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Fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy: A retrospective study at a single center

第二届中国国际暨第五届全国口腔颌面外科学术会议

作者： A．eckardt DEPARTMENT OF ORAL AND MAXILLOFACIAL SURGERY HANNOVER MEDICAL UNIVERSITYHANNOVERGERMANY

＜正＞Intraarterial drug therapy has been used for treatment of head and neck cancer for over 30 years. Although this method was abandoned in most institutions, the development of subcutaneously implantable injection ports has renewed interest in regional drug delivery. Furthermore the technical advances in vascular radiology allow placement of microcatheters in the tumor area. Since 1992 a total of 36 injection ports have been implanted in the external carotid artery in 35 patients with

关键词： INTRAARTERIAL CHEMOTHERAPY OF ADVANCED,INOPERABLE HEAD AND NECK MALIGNANCIES USING IMPLANTABLE PORT CATHETERS:INDICATIONS,TECHNIQUES AND RESULTS

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World Journal of Gastroenterology 2017年第9期23卷 1637-1644页

作者： Wen-Gang Zhang En-Qiang Linghu Hui-kai Li Departmen of Gastroenterology Chinese PLA General HospitalBeijing 100853China

AIM To assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy(POEM).METHODS Twenty-four patients who underwent POEM and experienced mucosal injury of the cardia during the procedure were retrospectively identified. Of the 24 patients, 21 had mucosal penetration and 3 had only slight mucosal damage without penetration. The 21 patients with mucosal penetration received fibrin sealant for closure at the site of penetration. Penetration-related characteristics, treatment, and recovery were reviewed for all 21 patients to assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia. Clinical data, including general characteristics, procedure-related parameters, eckardt scores, lower esophageal sphincter pressures (LESP), and esophagogastroduodenoscopy(EGD) results, were analyzed to determine their influence on treatment success after mucosal penetration during *** All 21 patients had a solitary mucosal penetration in the cardia (12 in esophageal region of the cardia, 9 in the stomach region of the cardia, and 1 in both the esophageal and stomach regions). Twelve had ahole-like penetration and 9 had a linear penetration. For those with a hole-like penetration, the mean size was 0.14 cm2 (0.02-0.32 cm2). For those with a linear penetration, the median size was 0.37 cm (0.10-1.00 cm). Closure of the mucosal penetration using fibrin sealant was performed successfully in all 21 patients(two patients required 5 m L fibrin sealant, and the remaining 19 patients required 2.5 mL). Two patients had a nasogastric tube placed for five days after POEM; the remaining 19 patients were kept fasting for 3 d. All 21 patients were discharged after a median of 5 d(range: 5-7 d) postoperatively. During a median 42 mo (range: 9-62 mo) follow-up, all 21 patients with a mucosal penetration successfully healed without the occurrence of infection, ulcer, or esophagitis. Furth

关键词： Fibrin sealant Mucosal penetration Peroral endoscopic myotomy Efficacy Safety

Ling classification describes endoscopic progressive process of achalasia and successful peroral endoscopy myotomy prevents endoscopic progression of achalasia

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World Journal of Gastroenterology 2017年第18期23卷 3309-3314页

作者： wen-gang zhang en-qiang linghu ning-li chai hui-kai li Department of Gastroenterology Chinese PLA General Hospital

AIM To verify the hypothesis that the Ling classification describes the endoscopic progressive process of achalasia and determine the ability of successful peroral endoscopic myotomy (POEM) to prevent endoscopic progression of achalasia. METHODS We retrospectively reviewed the endoscopic findings, symptom duration, and manometric data in patients with achalasia. A total of 359 patients (197 women, 162 men) with a mean age of 42.1 years (range, 12-75 years) were evaluated. Symptom duration ranged from 2 to 360 mo, with a median of 36 mo. Patients were classified with Ling type I (n = 119), II a (n = 106),II b (n = 60),II c (n = 60), or III (n = 14), according to the Ling classification. Of the 359 patients, 349 underwent POEM, among whom 21 had an endoscopic follow-up for more than 2 years. Pre-treatment and post-treatment Ling classifications of these 21 patients were compared. RESULTS Symptom duration increased significantly with increasing Ling classification (from I to III) (p eckardt score eckardt sco

关键词： Ling classification Achalasia Progression Peroral endoscopic myotomy Endoscopy

在DNA损伤修复信号传导通路中ATM介导的BRCA1及RAD51作用机理的研究

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辐射研究与辐射工艺学报 2006年第2期24卷 115-119页

作者：冯爽曹建平朱巍宋建元李翀盛方军樊赛军 F.eckardt-Schupp 苏州大学放射医学与公共卫生学院苏州215123 GSF-National

为阐明毛细血管扩张性共济失调突变基因(Ataxia telangiectasia mutated,ATM)介导的乳癌基因1 (Breast cancer gene 1,Breal)磷酸化及其下游DNA修复相关蛋白(DNA damage repair protein 51,RAD51) 在DNA损伤修复信号传导通路中作用机理,以源于正常人皮肤的成纤维细胞系GM细胞(Originated from human skin fibroblast GM Cell,GM0639)为对照,用免疫共沉淀与Western blot方法,观察60Coγ射线照射后共济失调症(Ataxia telangiectasia,AT)细胞、ATM转染的AT细胞(ATM+-AT)和GM细胞的BRCA1及 RAD51蛋白表达的变化。经0、5、10、20Gy辐照后,AT细胞通过免疫共沉淀及Western Blot法分析其中 ATM和BRCA1蛋白以及BRCA1和RAD51蛋白之间的相互作用以及PI3K抑制剂对ATM磷酸化其下游基因的影响。0Gy照射ATM+-AT和GM细胞未出现BRCA1表达条带;照射后,GM细胞、ATM细胞BRCA1 和RAD51蛋白均有表达,而AT细胞无表达;PI3 K抑制剂Wortmannin对经电离辐射照射后的AT、ATM+-AT 和GM细胞中BRCA1蛋白表达具有抑制作用;照射后ATM+-AT和GM细胞中BRCA1和RAD51蛋白均有表达。因此,电离辐射照射后,BRCA1由ATM介导磷酸化后可进一步与RAD51相互作用,这是信号通路传导过程中的—个级联反映,从而修复损伤的DNA,保持基因组的稳定性。

关键词：毛细血管扩张性共济失调突变基因乳癌基因1 DNA修复相关蛋白磷酸化

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Bioabsorbable Barrier Membrane Combined with rhBMP-2 Improved Bone Formation in an Experimental Model of Compromised Healing But Was Not Superior to rhBMP-2 Alone

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Open Journal of Orthopedics 2014年第2期4卷 31-37页

作者： Henrik eckardt Knud Stenild Christensen Martin Lind Ebbe Stender Hansen Ivan Hvid Department of Orthopedic Surgery Aalborg Hospital Aalborg Denmark Department of Orthopedic Surgery Aarhus University Hospital Aarhus Denmark Trauma Division Orthopedic Department Copenhagen University Hospital Rigshospitalet Denmark

Objective: Bioabsorbable barrier membranes placed over alveolar ridge bone defects are routinely used in dental surgery to promote bone formation. Combining these osteoconductive membranes with osteoinductive Bone Morphogenetic Proteins could prove useful in long bone fracture treatment. The hypothesis was tested in a clinically relevant model of compromised healing. Methods: Four groups of 8 rabbits underwent unilateral mid-tibial osteotomy, excision of periosteum and endosteum, and plate fixation. One group had rhBMP-2 deposited between the bone ends and Membrane wrapped around the osteotomy, the second group had Membrane wrapped around the osteotomy, the third group had rhBMP-2 placed between the bone ends, and the fourth group received no additional treatment. Results: After 7 weeks, callus size and blood flow were significantly higher in the Membrane+rhBMP-2 group than in the rhBMP-2 treated group, but torsion to failure test showed no significant difference. Membrane treatment and no treatment led to non-union. Conclusion: Absorbable barrier membrane combined with rhBMP-2 enhances bone formation, but has no advantage to rhBMP-2 alone. Membrane alone wrapped around the osteotomy was unable to prevent non-union formation.

关键词： Bioabsorbable Barrier Membrane Bone Morphogenetic Protein 2 Non Union Pseudartrhrosis Rabbit Bone Blood Flow Torsion to Failure

适用于流程工业——通过有效的精益管理提高生产效率

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流程工业 2006年第5期 58-59页

作者： eckardt Grethlein 德国Aachen市精益管理学院

严谨的成本核算、删除一切多余无用的步骤、提高生产过程的效率，这就是所谓的精益管理，精益管理的主要任务是企业减肥、并通过企业减肥提高生产过程的效益和能力。这一源于汽车工业的有效管理方法也可用于医药制造企业，如本文所介绍... 详细信息

严谨的成本核算、删除一切多余无用的步骤、提高生产过程的效率，这就是所谓的精益管理，精益管理的主要任务是企业减肥、并通过企业减肥提高生产过程的效益和能力。这一源于汽车工业的有效管理方法也可用于医药制造企业，如本文所介绍的一样。

关键词：流程工业制造企业有效管理生产过程成本核算汽车工业

机油中的杂质对发动机滑动轴承运用特性的影响

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国外铁道机车与动车 1984年第5期 50-56页

作者： Christian eckardt 孙翔

1.导言在一定的气缸容积范围内提高升功率是发动机发展中的一种明显趋势。就滑动轴承来讲,通过采用较新的材料及根据先进的计算方法确定结构参数可以在不影响使用寿命的条件下大大提高承载能力。发展的结果是,当现代的滑动轴承以较大

关键词：滑动轴承轴承间隙极限浓度发动机

Long-term outcomes of peroral endoscopic myotomy in achalasia patients with a minimum follow-up of 7 years

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Chinese Medical Journal 2020年第8期133卷 996-998页

作者： Wen-Gang Zhang Ning-Li Chai Ya-Qi Zhai En-Qiang Linghu Hui-kai Li Department of Gastroenterology Chinese People's Liberation Army General HospitalBeijing 100853China.

There was an enormous increase in reports confirming the safety and efficacy of using peroral endoscopic myotomy(POEM)to treat achalasia since the pioneering of the technique in 2010.[1]However,the reports focused on short to medium-term follow-ups,and data on long-term outcomes of POEM for achalasia were very *** still remains unknown whether the satisfactory short-term outcomes are long ***,some achalasia patients receiving POEM noted that they could benefit from post-operative dietary recommendations that would be helpful for symptom ***,this study aimed to determine the long-term treatment outcomes of using POEM to treat achalasia,and to assess postoperative eckardt scores over this *** also crafted a set of post-POEM dietary recommendations according to the feedback from achalasia patients who underwent this treatment to achieve better symptom remission for post-POEM patients.

关键词： patients operative treatment

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A Comparison of Polysomnographic Variables between Adolescents with Polycystic Ovarian Syndrome and Healthy Controls

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International Journal of Clinical Medicine 2010年第2期1卷 48-53页

作者： Gideon de Sousa Bernhard Schlüter Thomas Menke eckardt Trowitzsch Werner Andler Thomas Reinehr 不详

The prevalence of obstructive sleep apnea syndrome (OSAS) is clearly increased in adults with polycystic ovarian syndrome (PCOS). The symptoms of PCOS usually begin around menarche. However, data concerning poly?somnographic variables in adolescents with PCOS are limited. As obesity is a well-known risk factor for OSAS, we aimed to analyze differences in polysomnographic variables between obese and extremely obese adolescents with PCOS and healthy, normal-weight, obese, and extremely obese controls. Methods: Sixteen obese and 17 extremely obese adolescents with PCOS, 18 normal-weight, 17 obese, and 13 extremely obese controls underwent polysomno?graphy to compare mean transcutaneous arterial oxygen saturation (Sat O2), apnea-index (AI), hypopnea- index (HI), apnea-hypopnea index (AHI), the absolute number of obstructive apneas (NOA), percentage sleep stages 3 and 4 of non REM-sleep (stages 3 & 4), percentage of REM-sleep (% REM), sleep-onset latency, and sleep efficiency. Results: We found no significant differences between the groups concerning AI, HI, AHI, NOA, and stages 3 & 4. Significant differ?ences between the groups were found regarding Sat O2, % REM, sleep-onset latency, and sleep efficiency. Conclusions: Concerning the respiratory variables, adolescents with PCOS do not seem to differ from healthy controls regardless of weight status, but there seem to be differences in sleep architecture.

关键词： PCOS OSAS Adolescents Obesity Extreme Obesity Polysomnography

成人黄斑中心凹卵黄样营养不良患者中心凹下组织切除术后黄斑转位的光镜和电镜观察

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 40-41页

作者：张晓光 eckardt C eckardt U Groos S Aug enklinik der Stadtischen Kliniken Frankfurt a .M.-H chstGotenstras se 6-865929Frankfurt am MainGermany

Purpose:To correlate the functional results of maculartranslocation(MT )in a patient suffering from an adult-onset foveomacular vitellif orm dystrophy(AFVD)with the microscopic findings of the surgically removed subfoveal retinal pigment epithelium(RPE).Methods:A78-year-old woman with AFVD underwe nt MT with 360°retinotomy 3-4months after loss of r eading *** of the vitelliform material was lost during surgery;the subfoveal tissue was excised,fixed in aldehydes,postfixed in reduced OSO4and embedded in epoxy *** sections were stained with toluidin e blue for light mi-croscopy(LM)and thin sections with uranyl acetate and lead citrate for transmission electron microscopy(TEM).Results:Postoperatively,the pati ent developed a retinal detachment complicated by proliferative vitreoretinopathy(PVR)requiring two additional vitreoretinal procedures before finally the silicone oil coul d be ***-ty-two months after MT the distance v isual acuity was un-changed at 0.2;the near visual acuit y had improved from less than 0.1before MT to *** retina was completely *** and TEM revealed seriou s alterations in-dicative of a breakdown of the outer l ayer of the ***:Through the present sin gle case it is not possible to determine whether MT cou ld be a therapeutic approach in patients with *** m ost important cause for the limited postoperative visual improvement seems to be a primary injury of the foveal function due to the *** is supported by the extensive subfoveal degeneration and necrosis affectin g not only the RPE cells but also their basement membrane and the interposed basal laminar deposits.

关键词：黄斑中心凹转位术切除术光镜营养不良患者视网膜色素细胞视网膜脱离近视力术后视力远视力

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