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Research Progress of Chinese Medicine Monomers in Treatment of Cholangiocarcinoma

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Chinese Journal of Integrative Medicine 2025年第2期31卷 170-182页

作者： WANG Xiang WANG Xiao-qing LUO kai bai He QU Jia-lin ZHANG Gui-xin Department of General Surgery the Second Hospital of Dalian Medical UniversityDalianLiaoning Province(116027)China Clinical Laboratory of Integrative Medicine First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning Province(116021)China Hepatobiliary Surgery Department Shandong Provincial Third HospittalShandong UniversityJinan(250031)China Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning Province(116044)China

Cholangiocarcinoma(CCA)is a malignant tumor originating from ***,it remains unclear about the pathogenesis of this carcinoma,which may be related to multiple ***,CCA is mainly treated by surgery,chemotherapy,and *** them,surgery is the only potentially curative option for ***,the high malignancy and asymptomatic nature of CCA may lead to poor treatment *** has been demonstrated that Chinese medicine(CM)plays a significant role in various antitumor ***,CM exhibits fewer side effects and high ***,the in vitro application of CM monomers has been explored in many domestic and foreign *** article mainly reviews the signaling pathways and molecular mechanisms of CM monomers in the treatment of CCA in recent *** findings are expected to provide new insights into the treatment of CCA.

关键词： cholangiocarcinoma Chinese medicine monomers antitumor signaling pathways molecular mechanisms review

Lattice-mismatch-induced formation of defect-rich Pd-Cu alloy nanocages for enhanced formic acid oxidation activity

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SCIENCE CHINA-CHEMISTRY 2025年第2期68卷 481-491页

作者： Liu, Zhaojun Wang, Zhengyan Wang, Zhaoyu Yuan, Hao bai, Yuke Wang, Xiaoxiao Mu, Zerui Wu, Chunxia Liu, kai Hu, Zhun Gao, Chuanbo Xi An Jiao Tong Univ Frontier Inst Sci & Technol Sate Key Lab Multiphase Flow Power Engn Xian 710049 Peoples R China Xi An Jiao Tong Univ Inst Ind Catalysis Sch Chem Engn & Technol Xian 710049 Peoples R China

Crystallographic defects in noble metal nanocrystals are recognized as highly active catalytic sites, significantly enhancing activities in many important reactions. Despite their importance, synthesizing noble metal nanocrystals with a high density of defects poses a considerable synthetic challenge. Here, we present a novel lattice mismatch-induced formation mechanism to create high-density defects in noble metal nanocrystals. This approach takes advantage of lattice mismatch to enable non-epitaxial nucleation and growth of a noble metal on a foreign metal substrate, forming abundant noble metal crystallites with random lattice orientations not dictated by the substrate lattice. As these crystallites grow extensively, they merge, forming numerous grain boundaries and yielding defect-rich noble metal nanocrystals. Defect-rich alloy nanocrystals can also be synthesized through a subsequent vacancy-diffusion alloying process. We take defective PdCu alloy nanocages as an example and demonstrate the effectiveness of crystallographic defects in enhancing catalytic performance of noble metal nanocrystals. The nanocages exhibit superior activity in the electrocatalytic formic acid oxidation reaction, which is 1.6 times greater than their defect-free counterparts. Our strategy offers a new avenue for creating defect-rich noble metal nanocrystals as highly efficient catalysts for a wide array of catalytic applications.

关键词： noble metal nanocrystals defects non-epitaxial growth electrocatalysis formic acid oxidation reaction

超特高压变电站无人机飞行安全距离测定方法研究

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高压电器 2025年第1期61卷 165-172页

作者：曹凯张白杨炯李波国网宁夏电力有限公司超高压公司银川750011 北方民族大学银川750021

针对无人机在超特高压变电站巡检作业中的飞行安全问题,文中以电力巡检领域典型无人机为研究对象,开展了500、750、1000 kV电压等级的变电站关键设备无人机飞行安全距离测定方法研究。首先,通过仿真建模与分析,获取关键设备的电磁场极值... 详细信息

针对无人机在超特高压变电站巡检作业中的飞行安全问题,文中以电力巡检领域典型无人机为研究对象,开展了500、750、1000 kV电压等级的变电站关键设备无人机飞行安全距离测定方法研究。首先,通过仿真建模与分析,获取关键设备的电磁场极值;进一步提出了超特高压变电站无人机动态飞行安全距离测定方法,并开展了无人机在超特高压环境下的动态飞行试验,包括无人机在强电磁、强电流、高电压等环境下的动态飞行数据,获得了不同高电压等级下的无人机安全飞行参数,测定了无人机在超特高压环境下动态飞行的安全距离。文中研究内容可为变电站无人机巡检安全作业提供理论与实验参考。

关键词：变电站 1000 kV 无人机动态飞行安全距离

Mapping QTLs for fiber-and seed-related traits in Gossypium tomentosum CSSLs with a G. hirsutum background

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Journal of Integrative Agriculture 2025年第2期24卷 467-479页

作者： Yongshui Hao Xueying Liu Qianqian Wang Shuxin Wang Qingqing Li Yaqing Wang Zhongni Guo Tiantian Wu Qing Yang Yuting bai Yuru Cui Peng Yang Wenwen Wang Zhonghua Teng Dexin Liu kai Guo Dajun Liu Jian Zhang Zhengsheng Zhang Engineering Research Center of South Upland Agriculture Ministry of Education

Introducing the inherent genetic diversity of wild species into cultivars has become one of the hot topics in crop genetic breeding and genetic resource research. Fiber-and seed-related traits, which are critical to the global economy and people's livelihoods, are the principal focus of cotton breeding. Here, the wild cotton species Gossypium tomentosum was used to broaden the genetic basis of G. hirsutum and identify QTLs for fiber-and seed-related traits. A population of 559 chromosome segment substitution lines(CSSLs) was established with various chromosome segments from G. tomentosum in a G. hirsutum cultivar background. Totals of 72, 89, and 76 QTLs were identified for three yield traits, five fiber quality traits, and six cottonseed nutrient quality traits, *** alleles of 104 QTLs were contributed by G. tomentosum. Sixty-four QTLs were identified in two or more environments, and candidate genes for three of them were further identified. The results of this study contribute to further studies on the genetic basis of the morphogenesis of these economic traits, and indicate the great breeding potential of G. tomentosum for improving the fiber-and seed-related traits in G. hirsutum.

关键词： Gossypium tomentosum chromosome segment substitution lines yield fiber quality cottonseed nutrient quality

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高寒生态脆弱区露天矿山碳排放核算模型研究

工程科学学报 2025年第3期47卷 430-440页

作者：李国清白斌李桂奇关凯侯杰林春平北京科技大学资源与安全工程学院北京100083 金属矿山高效开采与安全教育部重点实验室北京100083 东北大学岩石破裂与失稳研究所沈阳110819 西藏巨龙铜业有限公司拉萨850200

为了准确掌握高寒生态脆弱区露天矿山的碳排放量,亟需建立一套体系完整、科学可行的核算方法,全面量化矿山生产作业的直接碳排放和生态扰动所导致的间接碳排放.通过分析高寒生态脆弱区露天矿山的碳循环机制,基于生命周期理论界定了露天... 详细信息

为了准确掌握高寒生态脆弱区露天矿山的碳排放量,亟需建立一套体系完整、科学可行的核算方法,全面量化矿山生产作业的直接碳排放和生态扰动所导致的间接碳排放.通过分析高寒生态脆弱区露天矿山的碳循环机制,基于生命周期理论界定了露天矿山开采活动的碳排放核算边界,通过梳理矿山开采、运输、选矿和辅助等环节的直接和间接碳排放过程,厘清了高寒生态脆弱区露天矿山的碳源、碳汇结构,编制了矿山的碳排放源清单.在此基础上,充分考虑矿山开采活动对高寒生态脆弱区的扰动,以及高海拔对矿山设备的能耗影响,构建了基于露天矿山生产环节及矿区碳汇变化的碳排放核算模型.以西藏某露天金属矿山为工程背景开展模型应用,计算出该矿2023年的碳排放总量为1.76295·10^(5)t CO_(2),为高寒生态脆弱区露天矿山开采活动的碳排放核算提供了理论依据.

关键词：高寒生态脆弱区露天矿山碳排放核算碳汇碳循环机制

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Digital twin-based sustainable intelligent manufacturing: a review

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Advances in Manufacturing 2021年第1期9卷 1-21页

作者： Bin He kai-Jian bai Shanghai Key Laboratory of Intelligent Manufacturing and Robotics School of Mechatronic Engineering and AutomationShanghai UniversityShanghai 200444People's Republic of China

As the next-generation manufacturing system,intelligent manufacturing enables better quality,higher productivity,lower cost,and increased manufacturing *** concept of sustainability is receiving increasing attention,and sustainable manufacturing is *** digital twin is an emerging technology used in intelligent manufacturing that can grasp the state of intelligent manufacturing systems in real-time and predict system *** intelligent manufacturing based on a digital twin has advantages in practical *** fully understand the intelligent manufacturing that provides the digital twin,this study reviews both technologies and discusses the sustainability of intelligent ***,the relevant content of intelligent manufacturing,including intelligent manufacturing equipment,systems,and services,is *** addition,thesustainability of intelligent manufacturing is ***,a digital twin and its application are introduced along with the development of intelligent manufacturing based on the digital twin ***,combined with the current status,the future development direction of intelligent manufacturing is presented.

关键词： Intelligent manufacturing Digital twin Advanced manufacturing Industry 4.0 Sustainable manufacturing

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宽缓河谷地形高墩桥梁桥位桥型方案比选研究

公路 2025年第1期70卷 240-245页

作者：牛雨竹林永楷徐百成山西离隰高速公路有限公司吕梁市033400 中交第一公路勘察设计研究院有限公司西安市710075

以S28灵华高速东延线黑河特大桥为工程依托,针对宽缓河谷地形,从地质、地形角度研究桥位,从地物控制、桥梁高度等因素研究桥梁跨径,进而选择连续刚构、矮塔斜拉桥、斜拉桥等适宜的桥型方案进行比选研究,从设计、施工、造价、景观角度进... 详细信息

以S28灵华高速东延线黑河特大桥为工程依托,针对宽缓河谷地形,从地质、地形角度研究桥位,从地物控制、桥梁高度等因素研究桥梁跨径,进而选择连续刚构、矮塔斜拉桥、斜拉桥等适宜的桥型方案进行比选研究,从设计、施工、造价、景观角度进行对比分析,最终确定黑河特大桥主桥采用矮塔斜拉桥方案。总结了整个方案研究过程,为同类型地形地貌的桥梁方案选择提供参考借鉴。

关键词：桥梁工程黑河特大桥高墩桥梁桥位桥型设计方案比选

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准原位X射线光电子能谱法分析薄膜半导体材料的环境失效行为

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中国无机分析化学 2025年第1期15卷 150-158页

作者：李夏郭佳睿庄敏陈瑜白杰严楷广东工业大学分析测试中心广州510006 广东工业大学材料与能源学院广州510006

处于使用和贮存状态的薄膜半导体材料因其经历的自然和诱导环境因素而引起器件的性能退化甚至失效,进而影响器件甚至整个系统的可靠性。目前对于环境失效行为的研究方法都很难捕获实时或准实时的表面成分及价态信息,难以判断其早期失效... 详细信息

处于使用和贮存状态的薄膜半导体材料因其经历的自然和诱导环境因素而引起器件的性能退化甚至失效,进而影响器件甚至整个系统的可靠性。目前对于环境失效行为的研究方法都很难捕获实时或准实时的表面成分及价态信息,难以判断其早期失效的行为特性以及深入掌握其失效机理。利用原位及准原位X射线光电子能谱(XPS)分析技术,通过调控环境失效因素研究薄膜半导体材料表界面成分、化学态以及电子结构的变化规律,揭示环境失效行为与失效机理,建立薄膜半导体相关材料及器件环境失效行为的分析新方法。结合准原位XPS对Au/Ni/Cu/HfO_(2)薄膜材料热过应力失效行为进行研究,结果表明:环境气氛中的氧气能够进一步诱导体相内Ni、Cu原子向表面层的扩散。热处理温度升高引起氧元素吸附模式由起初的物理吸附转变为化学吸附,并在Au层表面内反应产生NiO、Ni_(2)O_(3)以及CuO,导致薄膜材料表面成分的变化,表明利用准原位XPS法能够获取薄膜半导体材料准实时的表面成分及化学态信息,能更系统地剖析早期失效行为特性并分析其失效机理,对设备设计与生产过程中薄膜半导体材料体系的合理选择、设计改进以及提高电子芯片的环境适应性与可靠性具有重要意义。

关键词：准原位X射线光电子能谱环境失效薄膜半导体表面分析扩散机理

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Novel method of ordinal bearing estimation for more sources based on oblique projector

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Journal of Systems Engineering and Electronics 2009年第3期20卷 445-449页

作者： Sun Wei bai Jianlin Wang kai Missile Inst. Air Force Engineering Univ. Sanyuan 713800 P. R. China Aviation Equipment Academy Beijing 100085 P. R. China

A novel direction of arrival （DOA） estimation method is proposed when uncorrelated, correlated, and coherent sources coexist under color noise field. The uncorrelated and correlated sources are firstly estimated using the conventional spatial spectrum estimation method, then the noise and uncorrelated sources in Toeplitz structure are eliminated using differencing, finally by exploiting the property of oblique projection, the contributions of correlated sources are then eliminated from the covariance matrix and only the coherent sources remain. So the coherent sources can be estimated by the technique of modified spatial smoothing. The number of sources resolved by this approach can exceed the number of array elements without repeatedly estimating correlated sources. Simulation results demonstrate the effectiveness and efficiency of our proposed method.

关键词： spatial differencing oblique projector Toeplitz property direction of arrival estimation