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Unveiling the secrets of gastrointestinal mucous adenocarcinoma survival after surgery with artificial intelligence:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2404-2418页

作者： Jie Song Xiang-Xiu Yan Fang-Liang Zhang Yong-Yi Lei Zi-Yin Ke Fang Li kai Zhang Yu-qi He Wei Li Chao Li yuan-Ming Pan Department of Gastroenterology Dongying People’s HospitalDongying Hospital of Shandong Provincial Hospital GroupDongying 257000Shandong ProvinceChina Gastrointestinal Surgery Department Suining Central HospitalSuining 629000Sichuan ProvinceChina Obstetrical Department Suining Central HospitalSuining 629000Sichuan ProvinceChina School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Pathology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China General Department Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Gastroenterology Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Thoracic Surgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

BACKGROUND Research on gastrointestinal mucosal adenocarcinoma(GMA)is limited and controversial,and there is no reference tool for predicting postoperative *** To investigate the prognosis of GMA and develop predictive *** From the Surveillance,Epidemiology,and End Results database,we collected clinical information on patients with *** random sampling,the patients were divided into the discovery(70%of the total,for model training),validation(20%,for model evaluation),and completely blind test cohorts(10%,for further model evaluation).The main assessment metric was the area under the receiver operating characteristic curve(AUC).All collected clinical features were used for Cox proportional hazard regression analysis to determine factors influencing GMA’s *** This model had an AUC of 0.7433[95% confidence intervals(95%CI):0.7424-0.7442]in the discovery cohort,0.7244(GMA:0.7234-0.7254)in the validation cohort,and 0.7388(95%CI:0.7378-0.7398)in the test *** packaged it into Windows software for doctors’use and uploaded *** gastric adenocarcinoma had the worst prognosis,and these were protective factors of GMA:Regional nodes examined[hazard ratio(HR):0.98,95%CI:0.97-0.98,P<0.001]and chemotherapy(HR:0.62,95%CI:0.58-0.66,P<0.001).CONCLUSION The deep learning-based tool developed can accurately predict the overall survival of patients with GMA *** surgery,chemotherapy,and adequate lymph node dissection during surgery can improve patient outcomes.

关键词： Deep learning Gastrointestinal mucous adenocarcinoma Overall survival Surgery Clinical tool

Ultrafast pulse-dilation framing camera and its application for time-resolved X-ray diagnostic

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Nuclear Science and Techniques 2024年第7期35卷 101-114页

作者： Hou-Zhi Cai qiu-Yan Luo kai-Xuan Lin Xuan Deng Jun-kai Liu kai-Zhi Yang Dong Wang Jia-Jie Chen Jia-Heng Wang Jing-Hua Long Li-Hong Niu Yun-Fei Lei Jin-yuan Liu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen Key Laboratory of Photonics and BiophotonicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

An ultrafast framing camera with a pulse-dilation device,a microchannel plate(MCP)imager,and an electronic imaging system were *** camera achieved a temporal resolution of 10 ps by using a pulse-dilation device and gated MCP imager,and a spatial resolution of 100μm by using an electronic imaging system comprising combined magnetic *** spatial resolution characteristics of the camera were studied both theoretically and *** results showed that the camera with combined magnetic lenses reduced the field curvature and acquired a larger working area.A working area with a diameter of 53 mm was created by applying four magnetic lenses to the ***,the camera was used to detect the X-rays produced by the laser-targeting *** diagnostic results indicated that the width of the X-ray pulse was approximately 18 ps.

关键词： Inertial confinement fusion Plasma diagnostics Framing camera Combined lenses Pulse-dilation

Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration

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Nano Research 2024年第8期17卷 7449-7460页

作者： Yin yuan Lijun Chen Jing Yang Sining Zhou Yangxin Fang qi Zhang Ning Zhang Yifei Li Li yuan Fan Jia Shuo Ni Charlie Xiang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Biology The David H.Koch Institute for Integrative Cancer Research at MITMassachusetts Institute of TechnologyCambridgeMA 02139USA Research Units of Infectious disease and Microecology Chinese Academy of Medical SciencesHangzhou 310003China Innovative Precision Medicine(IPM)Group Hangzhou 311215China MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Cancer Immunology and Virology Dana-Farber Cancer InstituteBostonMA 02215USADepartment of ImmunologyHarvard Medical SchoolBoston MA 02115USA Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China

Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis ***,limited sources and poor tissue-homing efficiency limit their clinical *** this study,we isolated a kind of MSCs from women’s menstrual blood(MenSCs)noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet *** were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for *** this delivery system,MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse ***,scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting *** recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone *** study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis.

关键词： mesenchymal stem cells microfluidics bone marrow homing stem cell niche postmenopausal osteoporosis

DGK5-mediated phosphatidic acid homeostasis interplays with reactive oxygen species in plant immune signaling

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Journal of Integrative Plant Biology 2024年第7期66卷 1263-1265页

作者： Dian Wang Minhang yuan Yamei Zhuang Xiu-Fang Xin Guang qi Crop Research Institute Shandong Academy of Agricultural Sciences/National Engineering Research Center of Wheat and Maize/Shandong Technology Innovation Center of WheatJinan 252100China College of Agronomy Qingdao Agricultural UniversityQingdao 266109China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

Plants have evolved a complex innate immune system that deploys two interconnected receptor layers to detect the invasion of various *** surface-resident pattern recognition receptors(PRRs)perceive pathogen-or microbeassociated molecular patterns(PAMPs/MAMPs),initiating a basal defense response called pattern-triggered immunity(PTI)(Zhou and Zhang,2020).

关键词： pattern homeostasis immunity

Uncertainties of nuclear level density estimated using Bayesian neural networks

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Chinese Physics C 2024年第8期48卷 185-189页

作者： Xinyu Wang Ying Cui yuan Tian kai Zhao Yingxun Zhang China Institute of Atomic Energy Beijing 102413China China Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China

Nuclear level density(NLD)is a critical parameter for understanding nuclear reactions and the structure of atomic nuclei;however,accurate estimation of NLD is challenging owing to limitations inherent in both experimental measurements and theoretical *** paper presents a sophisticated approach using Bayesian neural networks(BNNs)to analyze NLD across a wide range of *** uniquely incorporates the assessment of model *** application of BNNs demonstrates remarkable success in accurately predicting NLD values when compared to recent experimental data,confirming the effectiveness of our *** reliability and predictive power of the BNN approach not only validates its current application but also encourages its integration into future analyses of nuclear reaction cross sections.

关键词： Bayesian neural network nuclear reaction nuclear level density

A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells

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Chinese Chemical Letters 2024年第10期35卷 390-395页

作者： Chuan-Zhi Ni Ruo-Ming Li Fang-qi Zhang Qu-Ao-Wei Li yuan-yuan Zhu Jie Zeng Shuang-Xi Gu School of Chemistry and Environmental Engineering School of Chemical Engineering & Pharmacy Pharmaceutical Research Institute Hubei Key Laboratory of Novel Reactor and Green Chemical Technology Wuhan Institute of Technology Nanjing Pusheng Biomedical Co. Ltd.

A novel and readily available binaphthyl-based fluorescent probe（S）-1 was designed and synthesized.（S）-1 can be used to not only chemoselectively discriminate 3 basic amino acids out of common amino acids, but also enantioselectively recognize histidine. Encouragingly, enantioselective imaging of histidine in cells was achieved for the first time by the probe（S）-1. These performances endowed it potential application in the chiral analysis of basic amino acids in asymmetric synthesis and cell imaging for diagnosis of diseases caused by racemization of histidine. Nuclear magnetic resonance（NMR） and mass spectrometry investigations suggested that different reaction extent of（S）-1 with L/D-histidine and different product structures generated the observed enantioselective fluorescent response. The molecular structures and thermodynamic stability of the complexes, formed from（S）-1 + Zn2+and enantiomers of histidine, were calculated by Gaussian 16 based on density functional theory（DFT） to validate the above action mechanism.

关键词： Basic amino acids Cell imaging Chemoselectivity Chiral recognition Enantioselectivity Fluorescent probe

Clinical implications of the latest advances in gastrointestinal tumor research

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4055-4059页

作者： Wei Dai yuan-qi Li You Zhou Tumor Biological Diagnosis and Treatment Center The Third Affiliated Hospital of Soochow UniversityChangzhou 213003Jiangsu ProvinceChina

In this editorial,we provide commentary on six articles recently published in the World Journal of Gastrointestinal *** articles collectively present the latest findings in the field of gastric and colorectal cancer(CRC)*** global incidence of gastric cancer varies based on geographical location,age,and *** disease predominantly affects middle-aged and elderly individuals,with a slightly higher prevalence in men than in *** is characterized by a low 5-year survival rate and high mortality *** primarily affects individuals over the age of 50,and the risk of disease increases with *** gastric and CRC pose significant health threats,thus requiring more effective diagnostic,therapeutic,and supportive care strategies to improve patient *** articles discussed in this editorial encompass topics such as screening,diagnosis,mechanisms of progression,and postoperative recovery in gastric and CRC,and the findings offer valuable insights for clinical decision-making in the diagnosis,treatment,and prognosis of gastrointestinal cancers.

关键词： Gastric cancer Colorectal cancer Screening Diagnosis Mechanisms of progression Postoperative recovery

Solid solution strategy modulated defects engineering of(Cr_(1-x)V_(x))_(2)AlC MAX phase toward superior electromagnetic wave absorption

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Rare Metals 2024年第7期43卷 3205-3219页

作者： Ji-Lin Gou Yu-kai Chang Shu Liu Peng-Hui Li Ping-Hao Cui qian-Ku Hu Li-Bo Wang Xin Zhang Jun-kai Wang qi-Xun Xia Ai-Guo Zhou School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454003China Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

Defects engineering is an effective strategy for manipulating electromagnetic parameters and enhancing electromagnetic wave(EMW)absorption ***,the relationship between them is not clear,especially in solid solution *** this work,a series of(Cr_(1-x)V_(x))_(2)AlC MAX phase solid solutions with layered structure were prepared via tuning the ratio of Cr and V to explore their EMW absorption *** experimental results indicated that the doping of V atoms at the M-site could effectively regulate its impedance matching and EMW absorption properties by introducing appropriate numbers of defects in the crystal,such as twin boundaries,dislocations and lattice *** them,if Cr:V=3:1,Cr_(1.5)V_(0.5)AlC,as radar absorption materials,could reach a strong reflection loss of-51.8 dB at the frequency of 12.8 GHz under an ultra-thin thickness of 1.3 *** reflection loss value could attain-10 dB in a wide frequency range of 2.7-18 GHz and thickness range of 1-5 *** addition,after high temperature and acid-alkali immersion treatment,this sample still had good EMW absorption capability,and the effective absorption bandwidth was enhanced from 2.3 to 2.6 GHz after concentrated acid immersion or 3.1 GHz after concentrated alkali *** work has great reference significance for the research and development of high-performance MAX-based EMW absorption materials in harsh environments.

关键词： MAX phases Solid solution Defects engineering Electromagnetic wave absorption Harsh environments

Development of Wheel-Legged Biped Robots:A Review

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Journal of Bionic Engineering 2024年第2期21卷 607-634页

作者： Xuefei Liu Yi Sun Shikun Wen kai Cao qian qi Xiaoshu Zhang Huan Shen Guangming Chen Jiajun Xu Aihong Ji Lab of Locomotion Bioinspiration and Intelligent Robots College of Mechanical and Electrical EngineeringNanjing University of Aeronautics and Astronautics29 Yudao StreetNanjing210016China State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

The wheel-legged biped robot is a typical ground-based mobile robot that can combine the high velocity and high efficiency pertaining to wheeled motion and the strong,obstacle-crossing performance associated with legged *** robots have gradually exhibited satisfactory application potential in various harsh scenarios such as rubble rescue,military operations,and wilderness ***-legged biped robots are divided into four categories according to the open–close chain structure forms and operation task modes,and the latest technology research status is summarized in this *** hardware control system,control method,and application are analyzed,and the dynamic balance control for the two-wheel,biomimetic jumping control for the legs and whole-body control for integrating the wheels and legs are *** summary,it is observed that the current research exhibits problems,such as the insufficient application of novel materials and a rigid–flexible coupling design;the limited application of the advanced,intelligent control methods;the inadequate understanding of the bionic jumping mechanisms in robot legs;and the insufficient coordination ability of the multi-modal motion,which do not exhibit practical application for the wheel-legged biped ***,this study discusses the key research directions and development trends for the wheel-legged biped robots.

关键词： Wheel-legged biped robot Wheeled motion Legged motion Control strategy