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Prevalence of Helicobacter pylori virulence genotypes among children in Eastern Turkey

World Journal of Gastroenterology 2013年第39期19卷 6585-6589页

作者： Gokben Ozbey Yasar Dogan kaan demiroren Vocational School of Health Services Firat University23119ElazigTurkey Department of Pediatric Gastroenterology Faculty of MedicineFirat University23119ElazigTurkey

AIM:To identify the virulence genotypes of Helicobacter pylori(***)if present in children in Eastern Turkey and if those genotypes are mostly associated with severe clinical ***:A total of 49 *** positive Turkish children(42 with antral nodularity and 7 with peptic ulcer)who underwent upper gastrointestinal endoscopy with abdominal symptoms during the period from March 2011 to September 2012 were enrolled in this *** nodularity was diagnosed endoscopically by two of the *** determined for the presence of cagA,vacA,cagE,iceA and babA2 genotypes of *** isolates in DNA obtained directly from frozen gastric biopsy samples by polymerase chain reaction test using specific ***:Of the 49 *** isolates studied,61.2%,91.8%,22.4%,28.6%,57.1%and 40.8%were positive for the cagA,vacA s1,cagE,iceA1,iceA2 and babA2 genes,*** showed that the most common vacA subtype was s1a(79.6%).However,the s2 gene was found less frequently with an isolation rate of 8.2%of the *** *** genotypes iceA2 and vacA s1m2 were the most frequently found types in children with antral *** addition,the genotypes iceA1,babA2 and vacA s1m1 were found in similar ratios in all the *** isolates obtained from children with peptic *** genotypes vacA s2m1and s1c were not observed in any of isolates ***:This study showed that vacA s1m2,cagA and iceA2 were the most common genotypes,and no association between antral nodularity and genotypes was observed.

关键词： Helicobacter pylori Children Genotype Polymerase chain reaction

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Possible relationship between refractory celiac disease and malignancies

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World Journal of Clinical Oncology 2022年第3期13卷 200-208页

作者： kaan demiroren Department of Pediatric Gastroenterology University of Health SciencesYuksek Ihtisas Teaching HospitalBursa 16000Turkey

Celiac disease(CeD)is a chronic autoimmune disorder that is triggered by gluten in genetically susceptible individuals,and that is characterized by CeD-specific antibodies,HLA-DQ2 and/or HLA-DQ8 haplotypes,enteropathy and different clinical pictures related to many *** lymphoma may develop as a result of refractory *** a patient diagnosed with CeD is symptomatic despite a strict gluten-free diet for at least 12 months,and does not improve with severe villous atrophy,refractory CeD can be considered *** second of the two types of refractory CeD has abnormal monoclonal intraepithelial lymphocytes and can be considered as pre-lymphoma,and the next picture that will emerge is enteropathy-associated T-cell *** manuscript addresses"CeD and malignancies"through a review of current literature and guidelines.

关键词： Refractory celiac disease Enteropathy-associated T-cell lymphoma Prelymphoma Low grade lymphoma

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