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An esterase-responsive ibuprofen nano-micelle pre-modified embryo derived nucleus pulposus progenitor cells promote the regeneration of intervertebral disc degeneration

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Bioactive Materials 2023年第3期21卷 69-85页

作者： kai-shun xia Dong-dong Li Cheng-gui Wang Li-wei Ying Jing-kai Wang Biao Yang Jia-wei Shu xian-peng Huang Yu-ang Zhang Chao Yu xiao-peng Zhou Fang-cai Li Nigel K.H.Slater Jian-bin Tang Qi-xin Chen Cheng-zhen Liang Department of Orthopedics 2nd Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009ZhejiangPR China Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhou310009ZhejiangPR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310009Zhejiang ProvincePR China Clinical Research Center of Motor System Disease of Zhejiang Province Hangzhou310009Zhejiang ProvincePR China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineering Collage of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027ZhejiangPR China The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou325000ZhejiangPR China Orthopedic Department Taizhou Hospital Affiliated to Wenzhou Medical UniversityLinhai317099ZhejiangPR China Department of Chemical Engineering and Biotechnology University of CambridgeCambridgeUnited Kingdom

Stem cell-based transplantation is a promising therapeutic approach for intervertebral disc degeneration(IDD).Current limitations of stem cells include with their insufficient cell source,poor proliferation capacity,low nucleus pulposus(NP)-specific differentiation potential,and inability to avoid pyroptosis caused by the acidic IDD microenvironment after *** address these challenges,embryo-derived long-term expandable nucleus pulposus progenitor cells(NPPCs)and esterase-responsive ibuprofen nano-micelles(PEG-PIB)were prepared for synergistic *** this study,we propose a biomaterial pre-modification cell strategy;the PEG-PIB were endocytosed to pre-modify the NPPCs with adaptability in harsh IDD microenvironment through inhibiting *** results indicated that the PEG-PIB pre-modified NPPCs exhibited inhibition of pyroptosis in vitro;their further synergistic transplantation yielded effective functional recovery,histological regeneration,and inhibition of pyroptosis during IDD ***,we offer a novel biomaterial pre-modification cell strategy for synergistic transplantation with promising therapeutic effects in IDD regeneration.

关键词： Intervertebral disc degeneration Nucleus pulposus progenitor cells Esterase-responsive nano micell Biomaterial pre-modification Synergistic transplantation therapy

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Developmental systems biology flourishing on new technologies

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Journal of Genetics and Genomics 2008年第10期35卷 577-584页

作者： Jing-Dong J. Han Yi Liu Huiling Xue kai xia Hong Yu Shanshan Zhu Zhang Chen Wei Zhang Zheng Huang Chunyu Jin Bo xian Jing Li Lei Hou Yixing Han Chaoqun Niu Timothy C. Alcon Chinese Academy of Sciences Key Laboratory of Molecular Developmental Biology Center for Molecular Systems Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Machine Perception （Ministry of Education） Peking University Beijing 100871 China Bioinformatics and Computational Biology Graduate Program Iowa State University Ames IA 50011-1040 USA

Organism development is a systems level process. It has benefited greatly from the recent technological advances in the field of systems biology. DNA microarray, phenome, interactome and transcriptome mapping, the new generation of deep sequencing technologies, and faster and better computational and modeling approaches have opened new frontiers for both systems biologists and developmental biologists to reexamine the old developmental biology questions, such as pattern formation, and to tackle new problems, such as stem cell reprogramming. As showcased in the International Developmental Systems Biology Symposium organized by Chinese Academy of Sciences, developmental systems biology is flourishing in many perspectives, from the evolution of developmental systems, to the underlying genetic and molecular pathways and networks, to the genomic, epigenomic and noncoding levels, to the computational analysis and modeling. We believe that the field will continue to reap rewards into the future with these new approaches.

关键词： developmental systems biology new technologies symposium

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A Study on Additional Electric Energy Accommodation of Three Gorges Hydropower Station

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Electricity 2011年第1期22卷 29-33页

作者： Chen Zheng Lin Tingwei Li Ke xia kai Wang Xue Central Southern China Electric Power Design Institute East China Electric Power Design Institute Southwest China Electric Power Design Institute

Considering the additional electric energy generated after the full operation of the underground hydropower station, the electric energy accommodation of the Three Gorges Project （TGP） is reviewed. It is .focused on the additional electricity accommodation, based on the research at the earl）, stage. The electric energ）, accommodation solutions ate recommended as that. based on the cost-benefit analysis of the power distribution area, the additional electric energy of the Three Gorges should be given ptqority to meet the needs at the supply end of Hubei and Chongqing. The results of this research has a reference value on the implementation of the Three Gorges electric power accommodation, after the further optimization of the transmission curves in both wet and dry seasons.

关键词： Three Gorges Hydropower Station electric energy accommodation cost-benefit analysis

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ZnO:Er^(3+)纳米晶的制备及发光性质研究

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光谱学与光谱分析 2006年第10期26卷 1806-1809页

作者：宋国利孙凯霞哈尔滨学院物理系黑龙江哈尔滨150086

为了探讨稀土Er3+与纳米ZnO基质之间的能量传递,利用化学方法制备了ZnO∶Er3+纳米晶,测量了样品的X射线衍射谱(XRD)、光致发光谱(PL)和激发谱(PLE)。X射线衍射结果表明,ZnO∶Er3+具有六角纤锌矿晶体结构。室温下,在365 nm激发下,在ZnO... 详细信息

为了探讨稀土Er3+与纳米ZnO基质之间的能量传递,利用化学方法制备了ZnO∶Er3+纳米晶,测量了样品的X射线衍射谱(XRD)、光致发光谱(PL)和激发谱(PLE)。X射线衍射结果表明,ZnO∶Er3+具有六角纤锌矿晶体结构。室温下,在365 nm激发下,在ZnO宽的可见发射背景上,观测到了Er3+的激发态4S3/2(550 nm),2H11/2(521 nm)和4F5/2(456 nm)的特征发射。分析了ZnO∶Er3+纳米晶的带边发射和稀土Er3+的特征发射的峰值强度随掺Er3+浓度的变化关系,比较了ZnO∶Er3+与未掺杂的ZnO的光致发射峰值强度的变化,给出了稀土Er3+的激发态4S3/2→4I15/2,2H11/2→4I15/2和4F5/2→4I15/2的发射机制,证实了纳米ZnO基质与稀土Er3+离子之间存在能量传递。

关键词： ZnO:Er^3+纳米晶光致发光能量传递

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Stent-based delivery of triptolide reduces neointimal formation in rabbit iliac arteries

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中华医学杂志(英文版) 2005年第2期 83-85页

作者： CHEN Ming, WANG kai xia, LIU Zhao ping and HUO Yong Department of Cardiology, Peking University First Hospital, Beijing 100034, China

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Biological basis of “depression with liver-qi stagnation and spleen deficiency syndrome”: A digital gene expression profiling study

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Journal of Traditional Chinese Medical Sciences 2015年第3期2卷 150-158页

作者： Junling Li Lifu Bi kai xia Kuo Gao Jianxin Chen Shuzhen Guo Tian Wang Xueling Ma Weiming Wang Huihui Zhao Yubo Li Wei Wang School of Basic Medical Science Beijing University of Chinese MedicineBeijing 100029China School of Nursing Beijing University of Chinese MedicineBeijing 100029China Division of Health Care Beijing University of Chinese MedicineBeijing 100029China Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical SciencesChina

Objective:To investigate the biological basis of“depression with liver-qi stagnation and spleen deficiency syndrome”.Methods:A digital gene expression profiling method was conducted to explore global changes in the mRNA transcriptome in a rat model of depression with liver-qi stagnation and spleen deficiency ***-time quantitative polymerase chain reaction(q-PCR)was performed to verify the five genes most interest based on the Kyoto Encyclopedia of Genes and Genome(KEGG)*** San,which disperses stagnated liver qi and strengthens the spleen,was administered to the model rats to observe whether it could reverse these genetic changes in the ***:Forty-six differentially expressed genes were *** of the five genes of most interestdHnf4a,Hnf4g and Cyp1a1dbased on KEGG analysis,were confirmed by realtime *** San reduced the gene expression changes of Hnf4a,Hnf4g and Cyp1a1 in the rat ***:Hnf4a,Hnf4g and Cyp1a1 are involved in“depression with liver-qi stagnation and spleen deficiency syndrome”.These findings indicate that depressed rats with liver-qi stagnation and spleen deficiency syndrome are at risk of liver ***,our results will inform exploration of the etiology of depression and help in the development of effective therapeutic strategies.

关键词： Depression Liver-qi stagnation and spleen deficiency syndrome Differentially expressed gene Liver Biological basis

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任意2^k点存储器结构傅里叶处理器

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浙江大学学报（工学版） 2016年第11期50卷 2239-2244页

作者：夏凯锋周小平吴斌中国科学院微电子研究所北京100029

针对任意,点数快速傳里叶变换（FFT）运算,设计并实现一种拥有并行地址无冲突策略的存储器结构FFT处理器.该策略可以支持原位回存,连续帧计算模式,可变多种点数和任意,长度的FFT运算.通过这种地址策略,FFT处理器所能达到的吞吐率由每一... 详细信息

针对任意,点数快速傳里叶变换（FFT）运算,设计并实现一种拥有并行地址无冲突策略的存储器结构FFT处理器.该策略可以支持原位回存,连续帧计算模式,可变多种点数和任意,长度的FFT运算.通过这种地址策略,FFT处理器所能达到的吞吐率由每一级抽取时的限制条件集合个数所决定.因此这种地址策略可以通过改变计算单元基底和调整计算单元并行度的方式可控地调整吞吐率.为了验证本地址策略的可行性,设计一款应用于长期演进（LTE）系统的128-2048点的可配置FFT处理器.处理器采用中芯国际55nmCMOS工艺实现,在122.88MHzX作频率下内核面积为0.615mm^2,功耗为***处理器的ASIC结果表明所提策略具有优秀的计算长度灵活性,硬件效率,可以支持任意,长度的FFT计算.

关键词：并行地址无冲突存连续帧处理原位回存存储器结构FFT处理器

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Application of Grey Relational Analysis on Gas Stations Safety Assessment

Application of Grey Relational Analysis on Gas Stations Safe...

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第三届教学管理与课程建设学术会议

作者： kai NI, Xin xia, Zhu-xia LI, Qiu-jing LI Shanghai Institute of Safety Sciences, Shanghai 200233, China

The theory of Grey Relational Analysis (GRA) is a new technique for relational analysis and decision making in many areas. In this paper, the use of grey relational analysis on the assessment of gas station security was presented. According to the features of gas station management and operation, the safety assessment index for gas station was proposed. The index was evaluated the safety status of a gas station from the aspects of equipments, personnel, management, and surroundings. Furthermore the grey relational analysis model of comprehensive appraisal of gas station security was founded. According to GRA theory, the evaluating method was validated. The results showed that the method was practical.

关键词： safety assessment grey relational analysis gas station safety assessment index

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基于稀疏表达的图像文档二值化技术仿真研究

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计算机仿真 2013年第9期30卷 221-224页

作者：夏开建夏瑜常熟市第一人民医院信息中心江苏常熟215500 江南大学物联网工程学院江苏无锡214122

研究了针对文档图像或者图形图像的去噪算法。传统二值化文档图像去噪算法无法满足识别准确性的需要的缺陷,利用文档图像或者图形图像中的线段方向信息,提出了一种利用曲线波变换和基追踪去噪算法相结合的图像去噪算法。首先进行曲线波... 详细信息

研究了针对文档图像或者图形图像的去噪算法。传统二值化文档图像去噪算法无法满足识别准确性的需要的缺陷,利用文档图像或者图形图像中的线段方向信息,提出了一种利用曲线波变换和基追踪去噪算法相结合的图像去噪算法。首先进行曲线波变化,从而得到一个噪声图像的稀疏表达,然后利用基追踪去噪算法得到一个对无噪声图像的最优估计。在最优化计算过程中引入了对图像噪声的估计,从而能获得更好的图形去噪效果。实验显示改进的方法能较传统方法能够提供更好的去噪结果。能为图形处理提供良好的输入图像,可被图形识别和处理系统广泛应用。

关键词：二值化图形处理滤波器稀疏矩阵

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肌醇对玉米幼苗低温胁迫伤害的缓解效应

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作物杂志 2014年第4期 133-138页

作者：姚慧夏凯南京农业大学生命科学学院江苏南京210095

为了探索外源肌醇对玉米幼苗低温胁迫的缓解效应及其可能的机理,以苏玉24玉米为供试材料,测定了常温和低温下肌醇对玉米幼苗生理生化指标的影响。结果表明,低温胁迫下的幼苗丙二醛(MDA)和过氧化氢(H2O2)含量、超氧化物歧化酶(SOD)、过... 详细信息

为了探索外源肌醇对玉米幼苗低温胁迫的缓解效应及其可能的机理,以苏玉24玉米为供试材料,测定了常温和低温下肌醇对玉米幼苗生理生化指标的影响。结果表明,低温胁迫下的幼苗丙二醛(MDA)和过氧化氢(H2O2)含量、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、过氧化物酶(POD)活性、超氧根阴离子(O2.-)产生速率和游离脯氨酸含量显著升高,叶绿素含量显著降低;外源施加0.8g/L肌醇后低温胁迫幼苗的MDA、H2O2含量和O2.-产生速率显著降低,SOD、CAT、POD活性、叶绿素和游离脯氨酸含量显著升高。外源施加肌醇能减轻活性氧积累,增强抗氧化系统活性,从而保护膜结构和功能,最终缓解低温胁迫的影响。

关键词：玉米肌醇低温胁迫缓解效应

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