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Earth-abundant Zn-dipyrrin chromophores for efficient CO2 photoreduction

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National Science Review 2024年第6期11卷 214-222页

作者： Song Guo fu-Gui Zeng Xiao-Di Li kai-kai Chen Ping Wang Tong-Bu Lu Zhi-Ming Zhang Institute for New Energy Materials and Low Carbon Technologies School of Materials Science& Engineering Tianjin University of Technology

The development of strong sensitizing and Earth-abundant antenna molecules is highly desirable for CO2reduction through artificial photosynthesis. Herein, a library of Zn–dipyrrin complexes（Z-1-Z-6） are rationally designed via precisely controlling their molecular configuration to optimize strong sensitizing Earth-abundant photosensitizers. Upon visible-light excitation, their special geometry enables intramolecular charge transfer to induce a charge-transfer state, which was first demonstrated to accept electrons from electron donors. The resulting long-lived reduced photosensitizer was confirmed to trigger consecutive intermolecular electron transfers for boosting CO2-to-CO conversion. Remarkably, the Earth-abundant catalytic system with Z-6 and Fe-catalyst exhibits outstanding performance with a turnover number of >20 000 and 29.7% quantum yield, representing excellent catalytic performance among the molecular catalytic systems and highly superior to that of noble-metal photosensitizer Ir（ppy）2（bpy）+under similar conditions. Experimental and theoretical investigations comprehensively unveil the structure–activity relationship, opening up a new horizon for the development of Earth-abundant strong sensitizing chromophores for boosting artificial photosynthesis.

关键词： Zn complex photocatalysis CO2 reduction charge transfer photosensitizer

In vivofluorescenceflow cytometry reveals that the nanoparticle tumor vaccine OVA@HA-PEI effectively clears circulating tumor cells

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 107-123页

作者： Wei Jin Yuting fu Sisi Ge Han Sun kai Pang Xunbin Wei The Department of Biomedical Engineering Institute of Advanced Clinical Medicine Peking University Beijing 100191P.R.China Institute of Medical Technology Peking University Health Science Center Beijing 100191 P.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijing 100142P.R.China School of Instrument Science and Opto-Electronics Engineering Beijing Information Science&Technology University Beijing 100192 P.R.China

Tumor vaccine therapy offers significant advantages over conventional treatments,including reduced toxic side ***,it currently functions primarily as an adjuvant treatment modality in clinical oncology due to limitations in tumor antigen selection and delivery *** vaccines often fail to elicit a su±ciently robust immune response against progressive tumors,thereby limiting their clinical e±*** this study,we developed a nanoparticle-based tumor vaccine,OVA@HA-PEI,utilizing ovalbumin(OVA)as the presenting antigen and hyaluronic acid(HA)and polyethyleneimine(PEI)as adjuvants and *** formulation significantly enhanced the proliferation of immune cells and cytokines,such as CD3,CD8,interferon-,and tumor necrosis factor-,in vivo,effectively activating an immune response against B16–F10 *** vivofluorescenceflow cytometry(IVFC)has already become an effective method for monitoring circulating tumor cells(CTCs)due to its direct,noninvasive,and long-term detection *** study utilized a laboratory-constructed IVFC system to monitor the immune processes induced by the OVA@HA-PEI tumor vaccine and an anti-programmed death-1(PD-1)*** results demonstrated that the combined treatment of OVA@HA-PEI and anti-PD-1 antibody significantly improved the survival time of mice compared to anti-PD-1 antibody treatment ***,this combination therapy substantially reduced the number of CTCs in vivo,increased the clearance rate of CTCs by the immune system,and slowed tumor *** greatly enhance the clinical application prospects of IVFC and tumor vaccines.

关键词： Tumor vaccines circulating tumor cells in vivofluorescenceflow cytometry.

Classification of high-ordered topological nodes towards Moiré flat bands in twisted bilayers

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 133-147页

作者： Fan Cui Congcong Le qiang Zhang Xianxin Wu Jiangping Hu Ching-kai Chiu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China RIKEN Interdisciplinary Theoretical and Mathematical Sciences(iTHEMS) Wako 351-0198Japan CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Kavli Institute of Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China New Cornerstone Science Laboratory Beijing 100190China

At magic twisted angles,Dirac cones in twisted bilayer graphene(TBG)can evolve into flat bands,serving as a critical playground for the study of strongly correlated *** chiral symmetry is introduced,rigorous mathematical proof confirms that the flat bands are locked at zero energy in the entire Moiré Brillouin zone(BZ).Yet,TBG is not the sole platform that exhibits this absolute band *** to this flatness phenomenon are topological nodes and their specific locations in the *** this study,considering twisted bilayer systems that preserve chiral symmetry,we classify various ordered topological nodes in base layers and all possible node locations across different ***,we constrain the node locations to rotational centers,such as Γ and M points,to ensure the interlayer coupling retains equal strength in all *** this classification as a foundation,we systematically identify the conditions under which Moiré flat bands ***,through the extension of holomorphic functions,we provide proof that flat bands are locked at zero energy,shedding light on the origin of the band ***,beyond Dirac cones,numerous twisted bilayer nodal platforms can host flat bands with a degeneracy number of more than two,such as four-fold,six-fold,and *** multiplicity of degeneracy in flat bands might unveil more complex and enriched correlation physics.

关键词： twisted bilayer systems high-ordered topological nodes Moriéflat bands high degeneracy

Steric hindrance shielding viologen against alkali attack in realizing ultrastable aqueous flow batteries

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Journal of Energy Chemistry 2024年第10期97卷 529-534,I0011页

作者： Liwen Wang kai Wan Xianzhi Yuan Zhipeng Xiang Zhiyong fu Zhenxing Liang Guangdong Provincial Key Laboratory of fuel Cell Technology School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641GuangdongChina State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510641GuangdongChina Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 522000GuangdongChina

Viologens known as a kind of promising negolyte materials for aqueous organic redox flow batteries,face a critical stability challenge due to the S_N2 nucleophilic attack by hydroxide ions(OH-)during the battery *** this work,a N-cyclic quaternary ammonium-grafted viologen molecule,viz.1,1'-bis(4,4'-dime thylpiperidiniumyl)-4,4'-bipyridinium tetrachloride((DBPPy)Cl_(4)),is developed by the molecular engineering *** obtained(DBPPy)Cl_(4) molecule shows a decent solubility of 1.84 M and a redox potential of-0.52 V ***/AgCl,Experimental and theoretical results reveal that the grafted N-cyclic quaternary ammonium groups act as the steric hindrance to prevent nucleophilic attack by OH~-,increasing the alkali resistance of the electroactive *** symmetrical battery with 0.50 M(DBPPy)Cl4shows negligible decay during the 13-day cycling *** demonstration,the flow battery utilizing 1.0 M(DBPPy)Cl_(4) as the negolyte and 1-(1-oxyl-2,2',6,6'-tetramethylpiperidin-4-yl)-1'-(3-(trimethylammonio)propyl)-4,4'-bipyridinium trichloride as the posolyte exhibits a high capacity retention rate of 99.99%per cycle at 60 mA cm^(-2).

关键词： Aqueous organic flow batteries Viologen Stability Steric hindrance Alkali resistance

The Effect of Blending Ratio on the Structure and Properties of the PPR/PS In situ Fiber Reinforced System Prepared by Multi-Flow Vibration Injection Molding

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Chinese Journal of Polymer Science 2024年第6期42卷 851-863页

作者： Yan-Jiang Li Meng-Long Hu Jun-Wen Zhang qiang fu Jie Zhang College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China

To enhance the mechanical properties of polypropylene random copolymer(PPR),polystyrene(PS)with four different contents were added to the PPR matrix through melt ***,using the Multi-Flow Vibration Injection Molding(MFVIM)technology,PPR/PS in situ microfiber composites(MFC)with different blending ratios were *** results indicated that blending ratio had a great impact on the phase morphology and crystal structure of MFVIM samples,which was different from those of conventional injection molding(CIM)*** ultrafine fibers could be formed under the shear field and could absorb the PPR molecular chains to form hybrid shish-kebab ***,the PPR matrix could also form shish-kebab structures under the effect of strong *** the PS content reached 20%,under the combined action of PS in situ microfibers and highly oriented crystal structure,the tensile strength and Young’s modulus of the sample were obviously improved and the impact strength remained at a relatively high *** a strong and tough balanced PPR based material was *** results provide valuable insights for expanding the industrial and daily-life applications of PPR and show promising development prospects.

关键词： PPR MFVIM In situ microfibers Shearfield Hybrid shish-kebab structures

Pre-MASLD:Should it be defined separately?

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 1-3页

作者： Hang-kai Huang You-Ming Li Cheng-fu Xu Department of Gastroenterology Zhejiang Provincial Clinical Research Center for Digestive Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases,yet it has not received sufficient attention[1].Over the past two decades,the overall global prevalence of NAFLD has risen from 25%to 37%[2].The disease burden of NAFLD is fueled by the epidemic of obesity and diabetes[3].It is estimated that more than half of patients with diabetes have NAFLD.

关键词： NAFLD liver diseases

Online Learning Behavior Analysis and Prediction Based on Spiking Neural Networks

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Journal of Social Computing 2024年第2期5卷 180-193页

作者： Yanjing Li Xiaowei Wang fukun Chen Bingxu Zhao qiang fu the Institute of Education Science Research Heilongjiang UniversityHarbin 150080China the School of Cyberspace Security Shandong University of Political Science and LawJinan 250014China the School of Computer Science and Technology Harbin Engineering UniversityHarbin 150001China the Faculty of Electrical and Computer Engineering University of VictoriaVictoriaV8P 5C2Canada. the Guangxi Key Lab of Brain-Inspired Computing and Intelligent Chips School of Electronic and Information EngineeringGuangxi Normal UniversityGuilin 541004China

The vast amount of data generated by large-scale open online course platforms provide a solid foundation for the analysis of learning behavior in the field of *** study utilizes the historical and final learning behavior data of over 300000 learners from 17 courses offered on the edX platform by Harvard University and the Massachusetts Institute of Technology during the 2012-2013 academic *** have developed a spike neural network to predict learning outcomes,and analyzed the correlation between learning behavior and outcomes,aiming to identify key learning behaviors that significantly impact these *** goal is to monitor learning progress,provide targeted references for evaluating and improving learning effectiveness,and implement intervention measures *** results demonstrate that the prediction model based on online learning behavior using spiking neural network achieves an impressive accuracy of 99.80%.The learning behaviors that predominantly affect learning effectiveness are found to be students’academic performance and level of participation.

关键词： online learning learning outcomes prediction learning behavior analysis spiking neural network

Marginal land in China suitable for bioenergy crops under diverse socioeconomic and climate scenarios from 2020 to 2100

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Big Earth Data 2024年第3期8卷 566-586页

作者： Jingying fu qiang Gao Gang Lin Dong Jiang Yanan Zhao Shuang Lue Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijingChina College of Resources and Environment University of Chinese Academy of SciencesBeijingChina Key Laboratory of Coupling Processes and Effects of Natural Resource Elements Ministry of Natural ResourcesBeijingChina Key Laboratory of Carrying Capacity Assessment for Resource and Environment Ministry of Natural ResourcesBeijingChina College of Geoscience and Surveying Engineering China University of Mining and Technology(Beijing)BeijingChina

Maximizing the development of renewable energy plays a critical role in mitigating the climate *** land provides space for the development of biomass energy;however,it remains unclear how the amount and spatial distribution of marginal land that is suitable for energy crop development will change in the ***,we project energy marginal land changes in China following the shared socioeconomic pathway(SSP)and/or repre-sentative concentration path(RCP).We provide datasets of mar-ginal land,agriculturally suitable land,and potentially suitable for energy crops under historical scenarios and six future scenarios(***1-1.9,SSP1-2.6,SSP4-3.4,SSP2-4.5,SSP4-6.0,and SSP3-7.0)for the period 2020-2100,with a spatial resolution of 5 *** the six scenarios,from 2020-2100,the area of suitable marginal land ranged from 1.90-16.28(Jatropha curcas L.)to 37.37-73.97(Panicum virgatum L.)(×10^(4)km^(2)),depending on the choice of energy crops and climate *** on the growing suitability of eight important bioenergy crops-Ricinus communis L.,Saccharum officinarum L.,Pistacia chinensis Bunge,Panicum virga-tum L.,Jatropha curcas L.,Miscanthus giganteus J.,Manihot esculenta Crantz,and Sorghum bicolor Moench-our dataset can be used to identify suitable locations for specific energy *** new syn-thetic dataset could support the development of multiscenariobased solutions related to carbon neutrality,ecosystem services,and energy transition.

关键词： Marginal land climate change energy crops liquid fuel

Engineered AAV13 variants with enhanced transduction and confined spread

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Zoological Research 2024年第4期45卷 781-790页

作者： Neng-Song Luo Yu-Xiang Cai Zeng-Peng Han Xiao-kai Sui Wen-Jia Yuan Zi-Lian Zhang Hao-Dong Guo Jie Wang Kun-Zhang Lin fu-qiang Xu Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Shenzhen Key Laboratory of Viral Vectors for Biomedicine Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Key Laboratory of Quality Control Technology for Virus-Based Therapeutics Guangdong Provincial Medical Products AdministrationNMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Zhongnan Hospital Wuhan UniversityWuhanHubei 430072China Brain Case Biotechnology Co. Ltd.ShenzhenGuangdong 518107China College of Life Sciences Wuhan UniversityWuhanHubei 430072China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Precise targeting of specific regions within the central nervous system(CNS)is crucial for both scientific research and gene therapy in the context of brain ***-associated virus 13(AAV13)is known for its restricted diffusion range within the CNS,making it an ideal choice for precise labeling and administration within small brain ***,AAV13 mediates relatively low expression of target ***,we introduced specifically engineered modifications to the AAV13 capsid protein to enhance its transduction *** first constructed AAV13-YF by mutating tyrosine to phenylalanine on the surface of the AAV13 *** then inserted the 7m8 peptide,known to enhance cell transduction,into positions 587/588 and 585/586 of the AAV13 capsid,resulting in two distinct variants named AAV13-587-7m8 and AAV13-585-7m8,*** found that AAV13-YF exhibited superior in vitro infectivity in HEK293T cells compared to AAV13,while AAV13-587-7m8 and AAV13-585-7m8 showed enhanced CNS infection capabilities in C57BL/6 mice,with AAV13-587-7m8 infection retaining a limited spread *** modified AAV13 variants hold promising potential for applications in gene therapy and neuroscience research.

关键词： Adeno-associated virus 13 AAV13-YF AAV13-587-7m8 AAV13-585-7m8 transduction efficiency