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Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-Rang Cao Yin-Long Xu Jia-Wei Chai kai zheng Jun-Jie Kong Jun Liu Shun-Zhen zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification *** analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe *** pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional *** Pretreatment RDW was a special parameter for patients who underwent *** was associated with malnutrition,severe inflammatory status and poorer short-term *** could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

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Chinese Chemical Letters 2025年第1期36卷 277-282页

作者： You Zhou Li-Sheng Wang Shuang-Gui Lei Bo-Cheng Tang Zhi-Cheng Yu Xing Li Yan-Dong Wu kai-Lu zheng An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs The First Dongguan Affiliated HospitalSchool of PharmacyGuangdong Medical UniversityDongguan 523808China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction *** key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one ***,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关键词： Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission

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Impact of Spinal Manipulative Therapy on Brain Function and Pain Alleviation in Lumbar Disc Herniation:A Resting-State fMRI Study

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Chinese Journal of Integrative Medicine 2025年第2期31卷 108-117页

作者： ZHOU Xing-chen WU Shuang WANG kai-zheng CHEN Long-hao WEI Zi-cheng LI Tao HUA Zi-han XIA Qiong LYU Zhi-zhen LYU Li-jiang Department of Spine The Third Affiliated Hospital of Zhejiang Chinese Medicine UniversityHangzhou(310053)China Department of Spine The Third School of Clinical MedicineZhejiang Chinese Medicine UniversityHangzhou(310053)China Research Institute of Tuina(Spinal Disease) Zhejiang Chinese Medicine UniversityHangzhou(310053)China

Objective:To elucidate how spinal manipulative therapy(SMT)exerts its analgesic effects through regulating brain function in lumbar disc herniation(LDH)patients by utilizing resting-state functional magnetic resonance imaging(rs-f MRI).Methods:From September 2021 to September 2023,we enrolled LDH patients(LDH group,n=31)and age-and sex-matched healthy controls(HCs,n=28).LDH group underwent rs-f MRI at 2 distinct time points(TPs):prior to the initiation of SMT(TP1)and subsequent to the completion of the SMT sessions(TP2).SMT was administered once every other day for 30 min per session,totally 14 treatment sessions over a span of 4 *** did not receive SMT treatment and underwent only one f MRI ***,participants in LDH group completed clinical questionnaires on pain using the Visual Analog Scale(VAS)and the Japanese Orthopedic Association(JOA)score,whereas HCs did not undergo clinical scale *** effects on the brain were jointly characterized using the amplitude of low-frequency fluctuations(ALFF)and regional homogeneity(Re Ho).Correlation analyses were conducted between specific brain regions and clinical ***:Following SMT treatment,pain symptoms in LDH patients were notably alleviated and accompanied by evident activation of effects in the *** comparison to TP1,TP2 exhibited the most significant increase in ALFF values for Temporal_Sup_R and the most notable decrease in ALFF values for Paracentral_Lobule_L(voxelwise P30;FDR correction).Additionally,the most substantial enhancement in Re Ho values was observed for the Cuneus_R,while the most prominent reduction was noted for the Olfactory_R(voxelwise P30;FDR correction).Moreover,a comparative analysis revealed that,in contrast to HCs,LDH patients at TP1 exhibited the most significant increase in ALFF values for Temporal_Pole_Sup_L and the most notable decrease in ALFF values for Frontal_Mid_L(voxelwise P30;FDR correction).Fur

关键词： functional magnetic resonance imaging lumbar disc herniation spinal manipulative therapy pain

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国内元宇宙建筑研究现状、热点及趋势——基于CiteSpace科学计量及可视化分析

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智能建筑与智慧城市 2025年第2期 14-17页

作者：郑凯丁炜南京工业大学建筑学院

由于技术进步和社会数字化转型,元宇宙作为一种新的数字互动平台,正在引起各行各业的极大关注和探索。这个数字世界融合了物理现实与虚拟现实,为建筑师提供了设计、模拟虚拟空间与虚拟空间互动的新机会。文章利用文献计量分析工具CiteSp... 详细信息

由于技术进步和社会数字化转型,元宇宙作为一种新的数字互动平台,正在引起各行各业的极大关注和探索。这个数字世界融合了物理现实与虚拟现实,为建筑师提供了设计、模拟虚拟空间与虚拟空间互动的新机会。文章利用文献计量分析工具CiteSpace,对CNKI中记载的建筑学元宇宙的研究现状进行了探索和可视化,对“元宇宙建筑研究领域的作者共现图谱”“元宇宙中的建筑应用研究关键词共现图谱”“相关研究机构的论文发表数量表”等内容进行了分析,通过研究出版趋势、确定主要贡献者并突出新兴主题,本分析旨在全面概述国内元宇宙相关建筑研究的现状和热点。

关键词：元宇宙建筑领域可视化分析 CiteSpace 知识图谱热点趋势

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基于CiteSpace可视化分析的建筑设计领域人工智能应用研究

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智能城市 2025年第1期11卷 17-20页

作者：郑凯丁炜南京工业大学建筑学院江苏南京211816

基于中国知网(CNKI)数据库,以人工智能和建筑设计为主题,比较2014—2024年该主题领域的研究成果和文献数据,对研究主题、基础文献、发展趋势和研究前沿进行了深入探究。通过CiteSpace科学可视化软件进行了定性和定量分析以及通过词频分... 详细信息

基于中国知网(CNKI)数据库,以人工智能和建筑设计为主题,比较2014—2024年该主题领域的研究成果和文献数据,对研究主题、基础文献、发展趋势和研究前沿进行了深入探究。通过CiteSpace科学可视化软件进行了定性和定量分析以及通过词频分析、聚类分析和时间轴分析,探讨了专题研究热点及其演变。通过解读可视化知识图谱发现,人工智能在建筑设计的研究趋势主要集中在建筑设计、深度学习、景观设计、机器学习等领域。

关键词：建筑设计人工智能 CiteSpace软件分析

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Numerical investigation on failure behavior of steel plate under explosive loading

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Science China(Technological Sciences) 2021年第6期64卷 1311-1324页

作者： zheng kai WANG ZhiHua State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology.Beijing 100081China Institute of Applied Mechanics College of Mechanical and Vehicle EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength and Stndctural Impact Taiyuan University of TechnologyTaiyuan 030024China

The failure behavior of metal materials under strong dynamic loading such as explosive and impact loading has important applications in the fields of defense industry and civil security. In this study, a novel coupled bidirectional weighted mapping method between Lagrange particles and Euler meshes is proposed to numerically simulate the dynamic response and failure process of steel structure under explosive loading. In this method, the Lagrange particles and Euler meshes are used to describe the materials that need to be accurately tracked and can more accurately characterize the deformation history and failure process of the material. A comparison between the numerical results and experimental data shows that this method can be used to solve large deformation problem of multi-medium materials and the failure problems of complex structures under strong impact loading.

关键词： steel plate explosive loading coupled bidirectional mapping method failure behavior

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A seismogram digitization and database management system

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Acta Seismologica Sinica(English Edition) 2001年第3期14卷 333-341页

作者： LIU zheng-kai Department of Electronic Engineering and Information Science University of Science and Technology of China Hefei China Seismological Bureau of Shanghai Shanghai China Institute of Geophysics China Seismological Bureau Beijing China Seismological Bureau of Anhui Province Hefei China

This paper introduces a 'Seismogram Digitization and Database Management System' (SDDMS), which is developed using Delphi3, and present the key technique of automatically extracting wave data from paper seismograms. The system have various functions, such as paper seismogram digitization, database management and data analysis, etc. With this system it is possible to analyze historical paper seismograms using modern computers. Application of this system will be of help to the progress in earthquake prediction and seismological researchers.

关键词： Database management Seismogram digitization Wave data extraction

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防风趁鲜切制饮片的解热、镇痛作用

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中药新药与临床药理 2025年第1期36卷 24-29页

作者：郑凯田兆凤郑慧敏王建强张昊李伟王梓秦汝兰通化师范学院医药学院吉林通化134001 吉林农业大学中药材学院吉林长春130118

目的比较产地趁鲜切制与传统加工防风饮片对小鼠的解热、镇痛作用,并对解热作用机制进行探讨。方法以产地趁鲜切制及传统加工防风饮片水提液(1.7g·kg^(-1))进行药物干预,分别采用小鼠热板法镇痛实验及干酵母致小鼠发热实验考察其解热... 详细信息

目的比较产地趁鲜切制与传统加工防风饮片对小鼠的解热、镇痛作用,并对解热作用机制进行探讨。方法以产地趁鲜切制及传统加工防风饮片水提液(1.7g·kg^(-1))进行药物干预,分别采用小鼠热板法镇痛实验及干酵母致小鼠发热实验考察其解热、镇痛作用,测定并记录小鼠痛阈值及体温变化情况。采用ELISA法检测小鼠血清白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、一氧化氮(NO)水平;Western Blot法检测下丘脑组织中Toll样受体4(TLR4)、IL-6、核转录因子(NF-κB)、磷酸化核转录因子(p-NF-κB)、环氧化酶2(COX2)蛋白表达水平。结果(1)与空白组比较,给药组小鼠的痛阈值均显著升高(P0.05)。(2)与空白组比较,其他各组小鼠在皮下注射20%干酵母混悬液6h后,体温均显著升高(P0.05)。(3)与空白组比较,模型组小鼠的血清TNF-α、NO、IL-1β含量均显著升高(P0.05)。结论防风趁鲜切制与传统加工饮片的解热、镇痛效果相似,解热作用可能与其降低炎症细胞因子表达有关。防风产地趁鲜切制技术的实施具有药理学依据。

关键词：防风趁鲜切制解热镇痛炎症细胞因子小鼠

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机器人辅助与腹腔镜肝切除术治疗肝血管瘤的安全性及疗效比较

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中国普通外科杂志 2025年第1期34卷 70-78页

作者：姜改明郑凯李宇铠李婧康强柯阳李越华昆明医科大学第二附属医院肝胆胰外科二病区云南昆明650101

背景与目的:肝切除术作为肝血管瘤的重要治疗手段,已从传统的开腹手术逐渐转为腹腔镜手术和机器人辅助手术,但对于肝血管瘤,机器人辅助是否能比腹腔镜提供更好的治疗效果,目前尚未达成共识。因此,本研究评估和比较机器人辅助与腹腔镜肝... 详细信息

背景与目的:肝切除术作为肝血管瘤的重要治疗手段,已从传统的开腹手术逐渐转为腹腔镜手术和机器人辅助手术,但对于肝血管瘤,机器人辅助是否能比腹腔镜提供更好的治疗效果,目前尚未达成共识。因此,本研究评估和比较机器人辅助与腹腔镜肝切除术治疗肝血管瘤的临床疗效和安全性。方法:回顾性收集2021年2月—2024年7月在昆明医科大学第二附属医院肝胆胰外科因肝血管瘤行微创肝切除的184例手术患者的临床资料,其中,机器人组30例,腹腔镜组154例。使用患者基本情况、肿瘤特征、手术切除范围等基线资料对病例进行1∶2的倾向评分匹配法(PSM),比较PSM后两组的术中、术后相关指标。结果:按1∶2进行PSM后机器人组患者24例,腹腔镜组患者48例,两组术前指标平衡良好(受试者工作特征曲线下面积为0.588)。机器人组的手术时间(138 min vs.168 min,P=0.024)和肝门阻断时间(25 min vs.45 min,P0.05)。结论:对于适宜的肝血管瘤病例,机器人辅助腹腔镜肝切除术治疗是安全可行的,与传统腹腔镜相比,其缩短了手术时间及肝门阻断时间,减轻了手术对术后肝功能的影响,然而治疗费用也更高,需结合患者实际需求合理选用。

关键词：肝肿瘤血管瘤肝切除术机器人手术腹腔镜

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Analysis of floc morphology in a continuous-flow flocculation and sedimentation reactor

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Journal of Environmental Sciences 2017年第2期29卷 268-275页

作者： Pengfei Ren Jun Nan Xinran Zhang kai zheng School of Municipal and Environmental Engineering Harbin Institute of TechnologyHarbin 150090China State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China

The floc morphology was investigated in a continuous-flow reactor, in order to understand the evolution of flocs in practical flocculation and sedimentation processes in water utilities. Kaolin-humic acid suspension was used as the test water, and polyaluminum chloride was chosen as the coagulant. An in-situ recognition system was applied to analyze the floc size, boundary fractal dimension, and eccentricity ratios. Particle numbers and turbidity were also determined in the sedimentation stage. At a coagulant dose of 1 mg/L as Al, the average floc size increased from 62 to 78 μm and the boundary fractal dimension was around 1.14, suggesting that flocs were compact and continuously grew during the entire flocculation process. However, with the dose increased to 5 mg/L, the average floc size decreased and stabilized at around 65 μm, with the fractal dimension of 1.20. It can be concluded that the excess coagulant doses resulted in the formation of chain-shaped, lower density, and more branched structure flocs, thereby restricting flocs’ further growth in the subsequent flocculation. Floc morphology analysis suggested that charge neutralization dominated in the initial flocculation stage, then the bridge and sweep mechanisms were dominant in the subsequent flocculation. In addition, compared with the traditional inclined plate settler, a novel V-shaped plate settler introduced in this study had an advantage in small size floc（less than 5 μm） removal. The V-shaped region could promote aggregate restructuring and re-flocculation; therefore, the V-shaped plate settler provides an alternative method for sedimentation.

关键词： Flocculation Sedimentation Continuous-flow reactor In-situ recognition system V-shaped plate settler tank

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