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COVID-19 infection in a kidney transplant recipient—special emphasis on pharmacokinetic interactions:A case report

World Journal of Transplantation 2020年第11期10卷 365-371页

作者： Ebru Gok Oguz kadir gokhan atilgan Sanem Guler Cimen Hatice Sahin Tamer Selen Fatma AyerdenEbinc Sertac Cimen Mehmet Deniz Ayli Department of Nephrology Diskapi Yildirim Beyazit Training and Res HospAnkara 6500Turkey Department of Nephrology Health Sciences UniversityAnkara 6500Turkey Department of General Surgery Diskapi Research and Training HospitalHealth Sciences UniversityAnkara 65000Select OneTurkey Department of Urology and Transplantation Health Sciences UniversityAnkara 65000Select OneTurkey Department of Nephrology and Transplantation Diskapi Yildirim Beyazit Teaching and Research HospitalAnkara 6500Turkey

BACKGROUND Solid organ transplant recipients are considered to be at high-risk of developing coronavirus disease 2019(COVID-19)-related *** optimal treatment for this patient group is ***,the treatment of COVID-19 in kidney transplant recipients should be determined individually,considering patient age and comorbidities,as well as graft function,time of transplant,and immunosuppressive *** treatments may give rise to severe *** the contrary,they may also lead to a milder and atypical presentation by diminishing the immune system *** SUMMARY A 50-year old female kidney transplant recipient presented to the transplant clinic with a progressive dry cough and fever that started three days *** the COVID-19 test was found to be negative,chest computed tomography images showed consolidation typical of the disease;thus,following hospital admission,anti-bacterial and COVID-19 treatments were ***,despite clinical improvement of the lung consolidation,her creatinine levels continued to *** of the graft showed no *** tacrolimus blood level was determined and the elevation in creatinine was found to be related to an interaction between tacrolimus and *** During the COVID-19 pandemic,various single or combination drugs have been utilized to find an effective treatment *** has increased the possibility of drug interactions.A limited number of studies published in the literature have highlighted some of these pharmacokinetic *** used for COVID-19 therapy;azithromycin,atazanavir,lopinavir/ritonavir,remdesivir,favipiravir,chloroquine,hydroxychloroquine,nitazoxanide,ribavirin,and tocilizumab,interact with immunosuppressive treatments,most importantly with calcineurin ***,their levels should be frequently monitored to prevent toxicity.

关键词： COVID-19 Kidney transplantation Drug interaction Pharmacokinetics Azithromycin Case report Calcineurin inhibitor

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Radial Artery and Saphenous Vein Grafts in Coronary Artery Bypass Surgery Comparison in Terms of Patient Symptoms

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World Journal of Cardiovascular Surgery 2014年第4期4卷 43-46页

作者： Tugra Gencpinar Koray Aykut gokhan Albayrak Umut Ayoglu Muzaffer Yilmaz kadir Sagdic Mustafa Emmiler Cardiovascular Surgery Clinic Education and Research HospitalAntalyaTurkey Department of Cardiovascular Surgery Izmir UniversityIzmirTurkey

Background: The aim of this study is to compare radial artery with saphenous vein grafts which are widely used for coronary bypass, from views of patients’ satisfaction and postoperative findings. Methods: 42 isolated coronary bypass (CABG) patients performed during November 2012-April 2013 are included in the study. 30 days after the operation, in patients who had both RA and SV removal made responses to a questionnaire form which included 6 questions about symptoms of extremity. Results: After analyzing the responses and physical examination, there was no difference in terms of quality of life and usefulness of the extremity for daily use between two grafts. 2 patients (2%) have wound infection on the saphenous vein incision and additional surgical procedure was performed and a scar tissue has occurred. There was no statistically significance between uncomfortable symptoms and demographic data. Conclusion: Our study suggested that RA graft using showed a bit more comfortable and suitable effect against SV in our patients. We think that radial arterial grafts should be used more widely in coronary surgery with selected patients.

关键词： Radial Artery Saphenous Vein Coronary Artery Bypass Grafting

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Effect of Peripheral Arterial Disease on Serum Ischemia-Modified Albumin Levels in Type 2 Diabetic Patients

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World Journal of Cardiovascular Surgery 2014年第5期4卷 81-86页

作者： Tugra Gencpinar Umut Ayoglu Koray Aykut gokhan Albayrak Hamid Yasar Ellidag Muzaffer Yilmaz kadir Sagdic Mustafa Emmiler Cardiovascular Surgery Clinic Education and Research HospitalAntalyaTurkey Department of Cardiovascular Surgery Izmir UniversityIzmirTurkey Department of Biochemistry Education and Research HospitalAntalyaTurkey

Background: The aim of this study is to evaluate the role of IMA and the effect of Type-2 diabetes in peripheral arterial ischemic patient. Methods: In our study, randomized patient groups to be undergone peripheral surgery, consisting of 16 diabetic and 12 non-diabetic patients diagnosed with peripheral arterial disease, have been examined. After standard anesthesia, the surgery was performed by the same surgical team, blood samples were taken before and after cross-clamp, and the levels of ischemia modified albumin (IMA), which is a new ischemic marker, were studied spectrophotometrically. Demographic data were compared with the type-2 diabetes association. Results: In this study, we found that there were no correlation with the ankle brachial index (ABI) and risk factors of diabetes between postoperative IMA levels (P: 0.47). Preoperative IMA serum blood levels were significantly higher in patients with peripheral arterial disease (P: 0.70), and positively associated with ABI (diabetic group P: 0.04, non-diabetic group P: 00). Also, no correlation was found with X clamp times, ABI, and IMA blood levels (P: 0.30). In diabetic group, ischemia marker increase was high and there was a positive correlation between HbA1c levels (P: 0.002). Conclusion: Our study suggested that, preoperative serum IMA levels were positively associated with ABI. In diabetic group, the increase in IMA levels was high and there was positive correlation between HbA1c levels. IMA was a benefit marker for monitoring and early diagnosis of the peripheral arterial disease.

关键词： Artery Diabetes Mellitus Ischemia IMA

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Evaluating the phyto-complexity and poly-pharmacology of spices: The case of Aframomum melegueta K. Schum (Zingiberaceae)

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Food Bioscience 2022年第5期49卷 1230-1245页

作者： Simon Vlad Luca Adriana Trifan gokhan Zengin Kouadio Ibrahim Sinan Abdullahi Ibrahim Uba Izabela Korona-Glowniak Krystyna Skalicka-Wo´zniak Biothermodynamics TUM School of Life SciencesTechnical University of Munich85354FreisingGermany Department of Pharmacognosy Grigore T.Popa University of Medicine and Pharmacy Iasi700115IasiRomania Physiology and Biochemistry Research Laboratory Department of BiologyScience FacultySelcuk UniversityUniversity Campus42130KonyaTurkey Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Department of Pharmaceutical Microbiology Faculty of PharmacyMedical University of Lublin20-093LublinPoland Department of Natural Products Chemistry Medical University of Lublin20-093LublinPoland

The seeds of Aframomum melegueta K. Schum (grains of paradise, Zingiberaceae) are used as a common spice in African countries and a fine condiment in the European cuisine. In this study, we evaluated the phytochemical profile of various seed extracts of A. melegueta as well as their antimicrobial, antioxidant and enzyme inhibitory effects. In total, 25 diarylheptanoids, five gingerol derivatives and nine phenolic/organic acids were tentatively annotated in A. melegueta by liquid chromatography hyphenated with high resolution tandem mass spectrometry (LC-HRMS/MS). A. melegueta showed a moderate inhibitory activity against different human pathogenic microbial strains, with H. pylori the most sensitive microorganism. A strong antioxidant and enzyme inhibitory potential was shown in various radical scavenging, reducing and chelating assays as well as in cholinesterase, tyrosinase and glucosidase assays. Several specialized metabolites from A. melegueta (diarylheptanoids, gingerols) were shown to be directly linked with the investigated antioxidant and enzyme inhibitory activities, as evaluated through the correlation analysis. In addition, two diarylheptanoids (one heptan-3-ol and one heptan- 3,5-diol) displayed the strongest binding to acetylcholinesterase (AChE) via multiple H-bonds, a couple of π-π interactions and van der Waals interactions all over the catalytic channel of the enzyme, as evidenced by the molecular docking study. Overall, our work brings new contributions to the phyto-complexity and poly-pharmacology of spices from genus Aframomum than can find future applications in pharmaceutical, nutraceutical or cosmeceutical industry.

关键词： Aframomum melegueta Zingiberaceae Spices Gingerols Helicobacter

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Integration of in vitro and in silico approaches to assess three Astragalus species from Turkey flora:A novel spotlight from lab bench to functional applications

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Food Bioscience 2022年第5期49卷 1183-1194页

作者： gokhan Zengin Abdullahi Ibrahim Uba Mustafa Ocal Majid Sharifi-Rad Giovanni Caprioli Simone Angeloni Yasemin Celik Altunoglu Mehmet Cengiz Baloglu Evren Yıldıztugay Department of Biology Science FacultySelcuk University42130KonyaTurkey Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Department of Genetics and Bioengineering Faculty of Engineering and ArchitectureKastamonu UniversityKastamonuTurkey Department of Range and Watershed Management Faculty of Water and SoilUniversity of ZabolIran School of Pharmacy University of CamerinoVia Sant’Agostino 1I-62032CamerinoMCItaly Department of Biotechnology Science FacultySelcuk University42130KonyaTurkey

Members of the genus Astragalus have a great interest as a source of natural bioactive compounds on a scientific *** provide multidirectional insights into three Astragalus species(***,***,and ***),the current work focused on the chemical characterization and biological properties of their extracts(aerial parts and roots).The chemical characterization of the extracts was detected by HPLC-MS/MS *** biological properties were evaluated by antioxidant,enzyme inhibitory,and cytotoxic *** for radical quenching,reducing capacity,and metal chelation were also used to evaluate antioxidant *** test the enzyme inhibitory effects of the extracts,cholinesterases,tyrosinase,α-amylase,andα-glucosidase were utilized as target *** cancer cell lines,(MCF-7(human breast cancer cell line)and HeLa(Human cervix cancer cell line),were selected to evaluate cytotoxic ***,5-caffeoylquinic acid(2.43-283.92μg/g extract),hyperoside(4.33-216.22μg/g extract)and rutin(1.09-184.98μg/g extract)were the main *** extracts from aerial parts and roots of *** showed stronger radical scavenging and reducing power abilities compared to *** and *** best AChE and BChE inhibitory effects were determined in the aerial parts of ***(2.18 mg GALAE/g)and roots of ***(4.76 mg GALAE/g),*** extracts of *** had the highest tyrosinase inhibitory *** extract from aerial parts of *** showed stronger cytotoxic effects compared to other ***’s correlation analysis revealed that the presence of some compounds(resveratrol,p-coumaric,5-caffeoylquinic,and ferulic acids,etc)was linked to the observed biological *** docking was also provided for the possible interaction of enzymes as well as protein targets of the tested cell *** findings provide a scientific basis for the Astragalus species,which may serve as a source

关键词： Astragalus Phenolics Cytotoxic effect Molecular docking Bioactive agents

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Gathering scientific evidence for a new bioactive natural ingredient:The combination between chemical profiles and biological activities of Flueggea virosa extracts

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Food Bioscience 2022年第5期49卷 1254-1264页

作者： gokhan Zengin Stefano Dall’Acqua Kouadio Ibrahime Sinan Abdullahi Ibrahim Uba Stefania Sut Gregorio Peron Ouattara Katinan Etienne Manoj Kumar Carlos L.Cespedes-Acu˜na Julio Alarcon-Enos Adriano Mollica Mohamad Fawzi Mahomoodally Department of Biology Science FacultySelcuk UniversityKonyaTurkey Department of Pharmaceutical and Pharmacological Sciences University of PadovaVia Marzolo 535131 PadovaItaly Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Laboratoire de Botanique UFR BiosciencesUniversit´e F´elix Houphou¨et-BoignyAbidjanRepublic of Cˆote d’Ivoire Chemical and Biochemical Processing Division ICAR-Central Institute for Research on CottonTechnologyMumbai400019India Plant Biochemistry and Phytochemical Ecology Lab Departmento de Ciencias BasicasFacultad de CienciasUniversidad del Bio BioAv.Andres Bello#720ChillanChile Department of Pharmacy University“G.d’Annunzio”of Chieti-Pescara66100ChietiItaly Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusR´eduit80837Mauritius

Flueggea virosa (Roxb. ex Willd.) Royle is a plant with several traditional uses in tropical countries. To study the potential usefulness, extracts from stem barks and leaves of F. virosa were obtained with different solvents. The phytochemical composition was assessed using LC-MS and NMR. Triterpenes, as oleanolic (0.05-88.09 mg/g extract), and ursolic (0.03-94.36 mg/g extract) acids were determined. In addition, ellagic and gallic acid derivatives were present in large concentrations in some of the extracts. Antioxidant (radical scavenging, reduction ability, and metal chelating) and enzyme inhibitory (cholinesterase, tyrosinase, amylase, and glucosidase) effects were assessed by in vitro chemical assays. The methanol extracts and infusions from both parts show higher antioxidant ability when compared with ethyl acetate extracts, and the antioxidant capacity was correlated with the total phenolic contents of the tested extracts. The extracts demonstrate enzyme inhibitory abilities on AChE and BChE, and multivariate approaches allowed for correlating the activities with the presence of triterpenoids (R > 0.8). Furthermore, molecular docking was used to get insights into the interactions between the triterpenoids and the tested enzymes. Together, these results indicate that F. virosa represents a significant source of naturally-occurring bioactive compounds that can be exploited as a new ingredient for the development of novel functional products with promising biological properties.

关键词： Flueggea virosa Triterpenoids Antioxidant Bioactive agents Antidiabetic effect

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A multifunctional key to open a new window on the path to natural resources-lessons from a study on chemical composition and biological capability of Paeonia mascula *** Turkey

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Food Bioscience 2023年第1期51卷 1301-1316页

作者： Inci Kurt-Celep gokhan Zengin Engin Celep Stefano Dall’Acqua Stefania Sut Irene Ferrase Gunes Ak Abdullahi Ibrahim Uba Rıdvan Polat Deniz Canlı Ekrem Darendelioglu Muhammad Zakariyyah Aumeeruddy Mohammad Ali Shariati Mohamad Fawzi Mahomoodally Department of Pharmacognosy Faculty of PharmacyYeditepe University34755IstanbulTurkey Department of Biology Science FacultySelcuk UniversityKonya42300Turkey Department of Pharmacognosy Faculty of PharmacyAcıbadem Mehmet Ali Aydınlar University34752IstanbulTurkey Department of Pharmaceutical and Pharmacological Sciences University of PadovaVia Marzolo 535131PadovaItaly Department of Molecular Biology and Genetics Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul34083Turkey Department of Landscape Architecture Faculty of AgricultureBingol University12000BingolTurkey The Unit of Model University Coordination Center Bingol Unviersity12000Bing¨olTurkey Department of Molecular Biology and Genetics Faculty of Art and SciencesBing¨ol UniversityBingolTurkey Department of Health Sciences Faculty of Medicine and Health SciencesUniversity of MauritiusReduit80837Mauritius Department of Scientific Research K.G.Razumovsky Moscow State University of Technologies and Management(The First Cossack University)73 Zemlyanoy ValMoscow109004Russian Federation Department of Scientific Research Russian State Agrarian University-Moscow Timiryazev Agricultural Academy49 Timiryazevskaya str.Moscow127550Russian Federation Center for Transdisciplinary Research Department of PharmacologySaveetha Dental CollegeSaveethaInstitute of Medical and Technical ScienceChennai600077India Centre of Excellence for Pharmaceutical Sciences(Pharmacen) North-West UniversityPotchefstroom2520South Africa

The genus Paeonia has gained great interest from the scientific community for exploration as a source of bioactive *** current work focused on the chemical characterisation and biological properties of Paeonia mascula *** *** chemical characterisation of the extracts was analysed by LC-DAD-ESI and *** antioxidant,enzyme inhibitory and anticancer properties were evaluated in *** methanol extract was the most effective as antioxidant,metal chelator and was the most effective inhibitor of acetylcholinesterase(AChE)and *** chloroform extract showed highest inhibition of butrylcholinesterase(BChE)and *** acetate extract displayed glucosidase *** most abundant compounds were hexagalloyl glucose,penta galloyl glucose,gallic acid,tetragalloyl glucose,paeoniflorin and the most abundant flavonoid was quercetin-3-O-glucoside.β-sitosterol was the most abundant *** anticancer effect of *** was evaluated by using HELA cells evaluating different *** possible inhibition effect of *** on the reactive oxygen species(ROS)pathway was controlled by performing the advanced glycation end product(AGE).To determine the effect of *** on active molecular pathways in the HELA cancer cell line,the levels of Phospho-NF-Kβp65,AGE receptor RAGE protein,antiapoptotic BCL-2,proapoptotic BAX and P-53 proteins were checked,***-NF-Kβp65,RAGE and BCL-2,which are both ROS inducers and play an active role in cancer prognosis,were found to have decreased levels after the application of *** findings provide a scientific basis for Paeonia mascula,which may serve as a source of naturally occurring bioactive compounds for healthpromoting applications.

关键词： Paeonia Phenolics Antioxidant Enzyme inhibition Anticancer Insilico analysis

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