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Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease:Current Progress and Challenges

Engineering 2024年第9期40卷 51-60页

作者： Ernesto Saenz Nathally Espinosa Montagut Baohong wang Christoph Stein-Thöringer kaicen wang Honglei Weng Matthias Ebert Kai Markus Schneider Lanjuan Li Andreas Teufel Division of Hepatology Division of Clinical BioinformaticsDepartment of Medicine ⅡMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Clinical Cooperation Unit Healthy Metabolism Center for Preventive Medicine and Digital HealthMedical Faculty MannheimHeidelberg UniversityMannheim 68167Germany School of Medicine Universidad de Los AndesBogotá111711Colombia State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Internal MedicineⅠ University Clinic Tuebingen&CoE CMFI(Controlling Microbes to Fight Infections)Tuebingen 72074Germany Department of MedicineⅡ Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany DKFZ Hector Cancer Institute at the University Medical Center Mannheim 69120Germany Molecular Medicine Partnership Unit European Molecular Biology LaboratoryHeidelberg 69117Germany Department of MedicineⅢ University Hospital RWTH AachenAachen 52074Germany

The prevalence of metabolic-dysfunction-associated steatotic liver disease(MASLD)is alarmingly high;it is estimated to affect up to a quarter of the global population,making it the most common liver disorder *** is characterized by excessive hepatic fat accumulation and is commonly associated with comorbidities such as obesity,dyslipidemia,and insulin resistance;however,it can also manifest in lean ***,it is crucial to develop effective therapies for this complex ***,there are no approved medications for MASLD treatment,so there is a pressing need to investigate alternative *** research has characterized MASLD as a multifaceted disease,frequently linked to metabolic disorders that stem from dietary *** suggests that changes in the gut microbiome play a fundamental role in the development and progression of MASLD from simple steatosis to steatohepatitis and even hepatocellular carcinoma(HCC).In this review,we critically examine the literature on the emerging field of gut-microbiota-based therapies for MASLD and metabolicdysfunction-associated steatohepatitis(MASH),including interventions such as fecal microbiota transplantation(FMT),probiotics,prebiotics,short-chain fatty acids,antibiotics,metabolic pathway targeting,and immune checkpoint kinase blockade.

关键词： Microbiome Fecal microbiota transplantation Metabolic-dysfunction-associated steatotic liver disease Fatty liver

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A Predictive Nomogram for Predicting Improved Clinical Outcome Probability in Patients with COVID-19 in Zhejiang Province,China

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Engineering 2022年第1期8卷 122-129页

作者： Jiaojiao Xie Ding Shi Mingyang Bao Xiaoyi Hu Wenrui Wu Jifang Sheng Kaijin Xu Qing wang Jingjing Wu kaicen wang Daiqiong Fang Yating Li Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China State Key Laboratory of Genetic Engineering Institute of BiostatisticsSchool of Life SciencesFudan UniversityShanghai 200433China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryKey Lab of Combined Multi-organ Transplantation of the Ministry of HealthThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Division of of Endocrinology and Metabolism Department of Internal Medicine SystemThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China

The aim of this research was to develop a quantitative method for clinicians to predict the probability of improved prognosis in patients with coronavirus disease 2019(COVID-19).Data on 104 patients admitted to hospital with laboratory-confirmed COVID-19 infection from 10 January 2020 to 26 February 2020 were *** information and laboratory findings were collected and compared between the outcomes of improved patients and non-improved *** least absolute shrinkage and selection operator(LASSO)logistics regression model and two-way stepwise strategy in the multivariate logistics regression model were used to select prognostic factors for predicting clinical outcomes in COVID-19 *** concordance index(C-index)was used to assess the discrimination of the model,and internal validation was performed through bootstrap resampling.A novel predictive nomogram was constructed by incorporating these *** the 104 patients included in the study(median age 55 years),75(72.1%)had improved short-term outcomes,while 29(27.9%)showed no signs of *** were numerous differences in clinical characteristics and laboratory findings between patients with improved outcomes and patients without improved *** a multi-step screening process,prognostic factors were selected and incorporated into the nomogram construction,including immunoglobulin A(IgA),C-reactive protein(CRP),creatine kinase(CK),acute physiology and chronic health evaluation II(APACHE II),and interaction between CK and APACHE *** C-index of our model was 0.962(95%confidence interval(CI),0.931-0.993)and still reached a high value of 0.948 through bootstrapping validation.A predictive nomogram we further established showed close performance compared with the ideal model on the calibration plot and was clinically practical according to the decision curve and clinical impact *** nomogram we constructed is useful for clinicians to predict improved clinical outcome p

关键词： Coronavirus disease 2019(COVID-19) Nomogram Patient-relevant outcome

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GUT MICROBIOTA DEPLETION AGGRAVATED DDC-INDUCED CHOLESTATIC LIVER FIBROSIS VIA INHIBITING THE FXR SIGNALING PATHWAY

GUT MICROBIOTA DEPLETION AGGRAVATED DDC-INDUCED CHOLESTATIC ...

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第12届全国疑难及重症肝病大会

作者： kaicen wang Jiafeng Xia Lanjuan Li The First Affiliated Hospital School of Medicine Zhejiang University

Background: Primary sclerosing cholangitis (PSC) is a cholestatic liver disorder with an unknown etiology and has no specific therapeutic strategies. Changes in the composition and function of the gut microbiota are closely related to the progression of PSC. However, the essential role of the gut microbiota in its pathogenesis still remains obscure. In this study, with the help of a mouse model mimicking human PSC, we aim to dissect the role of gut microbiota in the pathogenesis of PSC.

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Simultaneous wireless information and power transfer transmitting architecture based on asynchronous space-time-coding digital metasurface[Invited]

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Chinese Optics Letters 2023年第8期21卷 17-22页

作者：祁振杰戴俊彦王思然周群焰唐万恺王凯岑张澎刘硕李龙程强崔铁军 State Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China Institute of Electromagnetic Space Southeast UniversityNanjing 210096China Frontiers Science Center for Mobile Information Communication and Security Southeast UniversityNanjing 210096China National Mobile Communications Research Laboratory Southeast UniversityNanjing 210096China National Key Laboratory of Electromagnetic Information Control and Effects Shenyang 110035China Key Laboratory of High-Speed Circuit Design and EMC of Ministry of Education Xidian UniversityXi'an 710071China

Simultaneous wireless information and power transfer(SWIPT)architecture is commonly applied in wireless sensors or Internet of Things(IoT)devices,providing both wireless power sources and communication ***,the traditional SWIPT transmitter usually suffers from cross-talk distortion caused by the high peak-to-average power ratio of the input signal and the reduction of power amplifier *** paper proposes a SWIPT transmitting architecture based on an asynchronous space-time-coding digital metasurface(ASTCM).High-efficiency simultaneous transfer of information and power is achieved via energy distribution and information processing of the wireless monophonic signal reflected from the *** demonstrate the feasibility of the proposed method through theoretical derivations and experimental verification,which is therefore believed to have great potential in wireless communications and the IoT devices.

关键词： simultaneous wireless information and power transfer asynchronous space-time-coding digital metasurface quadrature phase-shift keying modulation

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调节肠道菌群减轻脂肪性肝病肝脏炎症——当前进展及挑战（英文）

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Engineering 2024年第9期 51-60页

作者： Ernesto Saenz Nathally Espinosa Montagut Baohong wang Christoph Stein-Th?ringer kaicen wang Honglei Weng Matthias Ebert Kai Markus Schneider Lanjuan Li Andreas Teufel Division of Hepatology Division of Clinical Bioinformatics Department of Medicine Ⅱ Medical Faculty Mannheim Heidelberg University Clinical Cooperation Unit Healthy Metabolism Center for Preventive Medicine and Digital Health Medical Faculty Mannheim Heidelberg University School of Medicine Universidad de Los Andes State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital Zhejiang University School of Medicine Internal Medicine Ⅰ University Clinic Tuebingen & CoE CMFI (Controlling Microbes to Fight Infections) Department of Medicine Ⅱ Medical Faculty Mannheim Heidelberg University DKFZ Hector Cancer Institute at the University Medical Center Molecular Medicine Partnership Unit European Molecular Biology Laboratory Department of Medicine Ⅲ University Hospital RWTH Aachen

The prevalence of metabolic-dysfunction-associated steatotic liver disease(MASLD) is alarmingly high; it is estimated to affect up to a quarter of the global population, making it the most common liver disorder worldwide. MASLD is characterized by excessive hepatic fat accumulation and is commonly associated with comorbidities such as obesity, dyslipidemia, and insulin resistance; however, it can also manifest in lean individuals. Therefore, it is crucial to develop effective therapies for this complex ***, there are no approved medications for MASLD treatment, so there is a pressing need to investigate alternative approaches. Extensive research has characterized MASLD as a multifaceted disease, frequently linked to metabolic disorders that stem from dietary habits. Evidence suggests that changes in the gut microbiome play a fundamental role in the development and progression of MASLD from simple steatosis to steatohepatitis and even hepatocellular carcinoma(HCC). In this review, we critically examine the literature on the emerging field of gut-microbiota-based therapies for MASLD and metabolicdysfunction-associated steatohepatitis(MASH), including interventions such as fecal microbiota transplantation(FMT), probiotics, prebiotics, short-chain fatty acids, antibiotics, metabolic pathway targeting, and immune checkpoint kinase blockade.

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榕江月亮山植物群落的特征及多样性

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贵州农业科学 2013年第8期41卷 23-27页

作者：吴开岑王定江冯邦贤黔东南民族职业技术学院贵州凯里556000 黔东南州林业科学研究所贵州凯里556000 贵州大学林学院贵州贵阳550025

榕江月亮山位于榕江县西南部,保存有大面积的原生林,是榕江县境内生物多样性最特殊、最丰富、最敏感的区域。为了能直观地反映该区群落生态的实际状况,引起有关部门的重视,以榕江月亮山的植物群落为研究对象,应用样方调查方法,对该区域... 详细信息

榕江月亮山位于榕江县西南部,保存有大面积的原生林,是榕江县境内生物多样性最特殊、最丰富、最敏感的区域。为了能直观地反映该区群落生态的实际状况,引起有关部门的重视,以榕江月亮山的植物群落为研究对象,应用样方调查方法,对该区域的植物群落物种组成、群落结构、特征、区系以及生物多样性进行了系统研究。结果表明:1)共记录维管植物387种,隶属于101科243属,生活型谱以高位芽植物为主;2)该区种子植物区系地理成分复杂,属的分布类型有22个,以温带分布型为主,同时东亚特有和中国特有占很大的比例,表现了属的地理分布类型多样性和特有现象并存的特征;3)群落垂直结构明显,分为乔木层、灌木层和草本层3个层次;4)不同群落类型不同层次的物种多样性指数差异性不明显,表现出群落结构越复杂、物种组成越丰富、优势种越不明显、共优种越多,物种多样性指数越高。

关键词：群落类型结构特征生物多样性榕江月亮山贵州

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基于SKF-KF-Bayes的滚动轴承剩余使用寿命预测方法

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振动与冲击 2021年第19期40卷 26-31,40页

作者：许艳雷邱明李军星刘璐牛凯岑河南科技大学机械工程学院河南洛阳471003 河南科技大学高端轴承先进制造与智能装备河南省工程技术研究中心河南洛阳471003

准确预测滚动轴承的剩余使用寿命(remaining useful life,RUL)对机械设备安全可靠运行有着至关重要的作用,针对滚动轴承寿命预测中存在的未能准确区分滚动轴承退化阶段与如何有效地利用历史退化数据与实时监测数据等问题,提出了一种SKF(... 详细信息

准确预测滚动轴承的剩余使用寿命(remaining useful life,RUL)对机械设备安全可靠运行有着至关重要的作用,针对滚动轴承寿命预测中存在的未能准确区分滚动轴承退化阶段与如何有效地利用历史退化数据与实时监测数据等问题,提出了一种SKF(switching Kalman filters)、KF(Kalman filters)和Bayes结合的滚动轴承性能退化建模与剩余使用寿命预测方法。结合滚动轴承振动信号性能监测数据,采用SKF方法识别出轴承性能退化的变点;利用随机效应指数退化模型描述轴承性能退化过程,结合同类轴承性能数据给出模型未知参数极大似然估计;利用KF单步预测对当前时刻监测数据进行修正,基于Bayes方法对模型中的随机参数进行实时更新,推导出轴承剩余使用寿命分布模型,计算滚动轴承剩余使用寿命;通过对滚动轴承试验数据分析,验证了该方法的适用性和有效性。

关键词：滚动轴承剩余使用寿命(RUL)预测 SKF识别 KF单步预测 Bayes更新

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基于LTSA融合降维法的滚动轴承可靠性评估方法

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航空动力学报 2021年第2期36卷 413-420页

作者：刘璐邱明李军星许艳雷牛凯岑河南科技大学机电工程学院河南洛阳471003 机械装备先进制造河南省协同创新中心河南洛阳471003

为了保障滚动轴承在给定工况下安全平稳地运行,提出了一种基于局部切空间排列(LTSA)和威布尔比例故障率模型(WPHM)的滚动轴承可靠性评估方法。该方法提取滚动轴承整个寿命周期的时域、频域、时频域及统计等不同分析域上的特征指标,从中... 详细信息

为了保障滚动轴承在给定工况下安全平稳地运行,提出了一种基于局部切空间排列(LTSA)和威布尔比例故障率模型(WPHM)的滚动轴承可靠性评估方法。该方法提取滚动轴承整个寿命周期的时域、频域、时频域及统计等不同分析域上的特征指标,从中筛选出包含滚动轴承运行状态的特征指标,构建出高维多域特征集;利用局部切空间排列算法对高维多域特征集进行融合降维,得到可全面反映滚动轴承性能退化趋势的综合特征指标作为WPHM的响应协变量进行可靠性评估。通过滚动轴承的寿命试验,得到该试验轴承的寿命为491 min。该方法能够得出轴承在489 min左右失效,寿命误差小于1%,故验证了该方法可以对滚动轴承的运行可靠性进行有效地评估。

关键词：滚动轴承特征提取局部切空间排列(LTSA) 威布尔比例故障率模型(WPHM) 可靠性

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多重应力下滚动轴承剩余寿命预测

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航空动力学报 2022年第5期37卷 980-988页

作者：邱明牛凯岑李军星李燕科许艳雷河南科技大学机电工程学院河南洛阳471003 机械装备先进制造河南省协同创新中心河南洛阳471003

为了实现多重应力下滚动轴承的剩余寿命预测,有效利用不用应力下的退化数据,提出了一种基于加速模型和贝叶斯(Bayesian)理论的滚动轴承剩余寿命预测方法。通过拟合优度检验和威布尔(Weibull)概率图检验法对滚动轴承试验中的数据进行有... 详细信息

为了实现多重应力下滚动轴承的剩余寿命预测,有效利用不用应力下的退化数据,提出了一种基于加速模型和贝叶斯(Bayesian)理论的滚动轴承剩余寿命预测方法。通过拟合优度检验和威布尔(Weibull)概率图检验法对滚动轴承试验中的数据进行有效性分析。利用switching Kalman filters(SKF)判断滚动轴承各时刻的退化状态。当滚动轴承进入加速退化时,用指数模型拟合轴承退化过程,利用广义线性对数模型表示退化模型参数与应力的关系,根据修正后的轴承实时退化数据利用贝叶斯算法更新模型参数,得到滚动轴承剩余寿命的概率密度函数,从而实现滚动轴承剩余寿命预测。采用XJTU-SY轴承数据集进行验证,预测结果的均方根误差在20 min以内,证明该方法能够有效预测滚动轴承的剩余寿命。

关键词：滚动轴承多重应力加速模型剩余寿命预测贝叶斯

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贵州黔东南地区蕨类植物区系初探

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贵州农业科学 2013年第2期41卷 28-32页

作者：吴开岑苟光前魏奇何林健黔东南民族职业技术学院贵州凯里556000 贵州大学贵州贵阳550025

为了解黔东南地区蕨类植物区系的特点,采用野外调查与查阅资料相结合的方法,对该地区的蕨类植物进行调查和区系分析。结果表明:1)该区蕨类植物物种丰富,有48科110属390种、2亚种、17变种和2变型。2)优势科、属表现明显,优势科有鳞毛蕨... 详细信息

为了解黔东南地区蕨类植物区系的特点,采用野外调查与查阅资料相结合的方法,对该地区的蕨类植物进行调查和区系分析。结果表明:1)该区蕨类植物物种丰富,有48科110属390种、2亚种、17变种和2变型。2)优势科、属表现明显,优势科有鳞毛蕨科、蹄盖蕨科、水龙骨科、金星蕨科和铁角蕨科等,优势属有鳞毛蕨属、铁角蕨属、耳蕨属、卷柏属和蹄盖蕨属等。3)该区蕨类植物区系地理成分复杂,从属来看,是以热带、亚热带分布的属占优势,表明,该区蕨类植物有较高的热带亲缘;而从种来看,东亚地理成分的种有164个,占总种数的39.9%,说明,该区蕨类植物属于东亚区系。4)中国特有成分较丰富,有101种,表明,该地区的蕨类植物具有一定的特有性质。5)该地区蕨类处在热带亚洲和东亚2个植物分布区的过渡地段,有44属在这里仅有1种分布,构成属多种少的格局,具有过渡性质。6)与贵州省贵阳市和云南省迪庆州相比,该地区蕨类植物最丰富,且与贵阳市蕨类植物的相似性更大、亲缘关系更近。

关键词：蕨类植物区系分析黔东南贵州

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