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Molecular Dynamics Study of Star Polymer Melts under Start-up Shear

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Chinese Journal of Polymer Science 2022年第7期40卷 807-816页

作者： Dong-Dong Wang kai-feng yu Xiao-Lei Xu Wen-Sheng Xu Key Laboratory of Automobile Materials Ministry of Education and College of Materials Science and EngineeringJilin UniversityChangchun130025China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China

It has been established that star polymers with a large number of arms display both the conventional chain relaxation and a slower interchain relaxation due to the formation of hard cores,which is called the local structural ***,we demonstrate that this unique relaxation property of multi-arm stars leads to unusual rheological *** study the response of star polymer melts with various arm numbers to start-up shear flow via nonequilibrium molecular dynamics *** simulation results indicate that the stress-strain response of multi-arm star polymer melts differs from that of star polymers with a small number of arms in both quantitative and qualitative *** the multi-arm star polymer melts exhibit an overshoot peak in the stress-strain curve both at relatively small and sufficiently large shear rates,two overshoot peaks appear when the flow strength is comparable to the relaxation time of the star *** double stress overshoot is absent in linear polymers and star polymers with a small number of arms and is evidently related to the presence of the local structural relaxation in star polymers with a large number of *** present a detailed analysis of the conformational and dynamical properties of star polymer melts under start-up shear to gain a molecular understanding of their stress response.

关键词： Simulation Star polymer Start-up shear

Correlation between pre-anesthesia anxiety and emergence agitation in non-small cell lung cancer surgery patients

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World Journal of Psychiatry 2024年第6期14卷 930-937页

作者： Fen Yan Li-Hua yuan Xiao He kai-feng yu Department of Anesthesiology Wuhan Pulmonary HospitalWuhan Institute for Tuberculosis ControlWuhan 430000Hubei ProvinceChina

BACKGROUND Preoperative anxiety is a common emotional problem during the perioperative period and may adversely affect postoperative *** agitation(EA)is a common complication of general anesthesia that may increase patient discomfort and hospital stay and may be associated with the development of postoperative ***-anesthetic anxiety may be associated with the development of EA,but studies in this area are *** To determine the relationship between pre-anesthetic anxiety and EA after radical surgery in patients with non-small cell lung cancer(NSCLC).METHODS Eighty patients with NSCLC undergoing surgical treatment between June 2020 and June 2023 were conveniently *** used the Hospital Anxiety and Depression Scale’s(HADS)anxiety subscale(HADS-A)to determine patients’anxiety at four time points(T1-T4):Patients’preoperative visit,waiting period in the surgical waiting room,after entering the operating room,and before anesthesia induction,*** Riker Sedation-Agitation Scale(RSAS)examined EA after *** plots of HADS-A and RSAS scores assessed the correlation between patients’pre-anesthesia anxiety status and *** performed a partial correlation analysis of HADS-A scores with RSAS *** NSCLC patients’HADS-A scores gradually increased at the four time points:7.33±2.03 at T1,7.99±2.22 at T2,8.05±2.81 at T3,and 8.36±4.17 at *** patients’postoperative RSAS score was 4.49±1.18,and 27 patients scored≥5,indicating that 33.75%patients had ***-A scores at T3 and T4 were significantly higher in patients with EA(9.67±3.02 vs 7.23±2.31,12.56±4.10 vs 6.23±2.05,P<0.001).Scatter plots showed the highest correlation between HADS-A and RSAS scores at T3 and *** correlation analysis showed a strong positive correlation between HADS-A and RSAS scores at T3 and T4(r=0.296,0.314,P<0.01).CONCLUSION Agitation during anesthesia recovery in patients undergoing radical resection for NSCLC correlated with anxie

关键词： Non-small cell lung cancer Operative treatment Anesthesiology department Pre-anesthetic anxiety Emergence agitation Correlation study

Prospects of elafibranor in treating alcohol-associated liver diseases

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World Journal of Gastroenterology 2025年第2期31卷 132-137页

作者： Wei-Tong Cui Hua-Ru Xue Dian-Fang Wei Xiao-yu feng kai Wang School of Basic Medicine Qilu Medical UniversityZibo 255300Shandong ProvinceChina School of Medical Imaging Qilu Medical UniversityZibo 255300Shandong ProvinceChina

Alcohol-related liver disease(ALD),which is induced by excessive alcohol con-sumption,is a leading cause of liver-related morbidity and *** pa-tients exhibit a spectrum of liver injuries,including hepatic steatosis,inflam-mation,and fibrosis,similar to symptoms of nonalcohol-associated liver diseases such as primary biliary cholangitis,metabolic dysfunction-associated steatotic liver disease,and nonalcoholic *** has been approved for the treatment of primary biliary cholangitis and has been shown to improve symptoms in both animal models and in vitro cell models of metabolic dysfunc-tion-associated steatotic liver disease and nonalcoholic ***,the efficacy of elafibranor in treating ALD remains *** this article,we comment on the recent publication by Koizumi et al that evaluated the effects of elafibranor on liver fibrosis and gut barrier function in an ALD mouse *** findings indicate the potential of elafibranor for ALD treatment,but further experimental investigations and clinical trials are warranted.

关键词： Elafibranor Alcohol-associated liver diseases Peroxisome proliferator-activated receptor Lipid Apoptosis Steatosis Inflammation Fibrosis

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夏威夷果壳热解特性实验研究

科学技术与工程 2020年第7期20卷 2705-2710页

作者：冯锴瑜孙军王娟南京林业大学材料科学与工程学院南京210037

夏威夷果壳是一种农产品加工剩余物,随意处理会造成资源的极大浪费。采用同步热分析仪和红外光谱仪对夏威夷果壳的热解过程进行了研究,使用Coats-Redfern法计算了热解动力学。实验结果表明:夏威夷果壳的挥发分(78.67%)、木质素(42.81%)... 详细信息

夏威夷果壳是一种农产品加工剩余物,随意处理会造成资源的极大浪费。采用同步热分析仪和红外光谱仪对夏威夷果壳的热解过程进行了研究,使用Coats-Redfern法计算了热解动力学。实验结果表明:夏威夷果壳的挥发分(78.67%)、木质素(42.81%)和C元素(47.45%)含量均较高,其主热解温度区间在275~410℃,热解总失重率为76.31%。随着升温速率的增加,热解反应的活化能和频率因子均增大,分别由58.737 kJ·mol^-1、11.689 min^-1增加到59.796 kJ·mol^-1、43.773 min^-1,线性拟合系数均在0.99以上。傅里叶红外光谱仪对果壳热解固体产物进行了红外光谱分析,实验还表明夏威夷果壳的热解温度区间在300~500℃,热解过程主要是纤维素、半纤维素和木质素的解聚,与热重分析结果相一致。

关键词：夏威夷果壳热重动力学傅里叶红外光谱

Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： kai Chen Xu feng yuan Shi Xin-Lin Li Zheng-Rong Shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao yu-Gui Peng Peng Wu Zong-Lin Li Xue-feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： yu Li Chen-kai Huang Yi Hu Xiao-Dong Zhou Cong He Jia-Wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

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改性夏威夷果壳炭的吸附性能研究

应用化工 2022年第3期51卷 701-705页

作者：王娟沈忱冯锴瑜孙军南京林业大学材料科学与工程学院江苏南京210037

比较了化学一步活化法和直接炭化制备的夏威夷果壳炭的吸附性能。结果表明,采用化学一步活化法制备夏威夷果壳炭的最佳条件为:浸渍比(果壳∶氯化锌)为1∶2.5,升温速率为10℃/min,活化温度为550℃,保温时间60 min,在此条件下制备的夏威... 详细信息

比较了化学一步活化法和直接炭化制备的夏威夷果壳炭的吸附性能。结果表明,采用化学一步活化法制备夏威夷果壳炭的最佳条件为:浸渍比(果壳∶氯化锌)为1∶2.5,升温速率为10℃/min,活化温度为550℃,保温时间60 min,在此条件下制备的夏威夷果壳炭的亚甲基蓝值达169.6 mg/g,碘值达1254.46 mg/g。傅里叶红外光谱、元素分析、XRD和扫描电镜等分析表明,化学一步活化法制得的果壳炭表面形貌具有丰富的孔隙结构、较多的极性官能团,呈现高石墨化程度,比表面积达1504.998 m^(2)/g。

关键词：夏威夷果壳热解生物质炭吸附

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调整贵州行政区划,促进经济快速发展

贵州民族学院学报（哲学社会科学版） 2006年第1期 35-38页

作者：冯开禹安顺师范高等专科学校环境资源系贵州安顺561000

行政区划具有政治和经济的双重职能。合理的行政区划是行政管理和经济发展的有力保证,而随着社会的进步和经济的发展,客观上要求行政区划进行必要的调整。本文围绕西部大开发这一历史机遇,结合贵州省的经济现状及发展思路,提出了新的地... 详细信息

行政区划具有政治和经济的双重职能。合理的行政区划是行政管理和经济发展的有力保证,而随着社会的进步和经济的发展,客观上要求行政区划进行必要的调整。本文围绕西部大开发这一历史机遇,结合贵州省的经济现状及发展思路,提出了新的地级行政区划方案。

关键词：贵州省行政区划经济发展西部大开发