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分散液液微萃取/超高效液相色谱-串联质谱法测定环境水中7种新烟碱类农药

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分析测试学报 2024年第5期43卷 738-745页

作者：侯新茹仝凯旋陈辉张虹艳常巧英李相阳李玲薛晓晶中国检验检疫科学研究院北京100176 北京农学院食品科学与工程学院北京102206 国家乳业技术创新中心内蒙古呼和浩特010000

建立了巴氏滴管辅助的分散液液微萃取(PTD-DLLME)结合超高效液相色谱-串联质谱(UPLC-MS/MS)同时测定环境水中7种新烟碱类农药的方法。该方法首次以巴氏滴管作为萃取容器,低密度低毒性的乙腈作为萃取剂,丙酮为分散剂。采用BEH C_(18)(2.1... 详细信息

建立了巴氏滴管辅助的分散液液微萃取(PTD-DLLME)结合超高效液相色谱-串联质谱(UPLC-MS/MS)同时测定环境水中7种新烟碱类农药的方法。该方法首次以巴氏滴管作为萃取容器,低密度低毒性的乙腈作为萃取剂,丙酮为分散剂。采用BEH C_(18)(2.1 mm×50 mm,1.7μm)色谱柱分离,0.01%甲酸水溶液(含2.mmol/L甲酸铵)和0.01%甲酸乙腈溶液(含2.mmol/L甲酸铵)为流动相梯度洗脱,电喷雾离子源(ESI)正离子方式扫描,多反应监测(MRM)模式监测,以保留时间和特征离子定性,外标法定量。在最优实验条件下,目标化合物在0.05~100μg/L范围内线性关系良好,相关系数(r2.不低于0.996,检出限(LOD)为0.02.0.1μg/L,定量下限(LOQ)为0.05~0.2.g/L,富集倍数为10倍。在1倍、2.和10倍LOQ 3个加标水平下,各待测物的回收率为75.3%~116%,日内相对标准偏差(Intra-RSD,n=6)为2.7%~8.2.,日间相对标准偏差(Inter-RSD,n=3)为3.1%~10%,基质效应为-0.18%~6.66%。采用该方法对2.批环境水样进行检测,其中1批河水样品中检出吡虫啉与噻虫啉,其浓度低于LOQ。该方法具有便于操作、富集效果好、回收率稳定、绿色环保以及成本低廉的优点,为环境水样中新烟碱类农药的检测提供了一种全新的解决方案。

关键词：环境水巴氏滴管分散液液微萃取超高效液相色谱-串联质谱新烟碱类农药

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考虑低碳交通的电动汽车充电站优化配置方法

浙江电力 2024年第6期43卷 69-79页

作者：宣羿樊立波孙智卿蒋建陈铎文邓凯王梦瑶国网浙江省电力有限公司杭州供电公司杭州310007 上海电力大学电气工程学院上海200090

交通运输产生的碳排放是城市碳排放的主要来源之一,而城市充电站规划中较少考虑交通碳排放因素。对此,提出了一种考虑低碳交通约束的电动汽车充电站优化配置方法。首先,基于充电站候选点划分区域碳排放测算网格,在此基础上考虑充电站位... 详细信息

交通运输产生的碳排放是城市碳排放的主要来源之一,而城市充电站规划中较少考虑交通碳排放因素。对此,提出了一种考虑低碳交通约束的电动汽车充电站优化配置方法。首先,基于充电站候选点划分区域碳排放测算网格,在此基础上考虑充电站位置、容量等因素的影响并建立网格化交通碳排放模型;然后,建立综合考虑碳排放量、交通能源结构、交通电力能源清洁度以及充电站使用率四个因素的低碳交通指标体系,量化分析充电站规划方案对交通碳排放的影响;之后,以低碳交通指标为约束条件,兼顾经济性和节能减排,建立考虑交通碳排放因素的双目标优化配置模型;最后,通过某地区案例对所提方法进行仿真验证,结果表明,考虑低碳交通约束的优化配置方法可以在不增加投资成本的同时有效降低城市各区域交通碳排放水平。

关键词：低碳交通碳排放电动汽车充电站优化配置

儿童亚二倍体核型前体B细胞急性淋巴细胞白血病的临床特征及预后分析

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中国实验血液学杂志 2024年第5期32卷 1356-1364页

作者：陈成璇翁开枝温红庄树铨吴兴国郑湧智福建省血液病研究所福建省血液病学重点实验室福建医科大学附属协和医院福建福州350001 福建医科大学附属漳州市医院儿童血液风湿肾科福建漳州363000 厦门大学附属第一医院儿科福建厦门361000 福建医科大学附属泉州第一医院儿科福建泉州362000 福建省南平市第一医院儿科福建南平353000

目的:探讨儿童亚二倍体核型前体B细胞急性淋巴细胞白血病(BCP-ALL)的临床特征及预后。方法:回顾性分析2.11年4月至2.2.年12.福建省5家医院收治的12.7例初诊BCP-ALL患儿的临床资料。根据染色体核型将患儿分为伴亚二倍体核型BCP-ALL与不... 详细信息

目的:探讨儿童亚二倍体核型前体B细胞急性淋巴细胞白血病(BCP-ALL)的临床特征及预后。方法:回顾性分析2.11年4月至2.2.年12.福建省5家医院收治的12.7例初诊BCP-ALL患儿的临床资料。根据染色体核型将患儿分为伴亚二倍体核型BCP-ALL与不伴亚二倍体核型BCP-ALL组,对比两组患儿的临床特征、早期治疗反应[诱导治疗中及诱导后的微小残留病(MRD)]及远期疗效[总生存率(OS)及无事件生存率(EFS)],并进一步探讨伴亚二倍体核型BCP-ALL的预后影响因素。结果:12.7例B-ALL患儿中2.例(2.2.)为亚二倍体核型。伴亚二倍体核型BCP-ALL组初诊白细胞计数≥50×10^(9)/L的患者比例显著高于不伴亚二倍体核型BCP-ALL组(P=0.004),而两组在性别比例、初诊年龄分组、早期治疗反应方面差异均无统计学意义(P>0.05)。伴亚二倍体核型BCP-ALL组的5年EFS及OS率分别为75.0%(95%CI:66.8%-83.2.)、77.8%(95%CI:69.8%-85.8%)均低于不伴有亚二倍体核型BCP-ALL组的79.6%(95%CI:78.4%-80.8%)、86.4%(95%CI:85.4%-87.5%)但差异均无统计学意义(均P>0.05)。进一步按危险度分层进行亚组分析显示,伴亚二倍体核型BCPALL组5年EFS及OS率均显著低于不伴亚二倍体核型BCP-ALL的低危(LR)组[LR组EFS:91.4%(95%CI:88.4%-93.6%),P2.1%-96.4%),P2.),P=0.343;OS:87.3%(95%CI:83.6%-90.2.),P=0.111];均高于高危(HR)组,但差异无统计学意义[HR组EFS:58.7%(95%CI:52.6%-64.8%),P=0.178;OS:69.9%(95%CI:63.5%-75.4%),P=0.417]。单因素分析结果显示,性别、年龄、白细胞计数及诱导治疗中对OS及EFS均无显著的影响;染色体数目2.),但对EFS无显著影响;诱导治疗后MRD≥0.01%是更低OS及EFS的危险因素(P分别为0.002.0.001)。结论:儿童亚二倍体核型BCP-ALL预后中等,诱导治疗后MRD≥0.01%可能为其不良预后的危险因素。

关键词：亚二倍体核型前体B细胞急性淋巴细胞白血病预后

Nanostructural thermoelectric materials and their perfor- mance

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Frontiers in Energy 2018年第1期12卷 97-108页

作者： kai-xuan CHEN Min-Shan LI Dong-Chuan MO Shu-Shen LYU School of Chemical Engineering and Technology Sun Yat-senUniversity Guangzhou 510275 China Guangdong EngineeringTechnology Research Centre for Advanced Thermal Control Materialand System Integration (ATCMSI) Guangzhou 510275 China

In this review, an attempt was made to introduce the traditional concepts and materials in thermo- electric application and the recent development in search- ing high-performance thermoelectric materials. Due to the use of nanostructural engineering, thermoelectric materials with a high figure of merit are designed, leading to their blooming application in the energy field. One dimensional nanotubes and nanoribbons, two-dimensional planner structures, nanocomposites, and heterostructures were summarized. In addition, the state-of-the-art theoretical calculation in the prediction of thermoelectric materials was also reviewed, including the molecular dynamics （MD）, Boltzmann transport equation, and non-equilibrium Green＇s function. The combination of experimental fabrication and first-principles prediction significantly promotes the discovery of new promising candidates in the thermoelectric field.

关键词： nanostructuml low-dimensional thermoelec-tric material figure of merit first-principles

A novel non-iterative shape method for estimating the decay time constant of the finger photoplethysmographic pulse

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第6期12卷 438-445页

作者： Ling-xiao HOU Ming WEI xuan WANG Xin-zhong CHEN Ying FENG kai JIANG Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering Zhejiang University'Hangzhou 310027 China Department of Anaesthesia Women "s Hospital Hangzhou 310006 China Institute of Space Medical Engineering Beijing 100094 China

The photoplethysmogram(PPG) of a pulse wave,similar in appearance to the arterial blood pressure(ABP) waveform,contains rich information about the cardiovascular *** decay time constant RC,equal to the product of peripheral resistance R and total arterial compliance C,is a meaningful cardiovascular model parameter in vascular *** or ameliorating the existing ABP methods does not achieve a satisfactory estimation of RC from the PPG volume pulse(VRC).Thus,a novel non-iterative shape method(NSM) of evaluating VRC is introduced in this *** mathematic expression between a novel,readily available morphological parameter called the area difference ratio(ADR) and VRC was *** it was difficult to calculate VRC from the complicated expression analytically,we recommend estimating it using a piecewise linear interpolation ***,since the effect of the PPG magnitude is eliminated in the calculation of ADR,precaliberation or normalization is dispensable in the *** of human experiments indicated that the NSM was computationally efficient,and the simulation experiments confirmed that the NSM was theoretically available for ABP.

关键词： Photoplethysmogram(PPG) Decay time constant Non-iterative shape method(NSM) Area difference ratio(ADR)

Microprofiles of activated sludge aggregates using microelectrodes in completely autotrophic nitrogen removal over nitrite （CANON） reactor

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Frontiers of Environmental Science & Engineering 2016年第2期10卷 390-398页

作者： Yongtao LV xuan CHEN Lei WANG kai JU Xiaoqiang CHEN Rui MIAO Xudong WANG School of Environmental and Municipal Engineering Xi'an University of Architecture and Technology Xi'an 710055 China College of Environment and Resource Shaanxi University of Science and Technology Xi'an 710021 China

Microsensor measurements and fluorescence in situ hybridization （FISH） analysis were combined to investigate the microbial populations and activities in a laboratory-scale sequencing batch reactor （SBR） for completely autotrophic nitrogen removal over nitrite （CANON）. Fed with synthetic wastewater rich in ammo- nia, the SBR removed 82.54-5.4% ofinfluent nitrogen and a maximum nitrogen-removal rate of 0.52.gN.m 3.d-l was achieved. The FISH analysis revealed that aerobic ammonium-oxidizing bacteria （AerAOB） Nitrosomonas and anaerobic ammonium-oxidizing bacteria （AnAOB） dominated the community. To quantify the microbial activities inside the sludge aggregates, microprofiles were measured using pH, dissolved oxygen （DO）, NH＋, NO＋ and NO3 microelectrodes. In the outer layer of sludge aggregates （0-700 μm）, nitrite-oxidizing bacteria （NOB） showed high activity with 4.1 gmol-cm3＋ h-1 of maximum nitrate production rate under the condition of DO concentration higher than 3.3 mg. L 1. Maximum AerAOB activity was detected in the middle layer （depths around 1700 μm） where DO concentration was 1.1 μg. L-1. In the inner layer （2.00-3500μm）, where DO concentration was below 0.9 mg. L-1, AnAOB activity was detected. We thus showed that information obtained from microscopic views can be helpful in optimizing the SBR performance.

关键词： aerobic ammonium-oxidizing bacteria anae-robic ammonium-oxidizing bacteria nitrite-oxidizing bac-teria microelectrodes CANON

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术前日常活动量对全髋置换术的影响

中国矫形外科杂志 2024年第1期32卷 87-90,93页

作者：刘伟陆志剀段添栋王灵海许轩铭上海交通大学医学院附属瑞金医院舟山分院浙江舟山316000

[目的]明确全髋关节置换术术前活动量与术后下肢功能的关系。[方法]以接受全髋关节置换的66例患者为研究对象,按照国际体力活动问卷评估术前1周活动量,44例患者活动量≥1000 kcal,列为活动组,另外2.例患者活动量0.05)。相关分析方面,术... 详细信息

[目的]明确全髋关节置换术术前活动量与术后下肢功能的关系。[方法]以接受全髋关节置换的66例患者为研究对象,按照国际体力活动问卷评估术前1周活动量,44例患者活动量≥1000 kcal,列为活动组,另外2.例患者活动量2.40.0)kcal vs(42..0±312.0)kcal,P2.4)s vs(10.4±8.3)s,P=0.049]、术后2.月VAS评分[(1.6±0.8)vs(2.2.1.1),P=0.014]、术后2.月外展肌力[(82.1±2..5)%vs(67.1±2..9)%,P=0.047]、术前Harris评分[(54.7±10.2.vs(47.8±10.3),P=0.012.和术后2.月Harris评分[(75.0±7.3)vs(65.7±8.1),P2.月10 m步行时间、术前疼痛VAS评分、术前外展肌力、术前和术后2.月髋伸屈ROM和髋内-外旋ROM的差异均无统计学意义(P>0.05)。相关分析方面,术前1周活动量与术前的10 m步行时间呈显著负相关(r=-0.2.3,P=0.032.,但与术后10 m步行时间无显著相关性(P>0.05);与术前的VAS评分无显著相关性(P>0.05),但与术后VAS评分呈显著负相关(r=-0.2.1,P=0.02.);与术前的髋关节外展肌力无显著相关性(P>0.05),但与术后髋关节外展肌力呈显著正相关(r=0.337,P=0.012.;与术前术后的髋伸屈ROM、髋内-外旋ROM均无相关性(P>0.05);与术前(r=0.2.3,P=0.019)、术后2.月(r=0.389,P=0.003)的Harris评分均呈显著正相关。[结论]THA患者术前活动量和Harris髋关节功能、VAS评分以及外展肌力存在一定关系。术前活动量大有利于术后恢复。

关键词：髋骨关节炎全髋关节置换术国际体力活动问卷 Harris评分关节活动度

Expression of p2.^(WAF1) is related to acetylation of histone H3 in total chromatin in human coiorectai cancer

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World Journal of Gastroenterology 2007年第15期13卷 2209-2213页

作者： Ying-xuan Chen Jing-Yuan Fang Rong Lu De-kai Qiu Department of Gastroenterology Renji Hospital Shanghai Institute of Digestive Disease Shanghai Jiaotong University School of Medicine Shanghai 200001 China

AIM： To explore the relationship between acetylation of histone in total chromatin and p2.^WAF1 expression regulation in human colorectal carcinoma. METHODS： We analyzed the expression of tumor suppressor gene p2.^WAF1 mRNA by RT-PCR or realtime PCR in 33 samples of colorectal cancerous tissue, corresponding para-cancerous tissue and normal colorectal mucosa, and also examined the level of acetylated histone H3 in total chromatin using Western blotting. RESULTS： The expression level of p2.^WAF1 mRNA was significantly lower in colorectal cancerous tissue from 33 patients than in para-cancerous tissue and normal colorectal mucosa （2.77.95 ± 865.80 vs 32.6.58 ± 1149.42.and 3541.61 ± 1433.17 respectively, P 〈 0.01）. In addition, when p2.^WAF1 mRNA expression was undectectable or at very low level （50% less than that in adjacent tissue and normal colorectal mucosa） in all tissues, the level of acetylated histone H3 in colorectal cancerous tissue was significantly lower than that in corresponding para-cancerous tissue and normal colorectal mucosa in five of seven （71.43%） cases. The transcriptional level of p2.^WAF1 in colorectal carcinoma might not be associated with its biological behaviors.CONCLUSION： The down-regulation of p2.^WAF1 transcription is involved in the tumorigenesis and development of colorectal carcinoma. The down-expression of p2.^WAF1 mRNA in colorectal carcinoma might be associated with histone hypoacetylation in chromatin but not with biological behaviors.

关键词： Colorectal cancer p2.^WAF1 Histone acetylation

基于ANSYS的双螺杆挤出机长圆形夹套的优化设计

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化工机械 2024年第4期51卷 600-608页

作者：柏凯旋董金善孙项羽王涛南京工业大学机械与动力工程学院

对双螺杆挤出机长圆形夹套结构进行优化设计,在夹套外表面设置加强圈可以有效降低结构的最大应力和总变形量,进而减薄长圆形夹套的厚度。利用数值模拟分析方法对比不同截面形状的加强圈对结构的加强效果,发现L形截面加强圈对应力的影响... 详细信息

对双螺杆挤出机长圆形夹套结构进行优化设计,在夹套外表面设置加强圈可以有效降低结构的最大应力和总变形量,进而减薄长圆形夹套的厚度。利用数值模拟分析方法对比不同截面形状的加强圈对结构的加强效果,发现L形截面加强圈对应力的影响最为显著。确定合适的加强圈数量,利用ANSYS Workbench参数化优化平台,采用80组随机取样和等步长运算,分析各参数对夹套结构应力的敏感性。研究结果表明:加强圈厚度S、高度H、宽度L和夹套厚度T对夹套结构应力、变形的影响较为显著,而套管厚度t对其应力、变形几乎没有影响。基于目标驱动优化确定最佳结构。此时,长圆形夹套厚度减薄60%,设备总质量降低17.42.。

关键词：双螺杆挤出机加强圈长圆形夹套结构强度优化设计