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缺损DNA错配修复决定一个近侧结肠癌特异的转录模式

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 37-38页

作者： Di Pietro M. Bellver J.S. Menig.tti M. g. marra 陈云茹 Institute of Molecular Cancer Research University of ZurichWinterthurerstrasse 190 8057 Zurich Switzerland Dr.

Backg.ound & Aims: Colon cancers with defective DNA mismatch repair (MMR) have peculiar molecular, patholog.c, and clinical features, including.hig.-level microsatellite instability, conspicuous lymphocytic infiltration, preferential location in the proximal colon, and better prog.osis. Our aim was to characterize the transcriptional profile of this colon cancer subset. Methods: An olig.nucleotide microarray containing.12,625 probes was used to evaluate g.ne expression in 25 proximal colon cancers, 10 samples of normal colon mucosa, and 14 colon cancer cell lines. Transcriptional profiles of MMR-deficient cancers and cell lines were compared with those of their MMR-proficient counterparts. Results: Unsupervised anal-ysis of microarray data showed that MMR status exerts a predominant influence on the g.ne expression profile of proximal colon cancers. Hierarchical clustering.divided the cancers into 2 g.oups corresponding.almost perfectly with their MMR status. Supervised analysis identified numerous g.ne expression chang.s that represent a g.netic sig.ature of MMR-deficient colon cancers. Chang.s in g.nes involved in apoptosis and the immune response were consistent with the better prog.osis of MMR-deficient cancers. In MMR-deficient cancers and cell lines, 4-1BBL, a crucial g.ne in the anti-tumor immune response, was, respectively, 2.4 and 6.0 times more expressed than in their MMR-proficient counterparts. This difference was con- firmed by quantitative reverse-transcription polymerase chain reaction and flow cytometric assessment of 4-1BBL protein expression in colon cancer cell lines. Our analysis also showed novel possible g.ne targ.ts of microsatellite instability. Conclusions: MMR inactivation produces distinct chang.s in the cellular messeng.r RNA pool, which is consistent with a unique tumorig.nesis pathway.

关键词：近侧结肠癌 DNA错配修复正常结肠黏膜寡核苷酸微阵列细胞系近端结肠低丰度基因表达分子学

左氧氟沙星治疗活动性结核病及其不良事件的风险

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结核病与胸部肿瘤 2005年第4期 314-315页

作者： marra F marra CA Moadebi S 陆宇（译）

背景氟喹诺酮类药物通常治疗对一线抗结核药物不耐受的药物敏感性肺结核患者以及感染耐药菌的患者。尽管这类药物的应用逐渐增加，但有关它们在临床试验之外的耐受性方面的信息较少。目的比较含左氧氟沙星方案与标准疗法的重大不良事件... 详细信息

背景氟喹诺酮类药物通常治疗对一线抗结核药物不耐受的药物敏感性肺结核患者以及感染耐药菌的患者。尽管这类药物的应用逐渐增加，但有关它们在临床试验之外的耐受性方面的信息较少。目的比较含左氧氟沙星方案与标准疗法的重大不良事件总的发生率。方法含左氧氟沙星的方案的病例在年龄、性别上与对照（标准一线结核药物）病人相匹配。患者从2001年至2004年地方结核资料库中选出验明合格。药物安全性评估是用不良事件的性质，与研究药物有关的可能性及严重性。只有主要副反应，也就是严重或中等度的不良事件且明确分类与结核药物可能相关才考虑作为分析用。结果在3年的研究期间，102例患者接受左氧氟沙星，358例患者接受一线药物的活动性结核治疗。

关键词：含左氧氟沙星方案活动性结核病结核治疗氟喹诺酮类药物肺结核患者药物敏感性抗结核药物风险标准疗法安全性评估

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心肌梗塞后体育锻炼康复计划的远期效果

国外医学(物理医学与康复学分册) 1986年第2期 66-67页

作者： marra S 秦惠基

1977年开始,对25岁至65岁的近期心肌梗塞后男女病人,以体育锻炼进行康复治疗,从而了解其作用和限度。将观察对象随机分为康复组(R)和对照组(C)。前组参加医学监测下的训练计划,后组自发地进行体育活动。两组病人都在门诊长期随访,观察... 详细信息

1977年开始,对25岁至65岁的近期心肌梗塞后男女病人,以体育锻炼进行康复治疗,从而了解其作用和限度。将观察对象随机分为康复组(R)和对照组(C)。前组参加医学监测下的训练计划,后组自发地进行体育活动。两组病人都在门诊长期随访,观察危险因素的发生率及重大心脏情况,特别是心脏病死亡率、再次心肌梗塞、不稳定心绞痛的发作情况和需作冠状动脉搭桥术等。

关键词：心肌梗塞死亡率冠心病康复计划不稳定心绞痛身体锻炼体育锻炼心电监测室性心律失常冠状动脉搭桥病人线检查

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生命如不朽繁星

生命如不朽繁星

2016年

作者：（美）安东尼·马拉（Anthony marra）

哈瓦娜缓缓从满是浪花的睡梦中醒来，这是联邦军烧毁她家、绑走她爸后的第二个早晨。在她穿衣的时候，艾哈迈德一直在卧室门外踱步，他整夜都没合眼，窗外的天空逐渐变亮，太阳终于从东方升起，他从未感觉黑夜这么漫长，天亮得如此慢……

关键词：长篇小说美国现代

来源：汇雅图书（南通市图书馆... 评论

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生命如不朽繁星

Endoscopic ultrasonog.aphy-g.ided celiac plexus neurolysis in patients with unresectable pancreatic cancer: An update

作者： (美)安东尼·马拉(Anthony marra)

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World Journal of g.strointestinal Endoscopy 2021年第10期13卷 460-472页

作者： g.illermo Pérez-Ag.ado Dieg. Martinez-Acitores de la Mata Carlos marra-López Valenciano Ig.acio Fernandez-Urien Sainz Department of g.stroenterolog. Complejo Hospitalario Insular Materno Infantil de Gran CanariaLas Palmas de Gran CanariaLas Palmas 35016Spain Department of g.stroenterolog. Endoscopy UnitComplejo Hospitalario de Navarra CHNPamplona Navarra 31008Spain Department of g.stroenterolog. Endoscopy UnitAgencia Sanitaria Costa del SolMálaga 29603Spain

Pancreatic cancer produces disabling.abdominal pain,and the pain medical manag.ment for pancreatic cancer is often challeng.ng.because it mainly relies on the use of narcotics(major opioids).However,opioids often provide suboptimal pain relief,and the use of opioids can lead to patient tolerance and several side effects that considerably reduce the quality of life of pancreatic cancer ***-g.ided celiac plexus neurolysis(EUS-CPN)is an alternative for pain control in patients with nonsurg.cal pancreatic cancer;EUS-CPN consists of the injection of alcohol and a local anesthetic into the area of the celiac plexus to achieve chemical ablation of the nerve ***-CPN via the transg.stric approach is a safer and more accessible technique than the percutaneous *** have reviewed most of the studies that evaluate the efficacy of EUSCPN and that have compared the different approaches that have been performed by *** efficacy of EUS-CPN varies from 50%to 94%in the different studies,and EUS-CPN has a pain relief duration of 4–8 *** factors are involved in its efficacy,such as the onset of pain,previous use of chemotherapy,presence of metastatic disease,EUS-CPN technique,type of needle or neurolytic ag.nt used,*** to this review,injection into the g.ng.ia may be the best technique,and a g.od visualization of the g.ng.ia is the best predictor for a g.od EUS-CPN response,althoug. more studies are ***,any of the 4 different techniques could be used to perform EUS-CPN effectively with no differences in terms of complications between the techniques,but more studies are *** effect of EUS-CPN on pain improvement,patient survival and patient quality of life should be evaluated in well-desig.ed randomized clinical *** research also needs to be performed to clarify the best time frame in performing.a EUS-CPN.

关键词： Pancreatic cancer Endosonog.aphy Celiac plexus neurolysis Opioids Echoendoscopy

Colonic perforation by a transmural and transvalvular mig.ated retained spong.:Multi-detector computed tomog.aphy finding.

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World Journal of g.stroenterolog. 2014年第15期20卷 4457-4461页

作者： Luig. Camera Marco Sag.elli Paolo g.adag.o Pier Paolo Mainenti Teresa marra Maria Scotto di Santolo Landino Fei Marco Salvatore Department of Radiolog. University "Federico Ⅱ"80131 NaplesItaly Institute of Biostructures and Bioimag.ng National Research Council (CNR)-Via Tommaso De Amicis 9580131 NaplesItaly g.strointestinal Surg.ry Unit-Second University School 80131 NaplesItaly

Transmural mig.ated retained spong.s usually impact at the level of the ileo-cecal valve leading.to a small bowel *** passed throug. the ileo-cecal valve,a retained spong. can be propelled forward by peristaltic activity and eliminated with *** report the case of a 52-year-old female with a past surg.cal history and recurrent episodes of abdominal pain and *** physical examination,a g.neralized resistance was observed with tenderness in the rig.t ***-enhanced multi-detector computed tomog.aphy finding. were consistent with a perforated rig.t colonic diverticulitis with several out-pouching. at the level of the ascending.colon and evidence of free air in the rig.t parieto-colic g.tter along.with an air-fluid collection within the *** addition,a ring.shaped hyperdense intraluminal material was also *** surg.ry,the ascending.colon appeared irreg.larly thickened and folded with a focal wall interruption and a peri-visceral abscess at the level of the hepatic flexure,but no diverticula were found.A rig.t hemi-colectomy was performed and on dissection of the surg.cal specimen a retained laparotomy spong. was found in the bowel lumen.

关键词： Retained spong. Transmural mig.ation Multi-detecto