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Spatial transcriptomics:recent developments and insights in respiratory research

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Military Medical Research 2024年第3期11卷 430-448页

作者： Wen-Jia Wang Liu-Xi Chu Li-Yong He Ming-Jing Zhang kai-tong Dang Chen Gao Qin-Yu Ge Zhou-Guang Wang Xiang-Wei Zhao State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035ZhejiangChina Orthopaedic Bioengineering Research Group Division of Surgery and Interventional ScienceUniversity College LondonLondon HA74LPUK

The respiratory system's complex cellular heterogeneity presents unique challenges to researchers in this field.Although bulk RNA sequencing and single-cell RNA sequencing(scRNA-seq)have provided insights into cell types and heterogeneity in the respiratory system,the relevant specific spatial localization and cellular interactions have not been clearly elucidated.Spatial transcriptomics(ST)has filled this gap and has been widely used in respiratory studies.This review focuses on the latest iterative technology of ST in recent years,summarizing how ST can be applied to the physiological and pathological processes of the respiratory system,with emphasis on the lungs.Finally,the current challenges and potential development directions are proposed,including high-throughput full-length transcriptome,integration of multi-omics,temporal and spatial omics,bioinformatics analysis,etc.These viewpoints are expected to advance the study of systematic mechanisms,including respiratory studies.

关键词： Spatial transcriptomics Lung Tumor Spatial multi-omics

Quantitative Detection of Corrosion State of Concrete Internal Reinforcement Based on Metal Magnetic Memory

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结构耐久性与健康监测(英文) 2023年第5期17卷 407-431页

作者： Zhongguo Tang Haijin Zhuo Beian Li Xiaotao Ma Siyu Zhao kai tong Guangxi Xinxiang Expressway Co. Ltd.Nanning530000China College of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

Corrosion can be very harmful to the service life and several properties of reinforced concrete structures.The metal magnetic memory(MMM)method,as a newly developed spontaneous magnetic flux leakage(SMFL)non-destructive testing(NDT)technique,is considered a potentially viable method for detecting corrosion damage in reinforced concrete members.To this end,in this paper,the indoor electrochemical method was employed to accelerate the corrosion of outsourced concrete specimens with different steel bar diameters,and the normal components Bz and its gradient of the SMFL fields on the specimen surfaces were investigated based on the metal magnetic memory(MMM)method.The experimental results showed that the SMFL experimental Bz curves are consistent with the analytical results of the theoretical model.Furthermore,the crest-to-trough behavior on the Bz signal curve and its zero-point gradient spacing can more accurately indicate the corroded area’s extent.Then,a magnetic characteristic parameter W based on a large amount of experimental data was established to characterize the degree of corrosion of the steel bars.The magnetic characteristic parameter W is linearly related to the maximum cross-sectional area loss rateof the corroded reinforcement.This paper will lay the foundation for future research on corrosion detection of reinforced concrete structures based on the MMM method and provide a feasible way for non-destructive detection of corrosion independent of the influence of reinforcement diameter and magnetization history.

关键词： Reinforcing steel metal magnetic memory(MMM)method spontaneous magnetic flux leakage(SMFL) nondestructive testing local corrosion

Mechanical Property, Oxidation and Ablation Resistance of C/C–ZrB_2–ZrC–SiC Composite Fabricated by Polymer Infiltration and Pyrolysis with Preform of C_f/ZrB_2

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Journal of Materials Science & Technology 2017年第5期33卷 481-486页

作者： Dong Huang Mingyu Zhang Qizhong Huang Liping Wang kai tong College of Materials Science and Engineering Hunan University State Key Laboratory for Powder Metallurgy Central South University

CJC-ZrB2-ZrC-SiC composites were fabricated by polymer infiltration and pyrolysis （PIP） with a preform of G/ZrB2. The carbon fibers and the resin carbon were coated with ceramic layer after PIP in the com- posites. The composite presents a pseudo-plastic fracture due to deflection of cracks and pullout of fibers. The composite has a higher bending strength by this method in comparison with the conventional PIP process due to fewer heat treatment cycles. The static oxidation test shows that the mass loss of the composites is no more than 1% after 20 rain oxidation at 1100 ~C. The ＂core-shell＂ structure between ZrC-SiC ceramic and other phases plays a positive role in preventing the inward diffusion of oxygen. The ablation resistance of the C/C-ZrB2-ZrC-SiC composite samples was tested using a plasma generator. After ablation for 120 s, the mass and linear ablation rates of the composites are 4.65 mg cm-2 s-1 and 2.46 μm s-1, respectively. The short carbon layer shows a better ablation resistance than the nonwoven carbon fabric layer after the ceramic coating is peeled off because of its higher ceramic content.

关键词： C/C composite Ceramic-matrix composites High temperature corrosion

Capability of TMPA products to simulate streamflow in upper Yellow and Yangtze River basins on Tibetan Plateau

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Water Science and Engineering 2014年第3期7卷 237-249页

作者： Zhen-chun HAO kai tong Xiao-li LIU Lei-lei ZHANG State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchChinese Academy of Sciences

Due to the high elevation, complex terrain, severe weather, and inaccessibility, direct meteorological observations do not exist over large portions of the Tibetan Plateau, especially the western part of it. Satellite rainfall estimates have been very important sources for precipitation information, particularly in rain gauge-sparse regions. In this study, Tropical Rainfall Measuring Mission （TRMM） Multi-satellite Precipitation Analysis （TMPA） products 3B42, RTV5V6, and RTV7 were evaluated for their applicability to the upper Yellow and Yangtze River basins on the Tibetan Plateau. Moreover, the capability of the TMPA products to simulate streamflow was also investigated using the Variable Infiltration Capacity （VIC） semi-distributed hydrological model. Results show that 3B42 performs better than RTVSV6 and RTV7, based on verification of the China Meteorological Administration （CMA） observational precipitation data. RTVSV6 can roughly capture the spatial precipitation pattern but overestimation exists throughout the entire study region. The anticipated improvements of RTV7 relative to RTVSV6 have not been realized in this study. Our results suggest that RTV7 significantly overestimates the precipitation over the two river basins, though it can capture the seasonal cycle features of precipitation. 3B42 shows the best performance in streamflow simulation of the abovementioned satellite products. Although involved in gauge adjustment at a monthly scale, 3B42 is capable of daily streamflow simulation. RTV5V6 and RTV7 have no capability to simulate streamflow in the upper Yellow and Yangtze River basins.

关键词： TMPA CMA precipitation data VIC hydrological model streamflow simulation upper Yellow and Yangtze River basins

The gut-liver axis mechanism of increased susceptibility to non-alcoholic fatty disease in female offspring rats with prenatal caffeine exposure

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Food Science and Human Wellness 2023年

作者： Qian Wang Xiaoqian Lu Wen Hu Cong Zhang Kexin Liu kai tong kaiqi Chen Hui Wang Department of Pharmacology Wuhan University School of Basic Medical Sciences Hubei Provincial Key Laboratory of Developmentally Originated Diseases

Caffeine intake during pregnancy is common， while its effect on gut microbiota composition of offspring and the relationship with susceptibility to adult diseases remains unclear. This study aimed to confirm the effects of prenatal caffeine exposure (PCE) on the gut microbiota composition and its metabolites in female offspring rats， and to further elucidate its underlying mechanism and intervention targets in adult non-alcoholic fatty disease (NAFLD). The results showed that the gut microbiota of PCE female offspring at multiple time points from infancy to adolescence were significantly changed with depletion of butyric acid-producing bacteria， leading to a decrease in butyric acid in adulthood. It was also found that PCE female offspring rats were sensitive to NAFLD induced by a postnatal high-fat diet (HFD)， which is mainly related to the enhancement of hepatic triglyceride synthesis function. Through mechanism exploration， we found that HFD further reduced the fecal and serum butyric acid levels in the PCE female offspring， which was significantly negatively correlated with hepatic SREBP-1c/FASN mRNA expression and triglyceride level. In vivo and in vitro experiments confirmed that sodium butyrate (NaB) supplementation could reduce hepatic lipid accumulation through MCT1/GPR109A-AMPK， thereby effectively decreasing the susceptibility to NAFLD in the PCE female offspring rats.

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Three-dimensional finite element analysis with different internal fixation methods through the anterior approach

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World Journal of Clinical Cases 2021年第8期9卷 1814-1826页

作者： Xian-Jin Xie Sheng-Lu Cao kai tong Zi-Yi Zhong Gang Wang Department of Orthopaedic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Orthopaedic Surgery Zhongnan HospitalWuhan UniversityWuhan 430000Hubei ProvinceChina

BACKGROUND With the modernization of society and transportation in the last decades in China,the incidence of high-energy trauma increased sharply in China,including that of acetabular fractures.AIM To establish different finite element models for acetabular posterior column fractures involving the quadrilateral area of the acetabulum.METHODS The three-dimensional models of the normal and fractured pelvis and the five internal fixations were established using the computed tomography data of the pelvis of a living volunteer.After the vertebral body model was inserted in the way of origin matching and all cancellous bones were copied using the duplicated cancellous bone model as the subtractive entity,the Boolean operation was performed on the pelvis model to obtain the model of the complete pelvis cortical and cancellous bones.RESULTS In the standing position,the maximum stress was 46.21 MPa.In the sitting position,the sacrum bore the simulated gravity load at the upper end.When comparing the five fixations,there were no significant differences in the stress mean values among groups(sitting:P=0.9794;standing:P=0.9741).In terms of displacement,the average displacement of the internal iliac plate group was smaller than that of the spring plate group(P=0.002),and no differences were observed between the other pairs of groups(all P>0.05).In the standing position,there were no significant differences in the mean value of displacement among the groups(P=0.2985).It can be seen from the stress nephogram of the internal fixations in different positions that the stress of the internal fixation was mainly concentrated in the fracture segment.CONCLUSION There were no significant differences among the fixations for acetabular posterior column fractures involving the quadrilateral area of the acetabulum.

关键词： Acetabulum Hip fractures Analysis Finite element Fracture fixation Orthopedic fixation devices

基于网格搜索优化支持向量机多分类参数识别不同工艺酱酒的应用研究

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中国酿造 2024年第6期43卷 213-217页

作者：陈旭东许忠平童凯王德良四川轻化工大学生物工程学院四川宜宾644005 中国食品发酵工业研究院有限公司北京100015 国家酒类品质与安全国际联合研究中心北京100015 天津科技大学生物工程学院天津300457

为提升支持向量机(SVM)在不同工艺酱酒分类预测中的准确度,该实验利用网格搜索优化支持向量机参数,建立最优参数的支持向量机分类预测模型。通过对不同工艺酱香型白酒客观结构特征定量分析,将提取的特征信息数据经过预处理(异常值处理... 详细信息

为提升支持向量机(SVM)在不同工艺酱酒分类预测中的准确度,该实验利用网格搜索优化支持向量机参数,建立最优参数的支持向量机分类预测模型。通过对不同工艺酱香型白酒客观结构特征定量分析,将提取的特征信息数据经过预处理(异常值处理、归一化操作等)后存储为样本数据集。其中样本数据分为训练样本与测试样本,通过训练样本对最优参数的SVM白酒品牌分类预测模型进行训练,测试样本对模型进行预测分类。经过试验验证,该模型的不同工艺分类识别率达到94.44%,较传统的SVM等分类算法能够快速、有效地对不同工艺的酱酒进行分类识别,显著改善分类的精度,改进后的方法实现过程也比较简单。

关键词：不同工艺酱酒支持向量机网格搜索分类预测

数字化智慧建造管理平台在建筑施工中的探索与应用

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智能建筑与智慧城市 2024年第6期 92-94页

作者：李玺武开通贾琦甘肃一安建设科技集团有限公司甘肃省建筑科学研究院(集团)有限公司

当前,我国建筑业复杂度和规模不断增加,建设工程全过程服务内容越来越多,技术难度和要求也日益增高。传统模式在速度、可靠性及经济可行性方面已很难适应现代化建设与发展要求。采用5G、BIM及物联网等技术,可以打造符合工程项目的数字... 详细信息

当前,我国建筑业复杂度和规模不断增加,建设工程全过程服务内容越来越多,技术难度和要求也日益增高。传统模式在速度、可靠性及经济可行性方面已很难适应现代化建设与发展要求。采用5G、BIM及物联网等技术,可以打造符合工程项目的数字化智慧建造工程管理平台,实现建筑施工全过程、全要素、全参与方的数字化、智能化,提高项目的信息化管理水平,切实保障工程项目的施工质量和要求,从而推进建筑产业智能化发展。

关键词：项目管理数字化智慧建造管理平台智能化

Simple and rapid conversion of silicon carbide to nanodiamonds at ambient pressure

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Journal of Materials Science & Technology 2021年第35期94卷 230-238页

作者： Cheng Yang Bingqiang Wei Kejian He Ping Xu Xiangmin Xie kai tong Chen Zeng Yafeng Wang Xiaodong Wang Jinping Liu Mingyu Zhang Zhe'an Su Qizhong Huang State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Advanced Research Center.Central South University Changsha 410083China Hunan Changyu Science and Technology Development Co. Ltd.Changsha 410600China

Nanodiamonds(NDs)were prepared under ambient pressure by sublimation decomposition of silicon carbide in an intermediate frequency furnace for only 8 min.The synthesis proceeded in the temperature range of 2600-2800℃ without any catalyst or highly active gas components(such as H2,alkane,and halogen).The conversion began at 2600℃ and produced NDs with particle sizes in the range of 1-5 nm with a uniform particle shape and excellent dispersion.The linear reaction kinetics allowed for rapid transformation to any depth with reasonable control of the temperature.The linear rate constant(K_(l))for the reaction at 2800℃ was 37.5 mm/h,which is 31.2 times that of the reaction at 2600℃.The Si C sublimation decomposition produced carbon atoms that filled the Si C lattice vacancies or were combined with the suspended carbon chain bonds to form sp3 carbon,while the diffusion of amorphous carbon atoms promoted nucleation and growth of diamond.High-resolution transmission electron microscopy analysis indicated that the NDs were separated from the Si C matrix by break-off due to propagation of the reaction front.This Si C sublimation decomposition method is considered simple,fast,environmentally friendly and promising for industrial-scale production.

关键词： n-diamond SiC Nanodiamond Sublimation decomposition