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Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson's disease,with insights into Pink1 knockout models

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Zoological Research 2023年第3期44卷 559-576页

作者： Zhangting Wang See-Wing Chan Hui Zhao kai-Kei Miu wai-Yee Chan School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics School of Biomedical SciencesThe Chinese University of Hong KongHong Kong SARChina Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesThe Chinese University of Hong KongHong Kong SARChina

Parkinson’s disease(PD)relates to defective mitochondrial quality control in the dopaminergic motor *** studies have revealed that PINK1 and Parkin mutations are indicative of a heightened propensity to PD onset,pinpointing mitophagy and inflammation as the culprit pathways involved in neuronal loss in the substantia nigra(SNpc).In a reciprocal manner,LRRK2 functions in the regulation of basal flux and inflammatory responses responsible for PINK1/Parkin-dependent mitophagy *** intervention in these diseasemodifying pathways may facilitate the development of novel PD therapeutics,despite the current lack of an established drug evaluation *** such,we reviewed the feasibility of employing the versatile global Pink1knockout(KO)rat model as a self-sufficient,spontaneous PD model for investigating both disease etiology and drug *** rats retain clinical features encompassing basal mitophagic flux changes with PD *** demonstrate the versatility of this PD rat model based on the incorporation of additional experimental insults to recapitulate the proinflammatory responses observed in PD patients.

关键词： Parkinson’s disease Mitophagy Inflammatory response Genetic model Pink1 KO rats

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Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 40-46页

作者： Jeonghun Baek Chun wai Mai Wei Meng Lim Lai Chun wong School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Chemistry School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Technology School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia

AIM:To compare the effect of vegetable oils on the uptake of lutein and zeaxanthin by adult retinal pigment epithelial(ARPE)-19 cells in ***:ARPE-19 cells were cultured in Dulbecco’s Modified Eagle Medium-F-12 supplemented with 10%foetal bovine serum and 1%penicillin–streptomycin in a humidified 5%CO_(2) incubator maintained at 37℃.Cells were treated with 247μmol/L lutein,49μmol/L zeaxanthin and 1%(v/v)of either coconut oil,corn oil,peanut oil,olive oil,sunflower oil,soybean oil,castor oil,or linseed oil for *** and zeaxanthin concentration in the cells were quantified by high performance liquid ***:Among the oils tested,the highest lutein and zeaxanthin uptake was observed with coconut oil while the lowest was observed with linseed ***:ARPE-19 uptake of lutein and zeaxanthin are found to be dependent on the type of oils.

关键词： lutein zeaxanthin adult retinal pigment epithelial-19 cells vegetable oil

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Development of a dual targeting scaffold of SET7/MLL inhibitor for castration-resistant prostate cancer treatment

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Genes & Diseases 2023年第6期10卷 2260-2262页

作者： Guodong Li Qi Huang Vincent Kam wai wong Wanhe Wang Chung-Hang Leung Institute of Chinese Medical Sciences and State Key Laboratory of Quality Research in Chinese Medicine University of MacaoMacao SAR 999078China Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao SAR 999078China Institute of Medical Research Northwestern Polytechnical UniversityXi'anShaanxi 710072China Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China Department of Biomedical Sciences Faculty of Health SciencesUniversity of MacaoMacao SAR 999078China Zhuhai UM Science and Technology Research Institute ZhuhaiGuangdong 519000China

Histone methyltransferase enzyme SET7 and mixed-lineage leukemia protein(MLL)complex are crucial co-activators of androgen receptor(AR)and have recently emerged as potential therapeutic targets for advanced castration-resistant prostate cancer(CRPC).In this study,we described the identification of a rhodium-based hybrid complex(SM_1)as a potent blocker of AR activity via simultaneously inhibiting SET7 and MLL complex activity,which makes it a potential lead scaffold for CPRC drug development.

关键词： cancer inhibiting treatment

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Virtual reality based multiple life skill training for intellectual disability:A multicenter randomized controlled trial

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Engineered Regeneration 2022年第2期3卷 121-130页

作者： James Chung-wai Cheung Ming Ni Andy Yiu-Chau Tam Tim Tin-Chun Chan Alyssa Ka-Yan Cheung Ocean Yu-Hong Tsang Chi-Bun Yip Wing-kai Lam Duo wai-Chi wong Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Research Institute for Smart Ageing The Hong Kong Polytechnic UniversityHong Kong 999077China Jockey Club Smart Ageing Hub Department of Biomedical EngineeringFaculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Orthopaedics Pudong New Area People’s Hospital Affiliated to Shanghai Jiaotong UniversityShanghai 201299China Social Service Department Yan Chai HospitalHong Kong 999077China C2 Innovations and Research Limited Hong Kong 999077China Department of Kinesiology Shenyang Sport UniversityShenyang 110102China Sports Information and External Affairs Centre Hong Kong Sports InstituteHong Kong 999077China

Life skill-based training is essential for intellectual disabled individuals to regain autonomy and social *** reality(VR)could deliver a nascent application that is more engaging and *** objective of this study was to evaluate the training effects of the VR-based multiple life skill training program on life skill perfor-mance,self-efficacy,memory,cognitive and behavioral functions via a multicenter randomized controlled trial.A total of 145 intellectual disabled participants were recruited for a randomized controlled trial with three in-tervention arms:VR(n=42);traditional(n=53);and control(n=50).The life skill tasks for the interventions included 1)grocery shopping,2)cooking,and 3)kitchen *** measures were performance scores for the three tasks,self-efficacy scale,digit span score,and Frontal Assessment Battery score,graded by blinded ***-after effects of each group were evaluated using separated Wilcoxon Signed-rank *** sig-nificantly improved cooking,cleaning performance,and memory span,while traditional training significantly improved shopping,cooking,and cleaning *** generalized estimating equation evaluated effects between groups adjusted for age,gender and intelligence quotient(IQ).VR had significantly larger improvement effects in cooking and cleaning than the control group and memory span compared to traditional training and controls *** appeared to be a significant confounder on the training *** work may consider developing artificial intelligence to customize programs depending on IQ level.

关键词： Mental retardation Intellectual development X-reality Immersive rehabilitation Metaverse

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Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide-porphyrin double-decker complexes in aqueous solution

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Light(Science & Applications) 2019年第1期8卷 766-775页

作者： Jing-Xiang Zhang wai-Lun Chan Chen Xie Yan Zhou Ho-Fai Chau Partha Maity George T.Harrison Aram Amassian Omar F.Mohammed Peter A.Tanner wai-Kwok wong Ka-Leung wong Department of Chemistry Hong Kong Baptist UniversityKowloon TongHong Kong S.A.R.China Hanshan Normal University ChaozhouGuangdong ProvinceChina Department of Biology Hong Kong Baptist UniversityKowloon TongHong Kong S.A.R.China KAUST Solar Center Division of Physical Science and EngineeringKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties,their inferior water solubility has negated their biomedical ***,four water-soluble homoleptic lanthanide(Ln=Gd,Er,Yb and La)sandwiches with diethylene-glycoldisubstituted porphyrins(DD)are reported,with their structures proven by both quantum chemical calculations and scanning tunneling *** findings demonstrate that the near-infrared emission intensity and singlet oxygen(1O2)quantum yields of YbDD and GdDD in aqueous media are higher than those of the reported capped lanthanide monoporphyrinato analogues,YbN and GdN;the brightness and luminescence lifetime in water of YbDD are greater than those of *** work provides a new dimension for the future design and development of molecular theranostics-based water-soluble double-decker lanthanide bisporphyrinates.

关键词： lanthanide porphyrin complexes

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Self-attention reinforcement learning for multi-beam combining in mmW ave 3D-MIMO systems

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Science China(Information Sciences) 2023年第6期66卷 204-221页

作者： Yingzhi HUANG Zhaoyang ZHANG Jingze CHE Zhaohui YANG Qianqian YANG kai-Kit wong College of Information Science and Electronic Engineering Zhejiang University Department of Electronic and Electrical Engineering University College London

Machine learning(ML)has been empowering all aspects of the wireless communication system design, among which, the reinforcement learning(RL)-based approaches have attracted a lot of research attention since they can interact with the environment directly and learn from the collected experiences efficiently. In this paper, we propose a novel and efficient RL-based multi-beam combining scheme for future millimeter-wave(mmWave)three-dimensional(3D)multi-input multi-output(MIMO)communication systems. The proposed scheme does not require perfect channel state information(CSI)or precise user location information which both are generally difficult to obtain in practice, and well addresses the crucial challenge of computational complexity incurred by the extremely huge state and action spaces associated with multiple users, multiple paths, and multiple 3D beams. In particular, a self-attention deep deterministic policy gradient(DDPG)-based beam selection and combination framework is proposed to learn the 3D beamforming pattern without CSI adaptively. We aim to maximize the sum-rate of the mmWave 3D-MIMO system by optimizing the serving beam set and the corresponding combining weights for each user. To this end, the transformer is incorporated into the DDPG to obtain the global information of the input elements and capture the signal directions precisely, which leads to a near-optimal beamformer design. Simulation results verify the superiority of the proposed self-attention DDPG over conventional ML-based beamforming schemes in terms of sum-rate under various scenarios.

关键词： reinforcement learning (RL) deep deterministic policy gradient (DDPG) self-attention precoding/combining millimeter-wave (mmWave) multi-input multi-output (MIMO)

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Effects of biochar on soil water retention curves of compacted clay during wetting and drying

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Biochar 2022年第1期4卷 1117-1130页

作者： James Tsz Fung wong Ka Lai Chow Xun Wen Chen Charles Wang wai Ng Ming Hung wong Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongSARChina Department of Geography Hong Kong Baptist UniversityKowloon TongHong KongSARChina Consortium on Health EnvironmentEducation and Research(CHEER)Department of Science and Environmental StudiesThe Education University of Hong KongTai PoHong KongSARChina Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China State Environmental Protection Key Laboratory of Integrated Surface Water Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Compacted clay possesses a low water permeability and has been widely used in geo-environmental facilities such as landfill cover *** studies revealed the potential applications of compacted biochar-amended clay(BAC)as an alternative landfill cover ***,the effects of biochar on the soil water retention curves(SWRCs)of clay at low suction are not *** study can help fill this knowledge gap by measuring the wetting and drying SWRCs of clay and BAC(20%biochar).Soils were compacted in instrumented soil columns and subjected to a wetting and drying cycle,and soil water content and suction were measured along with the soil *** was saturated faster when compared with *** drying,the soil water content of clay at 65 mm depth dropped to almost zero,while about 5%of water was retained in *** showed that biochar increased the soil water retention capacity of compacted clay upon *** showed that biochar-clay composite possesses a higher soil water retention capacity at a low soil suction range(<1000 kPa)compared with clay *** revealed the benefits of using compacted biochar-clay composite as a hydraulic barrier to minimize desiccation-induced cracks and potentially promote its serviceability,especially in arid and semi-arid *** composite is also a carbon sink material that can reduce landfill gas emissions and pollutant leaching.

关键词： Soil amendment Biochar-clay composite Soil carbon Soil suction Soil depth

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The interaction effects of rocker angle and apex location in rocker shoe design on foot biomechanics and Achilles tendon loading

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Medicine in Novel Technology and Devices 2022年第1期13卷 96-101页

作者： Tony Lin-Wei Chen Duo wai-Chi wong Yinghu Peng Yan Wang Ivy Kwan-Kei wong Tsz-Kit Lam Wing-kai Lam Ming Zhang Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong The Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenChina Li Ning Sports Science Research Center Li Ning(China)Sports Goods Co.LtdBeijingChina Department of Kinesiology Shenyang Sports InstituteShenyangChina

The influences of rocker shoes on foot biomechanics were controversial because the interaction between two design factors—rocker angle and apex location,was usually *** study investigated the interaction effects of rocker angle and apex location on plantar foot pressure,metatarsophalangeal/ankle angle,and Achilles tendon force during *** participants performed walking trials under six rocker shoe conditions:2 rocker angles(mild and severe)×3 apex locations(distal,standard,and proximal),wherein the plantar foot pressure was measured and the movement data were processed by musculoskeletal modeling to report joint angle and Achilles tendon force.A two-way ANOVA repeated measures was used for *** interaction effects were reported in examinations of forefoot pressure,midfoot pressure,and metatarsophalangeal *** standard apex significantly reduced peak forefoot and midfoot pressures(p=0.008–0.034,Hedges'g=0.75–0.84),which was further decreased by a severe rocker angle(p=0.006,Hedges'g=0.51–0.81).Moving the apex proximally reduced Achilles tendon forces(p<0.001,Hedges'g=0.80)and facilitated both metatarsophalangeal dorsiflexion and ankle plantarflexion during push-off(p=0.003–0.006,Hedges'g=0.03–0.82).Rocker angle seemed to have fewer effects on ankle joint angle and Achilles tendon *** concluded that apex location was likely the dominant design factor of the rocker sole in influencing foot biomechanics,yet its interactions with rocker angle should be *** configuration of the two features could be varied to possess different therapeutic merits and adapt to specific application purposes.

关键词： Gait Rocker shoe Biomechanics Computer simulation Plantar pressure

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Genetically modified foods in China and the United States:A primer of regulation and intellectual property protection

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Food Science and Human Wellness 2016年第3期5卷 124-140页

作者： Alice Yuen-Ting wong Albert wai-Kit Chan Albert wai-Kit Chan Intellectual Property Limited Hong Kong Special Administrative Region United States-China Intellectual Property Institute New YorkUSA Law Offices of Albert wai-Kit Chan PLLCNew YorkUSA

Food is a basic and personal necessity to *** of food is a prime factor to consider apart from nutrition,quality and *** modified(GM)foods first came on the market in *** safety,transparency and traceability ofGMfoods are still under hot ***,the market of GM foods is huge and *** affairs and intellectual property(IP)are two critical factors affecting the development and commercial success of a food *** article will take a look at the GM food technology and regulatory framework for GM foods in China and the United *** article will also discuss the unique patent issues and non-patent IP tools for safeguarding the technology in these two countries.

关键词： property modified attractive

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Design of AIEgen-based porphyrin for efficient heterogeneous photocatalytic hydrogen evolution Special Collection:Aggregation-Induced Processes and Functions

Aggregate

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Aggregate 2023年第5期4卷 199-206页

作者： Govardhana Babu Bodedla Muhammad Imran Jianzhang Zhao Xunjin Zhu wai-Yeung wong Department of Applied Biology&Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHong KongP.R.China The Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenP.R.China Department of Chemistry Hong Kong Baptist UniversityHong KongP.R.China State Key Laboratory of Fine Chemicals and School of Chemical Engineering Dalian University of TechnologyDalianP.R.China

Tetraphenylethylene(TPE)-conjugated porphyrin TPE-ZnPF is synthesized in high yield and characterized by single-crystal X-ray *** propeller-shaped TPE groups not only enable exceptional aggregation-induced emission(AIE)in the solid state but also abolish the strongπ-πstacking of porphyrin moieties and thus prohibit aggregation-caused quenching(ACQ).TPE-ZnPF aggregates feature longlived photoexcited states,which subsequently suppress non-radiative decay channels and enhance emission ***,its aggregates show more efficient lightharvesting ability due to the Förster resonance energy transfer from the TPE energy donor to the porphyrin core energy acceptor,well-defined nanosphere morphology,and more efficient photoinduced charge separation than the porphyrin Ph-ZnPF,which possesses ACQ and agglomerated *** a result,an excellent photocatalytic hydrogen evolution rate(ηH_(2))of 56.20 mmol g^(‒1)h^(‒1)is recorded for TPE-ZnPF aggregates,which is 94-fold higher than that of the aggregates of Ph-ZnPF(0.60 mmol g^(‒1)h^(‒1))without the TPE groups.

关键词： aggregation-induced emission AIEgen porphyrin π-π-stacking photocatalytic hydrogen evolution

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