃冶金 2024年第1期46卷 34-38页

作者：周晓东安玉兆孙宝芳郭凯峰青岛特殊钢铁有限公司山东青岛266409

某厂在面临自产焦不足,外购焦炭种类繁多、原燃料质量持续下滑的情况下,从生产条件、铁水硅硫负荷控制、入炉原料质量管理以及高炉炉内操作管理等方面着手,改善高炉炉况稳定情况,提升铁水质量,实现高炉铁水合格率提升11%以上。

关键词：高炉焦炭原燃料质量铁水质量

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Broadband high-efficiency dielectric metalenses based on quasi-continuous nanostrips

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Opto-Electronic Advances 2024年第5期7卷 49-58页

作者： Xiaohu Zhang Qinmiao Chen Dongliang Tang kaifeng Liu Haimo Zhang Lintong Shi Mengyao He Yongcai guo Shumin Xiao Key Laboratory of optoelectronic Technology and Systems of the Education Ministry of China Chongqing University Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of Technology Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education & Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and ElectronicsHunan University

Benefiting from the abrupt phase changes within subwavelength thicknesses,metasurfaces have been widely applied for lightweight and compact optical systems.Simultaneous broadband and high-efficiency characteristics are highly attractive for the practical implementation of metasurfaces.However,current metasurface devices mostly adopt discrete micro/nano structures,which rarely realize both merits simultaneously.In this paper,dielectric metasurfaces composed of quasi-continuous nanostrips are proposed to overcome this limitation.Via quasi-continuous nanostrips metasurface,a normal focusing metalens and a superoscillatory lens overcoming the diffraction limit are designed and experimentally demonstrated.The quasi-continuous metadevices can operate in a broadband wavelength ranging from 450 nm to 1000nm and keep a high power efficiency.The average efficiency of the fabricated metalens reaches 54.24%,showing a significant improvement compared to the previously reported metalenses with the same thickness.The proposed methodology can be easily extended to design other metadevices with the advantages of broadband and high-efficiency in practical optical systems.

关键词： broadband high-efficiency metalens quasi-continuous sub-diffraction

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Innovations in metallurgical and materials processes:advancing liquid theory and honoring Prof.Han-jie guo's contributions to physical chemistry in metallurgy

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Journal of Iron and Steel Research(International) 2024年第1期31卷 1-2页

作者： Shuai Liu Jing guo Han-jie guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

Spanning three decades,Prof.Han-jie guo's research group has dedicated itself to exploring the fundamental theories and practical applications of physical chemistry within the realm of metallurgy.Operating under the a... 详细信息

关键词： chemistry liquid complexes

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基于OCML构造序列的Link16扩频方法

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系统工程与电子技术 2022年第12期44卷 3837-3842页

作者：罗海玲宁晓燕郭凯丰刁鸣哈尔滨工程大学信息与通信工程学院黑龙江哈尔滨150001 中国船舶工业系统工程研究院北京100094

Link16数据链因其强抗干扰性被广泛应用于各大信息化作战平台,但其传输速率和频带利用率并不高。针对这一问题,提出一种基于单向耦合映像格子(one-way coupled map lattice,OCML)模型时空混沌序列的缩短码移位键控(truncated code shift... 详细信息

Link16数据链因其强抗干扰性被广泛应用于各大信息化作战平台,但其传输速率和频带利用率并不高。针对这一问题,提出一种基于单向耦合映像格子(one-way coupled map lattice,OCML)模型时空混沌序列的缩短码移位键控(truncated code shift keying,TCSK)方法。系统以OCML模型下的混沌序列作为扩频基码,将每个承载信息的码片长度缩短为原来的1/P,并将每个码片进行镜像对称,获得一个总长度为2/P的扩频码片进行传输。相对于原循环码移位键控(cyclic code shift heying,CCSK)系统的扩频序列,该码片长度减少一半,从而提高系统的传输速率。OCML序列具有良好的伪随机性和自相关性,同时该模型下能生成大量扩频序列,各序列相互独立,一个信道可容纳多个扩频信号,极大地提高了频带利用率。对多径衰落信道下的误码性能进行了仿真,结果表明,所提方法能有效改善多径衰落下的系统性能。

关键词： Link16数据链单向耦合映像格子模型缩短码移位键控传输速率多径衰落

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Light People:Prof.Eric Mazur speaks about ultrafast optics and education

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Light(Science & Applications) 2024年第3期13卷 402-406页

作者： Chenzi guo Yang Li Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key Laboratory of Precision Measurement Technology and Instrument Department of Precision InstrumentTsinghua UniversityBeijingChina

Prof.Eric Mazur is a great influencer over and beyond the optics community.As a physicist,he is a pioneer of ultrafast optics and was one of the inventors of colliding-pulse mode-locked laser.As an educator,he not only gave talks to thousands,but also revolutionized teaching with his globally renowned methodology“Peer Instruction”.As a leader and entrepreneur,he co-founded several companies and was President of Optica(formerly the Optical Society)and currently is the Chair of the Optica Foundation.Here,Light:Science&Applications talked with Prof.Eric Mazur about his opinions on research,education and industry.The full interview video can be found in the Supplementary File.

关键词： optics education companies

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Emerging direct current triboelectric nanogenerator for high-entropy mechanical energy harvesting

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Science China(Technological Sciences) 2024年第5期67卷 1297-1316页

作者： CHEN Jie guo RuiLong guo HengYu College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Department of Applied Physics Chongqing UniversityChongqing 401331China

In the era of the Internet of Things(IoT),the provision of sustainable power to distributed,mobile,and low-power-consumption electronic devices is a critical challenge.To overcome this challenge,the triboelectric nanogenerator(TENG),a highly efficient high-entropy mechanical energy harvesting device,was developed in 2012.This device enables the direct conversion of irregular and low-frequency mechanical energy into pulsed alternating current(AC)signals.However,the incompatibility of most electronic devices with AC signals necessitates rectifier circuits or generators that deliver direct current(DC)signals.In recent years,DC-TENGs have undergone extensive development,achieving significant milestones in various application fields while also facing crucial challenges that require solutions.In this review,three categories of DC-TENG devices with distinct operating mechanisms are comprehensively explored:multiphase coupling,mechanical rectification,and air breakdown.Their typical structures and working mechanisms are thoroughly discussed,and specific output performance limitations,along with corresponding optimization strategies,are identified.Furthermore,the applications of DC-TENGs in various scenarios are summarized.Finally,the challenges faced by DC-TENGs and potential solutions are analyzed to guide further advancements in this technology.

关键词： TENG direct current working mechanisms output performance limitations optimization strategies

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Light People:Prof.Kei May Lau,newly elected US NAE member in Hong Kong,talks about future of photonics and women in science

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Light(Science & Applications) 2024年第4期13卷 602-608页

作者： Yating Wan Chenzi guo Electrical and Computer Engineering the ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology23955-6900 ThuwalSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial Photonics technology remains a driving force in today’s scientific landscape,marked by continuous innovation and crossdisciplinary relevance.In an enlighting conversation with Light:Science&Applications,Prof.Kei May Lau,a pioneer in photonics research,shares her deep insights on the evolution of technologies of LEDs,lasers,challenges of hetero-epitaxy,and the future of micro-LEDs and quantum dot lasers.Recently honored as a member of the US National Academy of Engineering(NAE)for her significant contributions to photonics and electronics using III-V semiconductors on silicon,Prof.Lau stands out as the sole Hong Kong scholar inducted into the NAE this year,joining 114 new and 21 international members.In this exclusive Light People interview,Prof.Lau shares her journey as a pioneering woman in engineering,her commitment to mentorship and academia,and her perspective on advancing female representation in science.The summary provided is distilled from Prof.Lau’s thoughtful responses during the interview.For a deeper exploration of Prof.Lau’s experiences and advice,the full interview is available in the Supplementary material.

关键词： interview lighting driving

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Improving benzene catalytic oxidation on Ag/Co_(3)O_(4) by regulating the chemical states of Co and Ag

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Journal of Environmental Sciences 2024年第9期143卷 201-212页

作者： Hao guo Tao guo Mengqi Zhao Yaxin Zhang Wenfeng Shangguan Yinnian Liao State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources Xinjiang UniversityXinjiang 830017China Xinjiang Key Laboratory of Coal Clean Conversion&Chemical Engineering Process Xinjiang UniversityXinjiang 830017China School of Chemical Engineering and Technology Xinjiang UniversityXinjiang 830017China Research Center for Combustion and Environmental Technology Shanghai Jiao Tong UniversityShanghai 200240China School of Applied Chemistry and Materials Zhuhai College of Science and TechnologyGuangdong 519041China

Silver(9 wt.%)was loaded on Co_(3)O_(4)-nanofiber using reduction and impregnation methods,respectively.Due to the stronger electronegativity of silver,the ratios of surface Co^(3+)/Co^(2+) on Ag/Co_(3)O_(4) were higher than on Co_(3)O_(4),which further led to more adsorbed oxygen species as a result of the charge compensation.Moreover,the introducing of silver also obviously improved the reducibility of Co_(3)O_(4).Hence the Ag/Co_(3)O_(4) showed better catalytic performance than Co_(3)O_(4) in benzene oxidation.Compared with the Ag/Co_(3)O_(4) synthesized via impregnation method,the one prepared using reduction method(named as Ag Co-R)exhibited higher contents of surface Co^(3+) and adsorbed oxygen species,stronger reducibility,as well as more active surface lattice oxygen species.Consequently,Ag Co-R showed lowest T_(90) value of 183℃,admirable catalytic stability,largest normalized reaction rate of1.36×10^(-4)mol/(h·m^(2))(150℃),and lowest apparent activation energy(E_(a))of 63.2 kJ/mol.The analyzing of in-situ DRIFTS indicated benzene molecules were successively oxidized to phenol,o-benzoquinone,small molecular intermediates,and finally to CO_(2) and water on the surface of Ag Co-R.At last,potential reaction pathways including five detailed steps were proposed.

关键词： Reduction method Co_(3)O_(4)-supported Ag catalyst,VOCs Benzene oxidation Reaction mechanism

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