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Artificial nerve graft constructed by coculture of activated Schwann cells and human hair keratin for repair of peripheral nerve defects

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Neural Regeneration Research 2023年第5期18卷 1118-1123页

作者： Han-Jun Qin Hang Li Jun-Ze Chen kai-rui zhang Xing-Qi Zhao Jian-Qiang Qin Bin Yu Jun Yang Department of Orthopedics Nanfang HospitalSouthern Medical UniversityGuangdong Provincial Key Laboratory of Bone and Cartilage Regenerative MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Orthopedics Baiyun Branch of Southern HospitalGuangzhouGuangdong ProvinceChina Department of Anatomy School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics The 74th Group Military Hospital of PLAGuangzhouGuangdong ProvinceChina

Studies have shown that human hair keratin(HHK) has no antigenicity and excellent mechanical properties. Schwann cells, as unique glial cells in the peripheral nervous system, can be induced by interleukin-1β to secrete nerve growth factor, which promotes neural regeneration. Therefore, HHK with Schwann cells may be a more effective approach to repair nerve defects than HHK without Schwann cells. In this study, we established an artificial nerve graft by loading an HHK skeleton with activated Schwann cells. We found that the longitudinal HHK microfilament structure provided adhesion medium, space and direction for Schwann cells, and promoted Schwann cell growth and nerve fiber regeneration. In addition, interleukin-1β not only activates Schwann cells, but also strengthens their activity and increases the expression of nerve growth factors. Activated Schwann cells activate macrophages, and activated macrophages secrete interleukin-1β, which maintains the activity of Schwann cells. Thus, a beneficial cycle forms and promotes nerve repair. Furthermore, our studies have found that the newly constructed artificial nerve graft promotes the improvements in nerve conduction function and motor function in rats with sciatic nerve injury, and increases the expression of nerve injury repair factors fibroblast growth factor 2 and human transforming growth factor B receptor 2. These findings suggest that this artificial nerve graft effectively repairs peripheral nerve injury.

关键词： artificial nerve graft bioactive human hair keratin interleukin-1β macrophages nerve graft nerve growth factor nerve repair peripheral nervous injury Schwann cells

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Simulation study of BESⅢwith stitched CMOS pixel detector using AcTs

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Nuclear Science and Techniques 2023年第12期34卷 264-270页

作者： Yi Liu Xiao‑Cong Ai Guang‑Yan Xiao Ya‑Xuan Li Ling‑Hui Wu Liang‑Liang Wang Jia‑Ning Dong Ming‑Yi Dong Qing‑Lin Geng Min Luo Yan Niu An‑Qing Wang Chen‑Xu Wang Meng Wang Lei zhang Liang zhang rui‑kai zhang Yao zhang Ming‑Gang Zhao Yang Zhou School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Physics Nanjing UniversityNanjing 210093China School of Physics Nankai UniversityTianjin 300071China Institute of High Energy Physics Chinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China University of Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China School of Information Science and Engineering Harbin Institute of TechnologyWeihai 264209China

The reconstruction of the tracks of charged particles with high precision is crucial for HEP experiments to achieve their physics *** BESⅢdrift chamber,which is used as the tracking detector of the BESⅢexperiment,has suffered from aging effects resulting in degraded tracking performance after operation for approximately 15 *** preserve and enhance the tracking performance of BESⅢ,one of the proposals is to add one layer of a thin cylindrical CMOS pixel sensor based on state-of-the-art stitching technology between the beam pipe and the drift *** improvement in the tracking performance of BESⅢwith such an additional pixel detector compared to that with only the existing drift chamber was studied using the modern common tracking software Acts,which provides a set of detector-agnostic and highly performant tracking algorithms that have demonstrated promising performance for a few high-energy physics and nuclear physics experiments.

关键词： BESⅢtracking detector CMOS pixel sensor Track reconstruction Common tracking software

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Dynamics simulation of Cu coating SiC composite particles

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材料科学与工程（中英文版） 2007年第1期1卷 67-70,66页

作者： LIU rui-yu FAN Bing-bing zhang Shi-xun LI Shou-shan LI kai zhang rui School of Materials Science and Engineering Zhengzhou University Henan 450001 China

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Investigation on the sintering behavior of SiC/Cu composites

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材料科学与工程（中英文版） 2008年第4期2卷 58-60页

作者： FAN Bing-bing LIU rui-yu zhang Shi-xun LI Shou-shan LI kai zhang rui Department of Material Science and Engineering Zhengzhou University Zhengzhou 450001 China

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu kai Zhao Guoqiang Liu Youming Lu Xinyan Li kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Synthesis of N-aryl-N'-(5-aryloxymethyl-1,3,4-thiadiazol-2-yl)-ureas Under Microwave Irradiation

Synthesis of N-aryl-N'-(5-aryloxymethyl-1,3,4-thiadiazol-2-y...

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甘肃省化学会第二十七届年会暨第九届甘肃省中学化学教学经验交流会

作者： Chai Lan-Qin~*,zhang Yu-li,Cui kai,Wang Zai-rui,zhang Yong-ze,zhang Li-wen (School of Chemical and Biological Engineering,Lanzhou Jiaotong University,730070)

The rapid heating effect of microwave irradiation has caught the attention of synthetic chemists in the recent times due to the remarkable reduction of reaction *** is an efficient method because of its virtue of rapid heating capability,high yield and simple *** superiority of these virtues goes beyond of traditional heating *** derivatives are widely used as medicines and agrochemicals because of their anticonvulsive,herbicidal,

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo Liu rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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Multi-receptive field interaction network for shape from polarization

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Science China(Information Sciences) 2025年第1期 394-395页

作者： Yini PENG rui LIU Zhiyuan zhang Zhongyuan WANG Jiayi MA Xin TIAN Electronic Information School Wuhan University Computer Science School Wuhan University Wuhan Institute of Quantum Technology

Shape from polarization (SfP) method can use the polarization information in reflected light to estimate the surface normal of the target,which can further reconstruct the shape of the *** a simple image capture process,it can use low-cost equipment to meet a high precision imaging requirement,which can be used in remote scenes and other applications.

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大型发电设备制造企业储运系统设计

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物流工程与管理 2017年第5期39卷 88-94,87页

作者：龙开睿张莉辉绵阳中学实验学校四川绵阳621000 东方汽轮机有限公司四川德阳618000

文中以某大型发电设备制造企业储运中心信息化优化为背景,基于"实物转送的装箱清单与MBOM集成"方案,设计并建立了装箱发运平台,打通了设计、生产、发运的全过程,解决了长期以来装箱发运与生产管理脱节的问题,建立了基于用户需求的产品... 详细信息

文中以某大型发电设备制造企业储运中心信息化优化为背景,基于"实物转送的装箱清单与MBOM集成"方案,设计并建立了装箱发运平台,打通了设计、生产、发运的全过程,解决了长期以来装箱发运与生产管理脱节的问题,建立了基于用户需求的产品成套及物流管理模式。

关键词：装箱清单装箱发运 ERP信息化

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基于OPNET的CPU调度仿真研究

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系统仿真学报 2009年第S1期21卷 227-230页

作者：张新宇胡凯杨锐张慧颖北京航空航天大学计算机学院北京100191

网络仿真是一种在网络研究中被普遍采用的研究手段,但是现有的仿真软件往往只针对协议正确性进行模拟,不考虑硬件性能和操作系统对CPU调度带来的影响,同时由于因特网规模急剧膨胀,路由器的负载大幅提升,某些情况下CPU成了制约路由协议... 详细信息

网络仿真是一种在网络研究中被普遍采用的研究手段,但是现有的仿真软件往往只针对协议正确性进行模拟,不考虑硬件性能和操作系统对CPU调度带来的影响,同时由于因特网规模急剧膨胀,路由器的负载大幅提升,某些情况下CPU成了制约路由协议性能的关键。基于广泛使用的网络仿真软件OPNETModeler,对其进行扩展,提出了支持单/多核CPU调度的仿真机制,引入Linux中的调度策略,并实现了一个自定义的协议模型进行验证,实验表明模型在重负载的情况下具有较好的仿真效果。

关键词：网络仿真 OPNET Modeler CPU调度仿真调度策略

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