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Optical colorimetric LiTaO_(3)wafers for highprecision lithography on frequency control of SAW devices

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Photonics Research 2024年第2期12卷 341-349页

作者： MING HUI FANG yinong xie FANGQI XUE ZHILIN WU JUN SHI SHENG YU yang YILIN LIU ZHIHUANG LIU HSIN CHI WANG FAJUN LI QING HUO LIU JINFENG ZHU School of Electronic Science and Engineering Xiamen UniversityXiamen 361005China Quanzhou San’an Integrated Circuit Co. Ltd.Quanzhou 362300China Eastern Institute of Technology Ningbo 315200China

Surface acoustic wave(SAW)resonators based on lithium tantalate(LT,LiTaO_(3))wafers are crucial elements of mobile communication *** use of intrinsic LT wafers typically brings about low fabrication accuracy of SAW resonators due to strong UV reflection in the lithography *** hinders their resonance frequency control seriously in industrial *** doping and chemical reduction could be applied to decrease the UV reflection of LT wafers for high lithographic ***,conventional methods fail to provide a fast and nondestructive approach to identify the UV performance of standard single-side polished LT wafers for highprecision frequency ***,we propose a convenient on-line sensing scheme based on the colorimetry of reduced Fe-doped LT wafers and build up an automatic testing system for industrial *** levels of Fe doping and chemical reduction are evaluated by the lightness and color difference of LT-based *** correlation between the wafer visible colorimetry and UV reflection is established to refine the lithography process and specifically manipulate the frequency performance of SAW *** study provides a powerful tool for the fabrication control of SAW resonators and will inspire more applications on sophisticated devices of mobile communication.

关键词： lithography doping wafer

Dielectric metasurface evolution from bulk to monolayer by strong coupling of quasi-BICs for second harmonic boosting

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Photonics Research 2024年第4期12卷 784-792页

作者： yinong xie QIANTING CHEN JIN YAO XUEYING LIU ZHAOGANG DONG JINFENG ZHU Institute of Electromagnetics and Acoustics and Key Laboratory of Electromagnetic Wave Science and Detection Technology Xiamen UniversityXiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518057China Department of Electrical Engineering City University of Hong KongHong Kong 999077China Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

2D materials are promising candidates as nonlinear optical components for on-chip devices due to their ultrathin structure. In general, their nonlinear optical responses are inherently weak due to the short interaction thickness with light. Recently, there has been great interest in using quasi-bound states in the continuum (q-BICs) of dielectric metasurfaces, which are able to achieve remarkable optical near-field enhancement for elevating the second harmonic generation (SHG) emission from 2D materials. However, most studies focus on the design of combining bulk dielectric metasurfaces with unpatterned 2D materials, which suffer considerable radiation loss and limit near-field enhancement by high-quality q-BIC resonances. Here, we investigate the dielectric metasurface evolution from bulk silicon to monolayer molybdenum disulfide (MoS2), and discover the critical role of meta-atom thickness design on enhancing near-field effects of two q-BIC modes. We further introduce the strongcoupling of the two q-BIC modes by oblique incidence manipulation, and enhance the localized optical field on monolayer MoS2dramatically. In the ultraviolet and visible regions, the MoS2SHG enhancement factor of our design is 105times higher than that of conventional bulk metasurfaces, leading to an extremely high nonlinear conversion efficiency of 5.8%. Our research will provide an important theoretical guide for the design of high-performance nonlinear devices based on 2D materials.

关键词： monolayer harmonic quasi

Genome-Wide Prediction of Highly Specific Guide RNA Spacers for CRISPR-Cas9-Mediated Genome Editing in Model Plants and Major Crops

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Molecular Plant 2014年第5期7卷 923-926页

作者： kabin xie Jianwei Zhang yinong yang Department of Plant Pathology and Environmental Microbiology The Huck Institutes of the Life Sciences Pennsylvania State University University Park PA 16802 USA National Key Laboratory of Crop Genetic Improvement Huazhong Aclricultural University Wuhan 430070 China Arizona Genomics Institute University of Arizona Tucson AZ 85721 USA Institute of Genetics College of Life Sciences Zhejiang University Hangzhou 310058 China

Dear Editor, RNA-guided genome editing （RGE） using the Streptococcus pyogenes CRISPR-Cas9 system （Jinek et al., 2012; Cong et al., 2013; Mall et al., 2013b） is emerging as a simple and highly efficient tool for genome editing in many organisms. The Cas9 nuclease can be programmed by dual or single guide RNA （gRNA） to cut target DNA at specific sites,

关键词： CAS9 ENDONUCLEASE MULTIPLEX SYSTEM

A FLASH pipeline for arrayed CRISPR library construction and the gene function discovery of rice receptor-like kinases

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Molecular Plant 2022年第2期15卷 243-257页

作者： Kaiyuan Chen Runnan Ke Manman Du Yuqing Yi Yache Chen Xiaochun Wang Lu Yao Hao Liu Xin Hou Lizhong Xiong yinong yang kabin xie National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Hubei Hongshan LaboratoryHuazhong Agricultural UniversityNo.1 Shizishan StreetHongshan DistrictWuhan 430070China Hubei Key Laboratory of Plant Pathology Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China Department of Plant Pathology and Environmental Microbiology The Huck Institutes of Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China

Clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPR-associated protein 9(Cas9)-mediated gene editing is revolutionizing plant research and crop ***,we present an effective and streamlined pipeline for arrayed CRISPR library construction and demonstrate it is suitable for small-to large-scale genome editing in *** pipeline introduces artificial PCR fragment-length markers for distinguishing guide RNAs(gRNAs)(FLASH),and a group of 12 constructs harboring different FLASH tags are co-transformed into plants each *** identities of gRNAs in Agrobacterium mixtures and trans-genic plants can therefore be read out by detecting the FLASH tags,a process that requires only conven-tional PCR and gel electrophoresis rather than *** generated an arrayed CRISPR library target-ing all 1,072 members of the receptor-like kinase(RLK)family in ***-shot transformation generated a mutant population that covers gRNAs targeting 955 RLKs,and 74.3%(710/955)of the target genes had three or more independent T0 *** results indicate that the FLASH tags act as bona fide surrogates for the gRNAs and are tightly(92.1%)associated with frameshift mutations in the target *** addition,the FLASH pipeline allows for rapid identification of unintended editing events without corresponding T-DNA integrations and generates high-order mutants of closely related RLK ***,we showed that the RLK mutant library enables rapid discovery of defense-related RLK *** study introduces an effective pipeline for arrayed CRISPR library construction and provides genome-wide rice RLK mutant resources for functional genomics.

关键词： CRISPR library gene editing high throughput receptor-like kinaserice

Experimental Investigation and Visualization Study of the Condensation Characteristics in a Propylene Loop Heat Pipe

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Journal of Thermal Science 2021年第5期30卷 1803-1813页

作者： YAN Kaifenu xie Rongjian LI Nanxi XU Guangming WU yinong University of Chinese Academy of Sciences Beijing 100049China Shanghai Institute of Technology and Physics Shanghai 200083China

At present,the structural design of a loop heat pipe(LHP)condenser mostly relies on *** analyze the condensation flow pattern in an LHP and to find a more accurate empirical correlation that can better guide condenser design in existing empirical correlations,a test system was designed and fabricated to observe the condensation phenomenon in the condenser and to evaluate the LHP’s heat transfer *** propylene has a wide temperature range to different temperature control requirements,it was chosen as the working *** this paper,the condensation process in the condenser was observed,and the operating parameters of a propylene LHP were measured at 283 *** condensation flow patterns in the 2.5 mm×2.5 mm channel mainly included stratified flow,wavy flow and intermittent *** comparing the experimental results with four typical condensation flow regime maps,it was found that the Breber and Cavallini flow regime maps can successfully predict most of the condensation flow patterns of the LHP even with ultra-small mass *** addition,four condensation heat transfer coefficient correlations were selected to compare the predicted values of heat transfer coefficient with the experimental *** study showed that the predicted values from the correlation by Cavallini et *** 90%of the experimental values well with an error of less than 20%,and this correlation is recommended for highly accurate LHP design.

关键词： loop heat pipe condensation visualization flow pattern

Engineering the endogenous RNA processing machineries for CRISPR-mediated multiplex genome editing

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Engineering the endogenous RNA processing machineries for CR...

无界区域上耦合sine-Gordon方程组的分裂局部人工边界条件

2018全国植物生物学大会

作者： Dan Ding Kaiyuan Chen yinong yang kabin xie National Key Laboraroty of Crop Genetic Improvement Huazhong Agricultural University The Huck Institutes of Life Sciences Department of Plant Pathology and Environmental MicrobiologyPennsylvania State University University Park

The cluster regularly interspaced short palindromic repeats(CRISPR) system revolutionizes genetic engineering in recent *** this system,a small RNA molecule is used to direct a CRISPR effector nuclease(e.g.,Cas9 and Cpf1) to a specific DNA *** date,methods to efficiently express RNA guide with defined terminus are still limited in *** previously hijacked the endogenous tRNAprocessing enzymes to produce many guide RNAs(gRNAs) from a polycistromc tRNA-gRNA(PTG) *** strategy greatly boosts CRISPR-Cas9 multiplex genome editing capacity and efficiency in plants and *** further optimize Cas9 and gRNA expression,we recently developed anartificial recombinant gene to express Cas9 nuclease and gRNAssimultaneously from one *** recombinant gene encodes Cas9 and also contains intronic PTG(referred as inPTG-Cas9).As a result,the inPTG is spliced from its primary transcript and then processing by endogenous tRNA processing *** demonstrated that such recombinant genes of inPTG-Cas9 could be expressed with one Pol II promoter for genome editing without trade-off ***,we also tested the genome editing efficiencies of LbCpfl and FnCpfl with different RNA guides expression *** results showed that recombinant gene of Cpfl containing intronic crRNA array exhibited robust and high efficiency in multiplex genome editing in ***,we provide general strategies to hijack endogenous intron splicing and tRNA processing machineries to simultaneously express many RNA guides for CRISPR *** to its simplicity,flexibility and versatility,thesemethods could be broadly used to develop sophisticated CRISPR tools in different eukaryotes.

关键词： CRISPR Cas9 tRNA Cpfl intron multiplex

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齐鲁工业大学学报 2024年第4期38卷 72-80页

作者：谢冰台怡农李宏伟济南育英中学山东济南250001 山东师范大学数学与统计学院山东济南250358

研究了在等离子体物理学中有广泛应用的无界区域上耦合sine-Gordon方程组的数值解法,由于物理区域的无界性和方程组的非线性,使得常用的数值方法不能直接用于求解此问题。利用人工边界方法和算子分裂方法设计了合理的分裂局部人工边界条... 详细信息

研究了在等离子体物理学中有广泛应用的无界区域上耦合sine-Gordon方程组的数值解法,由于物理区域的无界性和方程组的非线性,使得常用的数值方法不能直接用于求解此问题。利用人工边界方法和算子分裂方法设计了合理的分裂局部人工边界条件,解决了物理区域的无界性和方程组的非线性给数值计算带来的困难。无界区域上的Cauchy问题简化为有界区域上的初边值问题,从而可以利用有限差分方法进行数值求解。最后,通过数值算例验证了所设计边界条件的精确性和有效性,并模拟了多孤立波的传播。

关键词：耦合sine-Gordon方程组人工边界方法算子分裂方法无界区域有限差分法

涤痰汤加减联合电针治疗痰气郁结型难治性精神分裂症的疗效

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西北药学杂志 2024年第3期39卷 128-133页

作者：刘医农谢春平焦英霞衡水市第七人民医院精神科衡水053000

目的分析涤痰汤加减联合电针治疗痰气郁结型难治性精神分裂症的疗效及对患者睡眠、记忆功能的影响。方法将收治的难治性精神分裂症患者150例,用随机数字表法分为对照组与试验组,每组75例。对照组予以氯氮平治疗,试验组在对照组治疗的基... 详细信息

目的分析涤痰汤加减联合电针治疗痰气郁结型难治性精神分裂症的疗效及对患者睡眠、记忆功能的影响。方法将收治的难治性精神分裂症患者150例,用随机数字表法分为对照组与试验组,每组75例。对照组予以氯氮平治疗,试验组在对照组治疗的基础上予以涤痰汤加减联合电针治疗,2组均治疗8周。比较2组治疗前、治疗8周后的精神症状、记忆、认知功能、睡眠质量和神经因子;治疗8周后的疗效;治疗期间不良反应的发生情况。结果治疗8周后,试验组的总有效率(93.33%)高于对照组(78.67%),P<0.05。2组阳性和阴性症状量表(positive and negative symptom scale,PANSS)、匹茨堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)评分及血清胶质纤维酸性蛋白(glial fibrillary acid protein,GFAP)水平均降低,且试验组的下降更显著(P<0.05);2组韦氏成人记忆量表(Wechsler adult memory scale,WMS-RC)、精神分裂症认知功能成套测验(matrics consensus cognitive battery,MCCB)评分、睡眠效率(sleep efficiency,SE),血清神经生长因子(nerve growth factor,NGF)和脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平均升高,且试验组更高(P<0.05);2组睡眠总时间(total sleep time,TST)延长,且试验组长于对照组(P<0.05)。试验组的不良反应总发生率(5.33%)低于对照组(16.00%),P<0.05。结论涤痰汤加减联合电针治疗痰气郁结型难治性精神分裂症的疗效好,可改善患者的精神症状、记忆及认知功能,提高睡眠质量,可能与其调节血清神经因子的表达有关,且具有较好的安全性。

关键词：涤痰汤加减氯氮平难治性精神分裂症电针神经因子睡眠质量认知功能记忆功能

涤痰汤加减联合电针治疗难治性精神分裂症的临床研究

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长春中医药大学学报 2024年第1期40卷 65-69页

作者：刘医农谢春平焦英霞衡水市第七人民医院精神科河北衡水053000

目的探讨涤痰汤加减联合电针治疗难治性精神分裂症的疗效及认知功能、血清学指标变化情况。方法选取2019年7月-2021年7月衡水市第七人民医院精神科收治的150例难治性精神分裂症为研究对象,按随机数字表法将其分为对照组和试验组,各75... 详细信息

目的探讨涤痰汤加减联合电针治疗难治性精神分裂症的疗效及认知功能、血清学指标变化情况。方法选取2019年7月-2021年7月衡水市第七人民医院精神科收治的150例难治性精神分裂症为研究对象,按随机数字表法将其分为对照组和试验组,各75例。对照组给予氯氮平片进行治疗,试验组在对照组基础上给予涤痰汤加减联合电针治疗,2组均治疗8周。比较2组治疗8周后的临床疗效,治疗前后中医症候积分、精神症状、认知功能、脂代谢指标、血清学指标水平及治疗期间的安全性。结果与对照组治疗8周后的总有效率(78.67%)比较,试验组总有效率(93.33%)更高(P <0.05)。治疗8周后,2组神志呆钝、胸闷肋痛、喜静恶动、忧虑多疑、阳性和阴性症状量表(PANSS)、简明精神病量表(BPRS)评分及血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平与治疗前比较均降低,试验组低于对照组(P <0.05);2组韦氏成人记忆量表(WMS-RC)评分及血清高密度脂蛋白胆固醇(HDL-C)、脑源性神经营养因子(BDNF)、5-羟色胺(5-HT)、促甲状腺激素(TSH)、褪黑素(MT)水平与治疗前比较均升高,试验组高于对照组(P <0.05)。与对照组治疗期间的不良反应总发生率(16.00%)比较,试验组不良反应总发生率(5.33%)更低(P <0.05)。结论涤痰汤加减联合电针可明显调节难治性精神分裂症患者脂代谢及血清学指标水平,改善患者中医症候、精神症状及认知功能,进而可提高临床疗效,且具有较好的安全性。

关键词：难治性精神分裂症涤痰汤电针脂代谢血清学中医症候认知功能安全性