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The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han Colin Hanna David Baron Ashim Gupta Shan Kazmi Jag Khalsa Debasis Bagchi Thomas McLaughlin Rajendra D. Badgaiyan Edward J. Modestino Drew Edwards Catherine A. Dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney Mark S. Gold kai-uwe lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos Division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psychiatry Harvard School of Medicine Cambridge MA USA Department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA Department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANDAS CANS Genetic Addiction Risk Testing (GARS) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

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Long-Time Turbulence Model Deduced from the Navier-Stokes Equations

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 883-894页

作者： Roger lewandowski IRMAR and Fluminance Team University of Rennes 1 and INRIA Campus Beaulieu

The author shows the existence of long-time averages to turbulent solutions of the Navier-Stokes equations and determines the equations satisfied by them, involving a Reynolds stress that is shown to be dissipative.

关键词： Navier-Stokes equations Weak solutions Turbulence modeling Reynolds stress

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A Variational Finite Element Model for Large-Eddy Simulations of Turbulent Flows

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Chinese Annals of Mathematics,Series B 2013年第5期34卷 667-682页

作者： Toma's Chac'on REBOLLO Roger lewandowski Dpto. EDAN & IMUS Universidad de SevillaC/Tarfias/n. 41012 SevillaSpain BCAM-Basque Center for Applied Mathematics AvdaMazarredo14. 48009 BilbaoSpain. Mathematical Research Institute of Rennes UMR CNRS 6625University of Rennes 1 & Fluminance teamINRIABat 22Campus Beaulieu35042 Rennes cedexFrance.

The authors introduce a new Large Eddy Simulation model in a channel, based on the projection on finite element spaces as filtering operation in its variationM form, for a given triangulation （Th）h〉0. The eddy viscosity is expressed in terms of the friction velocity in the boundary layer due to the wall, and is of a standard sub grid-model form outside the boundary layer. The mixing length scale is locally equal to the grid size. The computational domain is the channel without the linear sub-layer of the boundary layer. The no-slip boundary condition （or BC for short） is replaced by a Navier （BC） at the computational wall. Considering the steady state case, the authors show that the variational finite element model they have introduced, has a solution （Vh,Ph）h〉O that converges to a solution of the steady state Navier-Stokes equation with Navier BC.

关键词： Navier-Stokes equations Turbulence modeling Finite elements

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Rotational Forms of Large Eddy Simulation Turbulence Models:Modeling and Mathematical Theory

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Chinese Annals of Mathematics,Series B 2021年第1期42卷 17-40页

作者： Luigi C.BERSELLI Roger lewandowski Dinh Duong NGUYEN Universita di Pisa Dipartimento di MatematicaVia Buonarroti 1/c1-56127 Pisa Italy IRMAR UMR CNRS 6625University of Rennes 1 and FLUMINANCE TeamINRIA RennesFrance

In this paper the authors present a derivation of a back-scatter rotational Large Eddy Simulation model,which is the extension of the Baldwin&Lomax model to nonequilibrium *** model is particularly designed to mathematically describe a fluid filling a domain with solid walls and consequently the differential operators appearing in the smoothing terms are degenerate at the *** the derivation of the model,the authors prove some of the mathematical properties coming from the weighted energy estimates,which allow to prove existence and uniqueness of a class of regular weak solutions.

关键词： Fluid mechanics Turbulence models Rotational Large Eddy Simulation models Navier-Stokes equations

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The study of biological activity of transformation products of diclofenac and its interaction with chlorogenic acid

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Journal of Environmental Sciences 2020年第5期32卷 128-141页

作者： Marzena Matejczyk Piotr Ofman Katarzyna Dabrowska Renata Swislocka Wlodzimierz lewandowski Bialystok University of Technology Faculty of Civil Engineering and Environmental SciencesDepartment of ChemistryBiology and Biotechnology15-341BialystokPoland Bialystok University of Technology Department of Environmental Engineering TechnologyBialystok15-341Poland Waclaw Dabrowski Institute of Agricultural and Food Biotechnology Department of Microbiology02-532WarsawPoland

In the present work we compared the biological activity of DCF,4’-OHDCF and 5-OHDCF as molecules of most biodegradation pathways of DCF and selected transformation products(2-hydroxyphenylacetic acid;2,5-dihydroxyphenylacetic acid and 2,6-dichloroaniline)which are produced during AOPs,such as ozonation and UV/H2 *** also examined the interaction of DCF with chlorogenic acid(CGA).CGA is commonly used in human diet and entering the environment along with waste mainly from the processing and brewing of coffee and it can be toxic for microorganisms included in activated *** the present experiment the evaluation of following parameters was performed:*** K-12 cells viability,growth inhibition of *** K-12 culture,LC50 and mortality of Chironomus aprilinus,ge no toxicity,sodA promoter induction and ROS *** addition the reactivity of *** SM recA:luxCDABE biosensor strain in wastewater matrices was *** results showed the influence of DCF,4’-OHDCF and 5-OHDCF on *** K-12 cells viability and bacteria growth,comparable to AOPs *** highest toxicity was observed for selected,tested AOPs by-products,in comparison to the DCF,4’-OHDCF and *** assay indicated that 2,6-dichloroaniline(AOPs by-product)had the highest toxic *** oxidative stress assays revealed that the highest level of ROS generation and sodA promoter induction were obtained for DCF,4’-OHDCF and 5-OHDCF,compared to other tested *** have also found that there is an interaction between chlorogenic acid and DCF,which resulted in increased toxicity of the mixture of the both compounds to *** K-12,comparable to parent *** strongest response of *** SM biosensor strain with recA:luxCDABE genetic construct in filtered treated wastewaters,comparable to control sample was *** indicates,that *** SM recA:luxCDABE biosensor strains is a good tool for bacteria monitoring in wastewater *** to toxicity and biological

关键词： Diclofenac Biodegradation Chlorogenic acid Advances oxidation processes (AOPs) Wastewaters Microbial biosensors

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Entrance Effects in Microchannel Gas Flow

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Journal of Thermal Science 2009年第4期18卷 345-352页

作者： T.lewandowski S.Jebauer J.Czerwinska P.Doerffer Institute of Fluid Flow Machinery Polish Academy of Science Institute of Fundamental Technological Research Polish Academy of Science

Motivation of this work has its origin in the boundary layer control for aeronautics and turbomachinery. For thatpurpose boundary layer can be modified by perforated plates with holes of specific sizes. The questions whichrise in such configuration are related to the existence of optimal size of the holes and the influence of microscalephenomena on the global flow patterns. This paper concentrates on the issue of the entrance effects on the microchannelflow. It is shown that mass flow rate is only insignificantly influenced by slip effects. Global parameterssuch as pressure difference and geometrical shape in more pronounced way alter flow behavior. In this paper weconcentrate on the numerical investigation of the microchannel flow for Kn < 0.01 and Re < 500. The channellength is finite. Hence, entrance and outlet effects on microchannel flow can be studied.

关键词： perforated plates microchanneis gas flow simulations

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A Damage-tolerant Bulk Metallic Glass at Liquid-nitrogen Temperature

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Journal of Materials Science & Technology 2014年第6期30卷 627-630页

作者： Jun Yi S.Mohsen Seifi Weihua Wang John J.lewandowski Department of Materials Science and Engineering Case Western Reserve UniversityClevelandOH 44106-7204 USA Institute of Physics Chinese Academy of Sciences

Tensile tests and notch toughness tests were conducted on Zr61Ti2Cu25Al12 glass （ZT） at room temperature and liquid-nitrogen temperature. The tensile strength of ZT was improved from 1.63 GPa at room temperature to 1.72 GPa at liquid-nitrogen temperature. Micro-notches with a root radius of 1-3μm were introduced to test the notch toughness of ZT at room temperature and liquid-nitrogen temperature. The test results revealed that the notch toughness of ZT at liquid-nitrogen temperature is comparable to that of ZT at room temperature. The combination of high yield strength and notch toughness of ZT at liquid-nitrogen temperature is comparable to that of the best cryogenic engineering materials.

关键词： Metallic glasses Yield strength Fracture toughness Liquid-nitrogen temperature

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Fully Kinetic, Electromagnetic Particle-in-Cell Simulations of Plasma Microturbulence

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Communications in Computational Physics 2007年第4期2卷 684-722页

作者： J.L.V.lewandowski L.E.Zakharov Plasma Physics Laboratory Princeton UniversityP.O.Box 451PrincetonNJ 08543USA.

A novel numerical method,based on physical intuition,for particle-in-cell simulations of electromagnetic plasma microturbulence with fully kinetic ion and electron dynamics is *** method is based on the observation that,for lowfrequency modes of interest[ω/ω_(ci)≪1,ωis the typical mode frequency andωci is the ion cyclotron frequency]the impact of particles that have velocities larger than the resonant velocity,v^(r)∼ω/k_(||)(k_(||) is the typical parallel wavenumber)is negligibly small(this is especially true for the electrons).Therefore it is natural to analytically segregate the electron response into an adiabatic response and a nonadiabatic response and to numerically resolve only the latter:this approach is termed the splitting ***,the exact separation between adiabatic and nonadiabatic responses implies that a set of coupled,nonlinear elliptic equations has to be solved;in this paper an iterative technique based on the multigrid method is used to resolve the apparent numerical *** is shown that the splitting scheme allows for clean,noise-free simulations of electromagnetic drift waves and ion temperature gradient(ITG)*** is also shown that the advantage of noise-free kinetic simulations translates into better energy conservation properties.

关键词： Plasma micro-turbulence particle-in-cell simulation multigrid solver.

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Remembering your A, B, C’s: Alzheimer’s disease and ABCA1

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Acta Pharmaceutica Sinica B 2022年第3期12卷 995-1018页

作者： Cutler T.lewandowski Megan S.Laham Gregory R.J.Thatcher Department of Pharmaceutical Sciences University of Illinois College of PharmacyChicagoIL 60612USA Department of Pharmacology and Toxicology University of Arizona College of PharmacyTucsonAZ 85721USA

The function of ATP binding cassette protein A1(ABCA1)is central to cholesterol *** ABCA1 expression or activity is implicated in Alzheimer’s disease(AD)and other *** approaches to boost ABCA1 activity have yet to be translated successfully to the *** risk factors for AD development and progression,including comorbid disorders such as type2 diabetes and cardiovascular disease,highlight the intersection of cholesterol transport and *** of ABCA1 can positively impact APOE lipidation,insulin sensitivity,peripheral vascular and blood-brain barrier integrity,and anti-inflammatory *** strategies towards ABCA1-boosting compounds have been described,with a bias toward nuclear hormone receptor(NHR)*** agonists display beneficial preclinical effects;however,important side effects have limited *** particular,ligands that bind liver X receptor(LXR),the primary NHR that controls ABCA1 expression,have shown positive effects in AD mouse models;however,lipogenesis and unwanted increases in triglyceride production are often *** longstanding approach,focusing on LXRβ*** selectivity,is over-simplistic and has *** approaches such as phenotypic screening may lead to small molecule NHR modulators that elevate ABCA1 function without inducing lipogenesis and are clinically translatable.

关键词： Alzheimer’s disease Cardiovascular disease Cholesterol Drug discovery Liver X receptor Nuclear hormone receptor Type 2 diabetes

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Selected Experiences with Optimization Tests of the Kaplan-Type Hydraulic Turbines

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Journal of Energy and Power Engineering 2014年第6期8卷 1002-1011页

作者： Adam Adamkowski Mariusz lewandowski Stanistaw lewandowski The Szewalski Institute of Fluid-Flow Machinery Polish Academy of Sciences Gdahsk 80-952 Poland lewandowski Stanistaw HydroConsult ul. Glihskiego 13 Bolszewo 84-239 Poland

The paper presents selected experience of the authors resulting from the optimization tests of double-regulated water turbines. Among the methods for measuring the discharge through the turbine used in such tests, particular attention was paid to index methods allowing to measure the relative discharge through the turbine-the index current meter method and the methods based on measuring the differential pressure between two points properly located at the turbine flow system （i.e., Winter-Kennedy method）. These methods contribute to effective reduction of the cost of optimizing the turbine that is extremely important for small hydropower plants regarding installed capacity. The paper presents selected examples of the optimization tests and experiences that arise from these tests.

关键词： Double-regulated water turbines cam dependence flow measurement index methods Winter-Kennedy index method current meter index method.

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