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选择外科导航系统的参考要素

中华创伤骨科杂志 2005年第7期7卷 651-656页

作者：吕宝仪邓宁苏伟权梁国穗王文吕红斌香港特别行政区香港中文大学矫形外科及创伤学系

外科导航系统可提供外科手术过程中的实时指导,是一种极具应用前景的互动式工具。它可以在术中为外科医生提供实时信息,从而有利于手术的进程,改善手术效果,减少并发症。该系统的运用可降低手术创伤。该系统中计算机的运用有助于术前计... 详细信息

外科导航系统可提供外科手术过程中的实时指导,是一种极具应用前景的互动式工具。它可以在术中为外科医生提供实时信息,从而有利于手术的进程,改善手术效果,减少并发症。该系统的运用可降低手术创伤。该系统中计算机的运用有助于术前计划的制定和术后资料的收集。计算机辅助外科手术导航系统的应用已有十多年历史。随着近年来技术的发展,该技术得以进一步改良,并精确化了手术程序。虽然外科导航系统是一门相对较新的技术,但由于其显著的优点,将会在临床上越来越广泛地应用。我们调研了五个外科导航系统的生产商,旨在介绍目前临床上可选择的外科导航系统和注意事项。

关键词：外科导航系统生产商选择要素

生态文明时代国土空间规划理论与技术方法创新

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自然资源学报 2022年第11期37卷 2763-2773页

作者：郝庆梁鹤年杨开忠封志明王晓阳卢庆强北京清华同衡规划设计研究院有限公司北京100085 加拿大女王大学城市与区域规划学院加拿大安大略金士顿K7L2P13 中国社会科学院生态文明研究所北京100006 中国科学院地理科学与资源研究所北京100101 牛津大学地理与环境学院英国牛津OX13QY

国土空间规划是现代国家实施国土空间治理的重要手段,是为实现特定战略意图而进行的理性设计,规划的编制实施理念会随时代的发展而变化。为了解生态文明时代国土空间规划理论与技术方法创新,特邀请本领域的五位知名专家就国土空间规划... 详细信息

国土空间规划是现代国家实施国土空间治理的重要手段,是为实现特定战略意图而进行的理性设计,规划的编制实施理念会随时代的发展而变化。为了解生态文明时代国土空间规划理论与技术方法创新,特邀请本领域的五位知名专家就国土空间规划和治理的价值导向、目标追求、重点任务、实施路径和主要领域等开展访谈。专家认为:(1)国土空间规划需要用更高的整体利益原则去处理个体利益之间的失衡,在整体利益的指引下提升特定利益的最大化和保证其他利益的最起码满足。(2)国土空间规划和治理的目标不是单纯追求“地理的普遍繁荣”,而是需要重视追求“人民的普遍幸福”,营造宜居宜业的高品质国土空间。(3)国土空间规划需要统筹安全与发展,合理适度开发利用自然资源,推动实现人与自然和谐共生。(4)需要以核心都市圈为支点,主要城市群为平台,打造宜居城市、韧性城市、智慧城市,建立高质量的城市生态系统和安全系统,重塑中国经济地理格局。(5)城市,特别是大城市是国土空间规划和治理的重点地区,需要通过拓展对城市多元属性的认知、系统研判大城市空间治理的问题与成因,完善大城市治理的逻辑。通过专家访谈,可以看出国土空间规划本质上是对空间关系的重建与重构,需要协调人地关系,推动实现人与自然和谐共生;需要处理好多元主体的利益关系,实现社会和谐;还需要尊重山水林田湖草沙生命共同体、城市有机体等不同层级国土空间单元的运行规律,维护和修复各要素之间的联系和作用机制。

关键词：国土空间规划国土空间空间治理生态文明

Using proteomic approach to discover the treatment mechanism of（Z）3,4,5,4’-trans-tetramethoxystilbene for inhibition of gefitinib-resistant non-small cell lung cancer

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Using proteomic approach to discover the treatment mechanism...

Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein

第21届全国色谱学术报告会及仪器展览会

作者： Xing-Xing Fan Xiao-Jun Yao So Wei Xu Vincent Kam-Wai Wong Jian-Xing He Jian Ding Min Huang Jun Huang Da-kai Xiao Ze-Bo Jiang Yan-Ling Zhou Richard Kin-Ting Kam Liang Liu Elaine Lai-Han leung State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health Macau University of Science and Technology Guangzhou Institute of Respiratory Disease State Key Laboratory of Respiratory DiseaseThe 1st Affiliated Hospital of Guangzhou Medical College State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academic of Sciences Department Chemical Pathology Faculty of Medicinethe Chinese University of Hong Kong

Calcium is a second messenger which is required for regulation of many cellular processes. However,excessive elevation or prolonged activation of calcium signaling would lead to cell death. As such,selectively regulating calcium signaling could be an alternative approach for anti-cancer therapy. Recently,we have identified an effective analogue of resveratrol,（Z）3,4,5,4’-trans-tetramethoxystilbene（TMS） which selectively elevated the intracellular calcium level in gefitinib-resistant（G-R） non-small-cell lung cancer（NSCLC） cells. TMS exhibited significantly inhibitory effect on G-R NSCLC cells, but not other NSCLC cells and normal lung epithelial cells. The phosphorylation and activation of EGFR was inhibited by TMS in G-R cells. TMS induced caspase-independent apoptosis and autophagy by directly binding to SERCA and causing endoplasmic reticulum（ER） stress and AMPK activation. Using i TRAQ proteomics analysis,we have further confirmed that mTOR pathway, which is the downstream of AMPK, was significantly suppressed by TMS. JNK, the cross-linker of ER stress and mTOR pathway was significantly activated by TMS. In addition, the inhibition of JNK activation can partially block the effect of TMS. Taken together,TMS showed promising anti-cancer activity by mediating calcium signaling pathway and inducing apoptosis as well as autophagy in G-R NSCLC cells, providing strategy in designing multi-targeting drug for treating G-R patients.

关键词： (Z)3,4,5,4’-trans-tetramethoxystilbene(TMS) non-small-cell lung cancer gefitinib resistance mTOR and autophagy

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中国药理学与毒理学杂志 2019年第10期 765-766页

作者： ZHANG Kun LI Yu-jiao GUO Yan-yan ZHENG kai-yin YANG Qi YANG Le CHEN Tao ZHUO Min ZHAO Ming-gao Department of Pharmacology School of PharmacyFourth Military Medical University Center for Neuron and Disease Frontier Institutes of Life Science and of Science and Technology Xi′an Jiaotong University Department of Anatomy Histology and Embryology and K.K.Leung Brain Research Center Fourth Military Medical University

OBJECTIVE Fragile X syndrome is an inheritable form of intellectual disability caused by loss of fragile X mental retardation protein(FMRP, encoded by the Fmr1 gene). METHODS Four protein level in brain homogenate were detected by ELISA. Morris water maze and novel object(location) were used to study changes of learning and memory. Golgi staining was used to study changes of dendritic spine density. Ed U staining was used to study number of neurogenesis in SGZ. Immunofluorescence staining was used to detect effects of exogenous protein on spine density and morphology. Patch clamp and Med64 electrophysiological technology were used to observe the effects of drugs on synaptic transmission and plasticity. Lentivirus expressing sh RNA was injected in medial prefrontal cortex(m PFC)to study gene function. RESULTS Absence of FMRP caused overexpression of progranulin(PGRN, encoded by Grn), a putative tumour necrosis factor receptor *** the present study, we found that PGRN m RNA and protein were upregulated in the of Fmr1 knock-out *** Fmr1 knock-out mice, elevated PGRN caused insufficient dendritic spine pruning and late-phase long-term potentiation in the m PFC of Fmr1 knock-out mice. Partial PGRN knock down restored spine morphology and reversed behavioural deficits, including impaired fear memory, hyperactivity, and motor inflexibility in Fmr1 knock-out mice. PGRN increased levels of phosphorylated glutamate ionotropic receptor Glu A1 and nuclear factor kappa B(NFκB) in cultured wild-type neurons. Tumour necrosis factor receptor 2(TNFR2) antibody perfusion blocked the effects of progranulin on Glu A1 phosphorylation; this result indicates that TNFR2 is required for PGRN mediated Glu A1 phosphorylation and late-phase long-term potentiation expression. However, high basal level of progranulin in Fmr1 knock-out mice prevented further facilitation of synaptic plasticity by exogenous PGRN. Partial downregulation of PGRN or TNFR2/NFκB signalling restored synaptic p

关键词： fragile X syndrome progranulin TNFR2 long-term potentiation synaptic plasticity

Differential Effects of Ursolic Acid and Oleanolic Acid on Mitochondrial ATP Generation in H9c2 Cardiomyocytes and Lipopolysaccharide-Induced Cell Proliferation in Mouse Splenocytes: Yang versus Yin

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塔克拉玛干沙漠腹地人工绿地风沙土的理化性质研究

Chinese Medicine（中医） 2021年第3期

作者： Hoi Yan leung kai Chit Cheung Kam Ming Ko

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干旱区资源与环境 2000年第1期14卷 74-79页

作者：顾峰雪文启凯潘伯荣胡玉昆徐海量中国科学院新疆生态与地理研究所乌鲁木齐830011 新疆农业大学农学分院乌鲁木齐830052

在极端干旱的塔克拉玛干沙漠腹地 ,利用地下咸水灌溉建立人工绿地后 ,绿地土壤理化性质与流沙相比 ,变化很大。本文通过分析测定 ,结果表明 :绿地土壤细粒含量增加 :比重、容重降低 ,孔隙度 ,饱和含水量增加 ;在 5 0 cm剖面内盐分含量降... 详细信息

在极端干旱的塔克拉玛干沙漠腹地 ,利用地下咸水灌溉建立人工绿地后 ,绿地土壤理化性质与流沙相比 ,变化很大。本文通过分析测定 ,结果表明 :绿地土壤细粒含量增加 :比重、容重降低 ,孔隙度 ,饱和含水量增加 ;在 5 0 cm剖面内盐分含量降低 ,但表层高于下层 ,p H增高 ,养分含量增加 ,肥力提高。

关键词：塔克拉玛干沙漠灌溉人工绿地土壤理化性质

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu kaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

*** rescue in retinitis pigmentosa by the treatment of Lycium barbarum(Random Clinical Trial)

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Annals of Eye Science 2017年第1期 356-356页

作者： Henry Chan Hang-I Lam Kwok-Fai So Raymond Chuen-Chung Chang Shiu-Ming Lai Chi-Wai Do Iris F.F.Benzie Chin-Pan leung kai-Yip Choi Man-Pan Chin Zhe-Chuang Li Wing-Yan Yu Laboratory of Experimental Optometry(Neuroscience) School of OptometryThe Hong Kong Polytechnic UniversityHong Kong SARChina Guangdong-Hongkong-Macao(GHM)Institute of CNS Regeneration Jinan UniversityGuangzhouChina School of Biomedical Sciences The University of Hong KongHong Kong SARChina Department of Ophthalmology The University of Hong KongHong Kong SARChina Laboratory of Experimental Optometry(Biophysic) School of OptometryThe Hong Kong Polytechnic UniversityHong Kong SARChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong SARChina Private practice Chinese medical doctor

Retinitis pigmentosa(RP)is a group of heredofamilial retinal diseases which is characterized by night blindness and progressive visual field *** study aims to study the treatment effect of Lycium barbarum(LB)on retinal functions and structure of RP *** study is a double-masked randomized controlled *** subjects received scheduled eye examination including visual acuity(VA),Humphrey field analysis(HFA),ganzfeld flash electroretinogram(ffERG)and optical coherence tomography(OCT).The suitable subjects were randomly allocated to either LB-treatment or placebo groups with the supply of LB or placebo for 12 *** were total 41 RP subjects(22 in LB group and 19 in placebo group)completed the 12 months *** compliance rates for LB and placebo groups were 89.8%±12.5%and 85.3%±7.7%*** compared with placebo group,there were no deteriorations of both high and low contrast VA in LB group(P<0.01).In addition,certain improvements of scotopic rod response and photopic cone response of ffERG were obtained in LB group(P<0.05).In the OCT measurement,an obvious thinning of macular thickness was observed in placebo group but not found in LB group(P<0.05).However,there were no changes found in the sensitivity of central visual field between two *** results confirm that the 12-month LB treatment for RP patients had neuroprotective effect on retina and is believed to delay or minimize the deterioration of visual function in RP.

关键词： Retinitis pigmentosa(RP) Lycium barbarum(LB) neuroprotection cone retina

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岭南医家梁觉玄对针灸海外传播的贡献

广州中医药大学学报 2023年第2期40卷 494-499页

作者：黄凯文刘芳曾召支晓娟广州中医药大学图书馆广东广州510006

岭南医家梁觉玄(亦称作leung Kok Yuen;1922-2013)出身于中医世家,自幼随父吟诵岐黄,其继承祖传医术,曾事多师。在中医学术思想方面,提出“精”“神”“气”是生命三宝;辨证推崇《医宗金鉴》;认为养生之要在于寡欲宁心;治病主要采用针... 详细信息

岭南医家梁觉玄(亦称作leung Kok Yuen;1922-2013)出身于中医世家,自幼随父吟诵岐黄,其继承祖传医术,曾事多师。在中医学术思想方面,提出“精”“神”“气”是生命三宝;辨证推崇《医宗金鉴》;认为养生之要在于寡欲宁心;治病主要采用针灸疗法,同时配合运动保健疗法。其长期从事中医针灸教育,积极推动针灸在北美洲的合法化,对中医的海外本地化产生重大的影响。梁觉玄的突出成就在于推动针灸在海外的传播:通过培养海外针灸人才,奠定针灸海外办学模式;在海外开展针灸医疗服务与演示,积极推动针灸在北美洲的立法;推动中医融入西方,促进中医针灸学术流派的海外繁荣与发展。梁觉玄一生致力于针灸的教学、海外传播工作,为培养澄江学派针灸人才、传播针灸知识、促进海外中医教育、推动中医的海外本地化做出了突出贡献。

关键词：梁觉玄岭南医家针灸海外传播