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印度结核病患者中的HIV感染率估算

国际结核病与肺部疾病杂志 2010年第1期5卷 39-41页

作者： P.K.Dewan D.Gupta B.G.Williams R.Thakur D.Bachani A.Khera D.F.Wares S.sahu D.C.S.reddy N.Raizada L.S.Chauhan 王冬梅王雪静 Office of the World Health Organization Representative to India New Delhi Central Tuberculosis Division Directorate General of Health ServicesMinistry of Health and Family WelfareGovernment of IndiaNew DelhiIndia Consultant GenevaSwitzerland National AIDS Control Organization Ministry of Health and Family WelfareGovernment of IndiaNew Delhi Foundation for Innovative New Diagnostics New DelhiIndia

使用全球的数据已经对印度结核病(TB)患者的人类免疫缺陷病毒(HIV)感染状况进行了间接估算。为了使用当地数据对HIV感染状况进行更加准确的估算,我们将县/区级产前门诊的HIV监测数据与结核病诊断中心的HIV监测数据联系起来,并将这一关... 详细信息

使用全球的数据已经对印度结核病(TB)患者的人类免疫缺陷病毒(HIV)感染状况进行了间接估算。为了使用当地数据对HIV感染状况进行更加准确的估算,我们将县/区级产前门诊的HIV监测数据与结核病诊断中心的HIV监测数据联系起来,并将这一关联性应用到省级对孕妇人群的HIV感染状况估算中。我们估计,2007年196万新发结核病患者的HIV感染率为4.85%(95%可信区间为4.12～5.73)或HIV感染人数为95 240(95%可信区间为80 730～112 478)例。从使用这些当地数据所进行的估算中,国家结核病防治规划能够更好的制定TB/HIV双重感染防治联合行动,并监控在这一大规模人群中发现HIV感染者的结果。

关键词： HIV 结核监测印度

酒精的使用、种族和病毒的交叉感染对美国退伍军人HCV自然清除的影响

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 51-51页

作者： Piasecki B.A. Lewis J.D. reddy K.R. 沈才飞 Penn Medicine Radnor GastroenterologyClinic 250 King of Prussia Road Radnor PA 19087 Unite d StatesDr.

Hepatitis C virus (HCV) is spontaneously cleared in 15%to 45%of individuals during primary infection. To define the role of alcohol, race, and HBV or HIV co infections in natural HCV clearance, we examined these parameters in 203 spontan eously HCV-recovered subjects (HCV Ab+/RNA-subjects without prior antiviral t herapy) and 293 chronically HCV-infected patients (HCV Ab+/RNA+). Subjects we re identified from 1,454 HCV antibody-seropositive US veterans tested for HCV R NA between January 2000 and July 2002 at the Philadelphia Veterans Affairs Medic al Center. In univariate analysis, alcohol use disorder (odds ratio > 0.52; 9 5%CI, 0.31-0.85; P = .006) and black race (OR 0.65;95%CI, 0.44-0.96;P = .024 ) were both associated with decreased likelihood of spontaneous HCV clearance. I n multivariate analyses adjusting for race, HIV infection, age, and alcohol use disorder, alcohol remained strongly associatedwith reduced HCV clearance (OR0.49 ;95%CI, 0.30-0.81; P = .005). In contrast, the association between black race and viral clearance was no longer statistically significant (adjusted OR 0.72; 9 5%CI, 0.48-1.09; P = .125). HIV coinfection was negatively associated with HCV clearance (OR 0.37; 95%CI, 0.16-0.83; P = .016), while HBV coinfection was po sitively associated with HCV clearance (unadjusted OR 5.0; 95%CI, 1.26-28.6; P = .008). In conclusion, the likelihood of spontaneous clearance of HCV may be i nfluenced by alcohol and viral coinfections.

关键词： HCV 黑色人种 RNA 单变量分析负相关多变量分析

EUS引导下的Trucut针吸活检:确定自身免疫性胰腺炎是否为梗阻性黄疽的病因

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 37-37页

作者： Levy M.J reddy R.P Wiersema M.J 陈云茹 Mayo Clinic Div. of Gastroenterol. and Hepatol. 200 First Street SW Rochester MN 55905 United St atesDr

Background: The diagnosis of autoimmune pancreatitis can be difficult and ofte n requires a larger specimen than can be provided by FNA alone to determine if t he tissue sample obtained with EUS trucut biopsy (TCB) is sufficient to allow ad equate histologic review to establish the diagnosis of autoimmune pancreatitis. Methods: EUS TCB was performed in patients presenting with obstructive jaundice who were suspected of having autoimmune pancreatitis based on their clinical, la boratory and imaging studies. The charts were retrospectively reviewed to determ ine the feasibility of TCB. Results: Between August 2002 and June 2004, 3 patien ts with obstructive jaundice and suspected autoimmune pancreatitis (AIP) underwe nt EUS TCB. In each case, a diagnosis of pancreatic cancer also was considered, and surgical resection was the planned therapy before the patient underwent EUS TCB. Histologic review of the TCB specimens established the diagnosis of AIP in two patients and identified nonspecific changes of chronic pancreatitis in the t hird patient. EUS-guided FNA was performed in two of the 3 patients and failed to establish the diagnosis in either patient. Other than mild transient abdomina l pain (n = 1), no complications were identified. Conclusions: This preliminary study suggests that EUS TCB can safely establish the diagnosis of AIP. Doing so helps guide management and may help to avoid unnecessary surgery. Prosp- ective studies are needed to verify these findings and to more clearly define the role of EUS TCB in these patients.

关键词： EUS Trucut 针吸活检阻性黄疽慢性胰腺炎黄疸者梗阻型影像学检查疑似患者

使用直接作用抗病毒药物实现持续病毒学应答后的新发肝细胞癌的发生率和预测因素:来自吉利德Svr和肝硬化登记处的结果

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使用直接作用抗病毒药物实现持续病毒学应答后的新发肝细胞癌的发...

超声引导下内镜引流合并门脉高压或有侧副管的胰腺假性囊肿

第十届全国疑难及重症肝病大会

作者： K.Rajender reddy Ira M.Jacobson Armand Abergel Barbara A.Leggett Charles S.Landis Robert Hyland Frances Chen Liyun Ni Anu O.Osinusi Diana Brainard Jose Luis Calleja Eric J.Lawitz Andrew Joseph Muir Alessandra Mangia UniversityofPennsylvania QIMRBerghoferMedicalResearchInstitute UniversityofWashington CentroDeInvestigacionBiomedicaEnRedDeEnfermedadesHepaticasyDigestivas(CIBERehd) Irccs-OspedaleCasaSollievoDellaSofferenza CHUClermontFerrand GileadSciencesInc. DukeClinicalResearchInstitute NewYorkUniversity GileadSciences Inc. TexasLiverInstitute UniversityofTexasHealthSanAntonio

背景一些研究表明,使用直接作用抗病毒药物(DAA)实现持续病毒学应答(SVR)与肝细胞癌(HCC)发生的减少相关。本研究评估了在吉利德登记处的一支包括6700余名患者的特征良好的队列中的SVR后新发HCC的发生率和预测因素。方法本研究进行了一...

背景一些研究表明,使用直接作用抗病毒药物(DAA)实现持续病毒学应答(SVR)与肝细胞癌(HCC)发生的减少相关。本研究评估了在吉利德登记处的一支包括6700余名患者的特征良好的队列中的SVR后新发HCC的发生率和预测因素。方法本研究进行了一项汇总分析,评估了吉利德SVR和肝硬化登记处的患者中的新发HCC的

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 17-17页

作者： Sriram P.V.J kaffes A.J reddy D.N 王志宇 Asian Institu te of Gastroenterology 6-3-652 Somajiguda 500-082 Hyderabad India.Dr

Background and Study Aims: Portal hypertension often coexists with pancreatic pseudocysts and is potentially dangerous if a collateral vessel is in the vicini ty of the needle puncture pathway. Hitherto, there have been no reports of pseud ocyst drainage in this setting. Patients and Methods: Patients who underwent end oscopic ultrasound (EUS)-guided pancreatic pseudocyst drainage complicated by i ntervening vessels were assessed for success and outcomes. An Olympus mechanical linear-array video echo endoscope GF-UM 140D was used for the drainage proced ure in all patients. Either a “hot"diathermy technique was employed or a “cold " technique using direct aspiration with a 19-G needle, followed by deployment of a nasocystic catheter. Results: Eight patients with a symptomatic pseudocyst and intervening vessels underwent drainage that was guided (n = 6) or assisted ( n = 2) by EUS. All were found to have successful resolution of the cyst at follo w-up 6 weeks later, while segmental portal hypertension had disappeared in one patient. There were no major *** patient had transient hemorrhagic drainage that resolved by itself. Conclusions: Pseudocysts complicated by porta l hypertension or by intervening vessels can be safely drained under EUS guidanc e, even in the absence of color Doppler imaging.

关键词：内镜引流门脉高压侧副管胰腺假性囊肿假性囊肿引流门静脉高压症流管潜在危险鼻囊热透

早产儿视网膜病变中新生儿视网膜血管成熟度在体评估的初步研究

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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 53-53页

作者： Jalali S. Madhavi C. reddy G.P. Nutheti R. 王文军 Smt kannuri santhamma Retina Vitreous Centre L V Prasad Eye InstituteHyderabadIndia

Purpose:To study the extent of retinal vascularization at ***:Prospective masked observational case ***:One hundred ten neonates,at different weeks of gestation and birth weights(BWs),had dilated fundus evaluation for zone of retinal vascularization by a masked *** and neonatal factors were ascertained by amasked ***:Irrespective of risk factors,eight of nine babies who were born at 34 weeks of gestational age and at >1700 g BW had mature *** who were born between 31 to 34 weeks of gestation and at 1501 to 1700 g BW had variable extent of retinal vascularization at *** was affected by maternal anemia and the need for oxygen for > 48 ***:There exists considerable variability in the extent of retinal vascularization in infants who are born between 31 to 34 weeks of *** maternal and fetal factors could influence extent of this vascularization birth.

关键词：视网膜血管眼底视网膜成熟度扩瞳儿科医师血管化盲法观察性生时临床资料

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LASIK术后1个月的反应性淋巴增生

世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 45-45页

作者： reddy S. Finger P.T. Chynn E.W. Iacob C.E. 王静波 The New York Eye Cancer Center 115 East 61st Street New York NY 10021 United States

Purpose: This study was conducted to investigate a case of reactive lymphoid hyperplasia following laser assisted in situ keratomileusis (LASIK). Methods: A 31- year-old man who underwent LASIK presented 1 month later with a fleshy conjunctival (plical) tumor in the left eye. An excision biopsy of the tumor was performed. Results: Histopathology of the excised tumor revealed reactive lymphoid hyperplasia. Discussion: Conjunctival lymphomas can masquerade as chronic conjunctivitis and can be preceded by reactive lymphoid hyperplasia. It is important to identify and differentiate these tumors. This report describes the unusual occurrence of a lymphoid conjunctival tumor after LASIK eye surgery.

关键词： LASIK术慢性结膜炎淋巴瘤组织病理学后反应能因

烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点

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中华高血压杂志 2017年第2期25卷 199-199页

作者： Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM sahni S reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉叶鹏

肺动脉高压（pulmonary arterial hypertension,PAH）是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶（nicotinamide phosphoribosyl transferase,NAMPT）是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还... 详细信息

肺动脉高压（pulmonary arterial hypertension,PAH）是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶（nicotinamide phosphoribosyl transferase,NAMPT）是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑,

关键词：烟酰胺腺嘌呤二核苷酸核糖基转移酶肺血管重塑肺动脉高压治疗靶点 hypertension 磷酸 arterial

骨关节炎的膝关节软骨损伤:ACRIN-PA 4001多中心试验研究分析MRI生物标记物的可重复性

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国际医学放射学杂志 2011年第3期 279-279页

作者： T.J.Mosher R.reddy S.Boudhar B.N.Milestone W.B.Morrison 赵芳 Department of Radiology Penn State University College of Medicine Penn State University Hospital 500 University DrHersheyPA 17033

目的多中心试验对骨关节炎(OA)病人及无症状对照者进行研究,前瞻性确定膝关节软骨形态学及构成(T1ρ纵向弛豫时间,T2)的MRI生物标记物的可重复性。材料与方法本研究符合HIPAA要求,经参与方伦理审查委员会

关键词：骨关节炎膝关节软骨可重复性 ACRIN-PA 4001 标记物 MRI