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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue wang Lijie Huang Su Zhang Ruixin Zhang Song wang Guangxu Lu Peifu Tang Zhongyang Liu kai wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu kai wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo wang Ruo-Ran Zhang Hao wang Peng Xu Jing-kai wang Bo Chen Hao Xu Deng Pan Yu-Yang Ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

踝关节骨折术后踝穴冠状位角度波动与关节功能恢复的关系

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中国组织工程研究 2025年第9期29卷 1820-1826页

作者：刘琰王铠吴敏泰州市中医院骨科江苏省泰州市225300

背景:踝关节骨折术后的踝穴形态指标会出现相应变化,而其中踝穴冠状位角度变化与踝关节的功能恢复之间存在一定的关联,既往研究大多探讨患者术后踝穴高度恢复,故研究踝关节骨折术后踝穴冠状位角度的波动与关节功能恢复的相关性具有一定... 详细信息

背景:踝关节骨折术后的踝穴形态指标会出现相应变化,而其中踝穴冠状位角度变化与踝关节的功能恢复之间存在一定的关联,既往研究大多探讨患者术后踝穴高度恢复,故研究踝关节骨折术后踝穴冠状位角度的波动与关节功能恢复的相关性具有一定参考意义。目的:探讨踝关节骨折术后踝穴冠状位角度变化对关节功能恢复的影响。方法:纳入进行手术治疗的86例踝关节骨折患者为研究对象,根据末次随访美国骨科足踝外科协会踝-后足评分结果分为优良组(n=45)和可差组(n=41),比较两组患者的一般资料。根据踝关节的踝穴位及侧位X射线片对比术后患者患侧和健侧的踝穴形态指标:包括踝穴宽度和深度、冠状位角度及矢状位角度,以及上述指标患侧和健侧之间的差值,并进一步进行组内比较分析。构建联合模型,利用Cox回归分析评估冠状位角度波动与关节功能恢复情况的关系。利用最小绝对收缩选择算子回归法和多因素Logistic回归分析影响患者关节功能恢复的危险因素。按踝穴冠状位角度从低到高等分为5分位数组(Q1-Q5),比较5组患者的临床资料特征,并采用多因素Logistic回归分析踝穴冠状位角度变化与关节功能恢复不良风险的相关性,建立限制性立方样条Logistic回归模型分析其剂量-反应关系。建立回归方程y=1-1/(1+e^(-z))预测模型并进行验证。结果与结论:①患者患侧的踝穴宽度和深度、冠状位角度及矢状位角度均显著大于健侧(P均<0.05);且与优良组患者相比,可差组患者踝穴宽度差值、深度差值、冠状位角度差值及矢状位角度差值均更大(P<0.05);②联合模型显示无论冠状位角度是否在正常范围内,冠状位角度每纵向增加1˚,关节功能恢复不良的风险增加3%;③最小绝对收缩选择算子回归和多因素Logistics回归分析显示,调整潜在混杂因素后发现年龄过大、早期功能锻炼缺乏、无跟骨牵引、内固定物未取出、术后并发症、踝冠状位角度增大均为影响患者关节功能恢复的独立危险因素(P<0.05);④术后3个月内的冠状位角度与关节功能恢复效果不良风险存在独立相关性(OR=1.57,95%CI:1.38-1.76,P=0.002),且术后各时间段冠状位角度从低到高5分位数组趋势性检验差异有统计学意义(P趋势<0.001);⑤限制性立方样条模型分析显示,男性或女性的踝穴冠状位角度变化与关节功能恢复效果不良风险均不存在非线性关系;经Bootstrap自抽样,预测模型区分度、准确度较好;⑥提示踝关节骨折术后踝穴冠状位角度减小对关节功能恢复起到明显的促进作用,因此在踝关节骨折术后重点检测踝穴冠状位角度有助于了解患者关节功能恢复情况。

关键词：踝关节骨折踝穴冠状位角度关节功能 Logistic回归分析

高河能源掘进工作面产尘机理及运移规律数值模拟研究

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煤矿现代化 2025年第1期34卷 12-18页

作者：王凯潞安化工集团高河能源有限公司山西长治046000

高河能源公司掘进工作面产尘强度大且回采深度逐年增加,在空气流场的作用下,常规治尘措施难以对粉尘进行有效拦截。为此,对掘进工作面产尘机理及运移规律开展数值模拟研究。首先,开展现场掘进过程压入式、抽出式风量测试,随后建立掘进... 详细信息

高河能源公司掘进工作面产尘强度大且回采深度逐年增加,在空气流场的作用下,常规治尘措施难以对粉尘进行有效拦截。为此,对掘进工作面产尘机理及运移规律开展数值模拟研究。首先,开展现场掘进过程压入式、抽出式风量测试,随后建立掘进工作面DPM模型,构建掘进面物理模型,得到巷道中粉尘浓度分布与粒径分布特性。最后开展掘进过程粉尘浓度分布测试。试验结果表明:掘进机司机位置处总尘浓度最高值、平均浓度、呼尘浓度最高值、平均浓度;转载机位置总尘、呼尘浓度的平均值;控风风筒后方总尘、呼尘浓度的平均值,经与数值模拟结果与现场实测结果对比,模拟精度大于85%,与现场情况基本一致。

关键词：高河能源工作面产尘数值模拟优化试验

Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor

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Chinese Journal of Chemical Engineering 2023年第6期58卷 170-178页

作者： Pengcheng Zou kai wang The State Key Lab of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

The methanolysis of amides,which is widely employed in the synthetic organic chemistry,hardly occurs under mild *** safely and controllably intensify the methanolysis reaction with hightemperature and high-pressure environment,a continuous tubular reaction technology is developed,whose space-time yield is over twice of that of the conventional batch *** methanolysis of acetanilide is selected as the representative reaction,and the influences of temperature,pressure,reactant and catalyst concentration,and residence time on the reaction performances are systematically *** the advantages of precise temperature and reaction time control by the tubular reactor,the kinetics of acetanilide methanolysis are determined and compared to the kinetics of acetanilide hydrolysis *** tubular reaction method is also employed to test a variety of other amides to show the effects of substituents,steric hindrance,and alkalinity on the reaction rate of methanolysis.

关键词： Amide methanolysis reaction Flow chemistry Continuous reaction Process intensification

Analytic Extension of Functions from Analytic Hilbert Spaces

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Chinese Annals of Mathematics,Series B 2007年第3期28卷 321-326页

作者： kai wang School of-Mathematical Sciences Fudan University Shanghai 200433 China.

Let M be an invariant subspace of H^2 v,It is shown that for each f∈ M^⊥,f can be analytically extended across эBd/σ（Sz1,…Szd）.

关键词： Analytic Hilbert space Spectrum Analytic extension

Comparison of different algicides on growth of Microcystis aeruginosa and microcystin release, as well as its removal pathway in riverways

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Frontiers of Environmental Science & Engineering 2017年第6期11卷 19-26页

作者： Naiyu wang kai wang Can wang School of Environmental Science and Engineering Tianjin University Tianjin 300350 China

Eutrophication with a large number of Microcystis aeruginosa commonly occurs worldwide, thereby threatening the aquatic ecosystem and human health. In this study, four kinds of algicides were tested to explore their influence on cell density and chlorophyll-a of M. aeruginosa. Results showed that aluminum silicate agent, which inhibited more than 90% cell growth compared with the control group, demonstrated the strongest inhibition effect immediately on M. aeruginosa growth. Furthermore, the production and release of microcystin （MC）-LR were investigated. Aluminum silicate, CuSO4, and Emma-11 were more effective than pyrogallic acid in disrupting the cells of M. aeruginosa, thereby increasing the extracellular MC-LR concentration. Aluminum silicate caused the highest extracellular MC-LR concentration of more than 45 mg·L^-1. Biotoxicity was also detected to evaluate the environmental risks of MC-LR release, which were related to the usages of different algicides. Extracellular MC-LR concentration mostly increased when the biotoxicity of algae solution increased. The experiments were also designed to reveal the effects of physical conditions in riverways, such as natural sunlight, aeration and benthal sludge, on MC-LR degradation. These findings indicated that UV rays in sunlight, which can achieve a MC-LR removal efficiency of more than 15%, played an important role in MC-LR degradation. Among all the physical pathways of MC-LR removal, benthal sludge adsorption presented the optimal efficiency at 20%.

关键词： Microcystis aeruginosa MC-LR release Algicides MC-LR degradation Biotoxicity

ANALYSIS OF A FULLY DISCRETE FINITE ELEMENT METHOD FOR PARABOLIC INTERFACE PROBLEMS WITH NONSMOOTH INITIAL DATA

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Journal of Computational Mathematics 2022年第5期40卷 777-793页

作者： kai wang Na wang Department of Mathematics Southern University of Science and TechnologyShenzhen 518005China Applied and Computational Mathematics Division Beijing Computational Science Research CenterBeijing 100193China

This article concerns numerical approximation of a parabolic interface problem with general L 2 initial *** problem is discretized by a finite element method with a quasi-uniform triangulation of the domain fitting the interface,with piecewise linear approximation to the *** semi-discrete finite element problem is furthermore discretized in time by the k-step backward difference formula with k=1,...,*** maintain high-order convergence in time for possibly nonsmooth L 2 initial value,we modify the standard backward difference formula at the first k−1 time levels by using a method recently developed for fractional evolution *** error bound of O(t−k nτk+t−1 n h 2|log h|)is established for the fully discrete finite element method for general L 2 initial data.

关键词： Parabolic interface problem Finite element method Backward difference formulae Error estimate Nonsmooth initial data.