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Follicle-stimulating hormone as a predictor for sperm retrieval rate in patients with nonobstructive azoospermia, a systematic review and meta-analysis

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Asian Journal of Andrology 2015年第2期17卷 281-284,I0010页

作者： Qi Yang Yan-Ping huang Hong-Xiang Wang kai hu yi-Xin Wang yi-Ran huang Bin Chen Department of Urology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai institute of Andrology Shanghai 200127 China.

Noninvasive parameters for predicating sperm retrieval rate （SRR） are desirables. Follicle-stimulating hormone （FSH） has been an important predictor since the first years of testicular sperm extraction. Recent studies showed continuous interests in FSH, with both pros and cons. Thus, we conducted a meta-analysis to evaluate the diagnostic value of FSH as a predictor for patients with nonobstructive azoospermia （NOA） taking testicular sperm retrieval. Eligible diagnosis tests were identified from electronic databases （Cochrane Central Register of Controlled Trials, Medline, and EMBASE） without language restrictions. The database search, quality assessment, and data extraction were performed independently by two reviewers. The reference standard was the sperm retrieval result. Diagnostic value of FSH were explored by area under receiver operation characteristics （ROC） curve using Review Manager, version 5.1.0 （Cochrane Collaboration, Oxford, UK） and Meta-DiSc, version 1.4. Meta regression will be done if there is heterogeneity. Then, we find 11 tests including a total of 1350 patients met the inclusion criteria. Our pooled analysis showed that the area under ROC curve of FSH was 0.72 ~ 0.04. Meta regression analyses showed that region and average age have an influence on the diagnostic value. FSH showed more diagnostic value with patients in East Asia and with younger patients. We concluded that FSH had moderate value in independently predicating SRR in men with NOA （area under curve 〉0.7）. More detailed diagnosis tests should be anticipated in the future to confirm the diagnostic value of other noninvasive parameters.

关键词： follicule-stimulating hormone meta-analysis nonobstructive azoospermia testicular sperm retrieval

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Thermal conductive proppant with self-suspension ability

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Petroleum Science 2023年第3期20卷 1742-1749页

作者： Guo-Qing Xu Xiu-Ping Lan Si-Si hao kai-yi hu Si-Meng Qi Li-Dong Geng Quan Xu Yang Zhou Sinopec Key Laboratory of Drilling Completion and Fracturing of Shale Oil and Gas SINOPEC Research Institute of Petroleum Engineering Co.LtdBejing102249China State Key Laboratory of Petroleum Resources and Prospecting Bejing Key Laboratoryof Biogas Upgrading UtilizationHarvard SEAS-CUPB Joint Laboratory on Petroleum ScienceChina University of Petroleum(Beijing)Beijing102249China

The in situ mining technology is applied to the exploitation of medium-and low-maturity shale oil,which can use heaters to warm up the oil shale formations and pyrolyze the *** to the low thermal conductivity of oil shale,electric heaters need extra equipment to improve heat transfer *** this study,a thermally conductive proppant is fabricated by coating epoxy-resin and graphite on ceramic proppants for the first time,which could support the fracturing crack and transfer *** thermal conduction property of epoxy-resin and graphite coated proppants(EGPs)is 245%higher than that of uncoated proppants,which can transfer more heat to the oil shale formation and accelerate the conversion of *** adhesive property of EGPs is improved by 47.9%under the load force of 1500 nN,which prolongs the time for the fracture to *** summary,this novel proppant is expected to assist in-situ mining technology in the production of medium and low-maturity shale oil.

关键词： Exploitation of shaleoil In situ mining Technology Thermally conductive proppant Heat transfer

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Shaly detritus embedded epoxy-resin coated proppants

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Petroleum Science 2022年第4期19卷 1735-1744页

作者： Zhao-hui Lu Xiu-Ping Lan Yong Yuan Jian-Kun Zhou Si-Yuan Chen Fan Fan ying-Chun Niu Shou-Zhen Li kai-yi hu Yang Zhou Quan Xu Key Laboratory of Shale Gas Exploration Ministry of Natural ResourcesChongqing Institute of Geology and Mineral ResourcesChongqing401120China State Key Laboratory of Petroleum Resources and Prospecting Bejing Key Laboratory of Biogas Upgrading UtlizationHarvard SEAS-CUPB Joint Laboratory on Petroleum ScienceChina University of Petroleum(Beijing)Beijing102249China

Proppant plays a significant role in the hydraulic fracturing process, which can affect the production of oil and gas wells. Due to the high density and low adhesion force, the settling speed of traditional proppants is fast, which will lead to the blockage of a crack channel. In this study, a proppant with double layer structure is fabricated by coating epoxy-resin and shaly detritus on ceramic proppants for the first time,respectively. The epoxy-resin enables the shaly detritus to be coated on the proppant successfully, which can provide a new method for shaly detritus treatment. The adhesive ability of shaly detritus and epoxyresin coated proppants(SEPs) is improved by 10.4% under the load force of 500 n N, which prolongs the time for the fracture to close. At the same time, the suspending ability of SEPs is two times higher than the uncoated proppants. Once the guar gum solution concentration is 0.3 wt%, the settling time of SEPs is36.7% longer than that of the uncoated proppants, which can effectively reduce the settlement of proppants in the crack. In addition, the hydrophobicity of the SEPs is enhanced, which reduces the wateroil ratio of crude oil and increases the liquid conductivity tested by deionized water. In summary, this new proppant is expected to promote the development of unconventional oil and gas resources.

关键词： Coated proppant Shaly detritus Hydrophobicity Conductivity

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： yi Ji Chaoyi Yang Xuerui Pang yibing Yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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超顺磁性氧化铁在肝脏局灶性病变中的诊断价值

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实用放射学杂志 2003年第3期19卷 228-231页

作者：吕国士许乙凯胡蓉第一军医大学南方医院影像中心第一军医大学南方医院影像中心广东广州510515

目的　探讨菲力磁增强在肝脏结节性病变中的诊断价值。方法　对 2 0例肝脏结节性病变进行常规肝脏平扫和菲力磁增强扫描 ,分析增强前后T2 WI检测病灶数目以及肝脏、病灶信号强度的变化。结果　菲力磁增强明显降低正常肝脏的信号强度 ,... 详细信息

目的　探讨菲力磁增强在肝脏结节性病变中的诊断价值。方法　对 2 0例肝脏结节性病变进行常规肝脏平扫和菲力磁增强扫描 ,分析增强前后T2 WI检测病灶数目以及肝脏、病灶信号强度的变化。结果　菲力磁增强明显降低正常肝脏的信号强度 ,而病灶的信号强度无明显变化 ,病灶 -肝脏的信号强度比增加 ;菲力磁增强可清晰地显示病变并可发现更多病变。结论　菲力磁增强在检测肝脏结节性病变中敏感性高

关键词：肝脏肿瘤对比剂磁共振成像

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： ying Wang kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang hui Zuo Zhengyang Zhou Feng Ding Yue hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Grain-size effect on dislocation source-limited hardening and ductilization in bulk pure Ni

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Journal of Materials Science & Technology 2023年第23期154卷 9-21页

作者： kai hu Jun yi Bo huang Gang Wang Institute of Materials School of Materials Science and Engineering Shanghai University Shanghai 200444 China

Dislocation source-limited hardening and ductilization is an effective strategy to obtain superior strength-ductility synergy in some engineering structural metals. Recent works demonstrated that the synergy could be enhanced by grain-size reduction. However, the mechanism of grain-size dependence is still a mystery. In this work, bulk pure Ni produced by electrodeposition and subsequent annealing, with grain sizes ranging from ∼20 nm to ∼20 µm, were methodically investigated to unravel the mechanism of the grain-size effect on dislocation source-limited hardening and ductilization. The high-density nano-twinning in the as-electrodeposited nanograined specimens exhibited better thermodynamic stability than the peers with random high-angle grain boundaries, leading to fine recrystallized grains with low-density dislocations. The low dislocation density enabled extra hardening beyond grain boundary strengthening via yield-point behavior with grain sizes ranging from ∼110 nm to ∼10 µm and extra ductilization over ∼500 nm. This work demonstrated that the prerequisite for dislocation source-limited hardening was that the dislocation density of the specimen should be lower than the size-dependent critical value of ((1.1 × 107 /d ) m^(–2), d is the grain size in unit of the meter) where a transition from forest-dominated hardening to dislocation source-limited hardening could occur. On the other hand, dislocation source-limited ductilization only worked when the grain size was comparable to/larger than the theoretical dislocation mean slip distance. Dislocation source-limited ductilization resulted from more room in grains for accumulation of dislocations and deformation nano-stacking faults enabling the higher work hardening rate. This work offered an altogether new avenue to obtain stronger and more ductile metallic materials through utilizing grain-size dependent dislocation source-limited hardening and ductilization.

关键词： Dislocation source-limited hardening Dislocation source-limited ductilization Grain size yield point Hall-Petch slope

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A Scalable Infrastructure for Online Performance Analysis on CFD Application

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Chinese Journal of Aeronautics 2012年第4期25卷 546-558页

作者： hu kai DING yi ZHANG Xinyu JIANG Shu School of Computer Science and Engineering Beihang UniversityBeijing 100191China

The fast-growing demand of computational fluid dynamics（CFD） application for computing resources stimulates the development of high performance computing（HPC） and meanwhile raises new requirements for the technology of parallel application performance monitor and *** response to large-scale and long-time running for the application of CFD,online and scalable performance analysis technology is required to optimize the parallel programs as well as to improve their operational *** a result,this research implements a scalable infrastructure for online performance analysis on CFD application with homogeneous or heterogeneous *** infrastructure is part of the parallel application performance monitor and analysis system（PAPMAS） and is composed of two modules which are scalable data transmission module and data storage *** paper analyzes and elaborates this infrastructure in detail with respect to its design and ***,some experiments are carried out to verify the rationality and high efficiency of this infrastructure that could be adopted to meet the practical needs.

关键词： computational aerodynamics computational fluid dynamics scalability online analysis data transmission data storage

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PRKCQ-AS1通过Akt信号促进气道平滑肌细胞增殖的研究

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中国药理学通报 2025年第1期41卷 88-94页

作者：吴露依胡方启安庆医药高等专科学校临床科研中心安庆市立医院安徽安庆246000

目的探讨PRKCQ-AS1在气道平滑肌细胞(airway smooth muscle cells,ASMCs)的作用。方法首先通过转录组测序技术(RNA-seq)检测哮喘儿童肺泡灌洗液中的差异表达基因(differentially expressed genes,DEGs)。随后,分别构建PRKCQ-AS1慢病毒敲低和过表达载体并转染ASMCs。qRT-PCR方法检测了ASMCs中PRKCQ-AS1的表达;用CCK-8和流式细胞术分别检测ASMCs的增殖和凋亡;酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)检测ASMCs培养上清液中TNF-α和IL-1β的含量;lncRNA芯片检测PRKCQ-AS1敲低后的DEGs并进行KEGG通路富集;Western blot检测p-Akt和Akt的水平。结果RNA-seq结果显示,PRKCQ-AS1是上调最明显的DEGs之一。PRKCQ-AS1过表达促进了ASMCs的增殖和迁移并抑制了其凋亡,同时,PRKCQ-AS1过表达使上清液中炎性因子TNF-α和IL-1β的水平升高,而PRKCQ-AS1敲低则呈现相反的结果。对PRKCQ-AS1敲低后得到的606个DEGs进行KEGG信号通路富集分析,结果显示PI3K-Akt信号被明显富集。Western blot结果表明,PRKCQ-AS1敲低抑制了Akt的活化;相反,PRKCQ-AS1过表达则促进了Akt的水平。结论PRKCQ-AS1可能通过增强Akt信号促进ASMCs炎症反应,进而加剧了ASMCs的增殖和迁移,最终导致哮喘的发展。

关键词： PRKCQ-AS1 ASMCs 哮喘 Akt信号细胞实验炎性细胞因子

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序贯疗法治疗幽门螺杆菌阳性消化性溃疡的疗效观察及安全性分析

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实用医院临床杂志 2017年第2期14卷 88-90页

作者：彭廷勇何熙国周琮凯胡艺四川省江油市人民医院消化内科四川江油621700

目的探讨序贯疗法治疗幽门螺杆菌(Hp)阳性消化性溃疡(PU)的疗效及安全性。方法 86例Hp阳性PU患者按随机数字表法分为对照组(泮托拉唑+阿莫西林+克拉霉素)和观察组(前5d泮托拉唑+阿莫西林,后5d泮托拉唑+替硝唑+克拉霉素)各43例。以10 d作... 详细信息

目的探讨序贯疗法治疗幽门螺杆菌(Hp)阳性消化性溃疡(PU)的疗效及安全性。方法 86例Hp阳性PU患者按随机数字表法分为对照组(泮托拉唑+阿莫西林+克拉霉素)和观察组(前5d泮托拉唑+阿莫西林,后5d泮托拉唑+替硝唑+克拉霉素)各43例。以10 d作为1个疗程,疗程结束后一个月,对两组患者Hp转阴情况、疗效及治疗期间的不良反应进行比较。结果对照组Hp根除率76.7%,观察组Hp根除率88.4%,差异有统计学意义(χ~2=4.725,P0.05)。结论 Hp阳性PU采用序贯疗法治疗具有较高的Hp根除率及治疗有效率,无明显不良反应,值得临床进一步研究与推广运用。

关键词：幽门螺杆菌消化性溃疡序贯疗法疗效

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