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Endoplasmic Reticulum Stress-induced Endothelial Dysfunction Promotes Neointima Formation after Arteriovenous Grafts in Mice on High-fat Diet

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Current Medical Science 2023年第1期43卷 115-122页

作者： Yan-xia ZHONG Chen-chen ZHOU Ying-fang ZHENG Hong-kai DAi Ren-yu CHEN Yu-rou WANG Cheng-ye zhan Jin-long LUO Ai-ni XiE Emergency and intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Divison of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Endothelial dysfunction is one candidate for triggering neointima formation after arteriovenous grafts(AVGs),but the factors mediating this process are *** purpose of this study was to investigate the role of endoplasmic reticulum stress(ERS)-induced endothelial dysfunction in neointima formation following AVGs in high-fat diet(HFD)*** CCAAT-enhancer-binding protein-homologous protein(CHOP)knockout(KO)mice were *** were fed with HFD to produce HFD *** model were applied in the groups of WT ND,WT HFD,and CHOP KO *** umbilical vein endothelial cells(HUVECs)were cultured with oxidized low density lipoprotein(ox-LDL)(40 mg/L)for the indicated time lengths(0,6,12,24 h).ERS inhibitor tauroursodeoxycholic acid(TUDCA)was used to block *** staining was used to observe the changes of *** of ERS were detected by real-time *** expression levels and ERS activation were detected by Western *** cell function was determined by endothelial permeability assay and transendothelial migration *** HFD increased neointima formation in AVGs associated with endothelial *** the same time,ERS was increased in endothelial cells(ECs)after AVGs in mice consuming the *** vitro,ox-LDL was found to stimulate ERS,increase the permeability of the EC monolayer,and cause endothelial *** ERS with TUDCA or CHOP siRNA reversed the EC dysfunction caused by *** vivo,knockout of CHOP(CHOP KO)protected the function of ECs and decreased neointima formation after AVGs in HFD *** inhibiting ERS in ECs could improve the function of AVGs.

关键词： endoplasmic reticulum stress endothelial dysfunction neointima formation arteriovenous grafts high-fat diet

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Automatic Cooking Robot for Chinese Dishes

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international Journal of Plant Engineering and Management 2009年第1期14卷 30-33页

作者： GEN kai-ping XU Yu zhan Jing-wen School of Management Xi'an Jiaotong University Xi'an 710049 China

Until now, most of the kitchen works are done manually, which often make people bored and suffer from cooking oil smoke pollution. With the development of the robotic technology, it becomes more and more urgent for the appearance of the automatic cooking machines that can substitute man for most of those works. With this aim in mind, in this paper, a kind of automatic cooking robot is presented, which mainly consists of five parts ： the wok mechanism, the stirring-fry and dispersing mechanism, the feeding mechanism, fire control system and the assistant ingredients processing mechanism. Experiment results have proved that the robot has achieved the goal with respect to appearance, smell, and taste of the dishes cooked by the robot, according to the master cook＇s view.

关键词： automatic cooking robot cooking principle Chinese dishes

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邻二氮菲荧光法测定氯碱厂阳极泥中痕量钌

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光谱学与光谱分析 2006年第8期26卷 1520-1522页

作者：开小明占峰安庆师范学院化学与环境科学学院安徽安庆246011 安徽省桐城师范学校安徽桐城230003

研究了在乙酸-乙酸钠缓冲溶液中，在盐酸羟胺还原剂存在下，于水浴中加热近沸，保温5min，钌与邻二氮菲形成1：3络合物。它的荧光激发波长峰为448nm，发射波长峰为586nm。钌与荧光强度线性范围为O～10μg·（25mL）^-1。样品中的钌通过... 详细信息

研究了在乙酸-乙酸钠缓冲溶液中，在盐酸羟胺还原剂存在下，于水浴中加热近沸，保温5min，钌与邻二氮菲形成1：3络合物。它的荧光激发波长峰为448nm，发射波长峰为586nm。钌与荧光强度线性范围为O～10μg·（25mL）^-1。样品中的钌通过蒸馏分离，方法应用于氯碱厂阳极泥中钌的含量分析，具有满意的分析结果。

关键词：钌邻二氮菲荧光法阳极泥

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先导式截止阀在不同阀芯位置下流动和汽蚀特性的数值分析（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第1期17卷 54-64页

作者： Jin-yuan QiAN Bu-zhan LiU Zhi-jiang JiN Jian-kai WANG Han zhanG An-le LU institute of Process Equipment College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China China Tianchen Engineering Corporation Tianjin 300400 China Shanghai Nuclear Engineering Research and Design institute Shanghai 200233 China

目的:先导式截止阀可通过一个先导阀,利用流体在阀门前后自身的压差控制主阀的启闭,是一种新型节能型截止阀。本文探讨该阀在开启和关闭状态下、不同入口速度情况下和不同阀芯位置下的流动和汽蚀特性,为后期结构优化提供设计建议。创新... 详细信息

目的:先导式截止阀可通过一个先导阀,利用流体在阀门前后自身的压差控制主阀的启闭,是一种新型节能型截止阀。本文探讨该阀在开启和关闭状态下、不同入口速度情况下和不同阀芯位置下的流动和汽蚀特性,为后期结构优化提供设计建议。创新点:1.分析先导式截止阀的阀芯上下表面压差的变化情况,验证其可行性和模型准确性;2.建立数值模型,对先导式截止阀在不同启闭状态和不同阀芯位移情况下进行流动和汽蚀分析。方法:1.通过数值模拟,分析阀芯上下表面的压差,并与现有文献进行比较,验证模型的准确性(图3);2.建立开启和关闭条件下的阀门模型,比较两种状态下该阀的流动和汽蚀特性(图4和5);3.建立不同入口速度条件下的阀门模型,比较分析速度对该阀的汽蚀情况的影响(图6);4.建立不同阀芯位置的阀门模型,比较分析不同阀芯位置下的速度和压力情况,进一步验证该阀的可行性,并分析阀芯位置对阀门汽蚀的影响(图7)。结论:1.在开启和关闭状态下,流速和汽含率在阀座底部靠近出口处达到峰值;2.入口速度更高的情况下,阀的开启速度更快,但汽含率并不一定同步上升;3.当阀芯处于低位置时,虽然对阀门出口处影响位置较小,但其压力梯度较大、汽含率较高,选取合适的弹簧刚度非常重要。

关键词：计算流体动力学先导式截止阀阀芯位移汽蚀

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Neuroprotective effect and mechanism of daidzein in oxygen-glucose deprivation/reperfusion injury based on experimental approaches and network pharmacology

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Traditional Medicine Research 2021年第5期6卷 10-19页

作者： Ming-Hua Xian Si-kai zhan Ke-Ning Zheng Qu-liu Ke-Ning Li Jia-Yin Liang Shu-Mei Wang Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangzhou 510006China School of Traditional Chinese Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China

Background:Daidzein,phytoestrogens derived from the Pueraria lobata(Willd.)Ohwi root used in traditional Chinese medicine,has a wide range of biological activities,including antioxidant,anti-inflammatory,and ***,the neuroprotective role of daidzein in oxygen-glucose deprivation/reperfusion injury and its underlying mechanism are still ***:in this study,we used pheochromocytoma cells induced by oxygen-glucose deprivation and reperfusion to study the potential effect in the protection of the nerve ***,we used molecular docking simulation and network pharmacology to predict the possible targets and pharmacological pathways of *** blot was used to verify the expression of target proteins with or without adding the ***:After daidzein treatment,cell vitality had an upward trend(Pin dose-dependent compared with the model group by exposure to oxygen-glucose deprivation and *** core targets were analyzed through network pharmacology and molecular docking including catalase,peroxisome proliferator-activated receptor gamma,vascular endothelial growth factor A,interleukin-6,tumor necrosis factor,nitric oxide synthase 3,prostaglandin-endoperoxide synthase 2,and RAC-alpha serine/threonine kinase *** results suggest that catalase may be a first-ranked target for the neuroprotective role of *** Ontology enrichment analysis indicated the pathways mainly contained molecule metabolic process,while Kyoto Encyclopedia of Genes and Genomes enrichment analysis focus on pathways in terms of inflammation such as tumor necrosis factor signal ***,Western blot results showed that daidzein had a significant increase on the expression of protein catalase(Pidzein reversed catalase level alterations after oxygen-glucose deprivation reperfusion injury in a dose-dependent manner which was consistent with the cata

关键词： daidzein neuroprotection catalase oxygen-glucose deprivation and reperfusion network pharmacology

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声矢量阵自适应波束域广义似然比检测算法

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电子学报 2015年第1期43卷 135-139页

作者：梁国龙陶凯范展哈尔滨工程大学水声技术重点实验室黑龙江哈尔滨150001 哈尔滨工程大学水声工程学院黑龙江哈尔滨150001

为了解决水下强干扰背景下的远程弱目标被动探测问题,基于声矢量阵,本文提出了一种自适应波束域的检测算法.该算法首先对阵列接收数据进行波束域变换,令通带覆盖整个观测扇面,并自适应地抑制扇面外的强干扰信号;然后在波束域进行广义似... 详细信息

为了解决水下强干扰背景下的远程弱目标被动探测问题,基于声矢量阵,本文提出了一种自适应波束域的检测算法.该算法首先对阵列接收数据进行波束域变换,令通带覆盖整个观测扇面,并自适应地抑制扇面外的强干扰信号;然后在波束域进行广义似然比检测.仿真结果表明,该算法能在强干扰背景下实现对远程弱目标的检测,并且具有恒虚警率特性.

关键词：水声信号处理信号检测干扰抑制声矢量阵波束域变换恒虚警率

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Effect of annealing temperature on oxygen precipitation in fast neutron irradiated CZ-Si

Effect of annealing temperature on oxygen precipitation in f...

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2012 China Functional Materials Technology and industry Forum

作者： Qiao-yun Ma zhan-kai Li School of Science Tianjin University of Commerce Key Lab for New Type of Functional Materials in Hebei Province School of Material Science and EngineeringHebei University of Technology Province-Ministry joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability Hebei University of Technology

The effect of annealing temperature on oxygen precipitation was investigated in various dose fast neutron irradiated Czochralski silicon(CZ-Si).Fourier Transform infrared Absorption Spectrometer(FTiR) was used to measure the concentration of interstitial oxygen([O]).Bulk microdefects(BMDs) were observed by optical *** behavior of oxygen precipitation depends on the annealing temperature and the concentration of irradiation-induced *** mount of oxygen precipitates of irradiated samples is more than that in non-irradiation samples and increases with increasing the irradiation *** of the effect of temperature on critical radius r and the oxygen diffusivity,oxygen precipitation increase with the increase of temperature at the studied lower temperature range,while decrease with the increase of temperature at the studied higher temperature *** density dislocation and stacking faults generate in irradiated sample.

关键词： irradiation CZ-Si Oxygen precipitation [Oi]

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基于非线性最小二乘算法的超宽带TOA估计

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北京理工大学学报 2008年第6期28卷 536-540页

作者：卜祥元杨凯徐湛北京理工大学信息科学技术学院电子工程系北京100081

研究室内密集多径信道环境下的超宽带到达时间(TOA)估计技术.提出一种改进的门限比较TOA估计算法,利用非线性最小二乘算法同时估计多径延时和幅度,采用迭代算法提高参数估计精度,根据判决门限比较结果终止多径搜索过程并估计出TOA.分析... 详细信息

研究室内密集多径信道环境下的超宽带到达时间(TOA)估计技术.提出一种改进的门限比较TOA估计算法,利用非线性最小二乘算法同时估计多径延时和幅度,采用迭代算法提高参数估计精度,根据判决门限比较结果终止多径搜索过程并估计出TOA.分析该算法在室内多径信道模型中的性能,给出门限的设置方案.仿真结果表明,在不同的信噪比下设置合理的判决门限后,该算法具有较高的估计精度,能够满足精确定位需求.

关键词：超宽带到达时间非线性最小二乘迭代算法

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对策论在航空反潜搜索效能评估中的应用研究

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系统仿真学报 2006年第8期18卷 2086-2088页

作者：战凯陈建华海军兵种指挥学院广州510430

航空兵应召反潜是航空兵接获某时刻潜艇概略位置信息后,飞抵潜艇出没海域进行搜索的一种反潜作战样式,其实质是航空兵对水下潜艇的搜索和定位问题。从对策论的角度看,航空兵与潜艇的对抗实质是一种二人有限零和对弈。常规动力潜艇水下... 详细信息

航空兵应召反潜是航空兵接获某时刻潜艇概略位置信息后,飞抵潜艇出没海域进行搜索的一种反潜作战样式,其实质是航空兵对水下潜艇的搜索和定位问题。从对策论的角度看,航空兵与潜艇的对抗实质是一种二人有限零和对弈。常规动力潜艇水下规避机动能力不仅受到的速度制约,更受到电量的约束。通过对航空兵应召反潜搜索的分析,建立应召反潜搜索效能评估模型,并应用对策论与最优控制理论对模型进行分析,研究在潜艇速度和电量双约束条件下,影响搜索效能的关键因素,为航空兵战术决策提供依据。

关键词：应召反潜效能评估最优控制理论对策论

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Association of CDKN2B-AS1 Polymorphisms with Premature Triple-vessel Coronary Disease and Their Sex Specificity in the Chinese Population

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Biomedical and Environmental Sciences 2018年第11期31卷 787-796页

作者： XU Jing Jing JiANG Lin XU Lian Jun GAO zhan ZHAO Xue Yan zhanG Yin SONG Ying LiU Ru SUN kai GAO Run Lin XU Bo SONG Lei YUAN Jin Qing Department of cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College Department of Hypertension Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical College

Objective The aim of this study is to establish whether cyclin-dependent kinase inhibitor 2B antisense RNA 1(CDKN2 B-AS1) gene polymorphisms are associated with premature triple-vessel disease(PTVD). Methods Nine single-nucleotide polymorphisms(rs1063192, rs10757274, rs1333042, rs1333049, rs2285327, rs3217986, rs3217992, rs4977574, and rs9632884) were genotyped in 884 PTVD patients and 907 control subjects(males ≤ 50 years old and females ≤ 60 years old) using the improved multiplex ligase detection reaction method. Results The allele frequencies of rs10757274 G, rs1333049 C, rs4977574 G(all P ignificantly higher in the PTVD group than in the control group, but those of rs1063192 A, rs1333042 G, and rs9632884 C(all P ignificantly lower in the former than in the latter. Logistic regression analysis revealed that homozygote AA of rs1333042 is associated with decreased risk for PTVD(OR = 0.42, 95% Ci: 0.22-0.82, P = 0.011). in addition, the allele frequencies observed differed between genders. The G allele of rs3217986 was associated with increased risk for PTVD in male patients only(OR = 2.94, 95% Ci: 1.27-6.80, P = 0.012) in the dominant model, and no positively mutated allele was found in female patients. Conclusion Polymorphisms of the CDKN2 B-AS1 gene are associated with the incidence of PTVD in the Chinese population. Furthermore, the frequencies of mutated alleles differed between genders.

关键词： Premature triple-vessel disease Single-nucleotide polymorphism Risk

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