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Reproductive and Developmental Medicine 2024年第1期8卷 39-49页

作者： Suranga P.Kodithuwakku Ernest H.Y.Ng William S.B.Yeung kai-fai lee Department of Obstetrics and Gynaecology LKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka Shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-Shenzhen Hospital Shenzhen 518053China

Human fallopian tubes(FTs)play important roles in the whole reproductive *** are the site for the final maturation of gametes,fertilization,transport of preimplantation embryos,and early embryonic development before entering the *** these functions are critical in the establishment of a successful *** the embryo is in transit through the FT,the FT microenvironment changes through endocrine,paracrine,autocrine,and juxtacrine mechanisms which involve various hormones and bioactive substances mainly from the neighboring ***,the interactions between the embryo and the FT may be the earliest embryo-maternal communications that are essential for the establishment of *** review critically discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embryo-maternal ***,we highlight existing gaps in the knowledge and the importance of exploring more of the physiology of FTs which will hold the key to producing high-quality embryos for patients seekingin vitro fertilization(IVF)treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

Stromal cell decidualization and embryo implantation: a vulnerable step leading to successful pregnancy

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Reproductive and Developmental Medicine 2024年第2期8卷 101-110页

作者： Luhan Jiang Sudini R.Fernando Suranga P.Kodithuwakku Dandan Cao William S.B.Yeung kai-fai lee Department of Obstetrics and Gynaecology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science&Export AgricultureUva Wellassa UniversityBadulla 50000Sri Lanka Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka Shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-Shenzhen Hospital Shenzhen 518053China

Endometrial stromal cell decidualization is a crucial step in endometrial remodeling during *** is controlled by orchestrated ovarian hormones,followed by the activation of various downstream signaling *** evidence has shown multiple functions of decidualized endometrial stromal cells during embryo implantation,including tissue remodeling,antioxidative stress,angiogenesis,and immune *** distinct secretomes of decidualized stromal cells also reveal their intensive interactions with epithelial,endothelial,and immune ***,aberrant decidualization leads to pregnancy failures,such as recurrent pregnancy loss and repeated implantation *** review aimed to provide an overview of the molecular mechanisms underlying the divergent functions of decidualized endometrial stromal cells and their potential clinical ***,the use of single-cell RNA sequencing data further enhances our understanding of these biological *** review discusses decidualization-related signaling pathways that serve as potential therapeutic targets for treating implantation failure in in vitro fertilization and provides novel approaches to investigate the underlying causes of female infertility.

关键词： Endometrial stromal cell Decidualization Embryo implantation Recurrent pregnancy loss Repeated implantation failure

Multiomics approaches to uncover endometrial receptivity in embryo implantation:a mini-review

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Reproductive and Developmental Medicine 2024年第3期8卷 178-185页

作者： Sudini R.Fernando Yang Yan Manish Kumar Hoi-Lam Lai Yin-Lau lee Ernest H.Y.Ng William S.B.Yeung kai-fai lee Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong SAR 999077China Department of Animal Science Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadullaSri Lanka Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalFutian DistrictShenzhen 518053China

Successful implantation requires concerted interactions during the apposition,adhesion,and invasion of the embryo into a receptive ***,the embryo implantation rate for assisted reproduction remains low despite the transfer of good quality *** in endometrial transcriptomics,proteomics,lipidomics,and even microbiota all play important roles in embryo ***,the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the embryo implantation window is becoming an area of increasingly intense *** review(a)summarizes the different molecules expressed in the receptive endometrium and(b)proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility

Human embryonic stem cells as an in vitro model for studying developmental origins of type 2 diabetes

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World Journal of Stem Cells 2020年第8期12卷 761-775页

作者： Andy Chun-Hang Chen kai fai lee William Shu Biu Yeung Yin Lau lee Department of Obstetrics and Gynaecology The University of Hong KongHong KongChina Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina

The developmental origins of health and diseases(DOHaD)is a concept stating that adverse intrauterine environments contribute to the health risks of *** the theory emerged more than 30 years ago,many epidemiological and animal studies have confirmed that in utero exposure to environmental insults,including hyperglycemia and chemicals,increased the risk of developing noncommunicable diseases(NCDs).These NCDs include metabolic syndrome,type 2 diabetes,and complications such as diabetic *** the effects of different environmental insults on early embryo development would aid in understanding the underlying mechanisms by which these insults promote NCD *** stem cells(ESCs)have also been utilized by researchers to study the *** have pluripotent characteristics and can be differentiated into almost every cell lineage;therefore,they are excellent in vitro models for studying early developmental *** importantly,human ESCs(hESCs)are the best alternative to human embryos for research because of ethical *** this review,we will discuss different maternal conditions associated with DOHaD,focusing on the complications of maternal ***,we will review the differentiation protocols developed to generate different cell lineages from ***,we will review how hESCs are utilized as a model for research into the *** effects of environmental insults on hESC differentiation and the possible involvement of epigenetic regulation will be discussed.

关键词： Development origins of health and diseases Maternal diabetes Environmental insults Type 2 diabetes Human embryonic stem cells Epigenetics

A new osteogenic protein isolated from Dioscorea opposita Thunb accelerates bone defect healing through the mTOR signaling axis

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Bioactive Materials 2023年第9期27卷 429-446页

作者： John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Yin Lau lee kai-fai lee Stephen Cho Wing Sze Wei Qiao Kelvin Wai-Kwok Yeung Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)Hong Kong S.A.R.PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadHong Kong S.A.RPR China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Department of Biology Faculty of ScienceHong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Golden Meditech Center for NeuroRegeneration Sciences Hong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Applied Oral Sciences and Community Dental Care Faculty of DentistryHong Kong S.A.RPR China

Delayed bone defect repairs lead to severe health and socioeconomic impacts on patients. Hence, there are increasing demands for medical interventions to promote bone defect healing. Recombinant proteins such as BMP-2 have been recognized as one of the powerful osteogenic substances that promote mesenchymal stem cells (MSCs) to osteoblast differentiation and are widely applied clinically for bone defect repairs. However, recent reports show that BMP-2 treatment has been associated with clinical adverse side effects such as ectopic bone formation, osteolysis and stimulation of inflammation. Here, we have identified one new osteogenic protein, named ‘HKUOT-S2’ protein, from Dioscorea opposita Thunb. Using the bone defect model, we have shown that the HKUOT-S2 protein can accelerate bone defect repair by activating the mTOR signaling axis of MSCs-derived osteoblasts and increasing osteoblastic biomineralization. The HKUOT-S2 protein can also modulate the transcriptomic changes of macrophages, stem cells, and osteoblasts, thereby enhancing the crosstalk between the polarized macrophages and MSCs-osteoblast differentiation to facilitate osteogenesis. Furthermore, this protein had no toxic effects in vivo. We have also identified HKUOT-S2 peptide sequence TKSSLPGQTK as a functional osteogenic unit that can promote osteoblast differentiation in vitro. The HKUOT-S2 protein with robust osteogenic activity could be a potential alternative osteoanabolic agent for promoting osteogenesis and bone defect repairs. We believe that the HKUOT-S2 protein may potentially be applied clinically as a new class of osteogenic agent for bone defect healing.

关键词： Dioscorea spp protein Mesenchymal stem cells(MSCs) Osteoblast differentiation Bone mineral density(BMD) Bone defect repair mTOR signaling pathway

Mg/MgO interfaces as efficient hydrogen evolution cathodes causing accelerated corrosion of additive manufactured Mg alloys:A DFT analysis

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Journal of Magnesium and Alloys 2024年第1期12卷 110-119页

作者： Man-fai Ng kai Xiang Kuah Teck Leong Tan Daniel John Blackwood Department of Materials Science&Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Republic of Singapore Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A∗STAR)1 Fusionopolis Way#16-16 ConnexisSingapore 138632Republic of Singapore

The corrosion rates of additive-manufactured Mg alloys are higher than their as-cast counterparts,possibly due to increased kinetics for the hydrogen evolution reaction on secondary phases,which may include oxide *** Kelvin Probe Force Microscopy demonstrated that MgO inclusions could act as cathodes for Mg corrosion,but their low conductivity likely precludes ***,the density of state calculations through density functional theory using hybrid HSE06 functional revealed overlapping electronic states at the Mg/MgO interface,which facilitates electron transfers and participates in redox *** determination of the hydrogen absorption energy at the Mg/MgO interface reveals it to be an excellent catalytic site,with HER being found to be a factor of 23x more efficient at the interface than on metallic *** results not only support the plausibility of the Mg/MgO interface being an effective cathode to the adjacent anodic Mg matrix during corrosion but also contribute to the understanding of the enhanced cathodic activities observed during the anodic dissolution of magnesium.

关键词： Magnesium Magnesium oxide Interface Hydrogen evolution DFT

Function of Lin28a/Wnt/β-catenin in Regulating Premature Ovarian failure

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Function of Lin28a/Wnt/β-catenin in Regulating Premature Ov...

Use of biological and chemical molecules in regulating embryo implantation and endometrial receptivity

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Jing Chen Weimin Liu kai fai lee Shu Biu Yeung Department of Obestrics and Gynaecology Li Kai Shing Faculty of MedicineThe University of Hong Kong Institute of Shenzhen University of Hong Kong

Infertility is a prevalence of disease that besets 15%of couples in childbearing age around the *** ovarian failure(POF),defined as primary ovarian defection and characterized as cessation of menstruation or absent function of ovarian follicles in women under the age of 40,accounts for approximately 1%of infertility disease in women at childbearing *** study on the

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Reproductive and Developmental Medicine 2022年第4期6卷 234-242页

作者： Xian Chen Shu-Ya Sun Ernest Hung-Yu Ng Raymond Hang-Wun Li William Shu-Biu Yeung kai-fai lee Department of Obstetrics and Gynaecology LKS Faculty of Medicinethe University of Hong KongHong Kong SARChina Shenzhen Key Laboratory of Fertility Regulation the University of Hong Kong-Shenzhen HospitalShenzhen 518053China

This review summarizes the drugs and chemicals that may modulate embryo ***-hormonal molecules,including aspirin,improved endometrial blood flow,while low molecular weight heparin,vitamin E,sildenafil,and atosiban modulated the expression of endometrial *** factors,including human chorionic gonadotropin and growth hormones,can regulate the expression of endometrial receptivity *** immunomodulatory molecules,including granulocyte colony-stimulating factor,peripheral blood mononuclear cells,autologous platelet-rich plasma,and intralipid and intravenous immunoglobulins,may improve implantation rate by modulating endometrial immune *** extracts of the Chinese herbs Paeonia lactiflora and Perilla frutescens increased the expression of leukemia inhibitory factors in endometrial epithelial ***,the use of the commercially available Library of Pharmacologically Active Compounds with a high-throughput screening method has provided an approach to screen for compounds that may potentially enhance or suppress embryo *** these biomedical findings translate into clinical effects that enhance or suppress embryo implantation requires further investigation.

关键词： Embryo implantation Endometrial receptivity fertilization Repeated implantation failure Birth control Emergency contraception

Role of microRNAs in embryo–endometrial interactions:biological functions and clinical applications

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Reproductive and Developmental Medicine 2023年第4期7卷 238-251页

作者： Shiwen Qi Suranga P.Kodithuwakku Ronald T.K.Pang Philip C.N.Chiu Mary H.Y.Tang kai-fai lee Department of Obstetrics and Gynaecology School of Clinical MedicineLKs Faculty of MedicineThe University of Hong KongHong Kong SARChina Department of Animal Science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka Shenzhen Key Laboratory of Fertility Regulation The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina.

The human endometrium and embryo both produce microRNAs(miRNAs),which are involved in various physiological *** evident suggested that endometrial miRNAs are regulated by steroid hormones that modulate endometrial functions,whereas embryo-derived miRNAs play vital roles in maternal–embryo *** aberrant expression of endometriumor embryo-derived miRNAs can cause early pregnancy and gestational disorders,including repeated implantation failure,recurrent miscarriage,and pathological conditions such as *** are,therefore,ideal candidates for conducting clinicopathological *** diagnostic and prognostic tests using miRNAs are under development;however,the therapeutic applications of miRNAs in regulating gestational disorders require further investigation.

关键词： MicroRNAs Endometrial receptivity Diagnostic biomarkers Therapeutic targets

Effect of stimulated IVF cycles on global endometrial gene expression and receptivity

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Effect of stimulated IVF cycles on global endometrial gene e...