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Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory

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Chinese Journal of Polymer Science 2023年第9期41卷 1342-1354,I0005页

作者： Hai-Xiao Wan duo Xu Xue-Wei Dong kai Yang Li-Tang Yan State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing100084China Center for Soft Condensed Matter Physics and Interdisciplinary Research&School of Physical Science and Technology Soochow UniversitySuzhou215006China

The development of biopolymers for biomedical applications has traditionally been based on new ***,there is growing recognition that the biological responses can be regulated by the physical as well as the chemical properties of *** the biophysicochemical principles regarding biopolymers is thereby of great importance in the generation of advanced ***,this review article seeks to provide a conceptual framework demonstrating how the approaches of tailored computer simulations and theoretical analysis are harnessed to explore the physicochemical principles of biopolymer cellular *** briefly introduce the theoretical and simulation methods used in this field,summarize the typical findings based on these approaches,and describe the correlations between theoretical results and ***,the future prospects for the theoretical aspect of biopolymers and their biophysicochemical interactions are *** knowledge might be critical from the perspective of advantageous and safe use of designer biomaterials.

关键词： Biopolymers Computer simulation Theoretical analysis Biophysicochemical interaction Biophysics

Effects of climate change and human activity on lake shrinkage in Gonghe Basin of northeastern Tibetan Plateau during the past 60 years

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Journal of Arid Land 2016年第4期8卷 479-491页

作者： WU duo CheN Fahu LI kai XIE Yaowen ZHANG Jiawu ZHOU Aifeng College of Earth and Environmental Sciences MOE Key Laboratory of Western China's Environmental SystemsLanzhou University

Changes in the status of freshwater resources are a topic of major global, regional and local concern. This is especially so in the arid and semi-arid regions of China, where shortage of water resources plays a crucial role in limiting sustainable socioeconomic development, as well as in sustaining natural ecosystems. Recent climate change, as well as the effects of localized human activity, such as the use of water for irrigation agriculture, may have significant effects on the status of the water resources in the region. here, we report the results of a study of changes in the areas of lakes in Gonghe Basin, northeastern Tibetan Plateau of China, over the last 60 years. The data were acquired from optical satellite images and demonstrate that the total water area of lakes in Gonghe Basin decreased significantly from the 1950s to 1980s. The cause is ascribed mainly to human activity including exploitation of farmland, against a background of increasing population; in addition, climatic data for the region demonstrate a minor drying trend during this period as the temperature increased slightly. After the construction of several reservoirs, significant amounts of water were redistributed to promote irrigation agriculture and we conclude that this caused a significant shrinkage of the natural lakes. However, both the area of farmland and the population size remained approximately constant after 1990. We conclude that the variation of the total area of lakes during the second period was mainly controlled by climatic factors （precipitation and temperature）. As the regional temperature reached a new high, the area of some of the lakes decreased sharply before finally maintaining a relatively steady state. We emphasize that anthropogenic climate change and human activity have both significantly influenced the status of water resources in the arid and semi-arid regions of China.

关键词： Gonghe Basin lake shrinkage climate change human activity

Portal stent with endovascular brachytherapy improves the efficacy of TACE for hepatocellular carcinoma with main portal vein tumor thrombus

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hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 187-190页

作者： Tian Li Chong Liu Jin-Tong he kai-Da Sui Zhou-Bo Zhang duo Hong Hong-Ying Su Hai-Bo Shao Department of Interventional Radiology the First Hospital of China Medical UniversityShenyang 110001China

hepatocellular carcinoma(HCC)with portal vein tumor throm-bus(PVTT)yields poor prognosis with a median overall survival(OS)of 2.7–4 months[1].Once PVTT develops in the main portal vein,the sudden appearance of portal hypertension often leads to fatal complications,including esophagogastric variceal hemorrhage,refractory ascites,and liver *** chemoemboliza-tion(TACE)has been recommended for advanced HCC patients by China Liver Cancer Group due to its benefit of OS compared with using sorafenib alone[2].For the treatment of PVTT,portal stent with endovascular iodine-125 brachytherapy(PSEIB)was re-cently reported to be effective because it relieved portal hyper-tension rapidly and controlled PVTT effectively with an improved OS of 9.3–12.5 months[3,4].The combination of PSEIB and TACE had been applied in some studies[3,4].Nevertheless,these studies failed to demonstrate the effect of PSEIB on TACE *** we aimed to present a case how PSEIB improves the efficacy of TACE for HCC patients with main PVTT.

关键词： portal Portal alone

Microstructural evolution and mechanical properties of an Fe–18Ni–16Cr–4Al base alloy during aging at 950°C

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International Journal of Minerals,Metallurgy and Materials 2016年第3期23卷 314-322页

作者： Man Wang Yong-duo Sun Jing-kai Feng Rui-qian Zhang Rui Tang Zhang-jian Zhou School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610041China

The development of Gen-IV nuclear systems and ultra-supercritical power plants proposes greater demands on structural materials used for key components. An Fe-18Ni-16Cr-4Al（316-base） alumina-forming austenitic steel was developed in our laboratory. Its micro- structural evolution and mechanical properties during aging at 950℃were investigated subsequently. Microstructural changes were charac- terized by scanning electron microscopy, electron backscatter diffraction, and transmission electron microscopy. Needle-shaped NiAI parti- cles begin to precipitate in austenite after ageing for 10 h, whereas round NiA1 particles in ferrite are coarsened during aging. Precipitates of NiAI with different shapes in different matrices result from differences in lattice misfits. The tensile plasticity increases by 32.4% after aging because of the improvement in the percentage of coincidence site lattice grain boundaries, whereas the tensile strength remains relatively high at approximately 790 MPa.

关键词： austenitic steel alumina aging precipitates mechanical properties microstructural evolution nuclear power plants

Hofmeister Effect on Thermo-responsive Poly(N-isopropylacrylamide)Hydrogels Grafted on Macroporous Poly(vinyl alcohol) Formaldehyde Sponges

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Chinese Journal of Polymer Science 2020年第3期38卷 257-267,I0006页

作者： kai Shi Di Sha Jiu-duo Xu Xu Yang Bao-Long Wang Yan-Xiong Pan Xiang-Ling Ji State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Chinese Academy of Sciences Beijing 100049China

In this work,the Hofmeister effects of nine kinds of anions at different concentrations on the lower critical solution temperature(LCST)of the macroporous thermo-responsive poly(N-isopropylacrylamide)grafted poly(vinyl alcohol)formaldehyde(PVF-g-PNIPAM)hydrogels are investigated with differential scanning calorimetry(DSC).Four kinds of anions with strong hydration,including CO3^2–,SO4^2–,S2 O3^2–,and F^–,and four kinds of anions with weak hydration,including Br^–,NO3^–,I^–,and ClO4^–,and Cl^–as a medium anion are systematically studied and found to demonstrate the effects of the residual hydroxyl groups and network structure of PVF on the LCST values of PVF-g-PNIPAM hydrogels in comparison with that of neat *** the one hand,the existence of hydroxyl groups on PVF backbone promotes the solubility of grafted PNIPAM due to their hydrophilicity and hydrogen-bond interactions with *** the other hand,the network structure of as-prepared samples restricts free movements of grafted PNIPAM chains,which results in the increase of LCST *** addition,the difference of grafting percentage also influences the variation of LCST values of PVF-g-PNIPAM hydrogels under salt concentration.

关键词： Hofmeister effect Thermo-responsive PVF-g-PNIPAM Hydroxyl groups Network structure

Experimental Study on Crescent Waves Diffracted by A Circular Cylinder

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China Ocean Engineering 2018年第5期32卷 624-632页

作者： YAN kai SheN Liang-duo SHANG Jin-wei MA Liang ZOU Zhi-li School of Port and Transportation Engineering Zhejiang Ocean UniversityZhoushan 316022China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Crescent waves often observed on the sea surface are unusual wave pattern induced by the instability of Stokes *** paper presents the experimental results of the wave field around a circular cylinder generated by the diffraction of crescent wave in order to examine the difference of diffracted crescent waves from the commonly-used diffracted Stokes waves. The results show that with the existence of the cylinder, the crescent wave pattern can still get fully developed, and with the presence of this type of wave pattern, the symmetry breaking of the wave amplitude distribution occurs and there are extra wave components at the frequencies of 0.5 ω;, 1.5ω;and 2.5ω;（ω;is the frequency of Stokes waves） appearing in the wave amplitude spectrum.

关键词： Stokes wave amplitude spectrum cylinder symmetry breaking

A photopatterned SERS substrate with a sandwich structure for multiplex detection

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Chinese Chemical Letters 2022年第3期33卷 1595-1598页

作者： Yuan Xue duo Liu Xuebin Wang Yanxin Xiang Shengjie Du kai Ye Chunyan Bao Linyong Zhu Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry&Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China

Substrate photopatterning has provided versatile applications in biomedical fields. herein, an universal and efficient photoligation reaction has been used to prepare a patterned capture substrate for a sandwich SERS immunoassay. Photoirradiation induces mild and efficient immobilization of antibodies at the desired region of a gold surface, and the antibody-antigen interaction helps the substrate to capture the antigens in solution specifically. After exposing to SERS probes, i.e., the gold nanoparticles labelled with both antibodies and intrinsically strong Raman reporters, multiple quantitative SERS determination of antigens can be achieved with high sensitivity and specificity. The limit of detection can be as low as 10^(-12) mol/L for four kinds of cancer biomarkers, which provides a promising method for the construction of highly sensitive and high-throughput SERS detection chip and the application of in vitro diagnosis.

关键词： SERs detection Photopatterning Sandwich structure Multiplex detection Quantitative detection

Impact Damage Testing Study of Shanxi-Beijing Natural Gas Pipeline Based on Decision Tree Rotary Tiller Operation

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Structural Durability & health Monitoring 2024年第5期18卷 683-706页

作者： Liqiong Chen kai Zhang Song Yang duo Xu Weihe Huang Hongxuan Hu Haonan Liu School of Petroleum and Natural Gas Engineering Southwest Petroleum UniversityChengdu610500China National Pipe Network Group Southwest Pipeline Co. Chengdu610500China

The North China Plain and the agricultural region are crossed by the Shanxi-Beijing natural gas ***-dents in the area use rototillers for planting and harvesting;however,the depth of the rototillers into the ground is greater than the depth of the pipeline,posing a signiﬁcant threat to the safe operation of the ***,it is of great signiﬁcance to study the dynamic response of rotary tillers impacting pipelines to ensure the safe opera-tion of *** article focuses on the Shanxi-Beijing natural gas pipeline,utilizingﬁnite element simulation software to establish aﬁnite element model for the interaction among the machinery,pipeline,and soil,and ana-lyzing the dynamic response of the *** the same time,a decision tree model is introduced to classify the damage of pipelines under different working conditions,and the boundary value and importance of each inﬂuen-cing factor on pipeline damage are *** the actual conditions in the hemp yam planting area,targeted management measures have been proposed to ensure the operational safety of the Shanxi-Beijing natural gas pipeline in this region.

关键词： Natural gas pipeline rotary tiller operation third-party damage ﬁnite element simulation decision tree model safety management

CFD Investigation of Diffusion Law and Harmful Boundary of Buried Natural Gas Pipeline in the Mountainous Environment

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Energy Engineering 2024年第8期121卷 2143-2165页

作者： Liqiong Chen Kui Zhao kai Zhang duo Xv Hongxvan Hu Guoguang Ma Wenwen Zhan School of Petroleum Engineering Southwest Petroleum UniversityChengdu610000China National Pipe Network Group Southwest Pipeline Co. Ltd.Chengdu610000China National Pipeline Research Center Conveyance Pipe Institute Baoji Petroleum Steel Pipe Co.Ltd.Baoji721000China

The leakage gas from a buried natural gas pipelines has the great potential to cause economic losses and environmental pollution owing to the complexity of the mountainous *** this study,computational fluid dynamics(CFD)method was applied to investigate the diffusion law and hazard range of buried natural gas pipeline leakage in mountainous *** on cloud chart,concentration at the monitoring site and hazard range of lower explosion limit(LEL)and upper explosion limit(UEL),the influences of leakage hole direction and shape,soil property,burial depth,obstacle type on the diffusion law and hazard range are *** show that the leakage gas is not radially diffused until it reaches the ground,and the velocity of gas diffusion to the ground and the hazard range decrease as the angle between the leaking direction and the buoyancy direction *** and square leak holes have a faster diffusion rate and a wider hazard range than *** diffusion rate of leakage gas in soil rises as soil granularity and porosity *** time of leakage gas diffusion to the ground increases significantly with the increase of burial depth,and the hazard range reduces as burial depth ***-type obstacles will alter the diffusion path of the leakage gas and accelerate the expansion of the hazard distance,while trench-type obstacles will cause the natural gas to accumulate in the trench and form a high concentration region slowing the expansion of the surface gas concentration.

关键词： Mountainous environment buried pipeline leakage and diffusion hazard range numerical simulation