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Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma

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Chinese Medical Journal 2021年第21期134卷 2611-2618页

作者： Lei Meng kai-xuan xu Ming-Xi Zhao Kang Li Kun Zhu Da-Wei Yuan Hao-Nan Wang Peng-Gao Dai Rong Yan National Engineering Research Center for Miniaturized Detection Systems The College of Life SciencesNorthwest UniversityXi’anShaanxi 710069China Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China

Background:Nucleolar protein 6(NOL6)is a nucleolar RNA-associated protein that is highly conserved between *** has been proved to be associated with the prognosis of liver ***,the underlying mechanism has not been fully *** study aimed to assess the relationship between NOL6 and liver cancer ***:We constructed anNOL6-short hairpin RNA(shRNA)-expressing *** viral transfection,cell growth assay and fluorescence-activated cell sorting,we evaluated the effect of shRNA-mediatedNOL6 knockdown on the proliferation,colony formation,and apoptosis of hepatocellular carcinoma(HCC)*** relationship betweenNOL6 expression and HCC patient survival has been established through bioinformatics *** also explored the downstream molecular regulatory network ofNOL6 in HCC by performing an Ingenuity Pathway Analysis in the ***:IncreasedNOL6 expression was detected in HCC cells compared to normal controls;HCC patients with highNOL6 expression had poorer prognoses than those with low ***6 knockdown inhibited HCC cell proliferation,apoptosis,and colony ***,MAPK8,CEBPA,andFOSL1 were selected as potential downstream genes ***:NOL6 up-regulates HCC cell proliferation and affects downstream expression of related ***,NOL6 is considered to be associated with poor prognosis in HCC patients.

关键词： NOL6 Hepatocellular carcinoma Prognostic marker Bioinformatics MAPK8 CEBPA FOSL1

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang xuan Cheng Hui Gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao xu xuan Wu Jiarui Li Shiling Chen Danyang Chen Gaigai Li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao xu kai Zhao Guoqiang Liu Youming Lu Xinyan Li kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong xu Shoumin xuan Shuai Chen Dan Liu Qian Xiao Jie Tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. In this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. Interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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钒氧化物还原过程中物相转变热力学规律研究

钢铁钒钛 2016年第6期37卷 5-12页

作者：唐凯宣森炜徐扬吕学伟白晨光重庆大学材料科学与工程学院重庆400044

针对钒氧化物间接还原条件下的逐级还原规律进行理论计算,其逐级还原规律为：当温度在273~987K时,V_2O_5→VO_2→V_3O_5→V_2O_3→VO→V;当温度在987~2 500 K时,V_2O_5→VO_2→V_2O_3→VO→V;分析了钒氧化物稳定存在的温度区间,分别为：... 详细信息

针对钒氧化物间接还原条件下的逐级还原规律进行理论计算,其逐级还原规律为：当温度在273~987K时,V_2O_5→VO_2→V_3O_5→V_2O_3→VO→V;当温度在987~2 500 K时,V_2O_5→VO_2→V_2O_3→VO→V;分析了钒氧化物稳定存在的温度区间,分别为：VO_2为273~623 K,V_3O_5为623~713 K,V_2O_3为713~1 393 K,VO为1 393~1 882K,V为1 882~2 500 K;得到了V-O-CO系平衡状态图。同时考虑压力与活度对于平衡状态图的影响,获得了变化规律。增加C和S的含量能够降低钒的活度,增加Si、Mn、P、V、Ti、Cr的含量则会增加钒的活度,考虑钒的活度时氧化钒的初始还原温度变为1 213 K;压力的增加会使氧化钒还原的初始温度升高,压力分别为0.000 1、0.001、0.01、0.1、1 MPa下,初始还原温度分别为943、1 053、1 190、1 381、1 642 K。

关键词：钒氧化物间接还原还原热力学平衡状态图

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng xu Jing-kai Wang Bo Chen Hao xu Deng Pan Yu-Yang Ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Theoretical Studies on the Fe-M Interactions and 31p NMR in Fe（CO）3（EtPhPpy）2MX2 （X=NCS, SCN, CI; M=Zn, Cd, Hg）

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Chinese Journal of Chemical Physics 2008年第5期21卷 438-444页

作者： Xiao-xuan Huang xuan xu Mei-xiang Xie School of Chemistry and Environment Key Lab of Technology on Electrochemical Energy Storage and Power Generation in Guangdong Universities South China Normal University Guangzhou 510006 China

To study the Fe-M interactions and their effects on 31p NMR, the structures of Fe（CO）3（EtPhPpy）2 1, Fe（CO）3（EtPhPpy）2M（NCS）2 （2： M=Zn, 3： M=Cd, 4： M=Hg） and Fe（CO）3（EtPhPpy）2CdX2 （5： X=C1, 6： X=SCN） were investigated by density functional theory （DFT） PBE0 method. The stabilities S of complexes follow S（2）〉S（3）〉S（4） and S（3）,.~S（6）〉S（5）, indicating that 6 is stable and may be synthesized. The complexes with thiocyanate are more stable than that with chloride in Fe（CO）3（EtPhPpy）2CdX2. The strength I of Fe-M interactions follows I（2）≈I（3）〈I（4）. The Fe-Cd interactions of 3 and 6, which contain thiocyanate, are stronger than that of 5 with chloride. The charge-transfer, which enhances with the increasing of Fe-M interaction strength, comes from Et, Ph, py, CO groups towards P, Fe, and M atoms. Because the delocalization of thiocyanate disperses the charge of M2＋, the charge-transfer of the complexes with thiocyanate is stronger than that with chloride. There is a a-bond between Fe and Hg atoms in 4. However, in binuclear complexes except 4, the Fe-M interactions act as nFe→nM, σP-Fe→nM and σC-Fe→nM delocalization, and the N-M interactions mainly act as nN→nM delocalization. In binuclear complexes, due to the Fe→M interactions, the strong σFe--C→σ＊Fe--p or σFe-Hg→σ＊Fe--I2 delocalization and the charge-transfer, the electron density on P nucleus is increased, and thus upfield 31p chemical shifts are caused （compared with mononuclear complex 1）.

关键词： DFT 31p NMR Metal-metal interaction Nature bond orbital

A Compact Setup of Saturated Absorption Spectroscopy for Diode Laser Frequency Stabilization

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Chinese Physics Letters 2012年第7期29卷 114-117页

作者： ZHANG Xian HUANG kai-kai xu Hao xu Zhou-Xiang LI Nan LU xuan-Hui Institute of Optics Department of PhysicsZhejiang UniversityHangzhou 310027

A novel setup of saturated absorption spectroscopy (SAS) is *** is based on laser reflections at surfaces of a sample vapor *** only needs one cell and one photodiode and is more compact than conventional setups of *** spectrum is similar to a conventional *** frequency stabilization performance of an external-cavity diode laser with this setup is investigated.A frequency stability of 1.1 × 10^(-11) is achieved at an averaging time of 60s in the Allen variance measurements.

关键词： setup Compact stabilization