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Achillea biebersteinii extracts suppress angiogenesis and enhance sensitivity to 5-fluorouracil of human colon cancer cells via the PTEN/AKT/mTOr pathway in vitro

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 505-515页

作者： Mehmet kadir Erdoğan Can Ali Ağca Hakan Aşkın Department of Biology Faculty of Arts and SciencesBingol University12000BingolTurkey Department of Molecular Biology and Genetics Faculty of Arts and SciencesBingol University12000BingolTurkey Department of Molecular Biology and Genetics Faculty of SciencesAtaturk University25000ErzurumTurkey

Objective:To investigate the antiproliferative,anti-angiogenic,and apoptotic effects of extracts of Achillea biebersteinii(ABE)and combined treatments of ABE with 5-fluorouracil(5-FU)on HT-29 ***:The effects of ABE,5-FU,and combined treatments on the viability of HT-29 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** analysis was used to determine synergism between ABE and *** apoptotic and anti-angiogenic effects were determined by cell death detection and human vascular endothelial growth factor ELISA method,*** and translational expressions of p53,Bax,Bcl-2,p38 MAPK,Akt,PTEN,and m TOr were also evaluated by real-time PCr and Western blotting ***:ABE decreased the viability of HT-29 cells in a dosedependent *** treatment of hexane,chloroform,and methanol extracts of Achillea biebersteinii with 5-FU at IC50 doses decreased the cell viability to 26.0%,19.1%,and 14.9%,respectively(Prthermore,ABE treatment alone and combination with 5-FU,induced apoptosis,significantly downregulated m TOr,Akt,Bcl-2 expression,upregulated p53,Bax,PTEN,p38 MAPK expression,and exhibited anti-angiogenetic ***:Our findings indicate that ABE shows synergism with 5-FU and inhibits the proliferation of HT-29 cells by inducing apoptosis and suppressing angiogenesis,which may provide biological evidence for further use of ABE in the treatment of colorectal cancer.

关键词： angiogenesis doses colon

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利他偏好下多渠道绿色供应链定价决策研究

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佛山科学技术学院学报（自然科学版） 2024年第3期42卷 61-73页

作者：葛齐齐阿布都热合曼·卡的尔新疆财经大学信息管理学院新疆乌鲁木齐830012

由单一制造商及单一零售商组成的多渠道绿色供应链中,在制造商占主导地位时,利用Stackelberg模型构建无利他偏好、制造商利他偏好以及零售商利他偏好三种定价决策模型,分析并比较三种模型的均衡解,得出结论,并运用数字仿真的方法验证相... 详细信息

由单一制造商及单一零售商组成的多渠道绿色供应链中,在制造商占主导地位时,利用Stackelberg模型构建无利他偏好、制造商利他偏好以及零售商利他偏好三种定价决策模型,分析并比较三种模型的均衡解,得出结论,并运用数字仿真的方法验证相关结论的准确性。以数值仿真验证结论的有效性。结果表明:制造商或零售商单方面的利他对对方都是有利的,当制造商具有利他偏好时,产品的批发价格、线下零售价格、线上零售价格及自身利润下降,供应链整体利润上升;当零售商具有利他偏好时,产品的批发价格上升,线下及线上零售价格保持不变,自身利润下降,供应链整体利润不变;而当零售商线下或线上市场份额增大时,产品的线下及线上零售价格上升;且三种定价决策模型下,产品的直销价格始终保持不变。

关键词：多渠道绿色供应链渠道偏好利他偏好定价决策

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Mechanical and corrosion properties of partially degradable bone screws made of pure iron and stainless steel 316L by friction welding

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Science China Materials 2018年第4期61卷 593-606页

作者： Ahmad Kafrawi Nasution Mokhamad Fakhrul Ulum Mohammed rafiq Abdul kadir Hendra Hermawan Department of Mechanical Engineering Faculty of Engineering Muhammadiyah University of Riau Faculty of Veterinary Medicine Bogor Agricultural University Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia Department of Mining Metallurgical and Materials Engineering & CHU de Québec Research Center Laval University

This paper reports a series of in vitro, ex vivo and in vivo mechanical and corrosion studies of pin and screw prototype made of friction welded pure iron and 316 L type stainless steel aiming to evaluate the applicability of the partially removable bone screws. results showed that the pin possesses bending, tensile and torsional strengths of1706±147, 666±7 and 0.34±0.03 MPa, respectively. The pin degraded at an average weight loss rate of 17.15×10-5 g cm-2 day-1 and released Fe ions at an average concentration of 2.38 ppm. Plastic deformation induced by torsion increased the corrosion rate of the pin from 0.0014 to 0.0137 mm *** maximum pull-out load of the screw prototypes was3800 N with a calculated failure strength by shear load equal to22.2 k N which is higher than the strength of the cortical *** analysis of the rat's blood cells during 60 days of the pin implantation indicated a normal response with low neutrophils/lymphocytes ratio of 0.3-0.5. Iron ion concentration in the rat's blood slightly increased from 55 to 61 ppm without affecting the tissue recovering and healing phase. Histological evaluation confirmed the presence of macrophage cells as a normal response to the released iron particles around the iron section of the pin.

关键词： biodegradable metal bone screw friction welding iron stainless steel

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Effects of geraniin(rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet

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Journal of Integrative Medicine 2019年第2期17卷 100-106页

作者： Sonia Chew Wen Phang Uma Devi Palanisamy Khalid Abdul kadir School of Medicine and Health Sciences Monash University Malaysia

Objective: A preliminary study showed that geraniin extracted from Nephelium lappaceum L. at 50 mg/kg caused reduction in blood glucose and insulin resistance. The present study serves to further investigate the effects of geraniin at increasing doses between 3.125 and 100 mg/kg in high-fat diet-treated ***: Geraniin(95% purity) was extracted and purified from rambutan rind. Two groups of male Sprague-Dawley rats were fed with 60% high-fat diet and standard rat chow, respectively, for 12 ***-fat diet-treated rats were then administered geraniin at different doses. Body weight, blood pressure and blood glucose readings were measured. At the end of treatment, blood was collected for analysis of glycated haemoglobin A1c(HbA1c), insulin, advanced glycation end-product(AGE) levels, renin, aldosterone and ***: Within the first week of treatment, even the lowest dose of geraniin caused a significant reduction in blood pressure, which was comparable to control diet-treated rats. There were no changes in serum electrolytes, renin or aldosterone. Similarly, there was a significant reduction in serum insulin,insulin resistance and AGE levels at the lowest dose. However, there was no significant decrease in fasting blood glucose or HbA1c. The effects of decreasing insulin, insulin resistance and AGEs were observed only at the lower doses, unlike the results observed for blood pressure ***: Geraniin at lower doses improved blood pressure and other metabolic parameters. Secondary metabolites of geraniin, associated with antihypertensive activity, are relatively different to those involved in inhibiting AGE formation and increasing insulin sensitivity. The secondary metabolites of geraniin may be individually responsible for the bioactivities demonstrated.

关键词： Metabolic syndrome Hypertension Hyperglycemia Insulin resistance Advanced glycation end-product levels Geraniin

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Novel Inhibitory Effects of Glycyrrhizic Acid on the Accumulation of Advanced Glycation End Product and Its receptor Expression

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Natural Products and Bioprospecting 2014年第6期4卷 325-333页

作者： Hong Sheng Cheng Joana Magdelene Xiao Fang Kong Athena Xin Hui ng Weng Keong Chan So Ha Ton Khalid Abdul kadir School of Science Monash University Malaysia46150 Bandar SunwaySelangorMalaysia School of Medicine and Health Sciences Monash University Malaysia46150 Bandar SunwaySelangorMalaysia

Beneficial effects of glycyrrhizic acid(GA),a bioactive extract of licorice root,in the prevention of metabolic syndrome have been consistently reported while advanced glycation end products(AGE)and receptor for advanced glycation end product(rAGE)are the leading factors in the development of diabetes *** aim of this study was to investigate the effects of GA on the AGE-rAGE axis using high-fat/high-sucrose(HF/HS)diet-induced metabolic syndrome rat *** four male Sprague–Dawley rats were randomly assigned into three groups for 4 weeks:(1)Group A,normal diet with standard rat chow;(2)Group B,HF/HS diet;(3)Group C,HF/HS diet and oral administration of 100 mg/kg GA per *** results showed that HF/HS diet elevated the fasting blood glucose level and insulin resistance index which was prevented by GA *** treatment significantly lowered the circulating AGE independent of its glucose-lowering ***/HS diet also triggered rAGE upregulation in the abdominal muscles while GA administration downregulated rAGE expression in the abdominal muscles,aorta and subcutaneous adipose *** conclusion,HF/HS diet could cause glucose intolerance,insulin resistance and upregulation of rAGE expression while GA ameliorated the metabolic dysregulation besides exhibiting inhibitory effects on the AGE-rAGE axis.

关键词： Metabolic syndrome receptor for advanced glycation end product Licorice High-fat/high-sucrose diet

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Trace Metal Levels in Lichen Samples From roadsides in East Black Sea region,Turkey

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Biomedical and Environmental Sciences 2007年第3期20卷 203-207页

作者： OZGUr DOGAN ULUOZLU kadir KINALIOGLU MUSTAFA TUZEN MUSTAFA SOYLAK Gaziosmanpasa University Faculty of Science and Arts Chemistry Department60250 TokatTurkey Giresun University Faculty of Science and Arts Department of Biology Giresun Turkey Erciyes University Faculty of Science and Arts Chemistry Department 38039 Kayseri Turkey

Objective To determine the metal contents of lichen species from East Black Sea region of Turkey for investigation of trace metal pollution sourced traffic. Methods The levels of copper, cadmium, lead, zinc, manganese, iron, chromium, nickel, cobalt, palladium in lichen samples collected from East Black Sea region of Turkey were determined by flame and graphite furnace atomic absorption spectrometry after microwave digestion method. The accuracy of the method was corrected by standard reference material （NIST SrM IAEA-336 Lichen）. results The contents of invest!gated trace metals in lichen samples were 7.19-22.4 μg/g for copper, 0.10-0.64 μg/g for cadmium, 4.03-44.6 μg/g for lead, 14.5-41.8 μg/g for zinc, 25.8-208 μg/g for manganese, 331-436 μg/g for iron, 1.20-3.01 μg/g for chromium, 1.48-3.90 μg/g for nickel, 0.20-3.55 μg/g for cobalt, 0.11-0.64 μg/g for palladium. The results were compared with the literature values. Conclusion Some lichen species such as Xanthoparmelia conspersa, Xanthoria calcicola, Peltigera membranacea, and Physcia adscendens are accumulated trace metals at a high ratio.

关键词： Trace metals Lichen Atomic absorption spectrometry East Black Sea region-Turkey

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An Analysis of Sinop and Izmir Environmental Movements Within the Framework of the Neo-Gramscian Perspective

An Analysis of Sinop and Izmir Environmental Movements Withi...

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作者： kadir Eyol 上海交通大学

学位级别：硕士

This study examines the environmental movement emerged against the energy policy that has been supported by an economic development in *** particular the study discussed the antinuclear movement that emerged against the problems caused by neoliberal policies implemented in the field of energy and movement against a thermal power plant in ***-nuclear and thermal power plant movements have been evaluated in the framework of the counter-hegemony movements and are supported by the values built by the *** study highlights and analyses that Turkey’s transition to neoliberal policies,changes in energy policy,the formation opposing groups in the energy field,and the objectives,discourses,and actions of those are against thermal power *** upon Antonio Gramsci’s concepts of hegemony,counterhegemony,and robert Cox’s ideas are utilized to form the theoretical framework of the *** and Cox’s assumptions used in evaluating the reasons,discourses,actions,and aims of these *** research utilized both empirical methods focused on interview with activists who are lead and participated in the movements,and literature,report and documents *** focusing on environmental movements in Turkey,this research contributes new insights into the energy policies implemented in Turkey and anti-hegemonic environmental movements against these energy policies.

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An Alternative to the Marshall-Olkin Family of Distributions:Bootstrap,regression and Applications

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Communications on Applied Mathematics and Computation 2022年第4期4卷 1229-1257页

作者： Christophe Chesneau kadir Karakaya Hassan S.Bakouch Coskun Kus LMNO Université de CaenCampus ⅡScience 314032 CaenFrance Department of Statistics Faculty of ScienceSelcuk University42250 KonyaTurkey Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt

This paper introduces a new rich family of distributions based on mixtures and the so-called Marshall-Olkin family of *** includes a wide variety of well-established mixture distributions,ensuring a high ability for data *** distributional properties are derived for the general *** Weibull distribution is then considered as the base-line,exhibiting a pliant four-parameter lifetime *** estimation methods for the related parameters are *** confidence intervals are also considered for these *** distribution is reparametrized with location-scale parameters and it is used for a lifetime regression *** extensive simulation is carried out on the esti-mation methods for distribution parameters and regression model *** are given to two practical data sets to illustrate the applicability of the new family.

关键词： Marshall-Olkin family of distributions Estimation Confidence intervals Bootstrap Data analysis

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Modeling optimal long-term investment strategies of hybrid wind-thermal companies in restructured power market

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Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1267-1279页

作者： Mohammad Tolou ASKArI Mohd.Zainal Abdin Ab.kadir Mehrdad TAHMASEBI Ehsan BOLANDIFAr Department of Electrical Engineering Semnan BranchIslamic Azad UniversitySemnanIran Centre for Electromagnetic and Lightning Protection research(CELP) Faculty of EngineeringUniversiti Putra MalaysiaSerdangMalaysia Institute of Power Engineering(IPE) Universiti Tenaga NasionalKajangMalaysia Department of Electrical Power Engineering Eyvan-e-Gharb BranchIslamic Azad UniversityEyvanIran Department of Decision Sciences and Managerial Economics Chinese University of Hong KongHong KongChina

In this paper,a novel framework for the estimation of optimal investment strategies for combined wind-thermal companies is *** medium-term restructured power market was simulated by considering the stochastic and rational uncertainties,the wind uncertainty was evaluated based on a data mining technique,and the electricity demand and fuel price were simulated using the Monte Carlo *** Cournot game concept was used to determine the Nash equilibrium for each state and stage of the stochastic dynamic programming(DP).Furthermore,the long-term stochastic uncertainties were modeled based on the Markov chain *** longterm optimal investment strategies were then solved for combined wind-thermal investors based on the semi-definite programming(SDP)***,the proposed framework was implemented in the hypothetical restructured power market using the IEEE reliability test system(rTS).The conducted case study confirmed that this framework provides robust decisions and precise information about the restructured power market for combined wind-thermal investors.

关键词： Wind resources Power market Generation expansion planning Uncertainties Cournot game theory Stochastic dynamic programming

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Adomian decomposition method simulation of von Kármán swrling bioconvection nanofluid flow

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Journal of Central South University 2019年第10期26卷 2797-2813页

作者： M D SHAMSHUDDIN S r MISHrA O ANWAr BEG A kadir Department of Mathematics Vaagdevi College of EngineeringWarangalTelanganaIndia Department of Mathematics Siksha'O’Anusandhan Deemed to be UniversityKhandagiriBhubaneswarOdishaIndia Department of Aeronautical and Mechanical Engineering University of SalfordManchesterEnglandUK

The study reveals analytically on the 3-dimensional viscous time-dependent gyrotactic bioconvection in swirling nanofluid flow past from a rotating *** is known that the deformation of the disk is along the radial *** addition to that Stefan blowing is *** Buongiorno nanofluid model is taken care of assuming the fluid to be dilute and we find Brownian motion and thermophoresis have dominant role on nanoscale *** primitive mass conservation equation,radial,tangential and axial momentum,heat,nano-particle concentration and micro-organism density function are developed in a cylindrical polar coordinate system with appropriate wall(disk surface)and free stream boundary *** highly nonlinear,strongly coupled system of unsteady partial differential equations is normalized with the classical von Kármán and other transformations to render the boundary value problem into an ordinary differential *** emerging 11th order system features an extensive range of dimensionless flow parameters,i.e.,disk stretching rate,Brownian motion,thermophoresis,bioconvection Lewis number,unsteadiness parameter,ordinary Lewis number,Prandtl number,mass convective Biot number,Péclet number and Stefan blowing *** of the system are obtained with developed semi-analytical technique,i.e.,Adomian decomposition *** of the said problem is also conducted with earlier literature computed by runge-Kutta shooting technique.

关键词： nanofluids bioconvection rotating disk bioreactors von Kármán swirling flow Stefan blowing Adomian decomposition method(ADM)

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