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Association of Genetic Polymorphisms with Age at Onset in Han Chinese Patients with Bipolar Disorder

2009年中国运动医学与关节镜外科学术大会

作者：谢永廉 Ho Pak Cheong Hung Leung Lim chan kai Ming Department of Orthopaedics and Traumatology Prince of Wales HospitalThe Chinese University of Hong Kong

＜正＞Triangular fibrocartilage complex（TFCC）is the most important static stabilizer for the distal radioulnar *** supports the ulnar carpus and stabilizes the wrist during forearm *** is composed of an articular di...

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Neuroscience Bulletin 2019年第4期35卷 591-594页

作者： Shao-Hua Hu Yu-Qing Han Ting-Ting Mou Man-Li Huang Jian-Bo Lai Chee H Ng Jing Lu Qiao-Qiao Lu Qiu-Yan Lin Yu-Zhi Zhang Jian-Bo Hu Ning Wei Wei-Juan Xu Wei-Hua Zhou Jing-kai Chen chan-chan Hu Xiao-Yi Zhou Shao-Jia Lu Yi Xu Department of Psychiatry the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310058 China The Key Laboratory of Mental Disorder Management in Zhejiang Province Hangzhou 310003 China Brain Research Institute of Zhejiang University Hangzhou 310003 China Mental Health Center Zhejiang Xiaoshan Hospital Hangzhou 311200 China Department of Psychiatry University of Melbourne Melbourne Victoria 3010 Australia

Dear Editor,Bipolar disorder (BD) is a chronic and disabling disorder characterized by manic, hypomanic, or depressive episodes, with an estimated lifetime prevalence ranging from 1% to 5%. Globally, it is a leading c... 详细信息

关键词： Association Genetic Polymorphisms Bipolar Disorder

A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1042-1049页

作者： Jieling Xiao Cheng-Han Ng Yip-Han Chin Darren Jun Hao Tan Wen-Hui Lim Grace Lim Jingxuan Quek Ansel Shao Pin Tang kai-En chan Rou-Yi Soong Nicholas Chew Benjamin Tay Daniel Q.Huang Nobuharu Tamaki Roger Foo Mark Y.chan Mazen Noureddin Mohammad Shadab Siddiqui Arun J.Sanyaland Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingapore Lee Kong Chian School of Medicine Nan-yang Technological UniversitySingapore Department of Cardiology National University Heart CenterNational University HospitalSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Center for Organ Transplantation National University Health SystemSingapore NAFLD Research Center Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of California at San DiegoLa JollaCAUSA Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyoJapan Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehen-sive Transplant CenterCedars-Sinai Medical CenterLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background and Aims:Pharmaceutical therapy for NASH is associated with lipid modulation,but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness.A network meta-analysis was conducted to compare NASH drug classes in lipid ***:Online databases were searched for randomized controlled trails(RCTs)evaluating NASH treatments in biopsy-proven NASH *** were classified into four groups:(1)inflammation,(2)energy,(3)bile acids,and(4)fibro-sis based on the mechanism of action.A Bayesian network analysis was conducted with outcome measured by mean difference(MD)with credible intervals(Crl)and surface un-der the cumulative ranking curve(SUCRA).Results:Forty-four RCTs were included in the *** acid modulat-ing treatments(MD:0.05,Crl:0.03-0.07)were the best treatment for improvement in high-density lipid(HDL)cho-lesterol,followed by treatments modulating energy(MD:0.03,Crl:0.02-0.04)and fibrosis(MD:0.01,Crl:−0.12 to 0.14)compared with *** top three treatments for reduction in triglycerides were treatments modulating energy(MD:−0.46,Crl:−0.49 to−0.43),bile acids(MD:−0.22,Crl:−0.35 to−0.09),and inflammation(MD:−0.08,Crl:−0.13 to−0.03)compared with *** found treatment modulating fibrosis(MD:−1.27,Crl:−1.76 to−0.79)was the best treatment for reduction in low-density lipid(LDL)cholesterol followed by treatment modulating in-flammation(MD:−1.03,Crl:−1.09 to−0.97)and energy(MD:−0.37,Crl:−0.39 to−0.34)compared with placebo,but LDL cholesterol was worsened by treatments modulat-ing bile ***:Network analysis comparing the class effects of dyslipidemia modulation in NASH found that treatment targets can include optimization of athero-genic *** studies are required to evaluate the cardiovascular outcomes.

关键词： Lipid modulation NASH Dyslipidemia

Bone morphogenetic protein 2 promotes transforming growth factor β3-induced chondrogenesis of human osteoarthritic synovium-derived stem cells

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Chinese Medical Journal 2010年第21期123卷 3040-3048页

作者： RUI Yun-feng DU Lin WANG You WANG Yang LUI Pauline po-yee TANG Ting-ting chan kai-ming DAI Ke-rong Department of Orthopaedics Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 China Shanghai Key Laboratory of Orthopaedic Implant Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 China Department of Orthopaedics and Traumatology Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China The Hong Kong Jockey Club Sports Medicine and Health Sciences Centre Faculty of Medicine The Chinese University of Hong Kong Hong Kong SAR China Program of Stern Cell and Regeneration School of Biomedical Science The Chinese University of Hong Kong Hong Kong SAR China

Background Synovium-derived stem cells （SDSCs） with higher chondrogenic potential are attracting considerable attention as a cell source for cartilage regeneration. We investigated the effect of bone morphogenetic protein 2 （BMP-2） on transforming growth factor beta3 （TGF-β3）-induced chondrogenesis of SDSCs isolated from human osteoarthritic synovium in a pellet culture system. Methods The clonogenicity, stem cell marker expression and multi-differentiation potential of isolated SDSCs were determined by colony forming unit assay, flow cytometry and specific staining including alizarin red S, Oil red O and alcian blue staining, respectively. SDSCs pellet was cultured in chondrogenic medium with or without TGF-β3 or/and BMP-2. At day 21, the diameter and the weight of the pellets were measured. Chondrogenic differentiation of SDSCs was evaluated by Safranin O staining, immunohistochemical staining of collagen type Ⅱ, sulfated glycosaminoglycan （sGAG） synthesis and mRNA expression of collagen type Ⅱ, aggrecan, SOX9, link-protein, collagen type X and BMP receptor Ⅱ. Results Cells isolated under the optimized culturing density （104/60 cm2） showed clonogenicity and multi-differentiation potential. These cells were positive （〉99%） for CD44, CD90, CD105 and negative （〈10%） for CD34 and CD71. SDSCs differentiated to a chondrocytic phenotype in chondrogenic medium containing TGF-β3 with or without BMP-2. Safranin O staining of the extracellular matrix was positive and the expression of collagen type Ⅱ was detected. Cell pellets treated with TGF-β3 and BMP-2 were larger in diameter and weight, produced more sGAGs, and expressed higher levels of collagen type Ⅱ and other chondrogenic markers, except COL10A1, than medium with TGF-β3 alone. Conclusions SDSCs could be isolated from human osteoarthritic synovium. Supplementation with BMP-2 significantly promoted the in vitro TGF-β3-induced chondrogenic differentiation of SDSCs.

关键词： chondrogenesis synovial membrane mesenchymal stem cell osteoarthritis bone morphogenetic protein 2 transforming growth factor beta3

Serum insulin, insulin resistance, p-cell dysfunction, and gallstone disease among type 2 diabetics in Chinese population: A community-based study in Kinmen, Taiwan

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World Journal of Gastroenterology 2005年第45期11卷 7159-7164页

作者： Chi-Ming Liu Tao-Hsin Tung Shih-Tzer Tsai Jorn-Hon Liu Yeh-Kuang Tsai Victor Tze-kai Chen Tseng-Nip Tam Hsu-Feng Lu Kuang-Kuo Wang Chung-Te Hsu Hui-Chuan Shih De-Chuan chan Pesus Chou Community Medicine Research Center and Institute of Public Health National Yang-MingUniversity Cheng Hsin General Hospital Taipei Taiwan China Department of medicine Veterans GeneralHospital Taipei Taiwan China Cheng Hsin General Hospital Faculty ofMedicine School of Medicine National Yang-Ming UniversityTaipei Taiwan China University of California San Francisco SanFrancisco CA United States Cardinal Tien Hospital College ofMedicine Fu-Jen Catholic University National Defence MedicineCenter Taipei Taiwan China Cheng Hsin General Hospital Taipei Taiwan China Department of Nursing Kaohsiung MilitaryGeneral Hospital Kaohsing Taipei Taiwan China Division of General Surgery Tri-ServiceGeneral Hospital National Defence Medical Center TaipeiTaiwan China Community Medicine Research Center and Instituteof Public Health National Yang-Ming University Taipei TaiwanChina

AIM: To explore the association of serum insulin, insulin resistance, and β-cell dysfunction with gallstone disease (GSD) in type 2 diabetics. METHODS: We used a community-based study conducted between 1991 and 1993 in Kinmen, Taiwan to identify type 2 diabetics. A screening program for GSD was performed in 2001 by a panel of specialists who employed real-time ultrasound sonography to examine the abdominal region after the patient had fasted for at least 8 h. Screening was conducted in 2001 on 848 patients diagnosed with type 2 diabetes. The HOMA method was used to compare the profile differences for insulin resistance (HOMA IR) and β-cell dysfunction (HOMA β-cell). RESULTS: We studied 440 type 2 diabetics who attended sonography check-ups. After excluding eight insulin-treated diabetics, the prevalence of GSD among the remaining 432 was 13.9% (26/187) among males and 14.7% (36/245) among females. After adjustment for other GSD-associated risk factors in addition to age and obesity, GSD risk increased among females with levels of serum insulin [4th vs 1st quartile odds ratios (OR) = 4.46 (95%CI: 1.71-11.66)] and HOMA IR [4th vs 1st quartile OR = 4.46 (95%CI: 1.71-11.66)]. Better HOMA β-cell function was significantly related to decreased risk of GSD [4th vs 1st quartile OR = 0.16 (95%CI: 0.03-1.70)]. Among males, age and central obesity were the most significant risk factors for GSD. No association of GSD with serum insulin, HOMA IR, and HOMA β-cell was observed among males. CONCLUSION: Serum insulin, insulin resistance, and β-cell dysfunction are risk factors for GSD in females, but not males with type 2 diabetes.

关键词： Type 2 diabetes Gallstone disease Insulinresistance β-cell dysfunction Community-based study

SLIP PREVENTION IN WALKING-LOWER EXTREMITY BIOMEchanICS

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SLIP PREVENTION IN WALKING-LOWER EXTREMITY BIOMECHANICS

第23届国际运动生物力学学术年会

作者： Daniel Tik-Pui Fong Youlian Hong Jing-Xian Li kai-Ming chan Department of Orthopaedics and Traumatology The Chinese University of Hong Kong Department of Sports Science and Physical Education The Chinese University of Hong Kong School of Human Kinetics Faculty of Health ScienceUniversity of Ottawa

This study investigated the human slip prevention strategies when walking on slippery *** male subjects performed level walking without slips under sixteen simulated construction site ***,kinetics and electromyography parameters were *** slipperiness of the walkway conditions were quantified by the dynamic coefficient of friction（DCOF）.Gait changes in slippery condition included prolonged force and pressure exertion in hallux and lateral toes,more ankle plantarflexion moment during 30-50%stance,less knee extension moment during 10-30% stance,higher muscle activity at rectus femoris in late stance,and in gastrocnemius in swing *** strategies helped achieving walking without slips by reducing the RCOF from 0.188 to 0.092,which was just lower to the dropped available friction（DCOF=0.107）.

关键词： occupational slips and falls coefficient of friction gait adaptation

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换流变压器有载调压开关防爆试验研究与分析

高压电器 2024年第2期60卷 119-126页

作者：陈洪波曹培高凯曹燕明苏钟焕王群伟董弘川李凌南特变电工衡阳变压器有限公司湖南衡阳421007 国网上海市电力公司电力科学研究院上海200437 国网经济技术研究院有限公司北京100000 湖南大学电气与信息工程学院长沙410082

为研究有载调压开关的防爆能力,以换流变压器有载调压开关为研究对象,搭建了有载调压开关的防爆试验系统。在开关内部设置了一对电极,当试验大电流通过电极之间的细小铜丝使其发生熔断后,电极之间形成电弧通道。通过调整电弧电流、电弧... 详细信息

为研究有载调压开关的防爆能力,以换流变压器有载调压开关为研究对象,搭建了有载调压开关的防爆试验系统。在开关内部设置了一对电极,当试验大电流通过电极之间的细小铜丝使其发生熔断后,电极之间形成电弧通道。通过调整电弧电流、电弧间距、燃弧时长,从而获取了不同故障能量并测量了在此能量下的开关内的压力。计算并对比了在对应能量下开关油室的压力。试验研究表明:①开关的防爆能力有限,建议提高开关盖板强度,结合爆破膜对开关进行防爆;②为避免随着电弧能量增大使弧压变化过大,建议减小电极间距;③为避免电极烧蚀,建议使用比热容小、熔点低的材料,为保证电弧稳定,建议将电极改为半球形之间。

关键词：换流变压器有载调压开关燃弧防爆能量电极

Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

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Cellular & Molecular Immunology 2022年第5期19卷 588-601页

作者： Zi-Wei Ye Chon Phin Ong kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor Sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo chan Kelvin kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong Kong102 Pokfulam RoadPokfulamHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong102 Pokfulam RoadPokfulamHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong21 Sassoon RoadPokfulamHong KongChina

Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to ***,we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene,which encodes 2′-O-methyltransferase,is catalytically disrupted by a point *** virus,designated d16,was severely attenuated in hamsters and transgenic mice,causing only asymptomatic and nonpathogenic infection.A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters,thus preventing viral spread in a contact-based transmission *** also robustly stimulated humoral and cell-mediated immune responses,thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse *** neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 *** immunoglobulin A was detected in the blood and nasal wash of vaccinated *** work provides proof-of-principle evidence for harnessing NSP16-deficient SARS-CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain,to which new features might be introduced to improve safety,transmissibility,immunogenicity and efficacy.

关键词： Live attenuated vaccine NSP16 2'-O-methyltransferase T-cell response Mucosal immunity Sterilizing immunity

Diagnostic challenge of lipomatous uterine tumors in three patients

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World Journal of Radiology 2012年第2期4卷 58-62页

作者： Chi-Yeung Chu Yip-Kan Tang Tin-Sang Augustine chan Yu-Hon Wan kai-Hung Fung Department of Radiology Pamela Youde Nethersole Eastern Hospital Department of Radiology Union Hospital

Lipomatous uterine tumors are uncommon benign neoplasms, with incidence ranging from 0.03% to 0.2%. They can generally be subdivided into two types: pure or mixed lipomas. A third group of malignant neoplasm has been proposed, which is liposarcoma; however, this is very rare. In this article, we report three patients having lipomatous uterine tumors, including one uterine lipoma and two uterine lipoleiomyomas. All our patients are postmenopausal women, which is the typical presenting age group. They did not have any symptoms and the tumors were only found incidentally on imaging. However, in some patients, symptoms may uncommonly occur. If symptoms occur, these are similar to those of leiomyoma. We illustrate the imaging features of the tumors in our patients with ultrasound, computed tomography (CT) scan and magnetic resonance imaging (MRI). The tumor typically appears as a well-defined homogenously hyperechoic lesion on ultrasound. It shows fat density on CT scan and signal intensity of fat on MRI. MRI is the modality of choice because of its multiplanar capability and its ability to demonstrate fat component of the lesion, as illustrated in our cases. We also discuss the importance of differentiating lipomatous uterine tumors from other lesions, especially ovarian teratoma which requires surgical intervention. Despite the rarity and the common asymptomatic nature of the tumors, we believe that this series of three cases demonstrates a review of a rare tumor which provides important knowledge for patient management.

关键词： Uterus Uterine neoplasms Magnetic resonance imaging Leiomyoma Lipomatous