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Triclosan-conjugated,lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： Yan-qiang Huang Yuan-Feng li Yong liu lin-Qi Shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

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Data-driven mapping-relationship mining between hardness and mechanical properties of dual-phase titanium alloys via random forest and statistical analysis

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Rare Metals 2024年第2期43卷 829-841页

作者： Hai-Chao Gong Qun-Bo Fan Hong-Mei Zhang Xing-Wang Cheng Wen-qiang Xie kai Chen lin Yang Jun-Jie Zhang Bing-qiang Wei Shun Xu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China National Key Laboratory of Science and Technology on Materials Under Shock and Impact Beijing100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing401135China Department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNE68588USA

In order to accelerate the research on the property optimization of titanium alloy based on high-throughput methods,it is necessary to reveal the relationship between hardness and other mechanical properties which is still *** this work,taking Ti20C alloy as research object,almost all the microstructure of dual-phase titanium alloys were covered by traversing over 100 heat treatment ***,massive experiments including microstructure characterization and performance test were conducted,obtaining 51,590 pieces of microstructure data and 3591 pieces of mechanical property ***,based on large-scale data-driven technology,the quantitative mapping relationship between hardness and other mechanical properties was deeply *** results of random forest models showed that the correlation between hardness(H)and Charpy impact energy(A_(k))(or elongation,A)was hardly dependent on the microstructure types,while the relationship between H and tensile strength(R_(m))(or yield strength,R_(p0.2))was highly dependent on microstructure ***,combined with statistical analysis,it was found that the relationship between H and Ak(or A)were negatively ***,the relationship between H and strength was positively linear for equiaxed microstructure,and strength was linked to d^(−1/2)(d,equivalent circle diameter)ofα-grains in the form of classical Hall–Petch formula;but for other microstructures,the relationships were ***,the above rules were nearly the same in the rolling direction and transverse ***,a"four-quadrant partition map"between H and R_(p0.2)/R_(m) was established as a versatile material-screening tool,which can provide guidance for on-demand selection of titanium alloys.

关键词： Dual-phase titanium alloy Data-driven Hardness Mapping relationship

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Effect of Mn content on microstructure and properties of AlCrCuFeMnx high-entropy alloy

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China Foundry 2024年第2期21卷 147-158页

作者： Ning Wang kai Ma Qiu-da li Yu-dong Yuan Yan-chun Zhao li Feng School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050China State Key Laboratory of Advanced Processing and Reuse of Nonferrous Metals Lanzhou 730050China CNNC Nuclear Power Operation and Management Co. Ltd.Haiyan 314300ZhejiangChina

AlCrCuFeMnx(x=0,0.5,1,1.5,and 2)high-entropy alloys were prepared using the vacuum arc melting *** microstructure and mechanical properties of AlCrCuFeMnxwere analyzed and tested by XRD,SEM,TEM,nanoindentation,and electronic universal *** results indicate that the AlCrCuFeMnxhigh-entropy alloy exhibits a dendritic structure,consisting of dendrites with a BCC structure,interdendrite regions with an FCC structure,and precipitates with an ordered BCC structure that form within the ***(Mn)has a strong affinity for dendritic,interdendritic,and precipitate structures,allowing it to easily enter these *** an increase in Mn content,the size of the precipitated nanoparticles in the dendritic region initially increases and then ***,the area fraction initially decreases and then ***,the alloy’s strength and wear resistance decrease,while its plasticity *** Al Cr Cu Fe Mn1.5alloy boasts excellent mechanical properties,including a hardness of 360 HV and a wear rate of 2.4×10^(-5)mm^(3)·N^(-1)·mm^(-1).It also exhibits impressive yield strength,compressive strength,and deformation rates of 960 MPa,1,700 MPa,and 27.5%,respectively.

关键词： high-entropy alloys microstructure mechanical properties wear resistance strengthening mechanisms

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Derivative Spectroscopy and its Application at Detecting the Weak Emission/Absorption lines

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Research in Astronomy and Astrophysics 2024年第3期24卷 205-223页

作者： lihuan Yu Jiangdan li Jinliang Wang Jiajia li Jiao li qiang Xi Zhanwen Han Yunnan Observatories Chinese Academy of Sciences(CAS)Kunming 650011China Key Lab of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

The development of spectroscopic survey telescopes like Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST),Apache Point Observatory Galactic Evolution Experiment and Sloan Digital Sky Survey has opened up unprecedented opportunities for stellar *** types of stars,such as early-type emission-line stars and those with stellar winds,can be distinguished by the profiles of their spectral *** this paper,we introduce a method based on derivative spectroscopy(DS)designed to detect signals within complex backgrounds and provide a preliminary estimation of curve *** method exhibits a unique advantage in identifying weak signals and unusual spectral line profiles when compared to other popular line detection *** validated our approach using synthesis spectra,demonstrating that DS can detect emission signals three times fainter than Gaussian ***,we applied our method to 579,680 co-added spectra from LAMOST Medium-Resolution Spectroscopic Survey,identifying 16,629 spectra with emission peaks around the Hαline from 10,963 *** spectra were classified into three distinct morphological groups,resulting in nine subclasses as follows.(1)Emission peak above the pseudo-continuum line(single peak,double peaks,emission peak situated within an absorption line,P Cygni profile,Inverse P Cygni profile);(2)Emission peak below the pseudo-continuum line(sharp emission peak,double absorption peaks,emission peak shifted to one side of the absorption line);(3)Emission peak between the pseudo-continuum line.

关键词： line identification-line profiles-methods data analysis-techniques spectroscopic-techniques radial velocities

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Equipment damage measurement method of wartime based on FCE-PCA-RF

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Journal of Systems Engineering and Electronics 2024年第3期35卷 707-719页

作者： li Mingyu GAO Lu XU Hongwei li kai HUANG Yisong Shijiazhuang Campus of Army Engineering University Shijiazhuang 050003China Shijiazhuang Campus of Army Infantry Academy Shijiazhuang 050227China

As the“engine”of equipment continuous operation and repeated operation, equipment maintenance support plays a more prominent role in the confrontation of symmetrical combat systems. As the basis and guide for the planning and implementation of equipment maintenance tasks, the equipment damage measurement is an important guarantee for the effective implementation of maintenance support. Firstly,this article comprehensively analyses the influence factors to damage measurement from the enemy’s attributes, our attributes and the battlefield environment starting from the basic problem of wartime equipment damage measurement. Secondly, this article determines the key factors based on fuzzy comprehensive evaluation(FCE) and performed principal component analysis (PCA) on the key factors. Finally, the principal components representing more than 85%of the data features are taken as the input and the equipment damage quantity is taken as the output. The data are trained and tested by artificial neural network (ANN) and random forest (RF). In a word, FCE-PCA-RF can be used as a reference for the research of equipment damage estimation in wartime.

关键词： wartime equipment damage fuzzy comprehensive evaluation(FCE) principal component analysis(PCA) artificial neural network(ANN) random forest(RF)

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The interannual periodicity of precipitation and its links to the large-scale circulations over the Third Pole

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Journal of Geographical Sciences 2024年第8期34卷 1457-1471页

作者： liANG liqiao liU qiang li Jiuyi State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchCASBeijing 100101China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Key Laboratory for Water and Sediment Sciences Ministry of EducationSchool of EnvironmentBeijing Normal UniversityBeijing 100875China Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China

To understand the spatio-temporal variability of precipitation(P)in the Third Pole region(centered on the Tibetan Plateau-TP),it is necessary to quantify the interannual periodicity of P and its relationship with large-scale *** this study,Morlet wavelet transform was used to detect significant(plimate domains in the Third Pole,and to reveal the major large-scale circulations that triggered the variability of periodic P,in addition to bringing large amounts of water *** wavelet transform results were as follows.(1)Significant quasiperiodicity varied from 2 to 11 *** high-frequency variability mode(2 to 6 years quasi-periods)was universal,and the low-frequency variability mode(7 to 11 years quasi-periods)was rare,occurring mainly in the westerlies and Indian monsoon domains.(2)The majority of periods were base periods(53%),followed by two-base *** all stations in the Third Pole(95%)showed one or two periods.(3)Periodicity was widely detected in the majority of years(84%).(4)The power spectra of P in the four domains were dominated by statistically significant high-frequency oscillations(ie.,with short periodicity).(5)Large-scale circulations directly and indirectly influenced the periodic P variability in the different *** mode of P variability in the different domains was influenced by interactions between large-scale circulation features and not only by the dominant circulation and its control of water vapour *** results of this study will contribute to better understanding of the causal mechanisms associated with P variability,which is important for hydrological science and waterresourcemanagement.

关键词： precipitation interannual periodicity Morlet wavelet large-scale circulations Third Pole

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A novel fracture-cavity reservoir outcrop geological knowledge base construction method considering parameter collection and processing, mutual transformation of data-knowledge, application and update

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Petroleum Science 2024年第4期21卷 2184-2202页

作者： Qi-qiang Ren Jin-liang Gao Peng Zhu Meng-Ping li Jian-Wei Feng qiang Jin San Zhang Institute of Sedimentary Geology Chengdu University of Technology PetroChina Research Institute of Petroleum Exploration and Development School of Energy Chengdu University of Technology School of Resources and Geosciences China University of Mining and Technology School of Geosciences China University of Petroleum (East China) School of Geosciences Yangtze University

This study endeavors to formulate a comprehensive methodology for establishing a Geological Knowledge Base(GKB) tailored to fracture-cavity reservoir outcrops within the North Tarim Basin. The acquisition of quantitative geological parameters was accomplished through diverse means such as outcrop observations, thin section studies, unmanned aerial vehicle scanning, and high-resolution cameras. Subsequently, a three-dimensional digital outcrop model was generated, and the parameters were standardized. An assessment of traditional geological knowledge was conducted to delineate the knowledge framework, content, and system of the GKB. The basic parameter knowledge was extracted using multiscale fine characterization techniques, including core statistics, field observations, and microscopic thin section analysis. Key mechanism knowledge was identified by integrating trace elements from filling, isotope geochemical tests, and water-rock simulation experiments. Significant representational knowledge was then extracted by employing various methods such as multiple linear regression, neural network technology, and discriminant classification. Subsequently, an analogy study was performed on the karst fracture-cavity system(KFCS) in both outcrop and underground reservoir settings. The results underscored several key findings:(1) Utilization of a diverse range of techniques,including outcrop observations, core statistics, unmanned aerial vehicle scanning, high-resolution cameras, thin section analysis, and electron scanning imaging, enabled the acquisition and standardization of data. This facilitated effective management and integration of geological parameter data from multiple sources and scales.(2) The GKB for fracture-cavity reservoir outcrops, encompassing basic parameter knowledge, key mechanism knowledge, and significant representational knowledge, provides robust data support and systematic geological insights for the intricate and in-depth examination of the genetic

关键词： Geological knowledge base Karst fracture-cavity system Mutual transformation of data-knowledge Knowledge base content and application Tarim basin

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Earth-abundant Zn-dipyrrin chromophores for efficient CO2 photoreduction

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National Science Review 2024年第6期11卷 214-222页

作者： Song Guo Fu-Gui Zeng Xiao-Di li kai-kai Chen Ping Wang Tong-Bu Lu Zhi-Ming Zhang Institute for New Energy Materials and Low Carbon Technologies School of Materials Science& Engineering Tianjin University of Technology

The development of strong sensitizing and Earth-abundant antenna molecules is highly desirable for CO2reduction through artificial photosynthesis. Herein, a library of Zn–dipyrrin complexes（Z-1-Z-6） are rationally designed via precisely controlling their molecular configuration to optimize strong sensitizing Earth-abundant photosensitizers. Upon visible-light excitation, their special geometry enables intramolecular charge transfer to induce a charge-transfer state, which was first demonstrated to accept electrons from electron donors. The resulting long-lived reduced photosensitizer was confirmed to trigger consecutive intermolecular electron transfers for boosting CO2-to-CO conversion. Remarkably, the Earth-abundant catalytic system with Z-6 and Fe-catalyst exhibits outstanding performance with a turnover number of >20 000 and 29.7% quantum yield, representing excellent catalytic performance among the molecular catalytic systems and highly superior to that of noble-metal photosensitizer Ir（ppy）2（bpy）+under similar conditions. Experimental and theoretical investigations comprehensively unveil the structure–activity relationship, opening up a new horizon for the development of Earth-abundant strong sensitizing chromophores for boosting artificial photosynthesis.

关键词： Zn complex photocatalysis CO2 reduction charge transfer photosensitizer

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Density-Functional Theories for Polyelectrolyte Systems

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Chinese Journal of Polymer Science 2024年第9期42卷 1302-1312,I0006页

作者： Jia-Wei Zhang Yu-Hang Zhang Bao-Hui li qiang Wang School of Physics Nankai UniversityTianjin90001China Department of Chemical and Biological Engineering Colorado State University1370 Campus DeliveryFort CollinsCO80523-1370USA

Polymer density-functional theories(PDFTs)have distinct advantages in the study of polyelectrolyte(PE)systems over experiments and molecular *** we give an introductory review of some PDFTs recently developed for PE *** start with a general formalism of PDFTs and its relation to the widely used polymer self-consistent field theory(SCFT),then explain the various correlations that are neglected in SCFT but can be accounted for in PDFTs,including those due to the excluded-volume interaction and chain connectivity of uncharged polymers,the electrostatic correlations of small ions,and the chain correlations in *** also list some applications of PDFTs for PE systems,and finally give some perspectives on future *** hope that our review can attract more researchers to apply and further develop PDFTs as a promising class of theoretical and computational tools.

关键词： Polymer density-functional theories Polyelectrolytes Correlations

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An improved strain-softening constitutive model of granite considering the effect of crack deformation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1202-1215页

作者： Yapeng li qiang Zhang Qiuxin Gu Peinan Wu Binsong Jiang State Key Laboratory for Geomechanics and Deep Underground Engineering School of Mechanics and Civil EngineeringChina University of Mining and TechnologyXuzhou221116China

This paper presents an improved strain-softening constitutive model considering the effect of crack deformation based on the triaxial cyclic loading and unloading test *** improved model assumes that total strain is a combination of plastic,elastic,and crack *** constitutive relationship between the crack strain and the stress was further *** evolutions of mechanical parameters,*** parameters,dilation angle,unloading elastic modulus,and deformation parameters of crack,with the plastic strain and confining pressure were *** the increase in plastic strain,the cohesion,friction angle,dilation angle,and crack Poisson's ratio initially increase and subsequently decrease,and the unloading elastic modulus and the crack elastic modulus nonlinearly *** increasing confining pressure enhances the strength and unloading elastic modulus,and decreases the dilation angle and Poisson's ratio of the *** theoretical triaxial compressive stress-strain curves were compared with the experimental results,and they present a good agreement with each *** improved constitutive model can well reflect the nonlinear mechanical behavior of granite.

关键词： Strain-softening Crack deformation effect Plastic shear strain Constitutive model

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