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Chinese Chemical Letters 2024年第10期35卷 321-324页

作者： Xu Zhang Jiang Li kai-zhou lu Ya-Nan Yang Jian-Shuang Jiang Xiang Yuan Zi-Ming Feng Fei Ye Pei-Cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

Three highly oxidized hybrid flavonoids neosophoflavonoids A–C（1, 2a, and 2b） were isolated from the roots of Sophora flavescens. Neosophoflavonoid A possesses a unique highly oxidized heptacyclic6/6/6/6/6/6/5 system. Neosophoflavonoids B and C are isomers and share the same highly oxidized hexacyclic 6/6/6/6/6/6 systems. Their planar structures were elucidated from 1D/2D nuclear magnetic resonance（NMR）, ultraviolet spectroscopy（UV）, infrared spectroscopy（IR）, and high resolution electrospray ionization mass spectroscopy（HRESIMS） data. Their absolute configurations were determined by thorough GIAO13C NMR（DP4+） calculation protocol and electronic circular dichroism（ECD） calculation *** plausible biosynthetic routes for the compounds were also proposed. All compounds exhibited significant protein tyrosine phosphatase-1B（PTP1B） inhibitory activity with half maximal inhibitory concentration(IC50) values 3.94 ± 0.01, 0.38 ± 0.13, and 0.70 ± 0.01 μmol/L, respectively. In addition, compared to a positive control fenofibrate（Feno） at 20 μmol/L, compounds 2a and 2b exhibited stronger inhibitory effects on lipid accumulation in the oleic acid（OA）-induced cell model at 5 and 10 μmol/L.

关键词： Highly oxidized hybrid flavonoids Lipid accumulation inhibition Neosophoflavonoids A–C PTP1B inhibition Sophora flavescens

邱玲教授基于经筋理论治疗颈-心综合征经验浅析

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内蒙古中医药 2024年第2期43卷 77-79页

作者：许金菊周开陆陈倩田业邱玲成都中医药大学四川成都610075 成都市中西医结合医院四川成都610041 四川省名中医邱玲工作室四川成都610041

颈-心综合征是由于颈椎退行性变压迫颈部神经、血管等正常组织出现类似冠心病心绞痛的临床症候群,可归属于中医“胸痹”“心痛”“项痹”等范畴。邱玲教授认为本病多因体虚受邪,经筋失养,心脉痹阻不通而痛,治疗多通过补益气血、濡养经... 详细信息

颈-心综合征是由于颈椎退行性变压迫颈部神经、血管等正常组织出现类似冠心病心绞痛的临床症候群,可归属于中医“胸痹”“心痛”“项痹”等范畴。邱玲教授认为本病多因体虚受邪,经筋失养,心脉痹阻不通而痛,治疗多通过补益气血、濡养经筋以治其本,针筋解结、畅通经络以治其标,注重辨筋论治,常根据筋结分布选穴布针,临床取得良好疗效。

关键词：经筋针刺灸法颈-心综合征临床经验

Five Novel Pterocarpan Derivatives from Sophora flavescens

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Chinese Journal of Chemistry 2021年第10期39卷 2763-2768页

作者： kai-zhou lu Zi-Ming Feng Xiang Yuan Ya-Nan Yang Jian-Shuang Jiang Xu Zhang Pei-Cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050 China

Main observation and conclusion Five novel pterocarpan derivatives(1—5)and three known pterocarpans were isolated from the roots of Sophora flavescens *** structures were elucidated based on extensive spectroscopic data(UV,IR,1D and 2D NMR,and HR-ESI-MS).Notably,compounds 1—5 were the first reported natural products,which possess unique pterocarpan-glucose-long chain aliphatic acid *** kinds of aliphatic acids were determined by comparison with authentic aliphatic acids using HPLC-ELSD analysis after acid *** absolute configurations of 1—5 were confirmed by analysis of their ECD *** compounds were evaluated against lipopolysaccharide(LPS)-induced TNF-αproduction in RAW264.7 cells,and compound 1 showed significant inhibitory activity with inhibition rate of 86.22%,IC_(50)=0.79μmol/L(dexamethasone as positive control,inhibition rate of 71.38%).

关键词： Sophora flavescens Pterocarpan derivatives Natural products Structure elucidation Biological activity

Strategies for flame-retardant polymer electrolytes for safe lithiumbased batteries

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Nano Research 2024年第10期17卷 8754-8771页

作者： Xiao Ma Yang lu Yu Ou Shuaishuai Yan Wenhui Hou Pan zhou kai Liu Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

The advancement of lithium-based batteries has spurred anticipation for enhanced energy density,extended cycle life and reduced capacity ***,these benefits are accompanied by potential risks,such as thermal runaway and explosions due to higher energy ***,liquid organic electrolytes are the predominant choice for lithium batteries,despite their limitations in terms of mechanical strength and vulnerability to *** development of polymer electrolytes,with their high Young’s modulus and enhanced safety features,offers a potential solution to the drawbacks of traditional liquid *** these advantages,polymer electrolytes are still susceptible to burning and *** address this issue,researchers have conducted extensive studies to improve their flame-retardant properties from various *** review provides a concise overview of the thermal runaway mechanisms,flame-retardant mechanisms and electrochemical performance of polymer *** also outlines the advancements in flame-retardant polymer electrolytes through the incorporation of various additives and the selection of inherently flame-retardant *** review aims to offer a comprehensive understanding of flame-retardant polymer electrolytes and serve as a guide for future research in this field.

关键词： lithium batteries polymer electrolyte thermal runaway flame-retardant additives energy storage materials

Adaptive state-constrained/model-free iterative sliding mode control for aerial robot trajectory tracking

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 603-618页

作者： Chen AN Jiaxi zhou kai WANG College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong KongChina

This paper develops a novel hierarchical control strategy for improving the trajectory tracking capability of aerial robots under parameter *** hierarchical control strategy is composed of an adaptive sliding mode controller and a model-free iterative sliding mode controller(MFISMC).A position controller is designed based on adaptive sliding mode control(SMC)to safely drive the aerial robot and ensure fast state convergence under external ***,the MFISMC acts as an attitude controller to estimate the unmodeled dynamics without detailed knowledge of aerial ***,the adaption laws are derived with the Lyapunov theory to guarantee the asymptotic tracking of the system ***,to demonstrate the performance and robustness of the proposed control strategy,numerical simulations are carried out,which are also compared with other conventional strategies,such as proportional-integralderivative(PID),backstepping(BS),and *** simulation results indicate that the proposed hierarchical control strategy can fulfill zero steady-state error and achieve faster convergence compared with conventional strategies.

关键词： aerial robot hierarchical control strategy model-free iterative sliding mode controller(MFISMC) trajectory tracking reinforcement learning

Smart materials for safe lithium-ion batteries against thermal runaway

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Journal of Energy Chemistry 2024年第7期94卷 360-392页

作者： Yu Ou Pan zhou Wenhui Hou Xiao Ma Xuan Song Shuaishuai Yan Yang lu kai Liu Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

In recent years,the new energy storage system,such as lithium ion batteries(LIBs),has attracted much *** order to meet the demand of industrial progress for longer cycle life,higher energy density and cost efficiency,a quantity of research has been conducted on the commercial application of ***,it is difficult to achieve satisfying safety and cycling performance *** may be thermal runaway(TR),external impact,overcharge and overdischarge in the process of battery abuse,which makes the safety problem of LIBs more *** this review,we summarize recent progress in the smart safety materials design towards the goal of preventing TR of LIBs reversibly from different abuse *** from smart responsive materials and novel structural design,the safety of LIBs can be improved a *** expect to provide a comprehensive reference for the development of smart and safe lithium-based battery materials.

关键词： Lithium ion batteries(LIBs) Thermal runaway(TR) Smart materials Safe batteries Solid electrolyte interface(SEI)

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针刺治疗神经根型颈椎病相关机制的研究进展

中国疗养医学 2024年第2期33卷 59-62页

作者：田业欧阳建彬陈倩周开陆许金菊邱玲成都中医药大学成都市中西医结合医院

随着现代生活节奏的加快以及各种电子产品的普及，颈椎病的发病人群逐渐趋于年轻化。神经根型颈椎病(cervical spondylotic radiculopathy,CSR)是常见颈椎病类型之一，其临床发病率占颈椎病发病率的7成以上。CSR主要以颈部局部僵痛，相... 详细信息

随着现代生活节奏的加快以及各种电子产品的普及，颈椎病的发病人群逐渐趋于年轻化。神经根型颈椎病(cervical spondylotic radiculopathy,CSR)是常见颈椎病类型之一，其临床发病率占颈椎病发病率的7成以上。CSR主要以颈部局部僵痛，相应神经节段支配区域出现放射性麻痛为临床表现；目前现有研究证明针刺可有效缓解CSR的临床症状，然而CSR的针刺治疗机制尚无明确阐述。本文通过查阅相关文献，整理及归纳其研究成果以探讨针刺治疗CSR的相关机制。经总结与分析，本文将从3个方面阐述针刺治疗CSR相关可能性机制的研究进展：针刺治疗CSR相关发病机制；针刺治疗CSR相关中医机制；针刺治疗CSR相关可能机制。目前现有机制证明针刺治疗CSR主要与血清炎症细胞因子浓度、肥大细胞、小胶质细胞、脊髓背角神经元等因素可能相关；虽然现有机制研究相互关联，但仍存在不足之处；现有机制研究多集中在疼痛信号上行与下行通路中单一靶点的研究，尚未形成系统化研究。同时结合针刺治疗CSR临床特点，对未来CSR相关机制研究提出思考与展望。

关键词：神经根型颈椎病针刺治疗机制综述

Nuclei-rich galvanizing strategy for suppressing zinc dendrite growth

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Rare Metals 2024年第8期43卷 4016-4018页

作者： Hai-Xia Wu kai-lu Guo College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal UniversityLuoyang 471934China

The uncontrolled growth of zinc dendrites on zinc anode hinders the application of zinc ion *** solve this problem,lu's group proposed a nuclei-rich galvanizing strategy for suppressing the zinc dendrite *** allows the nuclei-rich zinc electrode to cycle steadily for1200 h and have a high Coulombic efficiency of 99.7%at15 mA·cm^(-2)with a deposited amount of 10 mAh·cm^(-2).Moreover,the Zn-MnO_(2) battery with a low N/P ratio of 1.9exhibited sustained cycling life.

关键词： cycling sustained battery

基于经络理论浅析针刺治疗膝骨关节炎的临床思路

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中国疗养医学 2024年第2期33卷 48-50页

作者：陈倩欧阳建彬许金菊周开陆田业邱玲成都中医药大学四川省名中医邱玲工作室成都市中西医结合医院

经络是经脉和络脉的总称，是人体内运行气血、联络脏腑、沟通内外、贯穿上下的通路。人体生命活动的维持、脏腑功能的发挥、肢体关节的正常活动都离不开经络之间的相互联络。正是由于经络之间的相互联系，气血才能得以正常运行，濡养周... 详细信息

经络是经脉和络脉的总称，是人体内运行气血、联络脏腑、沟通内外、贯穿上下的通路。人体生命活动的维持、脏腑功能的发挥、肢体关节的正常活动都离不开经络之间的相互联络。正是由于经络之间的相互联系，气血才能得以正常运行，濡养周身。经络是构成人体生命活动的基础，经络亦是反应疾病病理变化、气血阴阳盛衰的重要载体。经络理论是针灸的特色核心理论，是针灸诊疗疾病的核心内容。近年来，针灸越来越多地运用到了膝骨关节炎的治疗当中，并取得了较好的疗效。本文将立足于经络理论的基础之上，以经络辨证为指导，遵循审、切、循、扪、按的经络诊察方法，采取辨位归经、辨病归经的方式，浅析经络理论在针刺治疗膝骨关节炎中的临床应用，以期为临床提供参考。

关键词：经络理论针刺膝骨关节炎

Zeolite polymer membrane as protective interface for Mg battery

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Rare Metals 2024年第9期43卷 4636-4638页

作者： Hai-Xia Wu kai-lu Guo College of Chemistry and Chemical Engineering Henan Key Laboratory of Function-Oriented Porous MaterialsLuoyang Normal University

Excessive electrolyte decomposition seriously determines the performance of high-voltage Mg batteries. In Nazar?s work, the strategy using a zeolite polymer membrane as a protective interface was proposed to restrain the electrolyte decomposition. This strategy could boost Mg plating/stripping performance up to 6000 h in zeolite/Mg|zeolite/Mg symmetric cells and 91%capacity retention in zeolite/Mg||Mo3S4battery after 200 *** storage devices have been intensively explored because of their important roles in our daily lives [1D3].

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