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Construction of an immune-related gene signature for overall survival prediction and immune infiltration in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 919-932页

作者： Xiao-Ting Ma Xiu Liu kai ou Lin Yang Department of Medical Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGRouND Treatment options for patients with gastric cancer(GC)continue to improve,but the overall prognosis is *** use of PD-1 inhibitors has also brought benefits to patients with advanced GC and has gradually become the new standard treatment option at present,and there is an urgent need to identify valuable biomarkers to classify patients with different characteristics into *** To determined the effects of differentially expressed immune-related genes(DEIRGs)on the development,prognosis,tumor microenvironment(TME),and treatment response among GC patients with the expectation of providing new biomarkers for personalized treatment of GC *** Gene expression data and clinical pathologic information were downloaded from The Cancer Genome Atlas(TCGA),and immune-related genes(IRGs)were searched from *** were extracted from the intersection of the differentially-expressed genes(DEGs)and IRGs *** enrichment pathways of key genes were obtained by analyzing the Kyoto Encyclopedia of Genes and Genomes(KEGGs)and Gene Ontology(GO)*** identify genes associated with prognosis,a tumor risk score model based on DEIRGs was constructed using Least Absolute Shrinkage and Selection Operator and multivariate Cox *** tumor risk score was divided into high-and lowrisk *** entire cohort was randomly divided into a 2:1 training cohort and a test cohort for internal validation to assess the feasibility of the risk *** infiltration of immune cells was obtained using‘CIBERSORT,’and the infiltration of immune subgroups in high-and low-risk groups was *** GC immune score data were obtained and the difference in immune scores between the two groups was *** We collected 412 GC and 36 adjacent tissue samples,and identified 3627 DEGs and 1311 IRGs.A total of 482 DEIRGs were *** analysis showed that DEIRGs were mainly distributed in immunoglobulin complexes,receptor ligand activity,and s

关键词： Differentially expressed immune-related gene Immunotherapy Gastric cancer Risk score

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Human epidermal growth factor receptor 2 expression level and combined positive score can evaluate efficacy of advanced gastric cancer

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World Journal of Clinical Oncology 2024年第5期15卷 635-643页

作者： Xiao-Ting Ma kai ou Wen-Wei Yang Bi-Yang Cao Lin Yang Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGRouND Although treatment options for gastric cancer(GC)continue to advance,the overall prognosis for patients with GC remains *** present,the predictors of treatment efficacy remain controversial except for high microsatellite *** To develop methods to identify groups of patients with GC who would benefit the most from receiving the combination of a programmed cell death protein 1(PD-1)inhibitor and *** We acquired data from 63 patients with human epidermal growth factor receptor 2(HER2)-negative GC with a histological diagnosis of GC at the Cancer Hospital,Chinese Academy of Medical Sciences between November 2020 and October *** of the patients screened received a PD-1 inhibitor combined with chemotherapy as the first-line *** As of July 1,2023,the objective response rate was 61.9%,and the disease control rate was 96.8%.The median progression-free survival(mPFS)for all patients was 6.3 *** median overall survival was not *** analysis showed that patients with a combined positive score(CPS)≥1 exhibited an extended trend in progression-free survival(PFS)when compared to patients with a CPS of 0 after receiving a PD-1 inhibitor combined with oxaliplatin and tegafur as the first-line *** exhibited a trend for prolongation as the expression level of HER2 *** on PFS,we divided patients into two groups:A treatment group with excellent efficacy and a treatment group with poor *** mPFS of the excellent efficacy group was 8 months,with a mPFS of 9.1 months after excluding a cohort of patients who received interrupted therapy due to *** mPFS was 4.5 months in patients in the group with poor efficacy who did not receive *** good/poor efficacy as the endpoint of our study,univariate analysis revealed that both CPS score(P=0.004)and HER2 expression level(P=0.015)were both factors that exerted significant influence on the efficacy of treatment the combina

关键词： First line Gastric cancer Human epidermal growth factor receptor 2 Programmed cell death protein 1 Progression-free survival

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热处理对激光选区熔化高强铝合金组织及性能影响

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热加工工艺 2024年第6期53卷 35-40,47页

作者：李达吕非周凯刘瑞康田宗军南京航空航天大学机电学院江苏南京210016 南京先进激光技术研究院激光装备及工艺技术研发中心江苏南京210038 中国科学院上海光学精密机械研究所上海市全固态激光器与应用技术重点实验室上海201800

为了充分发挥高强铝合金材料的性能潜力,从热处理强化角度出发,选择了4种不同的热处理制度,并从物相、组织、性能对热处理后的铝合金SLM成形样件展开研究,最终筛选出最适合的热处理制度。结果表明,300℃/6 h/炉冷的强化时效(EA)热处理... 详细信息

为了充分发挥高强铝合金材料的性能潜力,从热处理强化角度出发,选择了4种不同的热处理制度,并从物相、组织、性能对热处理后的铝合金SLM成形样件展开研究,最终筛选出最适合的热处理制度。结果表明,300℃/6 h/炉冷的强化时效(EA)热处理后的样件具有最高的抗拉强度575 MPa,较未经热处理的原SLM成形件的抗拉强度提高25%,伸长率有一定程度的下降但仍满足正常需求。强化机制主要为:过饱和Mn元素固溶体带来的固溶强化、细密且具有一定热稳定性微观组织形貌带来的细晶强化以及热处理后生成的纳米级Al3Sc相沉淀粒子带来的第二相强化。

关键词：激光选区熔化高强铝合金热处理显微组织拉伸性能

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MOCVD技术在MgO基底沉积YBCO薄膜缓冲层LaMnO_(3)研究

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低温与超导 2024年第2期52卷 22-31页

作者：陈建华王其琛夏钰东赵睿鹏欧凯王维陶伯万西南交通大学物理科学与技术学院成都610031 松山湖材料实验室东莞523808 电子科技大学电子薄膜与集成器件国家重点实验室成都611731

在MgO基底使用金属有机化学气相沉积(MOCVD)法直接制备YBa_(2)Cu_(3)O_(7-δ)会出现MgO和YBCO晶格失配较大的问题,从而影响薄膜的生长和超导器件的制备。缓冲层的引入是一种可靠的解决手段。本文基于MOCVD技术,在MgO基底上生长LaMnO_(3... 详细信息

在MgO基底使用金属有机化学气相沉积(MOCVD)法直接制备YBa_(2)Cu_(3)O_(7-δ)会出现MgO和YBCO晶格失配较大的问题,从而影响薄膜的生长和超导器件的制备。缓冲层的引入是一种可靠的解决手段。本文基于MOCVD技术,在MgO基底上生长LaMnO_(3)缓冲层,用以解决YBCO薄膜混合生长模式的问题,并通过改变MOCVD系统的氧气流量和沉积温度等沉积参数,采用如XRD,SEM,AFM等多种分析测试方法研究LMO缓冲层的结构取向和表面形貌。结果表明:当沉积温度为800℃,氧气流量为1000 sccm时,所制备的LMO缓冲层的结构取向最佳,缓冲层上生长的YBCO薄膜Ф扫描曲线出现四个相距90°的独立尖峰,YBCO在LMO缓冲层上只有一种生长方向,LMO缓冲层能够解决YBCO在MgO衬底上混合生长模式的问题,从而提高YBCO薄膜质量和性能。

关键词： MOCVD YBCO LaMnO_(3) 缓冲层

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进口再生纸浆机械强度的快速检测

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中华纸业 2024年第7期45卷 87-90页

作者：吕晓峰孙燕萍程正柏周平艳欧凯浙江景兴纸业股份有限公司企业研究院浙江平湖314214

对国内外的回收纸板纤维和进口商品再生纸浆进行了检测分析,开发了一种进口再生纸浆机械强度的快速检测方法。

关键词：废纸进口再生纸浆纤维形态机械强度快速检测

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Smart materials for safe lithium-ion batteries against thermal runaway

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Journal of Energy Chemistry 2024年第7期94卷 360-392页

作者： Yu ou Pan Zhou Wenhui Hou Xiao Ma Xuan Song Shuaishuai Yan Yang Lu kai Liu Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

In recent years,the new energy storage system,such as lithium ion batteries(LIBs),has attracted much *** order to meet the demand of industrial progress for longer cycle life,higher energy density and cost efficiency,a quantity of research has been conducted on the commercial application of ***,it is difficult to achieve satisfying safety and cycling performance *** may be thermal runaway(TR),external impact,overcharge and overdischarge in the process of battery abuse,which makes the safety problem of LIBs more *** this review,we summarize recent progress in the smart safety materials design towards the goal of preventing TR of LIBs reversibly from different abuse *** from smart responsive materials and novel structural design,the safety of LIBs can be improved a *** expect to provide a comprehensive reference for the development of smart and safe lithium-based battery materials.

关键词： Lithium ion batteries(LIBs) Thermal runaway(TR) Smart materials Safe batteries Solid electrolyte interface(SEI)

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一步TCVD法制备大面积碳纳米管冷阴极及其场致发射性能研究

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四川大学学报（自然科学版） 2024年第3期61卷 290-296页

作者：孙泽奇王辉张远鹏唐永亮吕文梅刘庆想欧凯夏钰东张彦博薛嫱西南交通大学物理科学与技术学院成都610031 西南交通大学材料科学与工程学院成都610031

本文提出一步热化学气相沉积法(TCVD)热解二茂铁,并直接在硅衬底上制备大面积(1 cm^(2))、高质量碳纳米管(CNTs)场致发射冷阴极阵列的制备工艺.通过调控二茂铁的热解温度(650~1000℃),获得了最佳的二茂铁的碳转化效率以及高结晶度的碳... 详细信息

本文提出一步热化学气相沉积法(TCVD)热解二茂铁,并直接在硅衬底上制备大面积(1 cm^(2))、高质量碳纳米管(CNTs)场致发射冷阴极阵列的制备工艺.通过调控二茂铁的热解温度(650~1000℃),获得了最佳的二茂铁的碳转化效率以及高结晶度的碳纳米管阵列.研究了不同热解温度下制备的碳纳米管微观形貌及其对场致发射性能的影响机制.场致发射实验测试表明在热解温度850℃条件下制备的碳纳米管冷阴极其开启电场(10μA/cm^(2))和阈值电场(1 mA/cm^(2))分别为1.32 V/μm和2.64 V/μm,最大电流密度为14.51 mA/cm^(2),对应的场增强因子为13267,表现出良好的场发射性能.本文提出的一步制备碳纳米管冷阴极阵列的制备方法无需任何蚀刻气体或光刻图案工艺,该方法安全、经济、可重复性好,在碳纳米管场发射冷阴极领域具有广阔的应用前景.

关键词：碳纳米管化学气相沉积法二茂铁热解温度场致发射

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Angular momentum holography via a minimalist metasurface for optical nested encryption

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Light(Science & Applications) 2023年第4期12卷 646-656页

作者： Hui Yang Peng He kai ou Yueqiang Hu Yuting Jiang Xiangnian ou Honghui Jia Zhenwei Xie Xiaocong Yuan Huigao Duan National Research Center for High-Efficiency Grinding College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Nanophotonics Research Center Shenzhen Key Laboratory of Micro-scale Optical Information TechnologyInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060GuangdongChina Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300Guangdong ProvinceChina

Metasurfaces can perform high-performance multi-functional integration by manipulating the abundant physical dimensions of light,demonstrating great potential in high-capacity information *** orbital angular momentum(OAM)and spin angular momentum(SAM)dimensions have been respectively explored as the independent carrier for information ***,fully managing these two intrinsic properties in information multiplexing remains ***,we propose the concept of angular momentum(AM)holography which can fully synergize these two fundamental dimensions to act as the information carrier,via a single-layer,non-interleaved *** underlying mechanism relies on independently controlling the two spin eigenstates and arbitrary overlaying them in each operation channel,thereby spatially modulating the resulting waveform at *** a proof of concept,we demonstrate an AM meta-hologram allowing the reconstruction of two sets of holographic images,i.e.,the spin-orbital locked and the spin-superimposed ***,leveraging the designed dual-functional AM meta-hologram,we demonstrate a novel optical nested encryption scheme,which is able to achieve parallel information transmission with ultra-high capacity and *** work opens a new avenue for optionally manipulating the AM,holding promising applications in the fields of optical communication,information security and quantum science.

关键词： momentum dimensions orbital

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All-dielectric metasurface for fully resolving arbitrary beams on a higher-order Poincaré sphere

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Photonics Research 2021年第3期9卷 331-343页

作者： Hui Yang Zhenwei Xie Guanhai Li kai ou Feilong Yu Hairong He Hong Wang Xiaocong Yuan Nanophotonics Research Center Shenzhen Key Laboratory of Microscale Optical Information TechnologyInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore National Laboratory for Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

Characterizing the amplitude, phase profile, and polarization of optical beams is critical in modern optics. With a series of cascaded optical components, one can accurately resolve the optical singularity and polarization state in traditional polarimetry systems. However, complicated optical setups and bulky configurations inevitably hinder future applications for integration. Here, we demonstrate a metadevice that fully resolves arbitrary beams on a higher-order Poincaré sphere(HOPS) via a single-layer all-silicon metasurface. The device is compact and capable of detecting optical singularities and higher-order Stokes parameters simultaneously through a single intensity measurement. To verify the validity of the proposed metadevice, different beams on HOPS0,0 and HOPS1,-1 are illuminated on the metadevices. The beams are fully resolved, and the reconstructed higher-order Stokes parameters show good agreement with the original ones. Taking the signal-to-noise ratio into account, the numerical simulations indicate that the design strategy can be extended to fully resolve arbitrary beams on HOPS with order up to 4. Because of the advantages of compact configuration and compatibility with current semiconductor technology, the metadevice will facilitate potential applications in information processing and optical communications.

关键词： Poincaré arbitrary singularity

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Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

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Neural Regeneration Research 2024年第10期19卷 2249-2258页

作者： kai Li Zhanpeng Feng Zhiwei Xiong Jun Pan Mingfeng Zhou Weizhao Li Yichao ou Guangsen Wu Mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng Department of Neurosurgery Institute of Brain DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis.

关键词： arginine vasopressin growth hormone hypothalamo-neurohypophyseal system hypothalamus injury insulin-like growth factor 1 oxytocin regeneration

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