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Grading system modification and management of blunt aortic injury

Chinese Medical Journal 2013年第3期126卷 442-445页

作者： kaavya n reddy Tim Matatov Linda D Doucet Maureen Heldmann Cynthia X Zhao Wayne W Zhang Division of Vascular and Endovascular Surgery Louisiana State-University' Health Sciences Cemer Shreveport LA USA Department of Radiology Louisiana State University Health Sciences Center Shreveport LA USA Department of Pathology Louisiana State University Health Sciences Center Shreveport LA USA

Background The traditional approach to blunt aortic injury （BAI） has been emergent intervention. This study aimed to utilize a modified imaging grading system that may allow us to categorize these injuries as needing emergent, urgent, or non-operative management. Methods From January 2003 to December 2011, 28 patients with BAI were managed at our institution. Imaging and medical records were reviewed retrospectively. BAI was classified into 4 grades based on imaging studies. Grade la： intimal tear, Grade Ib： intramural hematoma; Grade Ⅱ： intimal injury with periaotic hematoma; Grade Ilia： aortic transection with pseudoaneurysm, Grade Illb： multiple aortic injuries; and Grade IV： free rupture. Progression and clinical outcomes of ABI were analyzed. Results Of the 28 patients, 22 were males and 6 were females with mean age of 38 （range, 7-69） years, Twenty-five （89.3%） had descending thoracic aortic injury, two （7.1%） had abdominal aortic injury and one （3.6%） presented with multiple aortic injuries. Three patients （10.7%） with Grade I, 1 （3.6%） Grade Ⅱ, 22 （78.6%） Grade Ⅲ, and 2 （7.1%） Grade IV injuries. Twenty-five patients underwent thoracic endovascular aortic repair and 3 were managed medically. Median time between injury and surgical intervention was （2±1） days. One （3.6%） patient developed paraplegia after thoracic endovascular aortic repair （TEVAR）. One Type 2 endoleak spontaneously sealed within 1 month, and another patient died from ruptured Type 1 endoleak 3 years later. Median follow-up time was 16 （range, 1-96） months. Perioperative 30-day mortality rate was 3.6%. Conclusions This study based on our modified BAI grading system indicated that Grade Ⅰ BAI can be managed conservatively. Grade Ⅱ injury requires close observation and repeated computerized tomography angiogram （CTA） within 48-72 hours. If injury appears worse on follow up imaging, surgery should be performed. Delayed repair of Grade Ⅲ BAI is acceptable if associated life threatenina traumatic i

关键词： blunt aortic injury imaging grading system endovascular management

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CompactChain:an efficient stateless chain for UTXO-model blockchain

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Frontiers of Computer Science 2024年第2期18卷 167-179页

作者： B Swaroopa reddy T Uday Kiran reddy Department of Electrical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In this work,we propose a stateless blockchain called CompactChain,which compacts the entire state of the UTXO(Unspent Transaction Output)based blockchain systems into two RSA *** first accumulator is called Transaction Output(TXO)commitment which represents the TXO *** second one is called Spent Transaction Output(STXO)commitment which represents the STXO *** this work,we discuss three algorithms:(i)To update the TXO and STXO commitments by the *** miner also provides the proofs for the correctness of the updated commitments;(ii)To prove the transaction’s validity by providing a membership witness in TXO commitment and non-membership witness against STXO commitment for a coin being spent by a user;(iii)To update the witness for the coin that is not yet spent;The experimental results evaluate the performance of the CompactChain in terms of time taken by a miner to update the commitments and time taken by a validator to verify the commitments and validate the *** compare the performance of CompactChain with the existing state-of-the-art works on stateless *** shows a reduction in commitments update complexity and transaction witness size which inturn reduces the mempool size and propagation latency without compromising the system throughput(Transactions per second(TPS)).

关键词： stateless blockchain RSA Accumulator STXO commitment TXO commitment UTXO non-interactive Proof of Exponentiation(nI-PoE) Transactions per second(TPS)

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Enhanced entropy generation and heat transfer characteristics of magnetic nano-encapsulated phase change materials in latent heat thermal energy storage systems

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1051-1070页

作者： P.S.reddy P.SREEDEVI Department of Mathematics Rajeev Gandhi Memorial College of Engineering and TechnologyNandyal 518501India

The objective of the current study is to investigate the importance of entropy generation and thermal radiation on the patterns of velocity,isentropic lines,and temperature contours within a thermal energy storage device filled with magnetic nanoencapsulated phase change materials(nEPCMs).The versatile finite element method(FEM)is implemented to numerically solve the governing *** effects of various parameters,including the viscosity parameter,ranging from 1 to 3,the thermal conductivity parameter,ranging from 1 to 3,the Rayleigh parameter,ranging from 102 to 3×10^(2),the radiation number,ranging from 0.1 to 0.5,the fusion temperature,ranging from 1.0 to 1.2,the volume fraction of nEPCMs,ranging from 2%to 6%,the Stefan number,ranging from 1 to 5,the magnetic number,ranging from 0.1 to 0.5,and the irreversibility parameter,ranging from 0.1 to 0.5,are examined in detail on the temperature contours,isentropic lines,heat capacity ratio,and velocity ***,the heat transfer rates at both the cold and hot walls are analyzed,and the findings are presented *** results indicate that the time taken by the nEPCMs to transition from solid to liquid is prolonged inside the chamber region as the fusion temperatureθf ***,the contours of the heat capacity ratio Cr decrease with the increase in the Stefan number Ste.

关键词： volume fraction of nano-encapsulated phase change material(nEPCM) radiation Stefan number heat capacity ratio entropy generation

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Trusted Certified Auditor Using Cryptography for Secure Data Outsourcing and Privacy Preservation in Fog-Enabled VAnETs

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Computers, Materials & Continua 2024年第5期79卷 3089-3110页

作者： nagaraju Pacharla K.Srinivasa reddy School of Computer Science and Engineering VIT-AP UniversityAmaravatiAndhra Pradesh522237India

With the recent technological developments,massive vehicular ad hoc networks(VAnETs)have been established,enabling numerous vehicles and their respective Road Side Unit(RSU)components to communicate with *** best way to enhance traffic flow for vehicles and traffic management departments is to share thedata they *** needs to be more protection for the VAnET *** effective and safe methodof outsourcing is suggested,which reduces computation costs by achieving data security using a homomorphicmapping based on the conjugate operation of *** research proposes a VAnET-based data outsourcingsystem to fix the *** keep data outsourcing secure,the suggested model takes cryptography models *** will keep the generated keys for the purpose of vehicle *** controlling and overseeingthe outsourced data while preserving privacy,the suggested approach considers the Trusted Certified Auditor(TCA).Using the secret key,TCA can identify the genuine identity of VAnETs when harmful messages *** proposed model develops a TCA-based unique static vehicle labeling system using cryptography(TCA-USVLC)for secure data outsourcing and privacy preservation in *** proposed model calculatesthe trust of vehicles in 16 ms for an average of 180 vehicles and achieves 98.6%accuracy for data encryption toprovide *** proposedmodel achieved 98.5%accuracy in data outsourcing and 98.6%accuracy in privacypreservation in fog-enabled *** curve cryptography models can be applied in the future for betterencryption and decryption rates with lightweight cryptography operations.

关键词： Vehicular ad-hoc networks data outsourcing privacy preservation cryptography keys trusted certified auditors data security

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Enhanced saturation magnetization in La^(3+) doped niCo ferrites prepared by sol-gel auto-combustion method

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Journal of Rare Earths 2024年第8期42卷 1546-1554,I0005页

作者： Maddileti Jelli Vidyasagar Thopudurthy Krishna reddy C.V. Department of Physics Rayalaseema UniversityKurnoolA.P518007.Iindia Department of Physics Government PolytechnicRayachotiA.P516269India

Lanthanum doped nickel-cobalt nano ferrites with chemical formula ni_(0.5)Co_(0.5)LaxFe_(2-x)O_(4)(x=0.05,0,10,0.15 and 0,20) were prepared using a simple sol-gel auto combustion *** basic structural properties were determined by X-ray diffraction method and the formation of single phased spinel ferrite was *** crystalline size decreased from 25 to 11 nm and lattice parameter a increases with increase of La *** surface morphology of these ferrites was observed by field-emission scanning electron microscopy(FESEM) and agglomerated irregular grains are observed with increase of the rare earth element La ***-dispersive X-ray spectroscopy(EDX) result confirms the presence of the required *** Fourier transform infrared spectroscopy(FTIR) spectrum indicates the formation of the spinel ferrite structure with M-O *** direct band measurements from ultraviolet-visible spectroscopy(UV-Vis) spectroscopy indicate that the direct band gap decreases from 1.39 to 1.19 eV for x=0.05 to x=0.15,then increases to 1.28 eV for x=*** room temperature magnetic properties of these ferrites were studied by a vibrating sample magnetometer(VSM).The enhanced saturation magnetization of 49.73 emu/g is observed for x=0.10 and then saturation magnetizations are gradually decreased for x=0.15 and x=*** the remanent magnetization and coercivity also follow the same trend.

关键词： Ferrites Sol-gel auto combustion La doping Magnetic properties Rare earths

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Aldo-keto reductases:Role in cancer development and theranostics

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Oncology Research 2024年第8期32卷 1287-1308页

作者： SIDDAVARAM nAGInI PRATHAP reddy KALLAMADI KRAnTHI KIRAn KISHORE TAnAGALA GEEreddy BHAnUPRAKASH reddy World neem Organization Mumbai400101India Department of Biochemistry ICMR-National Institute of NutritionHyderabad500007India Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York10032USA

Aldo-keto reductases(AKRs)are a superfamily of enzymes that play crucial roles in various cellular processes,including the metabolism of xenobiotics,steroids,and carbohydrates.A growing body of evidence has unveiled the involvement of AKRs in the development and progression of various *** are aberrantly expressed in a wide range of malignant *** expression of AKRs enables the acquisition of hallmark traits of cancer by activating oncogenic signaling pathways and contributing to *** have emerged as promising oncotherapeutic targets given their pivotal role in cancer development and *** of aldose reductase(AR),either alone or in combination with chemotherapeutic drugs,has evolved as a pragmatic therapeutic option for *** classes of synthetic aldo-keto reductase(AKR)inhibitors have been developed as potential anticancer agents,some of which have shown promise in clinical *** AKR inhibitors from natural sources also exhibit anticancer *** molecule inhibitors targeting speciﬁc AKR isoforms have shown promise in preclinical *** inhibitors disrupt the activation of oncogenic signaling by modulating transcription factors and kinases and sensitizing cancer cells to *** this review,we discuss the physiological functions of human AKRs,the aberrant expression of AKRs in malignancies,the involvement of AKRs in the acquisition of cancer hallmarks,and the role of AKRs in oncogenic signaling,and drug ***,the potential of aldose reductase inhibitors(ARIs)as anticancer drugs is summarized.

关键词： Aldo-keto reductases(AKRs) Aldo-keto reductase(AKR)inhibitors Cancer Drug-resistance Xenobiotics

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Vitamin D, selenium in type 2 diabetes and Hashimoto's thyroiditis: Is it effective?

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World Journal of Diabetes 2024年第5期15卷 1048-1050页

作者： Kotha Sugunakar reddy Vishakha Jain Sakthivadivel Varatharajan Janardhana reddy Pallavali Department of General Medicine All India Institute of Medical SciencesTelanganaHyderabad 508126India

The study by Feng et al,explores treatment approaches for these coexisting *** emphasizes the potential advantages of selenium and vitamin D supplementation but also raises methodological and patient selection *** indicate a complex interplay between interventions and disease markers,prompting the need for further *** limitations,the study offers valuable insights into managing the intricate relationship between type 2 diabetes mellitus and Hashimoto's *** authors'contributions shed light on potential treatment avenues,although careful consideration of study design and patient characteristics is warranted for future investigations in this domain.

关键词： Vitamin D Selenium Type 2 diabetes Mellitus Hashimoto’s thyroiditis

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Prediction,prevention and management of gastroesophageal reflux after per-oral endoscopic myotomy:An update

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World Journal of Gastroenterology 2024年第9期30卷 1096-1107页

作者： Zaheer nabi Pradev Inavolu nageshwar reddy Duvvuru Department of Gastroenterology Asian Institute of GastroenterologyHyderabad 500082TelanganaIndia Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500032TelanganaIndia

Achalasia cardia,the most prevalent primary esophageal motility disorder,is predominantly characterized by symptoms of dysphagia and *** principal therapeutic approaches for achalasia encompass pneumatic dilatation(PD),Heller's myotomy,and the more recent per-oral endoscopic myotomy(POEM).POEM has been substantiated as a safe and efficacious modality for the management of *** POEM demonstrates superior efficacy compared to PD and an efficacy parallel to Heller's myotomy,the incidence of gastroesophageal reflux disease(GERD)following POEM is notably higher than with the aforementioned *** symptomatic reflux post-POEM is relatively infrequent,the significant occurrence of erosive esophagitis and heightened esophageal acid exposure necessitates vigilant monitoring to preclude long-term GERD-related *** advancements in the field have enhanced our comprehension of the risk factors,diagnostic methodologies,preventative strategies,and therapeutic management of GERD subsequent to *** review focuses on the limitations inherent in the 24-h pH study for evaluating post-POEM reflux,potential modifications in the POEM technique to mitigate GERD risk,and the strategies for managing reflux following POEM.

关键词： Achalasia cardia Per-oral endoscopic myotomy Gastroesophageal reflux Esophagitis Gastroesophageal reflux disease

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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.reddy Erika Orlov PHemachandra reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDnA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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Cooperative Spectrum Sensing Deployment for Cognitive Radio networks for Internet of Things 5G Wireless Communication

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Tsinghua Science and Technology 2024年第3期29卷 698-720页

作者： Thulasiraman Balachander Kadiyala Ramana Rasineni Madana Mohana Gautam Srivastava Thippa reddy Gadekallu SRM Institute of Science and Technology Tamil Nadu 603203India Lebanese American University Beirut 1102Lebanonand also with Chaitanya Bharathi Institute of TechnologyHyderabad 500075India Chaitanya Bharathi Institute of Technology Hyderabad 500075India Brandon University BrandonR7A 0A1CanadaChinaMedical UniversityTaichung 404327Chinaand Lebanese American UniversityBeirut 1102Lebanon Department of Electrical and Computer Engineering Lebanese American UniversityBeirut 1102Lebanon

Recently,Cooperative Spectrum Sensing(CSS)for Cognitive Radio networks(CRn)plays a significant role in efficient 5G wireless *** sensing is a significant technology in CRn to identify underutilized *** CSS technique is highly applicable due to its fast and efficient performance.5G wireless communication is widely employed for the continuous development of efficient and accurate Internet of Things(IoT)networks.5G wireless communication will potentially lead the way for next generation IoT *** has established significant consideration as a feasible resource to improve identification performance by developing spatial diversity in receiving signal strength in *** this paper,an optimal CSS for CRn is performed using Offset Quadrature Amplitude Modulation Universal Filtered Multi-Carrier non-Orthogonal Multiple Access(OQAM/UFMC/nOMA)*** of spectrum and bandwidth utilization is a key challenge in CRn for IoT 5G wireless *** optimal solution for CRn in IoT-based 5G communication should be able to provide optimal bandwidth and CSS,low latency,Signal noise Ratio(SnR)improvement,maximum capacity,offset synchronization,and Peak Average Power Ratio(PAPR)*** Energy Efficient All-Pass Filter(EEAPF)algorithm is used to eliminate *** deployment approach improves Quality of Service(QoS)in terms of system reliability,throughput,and energy *** in-depth experimental results show that the proposed methodology provides an optimal solution when directly compares against current existing methodologies.

关键词： cooperative spectrum sensing cognitive radio network Internet of Things offset quadratureamplitude modulation universal filtered multi-carrier non-orthogonal multiple access

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