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Brassiere wearing and breast cancer risk:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2015年第4期3卷 193-205页

作者： Winnie KW So Dorothy NS Chan Yan Lou kai-chow choi Carmen WH Chan Kristina Shin Ava Kwong Diana TF Lee The Nethersole School of Nursing The Chinese University of Hong KongNew Territories Nursing Department School of MedicineHangzhou Normal University Institute of Textiles and Clothing the Hong Kong Polytechnic University Breast Surgery Division Department of SurgeryQueen Mary Hospital

AIM： To evaluate existing evidence for the association between different type of brassiere exposures and the risk of breast ***： Ovid Medline, CINAHL, Cochrane Data Base of Systematic Reviews, Pubmed, Scopus, Proquest, Sciencedirect, Wiley Online Library, WanFang Data, Hong Kong Index to Chinese Periodicals, China Journal Net, Chinese Medical Current Contents, Chinese Biomedical Literature Database, China Academic Journals Full-Text database, Taiwan Electronic Periodical Services and HyRead; reference lists of published studies; origi-nal research studies published in English or Chinese examining the association between type and duration of brassiere-wearing and breast cancer risk. Data were abstracted by a frst reviewer and verifed by a second. Study quality was rated according to predefned criteria. “Fair” or “good” quality studies were included. Results were summarised by meta-analysis whenever adequate material was ***： Twelve case-control studies were included in the review. Meta-analysis showed brassiere wearing during sleep was associated with a two times ofincreased odds. CONCLUSION： The present review demonstrates insuffcient evidence to establish a positive association between the duration and type of brassiere wearing and breast cancer. Further research is essential; specifcally, a large-scale epidemiological study of a better design is needed to examine the association between various forms of brassiere exposure in detail and breast cancer risk, with adequate control of confounding variables.

关键词： Breast cancer Brassiere Risk factors Systematic review Meta-analysis

Uptake of prostate cancer screening and associated factors among Chinese men aged 50 or more: a population-based survey

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Cancer Biology & Medicine 2014年第1期11卷 56-63页

作者： Winnie K.W.So kai chow choi Winnie P.Y.Tang Paul C.W.Lee Ann T.Y.Shiu Simone S.M.Ho Helen Y.L.Chan Wendy W.T.Lam William B.Goggins Carmen W.H.Chan The Nethersole School of Nursing The Chinese University of Hong Kong Department of Community Medicine The University of Hong Kong The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong

Objective: To investigate the uptake rate of prostate specific antigen(PSA) testing among Hong Kong Chinese males aged 50 or above, and identify factors associated with the likelihood of undergoing a PSA ***: A population-based telephone survey was conducted in Hong Kong in 2007. The survey covered demographic information, perceived health status, use of complementary therapy, cancer screening behavior, perceived susceptibility to cancer and family history of cancer. Descriptive statistics, percentages and logistic regression analysis were used for data ***: A total of 1,002 men aged 50 or above took part in the study(response rate =67%), and the uptake rate of PSA testing was found to be 10%. Employment status, use of complementary therapy, perceiving regular visits to a doctor as good for health and the recommendations of health professionals were significant factors associated with PSA ***: The uptake rate of PSA testing in the study population was very low. Among all the factors identified, recommendations from health professionals had the strongest association with the uptake of PSA testing, and they should therefore take an active role in educating this population about cancer prevention and detection.

关键词： Prostatic neoplasms early detection of cancer prostate-specific antigen (PSA) population-based survey

Supportive care needs and health-related quality of life among Chinese lung cancer survivors

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Advances in Lung Cancer 2012年第2期1卷 5-12页

作者： Dorothy Ngo-Sheung Chan kai-chow choi Carmen Wing-Han Chan Rayman Wai-Man Wan Suzanne So-Shan Mak Eliza Mi-Ling Wong Sek-Ying Chair Winnie Kwok-Wei So Department of Clinical Oncology Prince of Wales Hospital Hong Kong China The Nethersole School of Nursing The Chinese University of Hong Kong Hong Kong China

Purpose: The purpose of this study was to explore the supportive care needs and health-related quality of life (HRQoL) of lung cancer survivors, and to identify the association between patient characteristics, HRQoL and supportive care needs. Method: This was a sub-study of a larger scale survey of cancer survivors’ supportive care needs. A total of 48 lung cancer survivors were recruited from a regional teaching hospital, and a three-part structured questionnaire was used to collect 1) socio-demographic and clinical characteristics, 2) supportive care needs and 3) health-related quality of life data. Results: The three most commonly reported unmet needs were all in the health-system information domain: 1) being informed about your results as soon as possible (58%), 2) being informed about cancer which is under control or diminishing (50%), and 3) being informed about things you can do to help yourself get well (46%). The second most common unmet need domain was access to healthcare and ancillary support services. The survivors generally reported satisfactory HRQoL. However, household income and unmet physical and psychological needs were independently associated with HRQoL among these survivors. Conclusion: The high unmet needs in the health-system information area call for a review of the content and amount of information provided to lung cancer survivors. In addition, more attention should be given to lung cancer survivors with low incomes but high physical and psychological unmet needs, who require appropriate follow-up and long-term care of a physical, social and psychological kind.

关键词： Supportive Care Needs Health-Related Quality of Life Lung Cancer Survivor

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Type D personality negatively associated with self-care in Chinese heart failure patients

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Journal of Geriatric Cardiology 2016年第5期13卷 401-407页

作者： Xi CAO Xiu-Hua WANG Eliza ML Wong choi kai chow Sek Ying Chair The Nethersole School of Nursing The Chinese University of Hong Kong Hong Kong China Nursing School Central South University Changsha China

Background Little is known about the association between type D personality and self-care behaviors in heart failure （HF） patients. We examined the effect of type D personality on self-care behaviors and self-efficacy among Chinese HF patients. Methods A cross-sectional study with a convenience sample was conducted. All participants completed the questionnaires of the self-care of HF index （V6） and type D personality scale. Demographic and clinical variables were obtained from medical records and patient interviews. The me- thods used for data analysis included descriptive analysis, independent-sample t-test, Z2 test, and multiple linear regression. Results A total of 127 HF patients were included and 61.4% of them were male. The average age for this study sample was 64.9± 12.34 years. The majority of the participants were in a New York Heart Association class III or IV （87%）, and the average length of living with HF was 38.24 ± 41.1 months. A total of 33.1% of the participants were identified as having type D personality. No significant differences were determined in the demographic and clinical variables between type D and non-type D patients, except for the mean age and the length of living with HF. Type D patients were younger and had a shorter time of living with HF than their non-type D counterparts. Multiple regression demonstrated significant associations between type D personality and self-care maintenance and self-efficacy after adjusting the demographic and clinical factors. However, type D personality was not significantly associated with self-care management behaviors. Conclusions Type D personality was negatively related to self-care maintenance and self-efficacy in Chinese HF patients. Future study is warranted to develop a tailored intervention to improve engagement in self-care behaviors in HF patients with type D personality.

关键词： Heart failure Self care Self-efficacy Type D personality

政府卫生支出能否影响患者就医选择?——基于北京市郊区的实证研究

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中国全科医学 2024年第4期27卷 420-426页

作者：吕博孟开首都医科大学公共卫生学院北京市100069 首都医科大学附属北京天坛医院高质量发展研究中心北京市100070

背景我国优质医疗资源集中在大城市的城区,患者倾向到大医院就医,产生了不合理就医现象。为此,近几年政府加大财政支出以加强基层医疗卫生机构的建设,旨在促进患者合理就医,实现分级诊疗。目的分析郊区政府卫生支出对郊区患者就医选择... 详细信息

背景我国优质医疗资源集中在大城市的城区,患者倾向到大医院就医,产生了不合理就医现象。为此,近几年政府加大财政支出以加强基层医疗卫生机构的建设,旨在促进患者合理就医,实现分级诊疗。目的分析郊区政府卫生支出对郊区患者就医选择的影响,为推进分级诊疗制度改革提供参考依据。方法于2022-02-10选取2015—2017年北京市10个郊区的患者到北京市属医院、郊区医院和郊区基层医疗卫生机构的门、急诊人次数及住院人次数作为被解释变量,选取人均政府卫生支出作为解释变量,选取各郊区常住人口数、人均国内生产总值(GDP)和每千人口卫生技术人数作为控制变量。采用chow检验和Hausman检验选择恰当的数据分析模型(混合回归模型、固定效应模型和随机效应模型),以探讨北京市郊区患者到市属医院、郊区医院、郊区基层医疗卫生机构就医的影响因素。结果固定效应模型分析北京市郊区患者到市属医院和郊区医院就医选择影响因素的结果显示,人均政府卫生支出、每千人口卫生技术人员数、人均GDP、常住人口数不是郊区患者到市属医院门、急诊和住院就医的影响因素(P>0.05),人均政府卫生支出和人均GDP是郊区患者到郊区医院门、急诊就医的影响因素(P<0.05);随机效应模型分析北京市郊区患者到郊区基层医疗卫生机构就医选择影响因素的结果显示,常住人口数、人均GDP和人均政府卫生支出是郊区患者到郊区基层医疗卫生机构门、急诊就医的影响因素(P<0.05)。结论目前大医院对患者的“虹吸”现象依然存在,政府卫生支出未对郊区患者到市属医院就医产生明显影响。但是增加政府卫生支出能够促进郊区患者在区域内就医,有助于实现分级诊疗。每千人口卫生技术人员数对患者就医选择未产生明显影响,建议进一步增加郊区政府卫生支出,提升郊区医务人员医疗服务能力,促进患者在区域内就医。

关键词：卫生经费支出分级诊疗制度政府卫生支出就医选择影响因素分析

Spectral Properties and Photochromic Characteristics of Spiropyran Dyes

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Chemical Research in Chinese Universities 2006年第4期22卷 505-509页

作者： SHEN kai-hua HAN Jian-guo ZHANG Gang choi Dong-hoon The State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China The Key Laboratory of Cellulose and Lignocellulosics Chemistry Guangzhou Institute of Chemistry Chinese Academy of Sciences Guangzhou 510650 P. R. China Polymer and Fiber Material Engineering Kyunghee University Kyong Kido 449-701 Korea

A bis-benzospiropyran（BBSP） and nitro-substituted indoline spirobenzopyrans（SBP） were prepared by following a simple procedure. The reaction mechanism of synthesizing bis-benzospiropyran is discussed. A comparative analysis of the spectral and photochromic properties between SBP and BBSP was carried out with the aid of a PMMA film. The results indicate that chemical structures and UV irradiation played an important role in the spectral and photochromic properties of SBP and BBSP, which would readily affect λmax of the colored forms and the reversibility. The IR spectra and ^1H NMR spectra of these compounds are used to interpret the photochromic phenomena under different UV irradiation and determine the configurations of SBP and BBSP.

关键词： Photochromism Spiropyran UV radiation Protonation

Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic,histological,and urine analysis

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Nano Research 2022年第4期15卷 3356-3366页

作者： Liping Wang Wenqiong Su Khan Zara Ahmad Xin Wang Ting Zhang Youyi Yu Edward kai-Hua chow Dean Ho Xianting Ding State Key Laboratory of Oncogenes and Related Genes Institute for Personalized MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Cancer Science Institute of Singapore Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore The N.1 Institute for Health(N.1) National University of SingaporeSingapore 117456Singapore The Institute for Digital Medicine(WisDM) National University of SingaporeSingapore 117456Singapore Department of Pharmacology National University of SingaporeSingapore 117597Singapore Department of Biomedical Engineering National University of SingaporeSingapore 117583Singapore

While doxorubicin(DOX)is one of the most common chemotherapeutic drugs for treating cancer,use of DOX must be managed carefully due to dose-related ***(ND)drug delivery system conjugated with DOX(NDX)has been reported to enhance treatment efficacy and attenuate toxicity in murine cancer *** addition,extensive biocompatibility studies indicate that NDs seem to be well tolerated in non-human *** the clinical translation of NDX,it is necessary to verify the safety of ND in large *** of nanomedicine drug safety for large animal are not commonly reported,and this work represents a key milestone in bridging earlier advances towards clinical ***,NDs’safety as a drug-delivery platform was evaluated in Naïve Beagle *** study is performed with DOX,ND,and NDX in a dual-gender animal model using intravenous(IV)injection and hepatic portal vein(HPV)injection *** dogs are monitored for their health phenotype changes in continuous 5 *** and urine obtained are for clinical pathology *** results indicate that ND drug delivery platform significantly relieves DOX toxicity for Naïve Beagle dog *** study provides guidance for the pre-clinical safety assessment of NDX therapy at large animal level.

关键词： nanomedicine doxorubicin nanodiamonds safety biodistribution

Mean sea surface heights of the South and East China Seas from ocean circulation model and geodetic leveling

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Chinese Science Bulletin 2002年第4期47卷 326-329页

作者： FANG Guohong WEI Zexun FANG Yue WANG kai choi Byungho Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Department of Oceanography Texas A&M UniversityCollege StationTX 77843-3146USA Department of Civil Engineering Sungkyunkwan UniversitySuwon440-746Korea

The mean sea surface heights (sea surface topography) of the South China, East China, Yellow and Bohai Seas are derived from an ocean general circulation model and surface air pressure. The circulation model covers the global oceans, with fine grid (1/6°)? covering the East Asian marginal seas and coarse grid (3°) covering the rest part of the global oceans. The result shows that the China 1985 Na-tional Altitude Datum is 24.7 cm above the mean sea surface height of the world oceans. The mean sea surface in the coastal ocean adjacent to China is higher in the south than in the north. Intercomparison of the model results with the geodetic leveling measurements at 28 coastal tidal stations shows a standard deviation of 4.8 cm and a fitting coefficient of 95.3%. After correction through linear regression, the standard deviation is reduced to 4.5 cm. This indicates that the accuracy of model results is sufficient for practical application. Based on the model results, the mean sea surface heights for the

关键词： mean sea surface height ocean circulation model land leveling South China Sea East China Sea Yellow Sea Bohai Sea.