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Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila

Translational Neurodegeneration 2022年第1期11卷 262-279页

作者： Wei Liu kah-leong lim Eng-King Tan School of Plant Protection Anhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Agricultural UniversityHefei 230036China Department of Neurology National Neuroscience InstituteSingapore 308433Singapore Department of Research National Neuroscience InstituteSingaporeSingapore Research Lee Kong Chian School of Medi-cineSingaporeSingapore Neuroscience and Behavioural Disorders Program Duke-NUS Medical SchoolSingapore 169857Singapore.

Background:Aberrant aggregation ofα-synuclein(α-syn)is a key pathological feature of Parkinson’s disease(PD),but the precise role of intestinalα-syn in the progression of PD is *** a number of genetic Drosophila models of PD,α-syn was frequently ectopically expressed in the neural system to investigate the ***:We investigated the potential role of intestinalα-syn in PD pathogenesis using a Drosophila ***α-syn was overexpressed in Drosophila guts,and life span,survival,immunofluorescence and climbing were ***,Western blotting and reactive oxygen species(ROS)staining were performed to assess the effects of intestinalα-syn on intestinal ***‐throughput RNA and 16S rRNA gene sequencing,quantitative RT‐PCR,immunofluorescence,and ROS staining were performed to determine the underlying molecular ***:We found that the intestinalα-syn alone recapitulated many phenotypic and pathological features of PD,including impaired life span,loss of dopaminergic neurons,and progressive motor *** intestine-derivedα-syn disrupted intestinal homeostasis and accelerated the onset of intestinal ***,intestinal expression ofα-syn induced dysbiosis,while microbiome depletion was efficient to restore intestinal homeostasis and ameliorate the progression of ***α-syn triggered ROS,and eventually led to the activation of the dual oxidase(DUOX)-ROS-Jun N-terminal Kinase(JNK)*** addition,α-syn from both the gut and the brain synergized to accelerate the progression of ***:The intestinal expression ofα-syn recapitulates many phenotypic and pathologic features of PD,and induces dysbiosis that aggravates the pathology through the DUOX-ROS-JNK pathway in *** findings provide new insights into the role of intestinalα-syn in PD pathophysiology.

关键词： Intestine α-Synuclein Parkinson’s disease Microbiome

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Mitochondrial homeostasis in Parkinson＇s disease-a triumvirate rule？

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Neural Regeneration Research 2017年第8期12卷 1270-1272页

作者： Chee-Hoe Ng Liting Hang kah-leong lim National Neuroscience Institute Singapore Neuroscience & Behavioral Disorders Program Duke-NUSMedical School Singapore Department of Physiology National University of SingaporeSingapore NUS Graduate School for Integrative Sciences and Engineering Singapore

Mitochondrial dysfunction in Parkinson＇s disease：Mitochondria are the primary energy generator of the cell and they are important for cell survival and *** mitochondrial homeostasis is frequently reported in human d... 详细信息

关键词： PPAR PD cell PGC AMPK Mitochondrial homeostasis in Parkinson’s disease-a triumvirate rule

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A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors

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Journal of Integrative Plant Biology 2024年第5期66卷 1007-1023页

作者： Meijing Yang Shuai Chen Shey-Li lim Lang Yang Jia Yi Zhong Koon Chuen Chan Zhizhu Zhao Kam-Bo Wong Junqi Wang Boon leong lim School of Biological Sciences University of Hong KongPokfulam 999077Hong KongChina Department of Biology Southern University of Science and TechnologyShenzhen 518055China School of Biomedical Engineering Shenzhen UniversityShenzhen 518060China School of Life Sciences The Chinese Universityof Hong KongShatin 999077HongKongChina State Key Laboratory of Agrobiotechnology The Chinese University of Hong KongShatin 999077Hong KongChina HKU Shenzhen Institute of Research and Innovation Shenzhen 518052China

In plants,thousands of nucleus-encoded proteins translated in the cytosol are sorted to chloroplasts and mitochondria by binding to specific receptors of the TOC(translocon on the outer chloroplast membrane)and the TOM(translocon on the outer mitochondrial membrane)complexes for import into those *** degradation pathways for these receptors are ***,we discovered a converged ubiquitin-proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail-anchored *** receptors are ubiquitinated by E3 ligase(s)and pulled from the outer membranes by the AAA+adenosine triphosphatase CDC48,after which a previously uncharacterized cytosolic protein,transmembrane domain(TMD)-binding protein for tail-anchored outer membrane proteins(TTOP),binds to the exposed TMDs at the C termini of the receptors and CDC48,and delivers these complexes to the 26S proteasome.

关键词： 26S proteasome CDC48 SP1 TOC TOM ubiquitination

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Novel N-doped multichannel carbon nanofiber architecture with porous CoS nanoprisms for high-performance potassium-ion batteries

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Rare Metals 2024年第3期43卷 971-983页

作者： Jae Bong lim Seung-Keun Park Department of Advanced Materials Engineering Chung-Ang UniversityGyeonggi-do17546Republic of Korea Department of Intelligence Energy and Industry Chung-Ang UniversitySeoul06974Republic of Korea Western Seoul Center Korea Basic Science InstituteSeoul03759Republic of Korea

Potassium-ion batteries(PIBs)have gained significant attention as an alternative to lithium-ion batteries(LIBs)due to the abundance of potassium(K)and low ***,the difficulty in finding appropriate electrode materials that can efficiently store the larger K ions has hindered their practical ***,we report a novel anode material,N-doped multichannel carbon nanofibers embedded with porous CoS nanoprisms(CSP@NMCNF),for high-performance *** CSP@NMCNF was synthesized using a two-step strategy comprising of the electrospinning of Co acetate hydroxide nanoprism/binary polymer blend and a subsequent heat *** porous CoS nanoprisms with an anisotropic morphology were well aligned along the length axis of the N-doped multichannel carbon nanofibers,thus ensuring their structural stability during the repeated charge-discharge *** addition,numerous pores facilitated the transport of electrons and ***,the CSP@NMCNF anode exhibited excellent electrochemical performance,delivering a high specific capacity of 368 mAh·g^(-1)at 0.5 A·g^(-1)after 200 cycles and excellent rate capability(232 mAh·g^(-1)at 2.0 A·g^(-1)).

关键词： K-ion batteries Cobalt sulfide Multichannel structured composite Electrospinning Nanoprism Porous structure

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A short overview of the lead iodide residue impact and regulation strategies in perovskite solar cells

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Journal of Energy Chemistry 2024年第3期90卷 504-510,I0012页

作者： Eng Liang lim Zhanhua Wei Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021FujianChina

Lead iodide(PbI2) is a vital raw material for preparing perovskite solar cells(PSCs),and it not only takes part in forming the light absorption layer but also remains in the grain boundary as a *** other words,the PbI2 content in the precursor and as formed film will affect the efficiency and stability of the *** moderate residual PbI2,it passivates the bulk/surface defects of perovskite,reduces the interfacial recombination,promotes the perovskite stability,minimizes the device hysteresis,and so *** PbI2 residue will reduce the interfacial passivation effect and device *** addition to facilitating the non-radiative recombination,over PbI2 residue can also lead to electronic insulation in the grain boundary and deteriorate the device ***,the impact and regulation of PbI2 residue on the device performance and stability is still not fully ***,a comprehensive and detailed review is presented by discussing the PbI2 residue impact and its regulation strategies(i.e., elimination,facilitation and conversion of the residue PbI2) to manipulate the PbI2 content,distribution and ***,we also show future outlooks in this field,with an aim to help further the progression of high-efficiency and stable PSCs.

关键词： Lead iodide Residue Regulation Perovskite solar cells Efficiency Stability

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Reconfigurable transmissive metasurface with a combination of scissor and rotation actuators for independently controlling beam scanning and polarization conversion

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Microsystems & Nanoengineering 2024年第2期10卷 173-180页

作者： Chhunheng Lor Ratanak Phon Sungjoon lim Intelligent Semiconductor Engineering Chung-Ang UniversityHeukseok-DongDongjak-GuSeoul06974Republic of Korea School of Electrical and Electronic Engineering Chung-Ang UniversityHeukseok-DongDongjak-GuSeoul06974Republic of Korea

Polarization conversion and beam scanning metasurfaces are commonly used to reduce polarization mismatch and direct electromagnetic waves in a specific direction to improve the strength of a wireless ***,identifying suitable active and mechanically reconfigurable metasurfaces for polarization conversion and beam scanning is a considerable challenge,and the reported metasurfaces have narrow scanning ranges,are expensive,and cannot be independently *** this paper,we propose a reconfigurable transmissive metasurface combined with a scissor and rotation actuator for independently controlling beam scanning and polarization conversion *** metasurface is constructed with rotatable unit cells(UCs)that can switch the polarization state between right-handed(RHCP)and left-handed circular polarization(LHCP)by flipping the UCs to reverse their phase ***,independent beam scanning is achieved using the scissor actuator to linearly change the distance between the *** and experimental results confirm that the proposed metasurface can perform beam scanning in the range of 28°for both the positive and negative regions of a radiation pattern(RHCP and LHCP beams)at an operational frequency of 10.5 GHz.

关键词： beam rotation controlling

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Detection and defending the XSS attack using novel hybrid stacking ensemble learning-based DNN approach

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Digital Communications and Networks 2024年第3期10卷 716-727页

作者： Muralitharan Krishnan Yongdo lim Seethalakshmi Perumal Gayathri Palanisamy IMS Sungkyunkwan UniversitySuwon16419South Korea Department of Mathematics Sungkyunkwan UniversitySuwon16419South Korea Department of Information Technology Madras Institute of TechnologyChennaiIndia Department of Mathematics PSG College of Arts and ScienceTamilnaduIndia

Existing web-based security applications have failed in many situations due to the great intelligence of *** web applications,Cross-Site Scripting(XSS)is one of the dangerous assaults experienced while modifying an organization's or user's *** avoid these security challenges,this article proposes a novel,all-encompassing combination of machine learning(NB,SVM,k-NN)and deep learning(RNN,CNN,LSTM)frameworks for detecting and defending against XSS attacks with high accuracy and *** on the representation,a novel idea for merging stacking ensemble with web applications,termed“hybrid stacking”,is *** order to implement the aforementioned methods,four distinct datasets,each of which contains both safe and unsafe content,are *** hybrid detection method can adaptively identify the attacks from the URL,and the defense mechanism inherits the advantages of URL encoding with dictionary-based mapping to improve prediction accuracy,accelerate the training process,and effectively remove the unsafe JScript/JavaScript keywords from the *** simulation results show that the proposed hybrid model is more efficient than the existing detection *** produces more than 99.5%accurate XSS attack classification results(accuracy,precision,recall,f1_score,and Receiver Operating Characteristic(ROC))and is highly resistant to XSS *** order to ensure the security of the server's information,the proposed hybrid approach is demonstrated in a real-time environment.

关键词： Machine learning Deep neural networks Classification Stacking ensemble XSS attack URL encoding JScript/JavaScript Web security

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Alterations of protein homeostasis in Alzheimer's disease:beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response

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Neural Regeneration Research 2024年第8期19卷 1645-1646页

作者： Dmitry lim Alexei Verkhratsky Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain&Department of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of Stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

Alzheimer’s disease(AD)is a major age-related form of dementia with a number of cases exponentially growing,causing enormous social and economic impact on individuals and *** hallmarks of AD,evident in postmortem AD brains,include a massive loss of the grey matter in the neocortex,extracellular deposition of amyloid-β(Aβ)in the form of senile plaques and cerebrovascular amyloid angiopathy,and intra-neuronal accumulation of neurofibrillary tangles,formed by hyper-phosphorylated tau protein.

关键词： Alzheimer homeostasis cortex

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A review of understanding electrocatalytic reactions in energy conversion and energy storage systems via scanning electrochemical microscopy

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Journal of Energy Chemistry 2024年第4期91卷 155-177页

作者： Jihye Park Jong Hwan lim Jin-Hyuk Kang Jiheon lim Ho Won Jang Hosun Shin Sun Hwa Park Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Applied Measurement Science University of Science and TechnologyDaejeon 34113Republic of Korea

To address climate change and promote environmental sustainability,electrochemical energy conversion and storage systems emerge as promising alternative to fossil fuels,catering to the escalating demand for *** optimal energy efficiency and cost competitiveness in these systems requires the strategic design of electrocatalysts,coupled with a thorough comprehension of the underlying mechanisms and degradation behavior occurring during the electrocatalysis *** electrochemical microscopy(SECM),an analytical technique for studying surface electrochemically,stands out as a powerful tool offering electrochemical *** possesses remarkable spatiotemporal resolution,enabling the visualization of the localized electrochemical activity and surface *** review compiles crucial research findings and recent breakthroughs in electrocatalytic processes utilizing the SECM methodology,specifically focusing on applications in electrolysis,fuel cells,and metal–oxygen batteries within the realm of energy conversion and storage *** with an overview of each energy system,the review introduces the fundamental principles of SECM,and aiming to provide new perspectives and broadening the scope of applied research by describing the major research categories within SECM.

关键词： Scanning electrochemical microscopy Electrocatalyst Electrocatalysis Water splitting Fuel cell Metal-oxygen battery

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Probing the endoplasmic reticulummitochondria interaction in Alzheimer's disease:searching far and wide

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Neural Regeneration Research 2024年第10期19卷 2103-2104页

作者： Giulia Dematteis Laura Tapella Dmitry lim Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly

Alzheimer's disease(AD)is the most frequent,form of dementia in elderly people and is an incurable disease with an exponentially growing number of *** deposition of amyloid-β(Aβ)plaques and intraneuronal formation o... 详细信息

关键词： Alzheimer Aβ reticulum

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