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Theoretical and Experimental Study on the Performance of Hermetic Diaphragm Squeeze Film Dampers for Gas-Lubricated Bearings

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 151-169页

作者： Jianwei wang Haoxi Zhang Shaocun han hang Li Peng wang kai Feng State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

Low damping characteristics have always been a key sticking points in the development of gas *** application of squeeze film dampers can significantly improve the damping performance of gas lubricated *** paper proposed a novel hermetic diaphragm squeeze film damper(HDSFD)for oil-free turbomachinery supported by gas lubricated *** types of HDSFDs with symmetrical structure were proposed for good damping *** considering the compressibility of the damper fluid,based on hydraulic fluid mechanics theory,a dynamic model of HDSFDs under medium is proposed,which successfully reflects the frequency dependence of force *** on the dynamic model,the effects of damper fluid viscosity,bulk modulus of damper fluid,thickness of damper fluid film and plunger thickness on the dynamic stiffness and damping of HDSFDs were *** experimental test rig was assembled and series of experimental studies on HDSFDs were *** damper fluid transverse flow is added to the existing HDSFD concept,which aims to make the dynamic force coefficients independent of *** the force coefficient is still frequency dependent,the damping coefficient at high frequency excitation with damper fluid supply twice as that without damper fluid *** results serve as a benchmark for the calibration of analytical tools under development.

关键词： Hermetic diaphragm squeeze film damper Compressibility Dynamic model Experimental studies

New insight into the role of exosomes in idiopathic membrane nephropathy

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BIOCELL 2024年第1期48卷 21-32页

作者： JIANHONG LIU kai HE han wang XIAOHONG CHENG Department of Nephrology Shaanxi Provincial Hospital of Traditional Chinese MedicineXian710000China School of BasicMedical Sciences and State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengdu611137China Department of Pathophysiology West China College of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu610041China

Exosomes,nanoscale extracellular vesicles(EVs)derived from the invagination of the endosomal membrane,are secreted by a majority of cell *** carriers of DNA,mRNA,proteins,and microRNAs,exosomes are implicated in regulating biological activities under physiological and pathological ***-derived exosomes,which vary in origin and function,may either contribute to the pathogenesis of disease or represent a potential therapeutic *** nephropathy(MN),an autoimmune kidney disease characterized by glomerular damage,is a predominant cause of nephrotic ***,MN,especially idiopathic membranous nephropathy(IMN),often results in end-stage renal disease(ESRD),affecting approximately 30%of patients and posing a considerable economic challenge to healthcare *** substantial research,therapeutic options remain ineffective at halting IMN progression,underscoring the urgent need for innovative *** evidence has implicated exosomes in IMN’s pathophysiology;Providing a fresh perspective for the discovery of novel biomarkers and therapeutic *** review aims to scrutinize recent developments in exosome-related mechanisms in IMN and evaluate their potential as promising therapeutic targets and diagnostic biomarkers,with the hope of catalyzing further investigations into the utility of exosomes in MN,particularly IMN,ultimately contributing to improved patient outcomes in these challenging disease settings.

关键词： Exosomes Biomarkers Membranous nephropathy Therapeutic targets

COL4A2 enhances thyroid cancer cell proliferation through the AKT pathway

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Oncology Research 2024年第9期32卷 1467-1478页

作者： LIANG HE WEI han kai YUE XUDONG wang Department of Maxillofacial and Otorhinolaryngological Oncology Tianjin Medical University Cancer Institute and HospitalKey Laboratory of Basic and Translational Medicine on Head&Neck Cancer(Tianjin)Key Laboratory of Cancer Prevention and TherapyTianjin Cancer InstituteNational Clinical Research Center for CancerTianjin300060China Department of Thyroid&Breast Surgery Luoyang Central HospitalLuoyang471000China Department of Otorhinolaryngological Surgery Zhengzhou Central HospitalZhengzhou450000China

Objectives:Thyroid cancer(THCA)is the most common malignant tumor in endocrine system and the incidence has been increasing *** the number of patients dying from THCA has also gradually risen because the incidence continues to increase,so the mechanisms related to effective targets is necessary to improve the *** study was to preliminarily investigate the effects of the COL4A2 gene on the regulation of thyroid cancer(THCA)cell proliferation and the associated ***:Bioinformatics analysis revealed that COL4A2 was closely associated with cancer ***4A2 expression in THCA tissues was analyzed using immunohistochemistry,and survival information was determined via Kaplan-Meier *** expression of COL4A2 and AKT pathway-related genes were analyzed using qPCR and western blot *** formation as well as CCK-8 assays exhibited the cell proliferation level and cell activity,*** of COL4A2 was identified by Gene set enrichment analysis(GSEA).The effects of the COL4A2 and AKT pathways on THCA tumor growth in vivo were determined using a mouse ***:Bioinformatics analysis exhibited that COL4A2 plays a significant role in cancer and that the AKT pathway is downstream of *** patients with high COL4A2 expression had shorter recurrence-free *** of COL4A2 gene expression in 2 THCA cell lines promoted tumor cell growth and *** use of AKT pathway blockers also restrained the growth and activity of the 2 THCA cell *** use of AKT pathway blockers reduced tumor volume and mass and prolonged mouse ***:COL4A2 can promote the growth as well as development of THCA through the AKT pathway and COL4A2 could be used as a target for THCA.

关键词： Thyroid cancer(THCA) Proliferation COL4A2 AKT pathway Biomarker cancer progression

Explainable-AI-based two-stage solution for WSN object localization using zero-touch mobile transceivers

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Science China(Information Sciences) 2024年第7期67卷 27-45页

作者： kai FANG Junxin CHEN han ZHU Thippa Reddy GADEKALLU Xiaoping WU Wei wang School of Mathematics and Computer Science Zhejiang A&F University School of Software Dalian University of Technology Faculty of Applied Sciences Macao Polytechnic University Department of Electrical and Computer Engineering Lebanese American University School of Information Engineering Huzhou University Guangdong-Hong Kong-Macao Joint Laboratory for Emotional Intelligence and Pervasive Computing Artificial Intelligence Research Institute Shenzhen MSU-BIT University

Artificial intelligence technology is widely used in the field of wireless sensor networks(WSN).Due to its inexplicability, the interference factors in the process of WSN object localization cannot be effectively eliminated. In this paper, an explainable-AI-based two-stage solution is proposed for WSN object localization. In this solution, mobile transceivers are used to enlarge the positioning range and eliminate the blind area for object localization. The motion parameters of transceivers are considered to be unavailable,and the localization problem is highly nonlinear with respect to the unknown parameters. To address this,an explainable AI model is proposed to solve the localization problem. Since the relationship among the variables is difficult to fully include in the first-stage traditional model, we develop a two-stage explainable AI solution for this localization problem. The two-stage solution is actually a comprehensive consideration of the relationship between variables. The solution can continue to use the constraints unused in the firststage during the second-stage, thereby improving the performance of the solution. Therefore, the two-stage solution has stronger robustness compared to the closed-form solution. Experimental results show that the performance of both the two-stage solution and the traditional solution will be affected by numerical changes in unknown parameters. However, the two-stage solution performs better than the traditional solution, especially with a small number of mobile transceivers and sensors or in the presence of high noise. Furthermore,we have also verified the feasibility of the proposed explainable-AI-based two-stage solution.

关键词： explainable AI object localization semidefinite relaxation mobile transceiver two-stage solution closed-form solution

Detoxification strategy of Microcystis aeruginosa to the toxicity of Cd(Ⅱ):role of EPS in alleviating toxicity

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Journal of Oceanology and Limnology 2024年第3期42卷 802-815页

作者： Xingye han Fangyuan LIU Yibo ZhanG kai CHENG Heyun wang Hongmei GE Innovation Demonstration Base of Ecological Environment Geotechnical and Ecological Restoration of Rivers and Lakes School of Civil EngineeringArchitecture and EnvironmentHubei University of TechnologyWuhan 430068China School of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China National Engineering Research Center of Advanced Technology and Equipment for Water Environment Pollution Monitoring Wuhan 430068China

Although many studies have found that cadmium(Cd)can be toxic to microalgae,only a few reports focused on the role of extracellular polymeric substances(EPS)in Cd(Ⅱ)*** biochemical and physiological endpoints of Microcystis aeruginosa,including the composition and functional groups of soluble EPS(SL-EPS),loosely bound EPS(LB-EPS),and tightly bound EPS(TB-EPS),were detected to elucidate the toxicity and detoxification mechanisms of Cd(Ⅱ)for *** and physiological assays on *** showed that the 0.25-mg/L Cd(Ⅱ)resulted in a larger inhibition on growth and F_(v)/F_(m).Nevertheless,Cd(Ⅱ)significantly induced much higher contents of superoxide dismutase(SOD),intracellular microcystin LR(MC-LR),extracellular MC-LR,and *** electron microscopy with energy dispersive X-ray spectroscopy confirmed that Cd(Ⅱ)was absorbed into the EPS *** transform infrared spectrum analysis revealed that the functional groups bound with Cd(Ⅱ)of algae biomass,SL-EPS,LB-EPS,and TB-EPS were somewhat *** C=O/C=N groups ofδ-lactam or protein were their prominent functional groups,suggesting that amide or proteins in the EPS played a key role in the adsorption in Cd(Ⅱ).The concentration of 0.25 mg/L of Cd(Ⅱ)may change the chemical structure of EPS by altering the production of protein-like substances containing *** study indicated that *** could detoxify Cd(Ⅱ)stress via induction of antioxidant capacity(higher SOD activity and MC synthesis),EPS production,and modification in chemical structure of EPS.

关键词： Microcystis aeruginosa cadmium extracellular polymeric substances(EPS) microcystin detoxification

Masses of the conjectured H-dibaryon at different temperatures

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Chinese Physics C 2024年第8期48卷 83-93页

作者： Liang-kai Wu han Tang Ning Li Xin-Yang wang School of Physics and Electronic Engineering Jiangsu UniversityZhenjiang 212013China Center for Fundamental Physics School of Mechanics and PhysicsAnhui University of Science and TechnologyHuainan 232001China

We present a lattice QCD determination of masses of the conjectured H-dibaryon,denoted as mH,at nine different temperatures:T/T_(c)=0.24,0.63,0.76,0.84,0.95,1.09,1.27,1.52,and *** masses of baryons N,Σ,Ξ,andΛat different temperatures were also *** simulations were performed on an anisotropic lattice with N_(f)=2+1 flavours of clover fermion at a quark mass corresponding to mπ=384(4)*** thermal ensembles were provided by the FASTSUM collaboration,whereas the zero temperature ensembles were provided by the Hadspec *** also calculated the spectral density of the correlation function of those *** spectral density distributions show a rich peak structure at the lowest temperature;at intermediate temperatures,the mass values of those particles obtained by the extrapolation method reflect a two-peak *** the spectral density for the octet baryon becomes smooth at T/T_(c)=1.27,1.52,and 1.90,the spectral density for the H-dibaryon becomes smooth at T/T_(c)=*** T/T_(c)=0.24,the mass difference of the H-dibaryon andΛpair,expressed asΔm=m_(H)−2m_(Λ),was estimated to beΔm=−14.6(6.2)MeV,which suggests the existence of a bound H-dibaryon state.

关键词： lattice QCD H-dibaryon spectral function clover fermion finite temperature

Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer

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Science China Chemistry 2024年第2期67卷 652-663页

作者： Chong Li Minghao han Ji Gao Shuxian wang Song-Bo Lu Yaxi Li Zhao Liu Chen Zhang Zhaojin wang Fangliang wang Yuang Sun Chun Loong Ho kai wang Yun Shen kai Li Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced BiomaterialsDepartment of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen518055China Department of Chemical and Environmental Engineering University of California RiversideRiverside92521USA Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen518055China

The critical factor of spatial constraint,provided by the external confinement(e.g.,matrix),is often overlooked during photodynamic inactivation,despite playing a crucial role in determining the molecular photophysical process and subsequent antipathogen ***,as a proof-of-concept model,we employed two types of polymers with varying interaction energies with dopants to investigate the intrinsic relationship between spatial constraint and the essential excited-state behaviors of doped photosensitizer(4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)ethyl)-1-methylquinolin-1-ium iodine,TPP).Through experimental investigation and theoretical calculations,we found that TPP tends to remain in the excited state for a shorter dwell time under weaker spatial constraints due to less restricted molecular motion in polyurethane(PU) ***,the singlet oxygen(^(1)O_(2)) generated from doped-TPP shows a 9.23-fold enhancement in PU than in the polyvinylchloride(PVC) *** light irradiation,the PU@TPP nanofiber can efficiently eliminate the coronavirus MHV-A59(≥99.9997%) at a 220,000-fold higher concentration than the infected *** antibacterial efficacy has also been demonstrated,with a killing rate of ≥99%.

关键词： photodynamic antibacterial singlet oxygen triphenylamine nanofiber

Repurposing disulfiram with CuET nanocrystals:Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2698-2715页

作者： Xueming Xu Yuanfeng han Jiali Deng Shengfeng wang Shijie Zhuo kai Zhao Wenhu Zhou Hematology and Department of Critical Care Medicine The Third Xiangya HospitalCentral South UniversityChangsha 410013China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Hunan Chidren's Hospital Changsha 410007China Department of Pharmacy The Third Xiangya HospitalCentral South UniversityChangsha 410013China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

Drug repurposing offers a valuable strategy for identifying new therapeutic applications for existing ***,disulfiram(DSF),a drug primarily used for alcohol addiction treatment,has emerged as a potential treatment for inflammatory diseases by inhibiting pyroptosis,a form of programmed cell *** therapeutic activity of DSF can be further enhanced by the presence of Cu^(2+),although the underlying mechanism of this enhancement remains *** this study,we investigated the mechanistic basis of Cu^(2+)-induced enhancement and discovered that it is attributed to the formation of a novel copper ethylthiocarbamate(CuET)*** exhibited significantly stronger anti-pyroptotic activity compared to DSF and employed a distinct mechanism of ***,despite its potent activity,CuET suffered from poor solubility and limited permeability,as revealed by our druggability *** overcome these intrinsic limitations,we developed a scalable method to prepare CuET nanocrystals(CuET NCs)using a metal coordination-driven self-assembly *** studies demonstrated that CuET NCs exhibited a 6-fold improvement in ***,CuET NCs exhibited high biodistribution in the intestine,suggesting their potential application for the treatment of inflammatory bowel diseases(IBDs).To evaluate their therapeutic efficacy in vivo,we employed a murine model of DSS-induced colitis and observed that CuET NCs effectively attenuated inflammation and ameliorated colitis *** findings highlight the discovery of CuET as a potent anti-pyroptotic agent,and the development of CuET NCs represents a novel approach to enhance the druggability of CuET.

关键词： Drug repurposing Pyroptosis Nanoparticles Bioavailability Disulfiram DSS-induced colitis NLRP3 inflammasome CuET

Crystal phase control and ignition properties of HNS/CL-20 composite microspheres prepared by microfluidics combined with emulsification techniques

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Particuology 2024年第2期85卷 241-251页

作者： Yi Liu Yunyan Guo Rui Zhu Jinqiang Zhou Zhengxu Lin kai han Chongwei An Jingyu wang Bidong Wu School of Environment and Safety Engineering North University of ChinaTaiyuan030051China School of Engineering Beijing Institute of TechnologyBeijing100081China Shanxi Province Ultrafine Powder Engineering Technology Research Center Taiyuan030051China

Improved controllability and energy density of ignition agents are of great significance for the devel-opment of energetic composite *** this study,droplet microfluidics and emulsification tech-niques were combined to prepare HNS/CL-20 composite microspheres with polyglycidyl azide polymer(GAP)as the *** influence of binder content on the morphology of microspheres was investi-gated,and the microspheres were characterized and tested for particle size,crystal structure,thermal decomposition,dispersibility,mechanical sensitivity,combustion behavior and detonation *** results showed that microspheres prepared with a binder content of 3%had higher sphericity and particle size *** microspheres retained the crystal structure of both HNS and CL-20(ε-type).Compared with raw HNS,the microspheres had higher apparent activation energy,better safety per-formance,and good *** ignition experiments and detonation performance tests show that HNS/CL-20 composite microspheres have excellent ignition performance,obvious combustion flame,and significant energy release effects,which are expected to achieve high energy and high-speed response of the igniter,thus improving the ignition reliability in special environments or systems.

关键词： Droplet microfluidics Emulsification technology Energetic materials Composite microspheres Crystal phase control Ignition