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The feasible application ofmicrofluidic tissue/organ-on-a-chip as an impersonator of oral tissues and organs:a direction for future research

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Bio-Design and Manufacturing 2023年第4期6卷 478-506页

作者： Nima Farshidfar sahar Assar Mohammad Amin Amiri Sarina Sahmeddini Shahram Hamedani Moein Zarei Lobat Tayebi Orthodontic Research Center School of DentistryShiraz University of Medical SciencesShirazIran Section for Oral Ecology and Caries Control Department of Dentistry and Oral HealthAarhus UniversityAarhusDenmark Student Research Committee Shiraz University of Medical SciencesShirazIran Oral and Dental Disease Research Center School of DentistryShiraz University of Medical SciencesShirazIran Department of Polymer and Biomaterials Science Faculty of Chemical Technology and EngineeringWest Pomeranian University of TechnologySzczecinAl.Piastow 4571-311 SzczecinPoland Marquette University School of Dentistry MilwaukeeWI 53233USA

Currently,cell culture models play a key role in determining cell behavior under various ***,the accurate simulation of cellular behavior that imitates the body’s conditions remains a ***,to overcome this obstacle,three-dimensional cell culture models have been *** tissues/organs-on-chips(TOOCs)are new devices that have provided the opportunity to culture cells in a medium that is almost similar to the physiological conditions of the *** can be designed in simple or complex models,which are mostly fabricated by soft *** novel structures have been developed to mimic the conditions of various tissues and organs;however,microfluidic models for oral and dental tissues have not yet been widely *** application of TOOCs for oral tissues/organs can provide the opportunity to study cell interactions with biomaterials used in ***,TOOCs can provide the opportunity to study the cellular interactions and developmental stages of oral tissues/organs more *** review of the current advances in the field of TOOC development for oral tissues provides a comprehensive understanding of this burgeoning concept,shows the progress and applications of these novel models in the imitation of oral tissues/organs thus far,and reveals the limitations that TOOCs ***,it suggests further perspectives for future applications.

关键词： Microfluidics Tissue-on-a-chip Organ-on-a-chip Tooth-on-a-chip Oral mucosa-on-a-chip Salivary gland-on-a-chip

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Role of community health nurse in the prevention of elderly dehydration:A mini-review

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Journal of Integrative Nursing 2022年第3期4卷 166-171页

作者： Mostafa SHABAN Huda Hamdy MOHAMMED sahar HASSAN Community Health Nursing Department College Of Nursing Jouf UniversitySakakaSaudi Arabia Maternal and Newborn Department Faculty of NursingCairo UniversityCairoEgypt Department of Community Medicine Hammurabi College of MedicineUniversity of BabylonBabylonIraq

As dehydration is related to negative health outcomes in the elderly,including an increased risk of disability and death,prevention may help improve health,functional status,and quality of *** diagnosis can be challenging in the elderly as the traditional physical indications of dehydration may be absent or *** etiologies place the elderly at an increased *** role of the community health nurse(CHN)derives from the responsibilities attached to her,and the Betty Neuman’s Systems Model of health care with three levels of protection is usually applied to the *** this mini-review,we try to integrate the Betty Neuman’s Systems Model with the results of identified *** study includes a literature search of reputable international databases such as SpringerLink,PubMed,Embase,and Wanfang,particularly for the period 2005 to the *** articles that met the qualifying criteria were included in this *** findings of this study draw a picture of the role of CHN in preventing dehydration across the three levels of prevention as mentioned by Betty Neuman.

关键词： Community health nurse dehydration elderly prevention

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Anti-inflammatory and antipyretic potential of Arbutus andrachne *** leaf extract in rats

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Asian Pacific Journal of Tropical Biomedicine 2021年第11期11卷 491-499页

作者： sahar M.Jaffal Sawsan A.Oran Mohammad I.Alsalem Department of Biological Sciences Faculty of ScienceThe University of Jordan11942 AmmanJordan Department of Anatomy and Histology Faculty of MedicineThe University of Jordan11942 AmmanJordan

Objective:To explore the anti-inflammatory and antipyretic effects of methanolic leaf extract from Arbutus andrachne and its mechanism of ***:Paw edema was induced by intraplantar(***.)injection ofλ-carrageenan(1%w/v,100μL/paw)while pyrexia was evoked by intraperitoneal(i.p.)injection of 20% baker’s yeast(20 mL/kg body wt)in male Wistar *** anti-inflammatory and antipyretic effects of Arbutus andrachne methanolic leaf extract were explored by injecting rats with different doses of the plant extract(150,300,and 600 mg/kg body wt,i.p.).Selective antagonists for transient receptor potential vanilloid-1(TRPV1),cannabinoid receptor 1(CB1),and alpha-2 adrenergic receptor(α2-AR)were used to unravel the extracts’mechanism of *** samples were collected from the heart of rats to measure the levels of interleukin-6(IL-6)and prostaglandin E2(PGE2)by enzyme-linked immunosorbent ***:The extract exhibited potent anti-inflammatory activity by decreasing paw thickness and IL-6 *** addition,yeast-evoked pyrexia was attenuated by the extract treatment via TRPV1 and CB1 receptors and a reduction in PGE2 *** significant effects were found for α***,the rats that received the plant extract demonstrated similar responses to the positive control ***:Arbutus andrachne can be a good candidate for treating inflammation and pyrexia and should be further investigated.

关键词： Arbutus andrachne Anti-inflammatory Antipyretic PGE2 IL-6 TRPV1 CB1 α2-ARs

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Facile preparation of Nd2Zr2O7–ZrO2 nanocomposites as an effective photocatalyst via a new route

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Journal of Energy Chemistry 2017年第2期26卷 315-323页

作者： sahar Zinatloo-Ajabshir Zahra Zinatloo-Ajabshir Masoud Salavati-Niasari Samira Bagheri Sharifah Bee Abd Hamid Institute of Nano Science and Nano Technology University of KashanKashanP.O.Box.87317-51167I.R.Iran School of Pharmacy Mazandaran University of Medical SciencesSariP.O.Box.486717–887I.R.Iran Nanotechnology&Catalysis Research Centre(NANOCAT) IPS BuildingUniversity of Malaya50603 Kuala LumpurMalaysia

NdZrO–ZrOnanocomposites were prepared via a facile process with propylene glycol as novel connecting agent and benzene tricarboxylic acid as a new complexing agent. The as-obtained NdZrO–ZrOnanocomposites were characterized by transmission electron microscopy（TEM）, UV–vis diffuse reflectance spectroscopy, energy dispersive X-ray microanalysis（EDX）, Fourier transform infrared（FT-IR）spectroscopy, field emission scanning electron microscopy（FESEM）, and X-ray diffraction（XRD）. According to the morphological studies of the as-synthesized nanocomposites, it was found that the shape and particle size of NdZrO–ZrOnanocomposites depended on the space-filling template type, dosage of space-filling template and tricarboxylic acid as complexing agent. NdZrO–ZrOnanocomposites with different shapes and grain sizes have been synthesized. The photocatalytic behavior of as-produced NdZrO–ZrOnanocomposites was also investigated through photodegradation of methylene blue dye and 2-naphthol as water pollutants.

关键词： Photocatalyst Nanomaterials Photodegradation Nanocomposites Electron microscopy

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Effect of performed operations management on the amount of sediment production in natural forests

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Forestry Studies in China 2013年第3期15卷 214-221页

作者： Seyed Armin HASHEMI Alireza ESLAMI sahar TABIBIAN Department of Forestry Lahijan Branch Islamic Azad University Department of Agriculture Rasht Branch Islamic Azad University Department of Agriculture and Natural Resources Payamenoor University

The present study on the sediment production in natural forests was carried out on an 13,284 ha area,ocated in Guilan Province, in the north of Iran. This area is under intensive management. We first analyzed the physi- sal factors of the area. Then, the amount of road construction, afforestation and harvested wood volume, as well as the harvesting method in the region were determined for the years between 1993 and 2010. The results show that the aver- age annual amount of sediment production in the entire region, over this 18-year period, has increased annually at a rate of 3.54 ***-2 （R2 = 0.56） at a confidence level of 95%. Operations management and management methods used in ：his forest area has affected the amount of sediment production. Clear cutting and extensive harvesting methods in the region caused an increase in the amount of sediment production, as indicated by a coefficient of determination of 0.71, mplying that forest management may be considered effective and in harmony with the environment.

关键词： afforestation sediment forest road construction harvesting

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A Novel Binary Emperor Penguin Optimizer for Feature Selection Tasks

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Computers, Materials & Continua 2022年第3期70卷 6239-6255页

作者： Minakshi Kalra Vijay Kumar Manjit Kaur sahar Ahmed Idris Saban Oturk Hammam Alshazly Computer Science Department Government College BahadurgarhBahadurgarh124507India CSE Department National Institute of Technology Hamirpur177005India School of Engineering and Applied Sciences Bennett UniversityGreater Noida201310India College of Industrial Engineering King Khalid UniversityAbhaSaudi Arabia Department of Electrical and Electronics Engineering Amasya UniversityAmasyaTurkey Faculty of Computers and Information South Valley UniversityQena83523Egypt

Nowadays,due to the increase in information resources,the number of parameters and complexity of feature vectors *** offermore practical solutions instead of exact solutions for the solution of this *** Emperor PenguinOptimizer(EPO)is one of the highest performing meta-heuristic algorithms of recent times that imposed the gathering behavior of emperor *** shows the superiority of its performance over a wide range of optimization problems thanks to its equal chance to each penguin and its fast convergence *** traditional EPO overcomes the optimization problems in continuous search space,many problems today shift to the binary search ***,in this study,using the power of traditional EPO,binary EPO(BEPO)is presented for the effective solution of binary-nature *** algorithm uses binary search space instead of searching solutions like conventional EPO algorithm in continuous search *** this purpose,the sigmoidal functions are preferred in determining the emperor *** addition,the boundaries of the search space remain constant by choosing binary ***’s performance is evaluated over twenty-nine benchmarking *** evaluations are made to reveal the superiority of the BEPO *** addition,the performance of the BEPO algorithm was evaluated for the binary feature selection *** experimental results reveal that the BEPO algorithm outperforms the existing binary meta-heuristic algorithms in both tasks.

关键词： Metaheuristics optimization algorithms emperor penguin optimizer intensification diversification feature selection

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Sustained small and intermediate size proteins expression in phorbol 12-myristate 13-acetate/ionomycine prolonged stimulated human fibroblasts

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 432-436页

作者： Zeinab Abedian Sadegh Fattahi Roghayeh Pourbagher sahar Edrisi Amrollah Mostafazadeh Cellular and Molecular Biology Research Center Health Research InstituteBabol University of Medical SciencesBabolIran Dental Material Research Center Faculty of DentistryBabol University of Medical SciencesBabolIran

Objective:To compare the protein profile of culture supernatants in stimulated and unstimulated human fibroblasts to find some proteins indicating the presence of fibroblasts and their activation ***:Dermal fibroblasts were stimulated with phorbol 12-myristate 13-acetate(PMA)/ionomycine for 72 *** assay was done to determine cell viability and A/E fluorescent staining was used to evaluate the cell death *** analysis was performed by gradient SDS polyacrylamide gel electrophoresis 8%–16%.Results:The supernatant of 24 h cultured both stimulated and unstimulated fibroblasts showed two bands in SDS-PAGE analysis with relative molecular weights of 8.59 and78.8 k *** bands density was decreased during the next 48 h in unstimulated cells while their expression was continued in PMA or PMA/ionomycine stimulated cells and a new 85.3 k Da band was appeared in unstimulated and 72 h PMA stimulated ***,we found another seven small size(10–19.5 k Da) proteins in supernatants of48 h and 72 h unstimulated but not in PMA or PMA/Ionomycine stimulated *** of these proteins expression were down regulated following fibroblast *** down-regulation is consistent with our finding that PMA or PMA/ionomycine stimulated cells exhibited a significant level of apoptosis cell ***:Human fibroblasts produce some small to intermediate sized proteins with specific SDS-PAGE profile upon cell *** of these proteins can be excreted in urine and can be immunogen theoretically so this data provided a reliable clue for fibrosis biomarker screening based on designation of an appropriated immunoassay.

关键词： Fibroblast activation Apoptosis Protein electrophoresis phorbol 12-myristate 13-acetate Ionomycine Fibrosis Biomarker

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Hairy cell leukemia presenting as multiple discrete hepatic lesions

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World Journal of Gastroenterology 2009年第35期15卷 4453-4456页

作者： Nadav sahar Ginette Schiby Tima Davidson Abraham Kneller Sara Apter Zvi Farfel Department of Medicine E Sheba Medical CenterTel Hashomer 52621and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Pathology Sheba Medical CenterTel Hashomer 52621and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Nuclear Medicine Sheba Medical CenterTel Hashomer 52621and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Hematology Sheba Medical CenterTel Hashomer 52621and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Departments of Diagnostic Radiology Sheba Medical CenterTel Hashomer 52621and Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

The involvement of hairy cell leukemia in the liver is in the form of portal and sinusoidal cellular infiltration. Here we describe the first case of hepatic hairy cell leukemia presenting as multiple discrete lesions,which was treated *** suggest that in the inves- tigation of discrete hepatic lesions in cases of cancer of unknown primary,hairy cell leukemia should be consid- *** excellent response of hairy cell leukemia to therapy highlights the need for such a consideration.

关键词： Cancer of unknown primary Hairy cell leukemia Hepatic lesions

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Crohn's disease-related'gastrocnemius myalgia syndrome'successfully treated with infliximab:A case report

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World Journal of Gastroenterology 2022年第7期28卷 755-762页

作者： Julien Catherine Hazim kadhim Frédéric Lambot Claire Liefferinckx Virginie Meurant Lukas Otero Sanchez Institute for Medical Immunology UniversitéLibre de BruxellesGosselies 6041Belgium Department of Internal Medicine C.U.B.Hôpital ErasmeBrussels 1070Belgium NeuroMyopathology Unit(Anatomic Pathology Service)and Reference Center for Neuromuscular Pathology CHU BrugmannUniversitéLibre de BruxellesBrussels 1020Belgium Department of Internal Medicine Centre Hospitalier Universitaire TivoliLa Louvière 7100Belgium Department of Gastroenterology Hepatopancreatology and Digestive OncologyC.U.B.Hôpital ErasmeBrussels 1070Belgium Laboratory of Experimental Gastroenterology UniversitéLibre de BruxellesBrussels 1070Belgium Department of Emergency Medicine Centre Hospitalier Universitaire TivoliLa Louvière 7100Belgium

BACKGROUND Extra-intestinal manifestations in inflammatory bowel diseases(IBD)are frequent and involve virtually all ***,the clinical characteristics and course of inflammatory myopathies in IBD remain poorly described and mostly related to orbital ***,alternative therapeutic strategies in non-responder patients to corticosteroid therapy must still be *** SUMMARY A 33-year-old woman with a history of unclassified colitis presented with acute bilateral calf *** admission,her clinical and biological examinations were ***,magnetic resonance imaging showed bilateral inflammatory changes in gastrocnemius muscles suggestive of *** biopsy confirmed the diagnosis of myositis and demonstrated an inflammatory infiltrate mainly located in the perimysial compartment including lympho-plasmocytic cells with the formation of several granulomatous structures while the endomysium was relatively *** combined clinical,biological and histomyopathological findings were concordant with the diagnosis of‘gastrocnemius myalgia syndrome’(GMS),a rare disorder associated with Crohn’s disease(CD).Ileocolonoscopy confirmed CD diagnosis and systemic corticosteroids(CS)therapy was started,resulting in a rapid clinical *** CS tapering,however,she experienced a relapse of GMS together with a severe active *** was started and allowed a sustained remission of both conditions at the latest follow-up(20 mo).CONCLUSION The GMS represent a rare CD-associated inflammatory myopathy for which anti-tumour necrosis factor-αtherapy might be considered as an effective therapeutic option.

关键词： Crohn’s disease Extra-intestinal manifestation Gastrocnemius myalgia syndrome Granulomatous myositis Anti-tumour necrosis factor-αtherapy Case report

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An Improved DeepNN with Feature Ranking for Covid-19 Detection

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Computers, Materials & Continua 2022年第5期71卷 2249-2269页

作者： Noha E.El-Attar sahar F.Sabbeh Heba Fasihuddin Wael A.Awad Faculty of Computers and Artificial Intelligence Benha UniversityBenha13518Egypt University of Jeddah College of Computer Science and EngineeringJeddah21493Kingdom of Saudi Arabia Faculty of Computers and Information Damietta UniversityDamietta34711Egypt

The outbreak of Covid-19 has taken the lives of many patients so *** symptoms of COVID-19 include muscle pains,loss of taste and smell,coughs,fever,and sore throat,which can lead to severe cases of breathing difficulties,organ failure,and ***,the early detection of the virus is very ***-19 can be detected using clinical tests,making us need to know the most important symptoms/features that can enhance the decision *** this work,we propose a modified multilayer perceptron(MLP)with feature selection(MLPFS)to predict the positive COVID-19 cases based on symptoms and features from patients’electronic medical records(EMR).MLPFS model includes a layer that identifies the most informative symptoms to minimize the number of symptoms base on their relative *** the model with only the highest informative symptoms can fasten the learning process and increase *** were conducted using three different COVID-19 datasets and eight different models,including the proposed *** show that MLPFS achieves the best feature reduction across all datasets compared to all other experimented ***,it outperforms the other models in classification results as well as time.

关键词： Covid-19 feature selection deep learning

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