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Ammonia level at admission predicts in-hospital mortality for patients with alcoholic hepatitis

Gastroenterology Report 2017年第3期5卷 232-236,I0003页

作者： sujan Ravi kaely s.bade Mohsen Hasanin Ashwani K.singal Department of Internal Medicine University of Alabama at BirminghamBirminghamALUSA Division of Gastroenterology and Hepatology University of MissouriColumbiaMOUSA Division of Gastroenterology and Hepatology University of Alabama at BirminghamBirminghamALUSA

*** hepatitis(AH),a unique clinical syndrome among patients with chronic and active alcohol use,is associated with high short-term *** elevated ammonia level is associated with mortality in patients with acute liver failure;however,its impact in AH has not been ***.A retrospective study was performed on patients admitted to a tertiary-care hospital with the discharge diagnosis of *** meeting criteria for AH were included in the final data *** logistic regression models were built to examine the impact of serum ammonia in predicting in-hospital mortality(IHM)and 30-day mortality(TDM).subgroup analysis was also performed,which was limited to patients who had hepatic *** the 105 AH patients included,26(25%)died during the initial *** the 79 patients who survived initial hospitalization,30(39%)died within 30 *** about ammonia levels at admission was available for 82 *** these,25 patients had IHM and significantly higher ammonia level(97 vs.69 lmol/L,Psurvived hospitalization,ammonia levels were not significantly different(71 vs.67 lmol/L,P=0.69)in patients with and without *** addition of ammonia to the multivariate regression models including age,sex,cirrhosis,treatment and model for end-stage liver disease(MELD)score improved the C statistics for IHM from 0.708 to 0.801 and for TDM from 0.756 to 0.766,*** results were identical,even when limited to patients with hepatic *** patients with elevated ammonia levels at admission have higher IHM;however,they do not seem to play a significant role in 30-day mortality for patients who survived hospitalization.

关键词： alcoholic hepatitis hepatic encephalopathy ammonia mortality

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A global harmony search algorithm for finding optimal capacitor location and size in distribution networks

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Journal of Central south University 2015年第5期22卷 1748-1761页

作者： Reza sirjani Melkamu Gamene bade Cyprus International University Faculty of Engineering Nicosia Northern Cyprus Mersin 10 Turkey

shunt capacitors are broadly applied in distribution systems to scale down power losses, improve voltage profile and boost system capacity. The amount of capacitors added and location of deployment in the system highly determine the advantage of compensation. A novel global harmony search(GHs) algorithm in parallel with the backward/ forward sweep power flow technique and radial harmonic power flow was used to investigate the optimal placement and sizing of capacitors in radial distribution networks for minimizing power loss and total cost by taking account load unbalancing, mutual coupling and harmonics. The optimal capacitor placement outcomes show that the GHs algorithm can reduce total power losses up to 60 k W and leads to more than 18% of cost saving. The results also demonstrate that the GHs algorithm is more effective in minimization of power loss and total costs compared with genetic algorithm(GA), particle swarm optimization(PsO) and harmony search(Hs) algorithm. Moreover, the proposed algorithm converges within 800 iterations and is faster in terms of computational time and gives better performance in finding optimal capacitor location and size compared with other optimization techniques.

关键词： optimal capacitor placement harmonics unbalancing harmony search algorithm

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Identification of Differentially Expressed Genes During Ethylene Climacteric of Melon Fruit by suppression subtractive Hybridization

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Journal of Integrative Agriculture 2013年第8期12卷 1431-1440页

作者： GAO Feng NIU Yi-ding HAO Jin-feng bade Rengui ZHANG Li-quan HAsIAgula Inner Mongolia Key Laboratory of Herbage & Endemic Crop Biotechnology/College of Life sciences Inner Mongolia University

Melon （Cucumis melo L.） is an important horticultural crop worldwide. Ethylene regulates the ripening process and affects the ripening rate. To screen genes that are differentially expressed at the burst of ethylene climacteric in melon fruit, we performed suppression subtractive hybridization （ssH） to generate forward and reverse libraries, for which we sequenced 439 and 445 clones, respectively. Our BLAsT analysis showed that the genes from the 2 libraries were involved in metabolism, signal transduction, cell structure, transcription, translation, and defense. six genes were analyzed by qRT-PCR during the differential developmental stage of melon fruit. Our results provide new insight into the understanding of climacteric ripening of melon fruit.

关键词： Cucumis melo ethylene climacteric fruit ripening differentially expressed mRNA gene expression suppressionsubtractive hybridization

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Timely completion of multiple life-saving interventions for traumatic haemorrhagic shock: a retrospective cohort study

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Burns & Trauma 2019年第1期7卷 204-212页

作者： Biswadev Mitra Jordan bade-Boon Mark C.Fitzgerald Ben Beck Peter A.Cameron National Trauma Research Institute The Alfred Hospital89 Commercial RoadMelbourneVIC 3004Australia Emergency&Trauma Centre The Alfred HospitalMelbourneAustralia school of Public Health and Preventive Medicine Monash University MelbourneAustralia Trauma service The Alfred HospitalMelbourneAustralia Faculty of Medicine Laval University Quebec City QuebecCanada

Background:Early control of haemorrhage and optimisation of physiology are guiding principles of resuscitation after *** outcomes have been previously associated with single,timely *** aim of this study was to assess the association between multiple timely life-saving interventions(LsIs)and outcomes of traumatic haemorrhagic shock ***:A retrospective cohort study was undertaken of injured patients with haemorrhagic shock who presented to Alfered Emergency&Trauma Centre between July 01,2010 and July 31,*** studied included chest decompression,control of external haemorrhage,pelvic binder application,transfusion of red cells and coagulation products and surgical control of bleeding through angio-embolisation or operative *** primary exposure variable was timely initiation of≥50%of the indicated *** association between the primary exposure variable and outcome of death at hospital discharge was adjusted for potential confounders using multivariable logistic regression *** association between total pre-hospital times and pre-hospital care times(time from ambulance at scene to trauma centre),in-hospital mortality and timely initiation of≥50%of the indicated interventions were ***:Of the 168 patients,54(32.1%)patients had≥50%of indicated LsI completed within the specified time *** delivery of LsI was independently associated with improved survival to hospital discharge(adjusted odds ratio(OR)for in-hospital death 0.17;95%confidence interval(CI)0.03–0.83;p=0.028).This association was independent of patient age,pre-hospital care time,injury severity score,initial serum lactate levels and *** patients with pre-hospital time of≥2 h,2(3.6%)received timely ***-hospital care times of≥2 h were associated with delayed LsIs and with in-hospital death(unadjusted OR 4.3;95%CI 1.4–13.0).Conclusions:Timely completion of LsI when indicated was completed in a small

关键词： Wounds Bundle of care Haemorrhage shock Resuscitation Emergency department Blood products Timely life-saving interventions Trauma Injuries

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Assessment of a Downloadable Application with Avatar Guidance for PT-Prescribed Home Exercise after Total Knee Arthroplasty: A 30-Day Usability and Feasibility study

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Advances in Aging Research 2022年第4期11卷 98-115页

作者： Joel Carmichael sheryl Flynn Tamara struessel stefano Bini Michael bade Jennifer stevens-Lapsley Department of Physical Medicine and Rehabilitation School of Medicine University of Colorado Anschutz Medical Campus Aurora USA Blue Marble Health Altadena USA Department of Orthopedic surgery University of California San Francisco USA Veterans Affairs Geriatric Research Education and Clinical Center VA Eastern Colorado Healthcare System Aurora USA

Objective: To explore the usability and feasibility of a downloadable application (APP) compared to paper handouts (CONTROL) in guiding 30 days of PT-prescribed home exercise after total knee arthroplasty (TKA), and to compare functional outcomes at 30 days postoperatively between APP and CONTROL. Design: Randomized controlled usability and feasibility study. setting: Rehabilitation laboratories at two regional medical centers. Participants: Individuals with knee osteoarthritis undergoing unilateral TKA (APP group: N = 26;mean age, 67.0 ± 8.2 y;CONTROL group: N = 31;mean age, 64.7 ± 7.7 y). Interventions: This study assessed the user experience of a downloadable app to guide 30 days of home exercises and instruction after TKA and compared exploratory outcomes to a group using paper handouts. Main Outcome Measures: The system Usability scale (sUs) score was used to assess patient usability experience. Raw sUs scores were dichotomized (≥72% or sability against a 75% a priori criterion for mean APP group score. Feasibility for app use was similarly evaluated in the APP group only through a priori criteria applied to computing device ownership and study use, to the absence of technology-based barriers to participation, and to completion of app-based testing. Exploratory measures compared change from baseline to 30 days for functional and patient-reported outcomes between APP and CONTROL. Results: The APP group’s mean sUs score of 79.2% at 30 days exceeded the 75% threshold for good usability. The app met the predetermined a priori feasibility criteria for absence of technology-based barriers to participation (75% of participants) and completion of app-based testing (91.3% of participants). Personal computing devices were used by 71.4% of APP participants, which was below the 75% a priori feasibility criterion. No differences between the APP and CONTROL groups were observed for functional or patient-reported outcomes. Conclusions: The app-based pl

关键词： Mobile Health Technology Feasibility Usability Total Knee Replacement system Usability scale

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Purification of Moringa oleifera Leaves Protease by Three-Phase Partitioning and Investigation of Its Potential Antibacterial Activity

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American Journal of Plant sciences 2023年第1期14卷 64-76页

作者： Adam Abdoulaye Agossou D. P. Noumavo Durand Dah-Nouvlessounon Messan A. B. Ohin Hasan Bayraktar Farid T. bade Honoré s. Bankole Lamine Baba-Moussa Farid Baba-Moussa Laboratoire de Microbiologie et des Technologies Alimentaires Faculté des Sciences et Techniques Université d’Abomey-Calavi Abomey-Calavi Bénin Laboratory of Biology and Molecular Typing in Microbiology Faculty of Science and Technology University of Abomey-Calavi Abomey Calavi Benin Department of Nutrition and Dietetics Faculty of Health Sciences Yuksek Ihtisas University Balgat-Ankara Turkey Unité de Recherche en Microbiologie Appliquée et Pharmacologie des substances Naturelles Ecole Polytechnique d’Abomey-Calavi Abomey-Calavi Benin

One of plant-based products for dental care is plant-based proteolytic enzymes which are principally proteases. In order not to damage the protein and bioactive content, an efficient method should be employed for their purifications. As such, three-phase partitioning (TPP) was used to purify protease from moringa (Moringa oleifera). TPP is an emerging, promising, non-chromatographic and economical technology which is simple, quick, efficient and often one-step process for the separation and purification of bioactive molecules from natural sources. It involves the addition of salt (ammonium sulphate) to the crude extract followed by the addition of an organic solvent (butanol). The protein appears as an interfacial precipitate between upper organic solvent and lower aqueous phases. The various conditions such as ammonium sulphate, ratio of crude extract to t-butanol and pH which are required for attaining efficient purification of the protease fractions were optimized. Under optimized conditions, it was seen that, 35% of ammonium sulphate saturation with 1:0.75 ratio of crude extract to t-butanol at pH 7 gave 4.94-fold purification with 96.20% activity yield of protease in the middle phase of the TPP system. The purified enzyme from Moringa oleifera has no antimicrobial effect on the pathogenic bacteria tested. However, this purified enzyme, can be considered as a promising agent, cheap, and safe source which is suitable for using in various industries.

关键词： Three-Phase Partitioning Moringa oleifera Protease Protein Purification Antimicrobial

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Geoctenologies Applied to Evolution in Urban Design in a City in southern Brazil

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Journal of Civil Engineering and Architecture 2021年第10期15卷 541-545页

作者： Michele Bianchini Alcindo Neckel Maria Eduarda Cargnin bade Laura Pasa Cambrussi Emanuela Brandelero siqueira Julian Grub Luana Pasquetti Paloma Toscan Henrique Aniceto Kujawa Isadora Cezar Caino Postgraduate Program in Architecture and Urbanism(PPGArq-IMED) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS 99070-220Brazil Postgraduate Program in Architecture and Urbanism(PPG Arq e Urb-UNIsINOs) São Leopoldo/RS 93022-750Brazil University of Perugia Piazza Università1Perugia 06123Italy

The evolution process of urban design is the result of transformations due to population increase along the expansion of cities on a global *** applied to forms of mapping make it possible to understand the changes that have occurred in urban spaces in relation to temporal *** general objective of this study is to analyze the change that occurred from the year 2010 to 2021,in the evolution of urban design,in the city of Marau(southern Brazil).The identification of urban evolution in the years 2010 and 2021 was carried *** data were modeled using the QGIs software,in the sIRGAs(Geocentric Reference system for the Americas)database,related to the evolution of urban design in *** results demonstrate the need to apply geotechnologies not only in the city of Marau,but in other cities worldwide,because city halls need precision maps,avoiding the fragmentation of the urban fabric,a result of population expansion not projected in the built environment.

关键词： Urban evolution urban grid remote sensing urban design

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甜瓜WRKY转录因子家族基因生物信息学分析

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基因组学与应用生物学 2017年第11期36卷 4761-4769页

作者：马勇鲍牧兰张红霞巴德仁贵包头师范学院生物科学与技术学院包头014030 包头医学院中心实验室生物医学研究中心包头014040

WRKY转录因子是一类重要的调控分子,在高等植物中以基因家族的形式存在。本研究以甜瓜(Cucumis melo L.)基因组数据为材料,利用生物信息学手段对WRKY转录因子家族成员、系统进化、基因分类、保守基序(motif)的保守性进行预测和分析。研... 详细信息

WRKY转录因子是一类重要的调控分子,在高等植物中以基因家族的形式存在。本研究以甜瓜(Cucumis melo L.)基因组数据为材料,利用生物信息学手段对WRKY转录因子家族成员、系统进化、基因分类、保守基序(motif)的保守性进行预测和分析。研究表明,甜瓜WRKY家族包含61个基因,其中13个含有2个WRKY结构域和C_2H_2锌指型结构归为第Ⅰ类,43个含有1个WRKY结构域和C_2H_2锌指型结构的归为第Ⅱ类,5个含有1个WRKY结构域和C2HC锌指型结构的归为第Ⅲ类。

关键词：甜瓜生物信息学 WRKY转录因子进化分析

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基于电气工程自动化技术在电力系统运行中的应用

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今日自动化 2020年第8期 64-66页

作者：古丽赞·巴德尔汗昌吉职业技术学院新疆昌吉830011

随着我国科学技术的不断发展,我国各行各业的自动化程度均有所提高。电气工程自动化技术在人们日常生活、工作中发挥着重要作用,人们的生活水平提高,对电力能源的要求越高越高。将电气工程自动化技术应用于电力系统中,可以有效地优化电... 详细信息

随着我国科学技术的不断发展,我国各行各业的自动化程度均有所提高。电气工程自动化技术在人们日常生活、工作中发挥着重要作用,人们的生活水平提高,对电力能源的要求越高越高。将电气工程自动化技术应用于电力系统中,可以有效地优化电力系统的运行,提高工作效率,保障电力系统的运行稳定性,节省大量的人力,促进电力行业的健康发展。基于此,文章将分析电气工程自动化技术在电力系统运行应用中存在的问题及作用,提出应用电气工程自动化技术的有效策略,希望对相关人士有所帮助。

关键词：电气工程自动化技术电力系统应用策略

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1,10-邻二氮杂菲双过氧钒酸钾对HT22细胞增殖和周期的影响

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中国药理学与毒理学杂志 2019年第5期33卷 334-340页

作者：巴德仁贵田小莉鲍牧兰张晓璐崔钧贺许文强苏娇邵国包头医学院中心实验室生物医学研究中心内蒙古包头014010 内蒙古自治区低氧转化医学重点实验室内蒙古包头014010 首都医科大学宣武医院低氧适应转化医学北京重点实验室北京100053

目的探讨1,10-邻二氮杂菲双过氧钒酸钾〔BPV(phen)〕是否通过调节DNA甲基转移酶(DNMT)的表达,调控细胞周期相关基因表达,进而影响细胞周期。方法 BPV(phen)0.3和3.0μmol·L-1处理HT22细胞24 h,MTs法检测细胞存活;流式细胞术方法检测细... 详细信息

目的探讨1,10-邻二氮杂菲双过氧钒酸钾〔BPV(phen)〕是否通过调节DNA甲基转移酶(DNMT)的表达,调控细胞周期相关基因表达,进而影响细胞周期。方法 BPV(phen)0.3和3.0μmol·L-1处理HT22细胞24 h,MTs法检测细胞存活;流式细胞术方法检测细胞周期;ELIsA法检测DNMT活性;实时荧光定量PCR检测p21,DNMT1,DNMT3A和DNMT3B mRNA表达水平;Western印迹法分别检测相应蛋白表达水平。结果与DMsO对照组相比,BPV(phen)0.3μmol·L-1对细胞存活率无显著影响,BPV(phen)3.0μmol·L-1组细胞存活率显著降低(PsO对照组相比,BPV(phen)0.3μmol·L-1组各细胞周期百分比无显著差异,BPV(phen)3.0μmol·L-1组s期细胞显著增加,为(76.1±1.6)%(PsO对照组相比,BPV(phen)3.0μmol·L-1组细胞DNMT活性显著增加(PsO对照组相比,BPV(phen)0.3μmol·L-1组p21,DNMT1,DNMT3A和DNMT3B mRNA表达水平无显著差异,BPV(phen)3.0μmol·L-1组各基因表达水平均显著增加(Pstern印迹结果显示,与DMsO对照组相比,BPV(phen)0.3μmol·L-1组各蛋白表达水平均无显著性差异,只有BPV(phen)3.0μmol·L-1组DNMT3B和P21蛋白表达显著增加(P<0.05)。结论 BPV能够通过改变DNMT的表达,调节下游与细胞周期相关基因的表达,进而影响HT22细胞的生长和增殖。

关键词： 1,10-邻二氮杂菲双过氧钒酸钾 DNA甲基转移酶 HT22细胞 DNA甲基化

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