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Highly active antiretroviral therapy per se decreased mortality and morbidity of advanced human immunodeficiency virus disease in Hong Kong

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Chinese Medical Journal 2005年第16期118卷 1338-1345页

作者： CHAN Chi-wai CHENG Lai-sim CHAN Wai-kit WONG ka-hing Integrated Treatment Centre Department of Health Hong Kong China

Background Morbidity and mortality of advanced human immunodeficiency virus infection （HIV） have declined in Western industrialized countries since the availability of highly active antiretroviral therapy （HAART）. It is unclear if this has also happened in Hong Kong. Methods We studied a retrospective cohort of patients with advanced HIV disease in Hong Kong, China. First, the mortality of advanced HIV disease per year was calculated for the decade 1993 to 2002, both annually and according to patient observation before and after 1997. Second, the event rates were estimated for the clinical end points of acquired immune deficiency syndrome （AIDS） and death. Univariate and multivariate analyses were then performed to identify associated factors. Results The crude mortality of advanced HIV disease declined from 10. 8 - 30. 4 per 100 patients during 1993 - 1996, to 0. 8 - 6. 9 per 100 patients during 1997 - 2002. A rate ratio of 4. 04 （95% CI, 2. 52 - 6. 47） was evident for those observed in 1993 - 1996, compared to those in 1997 - 2002. In a multivariate analysis where calendar period was adjusted, use of＇highly active antiretroviral therapy was associated with rate ratios of 0. 13 （95% CI, 0. 05 -0. 33） for death after AIDS, 0. 08 （95% CI, 0. 04 -0. 19） for AIDS after a CD4 cell count 〈200/μ1, and 0.21 （95% CI, 0.07 -0.67） for death after CD4 cell count 〈200/μl. In the same analysis, calendar period ceased to be a significant factor after adjustment for use of HAART. Conclusions The mortality and morbidity of advanced human immunodeficiency virus disease have declined in Hong Kong. This improved prognosis was attributable to the use of highly active antiretroviral therapy.

关键词： highly active antiretroviral therapy mortality· morbidity acquired immunodeficiency syndrome

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Multi-exponential model to describe pressure-dependent P-and S-wave velocities and its use to estimate the crack aspect ratio

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 385-395页

作者： Mihály Dobróka Norbert Péter Szabó Tünde Edit Dobróka Mátyás Krisztián Baracza Department of Geophysics University of MiskolcMiskolc-Egyetemváros3515Hungary MTA-ME Geoengineering Research Group University of MiskolcMiskolc-Egyetemváros3515Hungary Research Institute of Applied Earth Sciences University of MiskolcMiskolc-Egyetemváros3515Hungary

We present new quantitative model describing the pressure dependence of acoustic P-and S-wave *** that a variety of individual mechanisms or defects(such as cracks,pore collapse and grain crushing)can contribute to the pressure-dependent change of the wave velocity,we order a characteristic pressure to all of them and allow a series of exponential terms in the description of the(Pand S-waves)velocity-pressure *** estimate the parameters of the multi-exponential rock physical model in inversion procedures using laboratory measured P-and S-wave velocity *** is known,the conventional damped least squares method gives acceptable results only when one or two individual mechanisms are *** the number of exponential terms leads to highly nonlinear ill-posed inverse *** to this reason,we develop the spectral inversion method(sim)in which the velocity amplitudes(the spectral lines in the characteristic pressure spectrum)are only considered as *** characteristic pressures(belonging to the velocity amplitudes)are excluded from the set of inversion unknowns,instead,they are defined in a set of fixed positions equidistantly distributed in the actual interval of the independent variable(pressure).Through this novel linear inversion method,we estimate the parameters of the multi-exponential rock physical model using laboratory measured P-and S-wave velocity *** characteristic pressures are related to the closing pressures of cracks which are described by well-known rock mechanical relationships depending on the aspect ratio of elliptical *** gives the possibility to estimate the aspect ratios in terms of the characteristic pressures.

关键词： Multi-exponential rock physical model Spectral inversion method(sim) Crack aspect ratio Characteristic pressures

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Study of the Chemical and Mineralogical Composition of Kindia Bauxite in the Republic of Guinea: The Case of the Saföfö Site

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Journal of Materials Science and Chemical Engineering 2024年第10期12卷 62-71页

作者： Mouctar Camara Mamadouba Aboubacar Fofana Mohamed Dubréka Sylla Alpha Madiou Diallo Aboubacar Diallo Aly Hawa Camara Sékou traore Department of Chemical Engineering Gamal Abdel Nasser University of Conakry Conakry Republic of Guinea Department of Physics University of NZerekore NZerekore Republic of Guinea Department of Chimie Gamal Abdel Nasser University of Conakry Conakry Republic of Guinea Institut Superieure dArchitecture and lUrbanisme (ISAU) Conakry Republic of Guinea National Laboratory of the Geology Department from Mines and of the Geology Conakry Republic of Guinea

The chemical and mineralogical composition of bauxite deposits is a key factor in the profitability of refining processes. The study of bauxites from the Saföfö site has assessed variations in chemical and mineralogical composition under various conditions, as well as the optimum conditions for their exploitation. The methodologies used in this study include experimental methods for determining moisture content, chemical composition, mineralogical composition, and specific density of bauxite. The results show significant variation in moisture content among the bauxite samples, with values ranging from 2.90% to 17.80%. The silica percentages in the samples range from 1.69% to 8.14%, while alumina percentages vary from 36.81% to 54.03%. After calcination, alumina oxide percentages range from 40% to 75%. After chemical activation, alumina oxides Al2O3 range from 40% to over 50%. Gibbsite is the most abundant mineral, accounting for about 60% - 70% of the total composition of the bauxite samples. Samples A to F have bulk densities varying between approximately 3.6 and 3.9. Sample B has the highest density, around 3.9, while sample C has the lowest, at around 3.5. Bauxite mining at the Saföfö site offers significant potential for the alumina industry, provided appropriate processing methods are selected to maximize quality and profitability while minimizing environmental impact.

关键词： Bauxite Chemical Composition Guinea Mineralogy and Saföfö

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Demons-Meigs Syndrome: A Case Report at the Fatick Regional Hospital

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Open Journal of Obstetrics and Gynecology 2021年第12期11卷 1735-1743页

作者： Abdoulaye Mihimit Alhassane Ismael Toure Oumar Abakar Oumar Bafode Camara Abdoulaye Keita Malick Bah Ermerlindo Rodrigues Pereira Ibrahima Dara Diamé Bangaly traore Sidy ka Ahmadou Dem Centre Hospitalier Régional de Fatick Fatick Sénégal Université de N’Djamena N’Djamena Tchad Université Cheikh Anta Diop de Dakar Dakar Sénégal Centre Hospitalier Universitaire de Fann Dakar Sénégal Hô pital Jean Paul II Conakry Guinée Centre Hospitalier Universitaire Le Dantec Dakar Sénégal

Demons-Meigs syndrome combines a benign tumor of the ovary with thoracic and abdominal effusion, it is a rare disease whose pathophysiological mechanism is not yet well understood. This rare syndrome often gives rise to fear of ovarian neoplasia due to the existence of ascites and the significant elevation of CA 125. In this observation, we report the case of Demons-Meigs syndrome diagnosed in a 36-year-old young woman who presented with pleural and peritoneal effusion syndrome with an ovarian mass and a CA 125 level = 406.6 IU/ml. Laparotomy performed revealed very abundant ascites, the uterus and tubes were healthy, no suspicious peritoneal lesions, the left ovary is healthy, a right ovarian mass of 300 × 150 mm. A right annexectomy was performed. The operative suites were simple with drying of the effusions. The control CA 125 returned to normal after 6 months of follow-up. A pathological anatomy result is a fibrothecoma. Demons-Meigs syndrome has a good progno

关键词： Demons-Meigs Syndrome Ovarian Tumor CA 125 Ascites Hydrothorax Senegal

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Blood Glucose Measurement in Diabetic Patients Undergoing Comparative Treatment with a Medicinal Plant

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Journal of Biomedical Science and Engineering 2024年第11期17卷 234-255页

作者： Fatoumata Bah Azonwakin Rodrigue Akotegnon Cé Camara Ousmane Sangare Elhadji Saidou Balde Mohamed Sahar traore Aliou Mamadou Balde Biology Laboratory Department of Biology Faculty of Sciences Gamal Abdel Nasser University Conakry Guinea Higher School of Tourism and Hospitality of Guinea Conakry Guinea Faculty of Pharmaceutical and Medical Sciences Gamal Abdel Nasser University Conakry Guinea

The management of non-communicable chronic diseases such as diabetes and hypertension remains a concern in developing countries. In Guinea, whether by choice or necessity, traditional medicine and herbal remedies are the primary recourse for the population, both in rural and urban areas. Previous investigations led to the development of two phytomedicines designed for managing essential hypertension (HTN) and type 2 diabetes (DT2), named “Guinex-HTN®” and “Sattagas.” An evaluation of their therapeutic benefits was conducted during a prevalence survey carried out in Dubréka. This survey revealed a prevalence of 73.52% (211/287) for HTN, 36.58% (105/287) for DT2, and 33.45% (96/287) for combined DT2/HTN. The therapeutic potential of Sattagas and the combination of Sattagas with Guinex-HTN were assessed in diabetic and hypertensive diabetic patients, respectively. Comparisons were made between Sattagas, Metformin, Sattagas plus Metformin, and Sattagas plus Guinex-HTN regarding their impact on blood glucose levels and/or blood pressure values. After 6 months of treatment with 2 x 2 capsules per day, the anti-diabetic potential of Sattagas was confirmed by a significant reduction in blood glucose levels (from 2.59 ± 0.43 to 1.22 ± 0.43) in 80.95% (85/105) of patients, as well as a significant decrease in blood pressure values (from 177 ± 20.77/98 ± 10.70 to 149 ± 29.02/85 ± 13.64) in 90.16% (55/61) of hypertensive diabetics. The anti-diabetic effect of Sattagas (from 2.19 ± 0.29 to 1.22 ± 0.31 g/l) was similar to that of Metformin (from 2.14 ± 0.23 to 1.28 ± 0.41 g/l), and a synergistic effect was observed when Sattagas was combined with Metformin (from 2.21 ± 0.49 to 1.10 ± 0.20 g/l). In hypertensive diabetics, the combination of Sattagas and Guinex-HTN demonstrated a beneficial effect on blood pressure values. Except for some symptoms (epigastric pain, nausea, diarrhea, drowsiness, fatigue) reported in 17 out of 103 patients that did not interfere with the continuation

关键词： Hypertension Diabetes Clinical Trial Urban Area Dubréka

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交流电子负载电感参数设计

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西安工程大学学报 2015年第4期29卷 431-435页

作者：方露党幼云康朋飞西安工程大学电子信息学院陕西西安710048

针对目前电感选取缺乏理论基础的缺点,利用电路拓扑为电压型PWM变换器的单相交流电子负载,采用双极性调制的滞环电流控制方法对交流侧电流进行控制来实现快速跟踪给定电流,从快速跟踪给定电流、抑制谐波及开关管频率限制3方面给出电感... 详细信息

针对目前电感选取缺乏理论基础的缺点,利用电路拓扑为电压型PWM变换器的单相交流电子负载,采用双极性调制的滞环电流控制方法对交流侧电流进行控制来实现快速跟踪给定电流,从快速跟踪给定电流、抑制谐波及开关管频率限制3方面给出电感参数范围确定的方法,并最终确定电子负载中电感的选取范围,最后在Matlab/simulink中进行仿真实验.仿真结果表明,选取合适的电感值有利于快速跟踪给定电流和抑制电流谐波,同时也证明了该电感选取方案的可行性.

关键词：电子负载电感电流电感参数

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预浓缩/柱箱制冷GCMS/FID法测定大气中117种挥发性有机物

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环境化学 2022年第1期41卷 398-404页

作者：单丹滢张烃曹冠汤卡陈春榕杜祯宇张秀蓝董树屏杜世娟刘金林张国忠国家环境分析测试中心北京100029 岛津企业管理(中国)有限公司北京100020

建立了罐采样、吸附剂辅助电子制冷预浓缩-柱箱制冷GCMS/FID同时测定大气中117种挥发性有机物(VOCs)的方法。样品经填充吸附剂的电子制冷预浓缩系统除水、除CO_(2)、浓缩和热脱附后,采用柱箱制冷及GCMS/FID的多维切割单元,将5种C_(2)-C_... 详细信息

建立了罐采样、吸附剂辅助电子制冷预浓缩-柱箱制冷GCMS/FID同时测定大气中117种挥发性有机物(VOCs)的方法。样品经填充吸附剂的电子制冷预浓缩系统除水、除CO_(2)、浓缩和热脱附后,采用柱箱制冷及GCMS/FID的多维切割单元,将5种C_(2)-C_(3)组分切到二维色谱柱进行分离并进入FID检测,甲醛及其他111种VOCs组分留在一维色谱柱进行分离并进入MS检测,甲醛采用sim模式检测,其余化合物采用Scan模式检测。FID采用外标法定量,MS采用内标法定量。考查了预浓缩系统条件、多维切割条件、质谱条件、气相条件等参数对测试结果的影响,对比了常温柱箱法和柱箱制冷法的效果,并评估了在此优化条件下的方法性能。117种VOCs在0.5—20 nmol·mol^(-1)(甲醛2.5—100 nmol·mol^(-1))范围内线性关系良好,相关系数(R)在0.9924—0.9999,方法检出限为0.071—0.718μg·m^(-3),定量限为0.284—2.872μg·m^(-3)。

关键词：电子制冷预浓缩 GCMS/FID 117种挥发性有机物多维切割柱箱制冷

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