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Biological characteristics and clinical management of uveal and conjunctival melanoma

Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA kaŠTELAN ANA DIDOVIĆpaVIČIĆ DARia paŠALIĆ TAMARA NIKUŠEVA-MARTIĆ SAMIRČANOVIĆ PETRA KOVAČEVIĆ SUzaNA KONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Department of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Department of Ophthalmology Zadar General HospitalZadar23000Croatia Department of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Department of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Department of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pathogenesis of melanoma at different sites is very similar,however,the prognosis for patients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of uveal and conjunctival melanoma remains a formidable *** enhance the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pathogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

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Modulation doping of p-type Cu_(12)Sb_(4)S_(13)toward improving thermoelectric performance

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Journal of Materials Science & Technology 2024年第4期171卷 71-79页

作者： Khak Ho Lim Mingquan Li Yu Zhang Yue Wu Qimin Zhou Qingyue Wang Xuan Yang Pingwei Liu Wen-Jun Wang ka Wai Wong ka Ming Ng Yu Liu Andreu Cabot Institute of Zhejiang University-Quzhou Quzhou 324000China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310007China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Ostia Technologies Limited United Kingdom Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina ICREA Pg.Lluis Companys 23Barcelona 08010Spain Catalonia Energy Research Institute-IREC Sant Adria del BesosBarcelona 08930Spain

The commercial viability of thermoelectric(TE)devices relies heavily on two factors:cost reduction and efficiency *** this study,we first produce p-type Cu_(12)Sb_(4)S_(16-x)(x=0,3,4)using a low-temperature bottom-up approach and demonstrate Cu_(12)Sb_(4)S_(13)to show the best TE performance among the three tested ***,the TE energy conversion efficiency of Cu_(12)Sb_(4)S_(13)is further enhanced by optimizing its electronic band structure through the incorporation of small amounts of *** an optimal Te content of 5 mol%,more than a twofold increase in the TE figure of merit(zT)is *** gain insight into the mechanism of improvement on the transport properties of the mate-rial,we compare the interphase transport mechanism by incorporating nanodomains of different metals(Ag and Cu)into the Cu_(12)Sb_(4)S_(13)*** improved electrical conductivity obtained with Cu_(12)Sb_(4)S_(13)-Te nanocomposites is attributed to a charge flooding of the Cu_(12)Sb_(4)S_(13)*** contrast,excessive down-ward band-bending at the interphases of Ag/Cu metal-semiconductor drastically reduces the electrical ***,a weighted mobility(μw)analysis shows a dominant thermal activation of carri-ers in Cu_(12)Sb_(4)S_(13)-Te *** this material,a strong decrease in lattice thermal conductivity is also found,which is associated with a phonon-carrier scattering *** work shows the impor-tance of proper band-engineering in TE nanocomposites to decouple electrical and thermal transport to enhance TE performance,and the efficacy ofμw for electrical and thermal transport analysis.

关键词： Modulation doping Thermoelectric Interphase transport Charge flooding Phonon-carrier scattering

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Ultra-low temperature cofired ceramics based on Li_(2)WO_(4)as perspective substrate materials for terahertz frequencies

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Journal of Advanced Ceramics 2023年第3期12卷 526-538页

作者： Dorota Szwagierczak Beata Synkiewicz-Musialska Jan Kulawik Elżbieta Czerwińska Norbert pałka Kraków Division Łukasiewicz Research Network-Institute of Microelectronics and PhotonicsKraków 30-701Poland Institute of Optoelectronics Military University of TechnologyWarszawa 00-908Poland

With the development of low dielectric permittivity materials having an ultra-low sintering temperature,testing their dielectric properties at terahertz frequencies suitable for 6G communication systems and implementation of the fabricated materials in ultra-low temperature cofired ceramics(ULTCC)were the main goals of the *** tungstate Li_(2)WO_(4)was synthesized by a solid-state reaction and used for the preparation of green tapes and test structures with cofired internal conductive layers,which are destined for substrates of microwave and submillimeter wave *** behavior,thermal effects,and mass changes of the green tapes during heating were studied using a hot-stage microscope,differential thermal analysis,and thermogravimetry.A single-phase composition was revealed for being undoped and doped with AlF3–CaB_(4)O_(7)*** impact of frequency,temperature,the addition of AlF3–CaB_(4)O_(7)and CuBi_(2)O_(4)dopants,and sintering temperature was the subject of in-depth characterization of dielectric properties in a terahertz region.A glass-free composition,ultra-low sintering temperature of 590–630℃,low roughness of the green tapes,dense microstructure,compatibility with Ag conductors,low and stable dielectric permittivity of 5.0–5.8 in a broad range of 0.2–2 THz,and low dielectric loss of 0.008–0.01 at 1 THz are the main advantages of the developed ULTCC substrates.

关键词： Li_(2)WO_(4) ultra-low temperature cofired ceramics(ULTCC) tape casting dielectric properties terahertz frequency range

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Microstructure and Property Relationships in Resistance Spot Weld between 7114 Interstitial Free Steel and 304 Austenitic Stainless Steel

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Journal of Materials Science & Technology 2006年第3期22卷 375-381页

作者： Ahmet Hasanba■o■lu Ramazan kaar Department of Metal Education karabük Technical Education Faculty Karabük 78100 Turkey

Due to the differences in physical, chemical and mechanical properties of the base metals, the resistance spot welding of dissimilar materials is generally more challenging than that of similar materials. The influence of the primary welding parameters affecting the heat input such as peak current on the morphology, microhardness, and tensile shear load bearing capacity of dissimilar welds between 304 grades austenitic and 7114 grade interstitial free steel has been investigated in this study. The optimum welding parameters producing maximum joint strength were established at a peak current of 9 ka, where the electrode force is kept 6×10^-5 pa and weld time is kept constant 17 cycles, respectively. The primary cause of weakening the weldment is identified as the excessive grain growing region of heat affected zone （HAZ） in case of 7114 grade interstitial free steel.

关键词： Resistance spot weld Interstitial free steel Austenitic stainless steel

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Magnetic Properties and Thermal Stability of Pr_(1-x)La_xCo_(5-y)Alloys

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Journal of Materials Science & Technology 1995年第6期11卷 463-465页

作者： Fazeng LiaN (Dept. of Materials Science and Engineering, Northeastern University, Shenyang, 110006, China)Meiqing HUANG, S.Simizu and W.E.Wallace (Carnegie Mellon Institute, Carnegie Mellon University, Pittsburgh, pa 15213, USA) Northeastern Univ Shanghai China

Pr1-xLaxCo5-y (x=0, 0.15. 0.25, 0.35,1.0, y=0.5, 0.7, 0.9, 1.0) alloys were investigated. The effect of the variation of x and y on magnetic properties and thermal stability of the alloys were studied. The magnetic properties for the Pr0.85La0.15Co4.3 and Pr0.75La0.25Co4.1 magnets are iHc=368 ka/m, Br=0.91 T, (BH)max=145.6 kJ/m3, αBr=-0.03%/℃ and iHc=568 ka/m,Br=0.8 T, (BH)max=127.2 kJ/m3,αBr,=-0.06%/℃, respectively The phase structures of as-cast alloys and magnets were investigated

关键词： La x)La_xCo Magnetic Properties and Thermal Stability of Pr y)Alloys

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The effect of severe plastic deformation on the Mg properties after CEC deformation

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Journal of Magnesium and Alloys 2020年第3期8卷 761-768页

作者： B.Suikowski M.Janoska G.Boczkal R.Chulist M.Mroczkowski P.paika Department of Non-Ferrous Metals Engineering Faculty of Non-Ferrous MetalsAGH University of Science and Technology30 Mickiewicza Av.Krakow 30-059Poland Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta St.Krakow 30-059Poland

In this study,the effect of severe plastic deformation on the Mg grain refinement and recovery mechanism was *** pure magnesium was deformed at room temperature by cycling extrusion-compression(CEC)process up to large *** steps of deformation have been used by applying 1,2 and 4 passes of CEC giving a total effective plastic strain ofε=*** and structural properties of Mg in initial state and the states after successive steps of deformation were *** mechanical properties were determined by microhardness and compression tests at room *** structural investigations involved light microscope observations,electron back scattered diffraction and texture measurements by X-ray *** was found that the CEC process refines the grain size down to 6.4μm and reduces strong rolling texture ***,only the first two passes had a strong effect on mechanical properties while a larger number of CEC cycles(above 4)led to failure of the samples with a small effect on *** observation correlates with texture evolution indicating a more random orientation distribution that slows down the typical for hep metals rapid work *** was found that the CEC process activated twin dynamic recrystallization in deformed *** process led to the formation of new randomly oriented grains inside the twinned areas and as a consequence it reduced the strong rolling texture components.

关键词： Magnesium Cyclic extrusion compression Texture Microhardness

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Evaluation of natural forest regeneration as a part of land restoration in the Khentii massif,Mongolia

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Journal of Forestry Research 2020年第5期31卷 1773-1786页

作者： David Juricka Antonın Kusbach Jana parılkova Jakub Houska pavlına Ambrozova Vaclav Pecina Zdena Rosicka Martin Brtnicky Jindrich Kynicky Department of Geology and Pedology Faculty of Forestry and Wood TechnologyMendel UniversityZemedelska 161300 BrnoCzech Republic Department of Forest Botany Dendrology and GeobiocoenologyFaculty of Forestry and Wood TechnologyMendel UniversityZemedelska161300 BrnoCzech Republic Faculty of Civil Engineering Institute of Water StructuresBrno University of TechnologyZizkova 1760200 BrnoCzech Republic Central European Institute of Technology Brno University of TechnologyPurkynova 656/12361200 BrnoCzech Republic

Forest stands in the semi-arid environment of northern Mongolia have an essential role in controlling ongoing desertification in the surrounding *** the last decade,the total forest area has decreased *** aim of this study was to evaluate the potential of natural regeneration as an essential element for ensuring sustainability of these *** on field measurements from 120 plots in six sites,our assessment tool revealed five qualitative categories of forest regeneration,allowing us to assess impacts of both grazing and environmental conditions on the regeneration *** is a crucial factor and adversely affects *** sites with relatively low grazing intensity,low soil moisture levels represent the main reason for reduced *** approach to classification proposed in this study allows for the identification and interpretation of stand conditions where natural regeneration has *** study provides an important foundation to inform decisionmaking related to land protection and restoration *** findings could be used in comparative studies and,importantly,may aid further mapping of Mongolian forests.

关键词： Mongolia Natural forest regeneration Seedlings Larix sibirica Land restoration Desertification

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Geodesic metrics on fractals and applications to heat kernel estimates

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Science China Mathematics 2023年第5期66卷 907-934页

作者： Qingsong Gu ka-Sing Lau Hua Qiu Huo-Jun Ruan Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics The Chinese University of Hong KongHong KongChina Department of Mathematics University of PittsburghPittsburghPA 15217USA School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China

It is well known that for a Brownian motion, if we change the medium to be inhomogeneous by a measure μ, then the new motion(the time-changed process) will diffuse according to a different metric D(·, ·).In 2009, Kigami initiated a general scheme to construct such metrics through some self-similar weight functions g on the symbolic space. In order to provide concrete models to Kigami’s theoretical construction, in this paper,we give a thorough study of his metric on two classes of fractals of primary importance: the nested fractals and the generalized Sierpinski carpets;we further assume that the weight functions g := ga are generated by“symmetric” weights a. Let M be the domain of a such that Dgadefines a metric, and let S be the boundary of M. One of our main results is that the metrics from ga satisfy the metric chain condition if and only if a ∈ *** determine M and S, we provide a recursive weight transfer construction on the nested fractals, and a basic symmetric argument on the Sierpinski carpet. As an application, we use the metric chain condition to obtain the lower estimate of the sub-Gaussian heat kernel. This together with the upper estimate obtained by Kigami allows us to have a concrete class of metrics for the time change, and the two-sided sub-Gaussian heat kernel estimate on the fundamental fractals.

关键词： Brownian motion heat kernel metric chain condition nested fractal quasisymmetry resistance metric Sierpinski carpet weight function

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Large-scale permafrost degradation as a primary factor in Larix sibirica forest dieback in the Khentii massif,northern Mongolia

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Journal of Forestry Research 2020年第1期31卷 197-208页

作者： David Juricka Jitka Novotna Jakub Houska Jana parilkova Jan Hladky Vaclav Pecina Hana Cihlarova Marcela Burnog Jakub Elbl Zdena Rosicka Martin Brtnicky Jindrich Kynicky Department of Geology and Pedology Faculty of Forestry and Wood TechnologyMendel University in BrnoZemedelska 161300 BrnoCzech Republic Central European Institute of Technology Brno University of TechnologyPurkynova 656/12361200 BrnoCzech Republic Institute of Water Structures Faculty of Civil EngineeringBrno University of TechnologyZizkova 1760200 BrnoCzech Republic

The objective of this study is to investigate the potential causes of widespread Larix sibirica *** observed in the Khentii massif of northern *** ratio of deadwood to living trees in affected stands in the Goricho region,the southernmost study site situated close to the Gobi Desert,was as high as 3.6:*** fluctuations monitored over 2 years using electrical impedance spectrometry revealed that the Goricho study site had higher soil moisture levels than the two less affected sites Barun Bayan and Dzun *** soil moisture was recorded in an area characterized by highly skeletal soils,ones with more than 35%by volume of rock fragments,and comparatively shallow soil horizons,from valley to *** layer of permafrost influencing hydrogeological processes is much deeper in the Goricho region compared to the undisturbed study *** analysis confirmed a significant number of dead *** on sites with developed *** forest stands,however damaged,grow in this region on well-drained scree slopes or on rocky *** mass mortality observed for *** may be directly linked to accelerated permafrost thaw in the area bordered by the Tuul and the Terelj *** assumption is that *** root system necrosis occurred as a result of long-term waterlogging of developed soils with high spatial heterogeneity,normally able to absorb high quantities of *** areas unaffected were scree fields and rocky bastions characterized by adequate *** of our findings support the primary stages of large-scale permafrost thaw,i.e.,correlating increases in soil moisture with increasing permafrost active layer thickness.

关键词： Larix sibirica Mortality Permafrost thawing Waterlogging Mongolia

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浅谈第巴雅郊巴所属的谿卡

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青海民族大学学报（藏文版） 2021年第2期 20-37页

作者：拉巴西藏日喀则市第一高级中学西藏日喀则857000

帕木竹巴时期前藏南部出现了一个强大的地方政治势力集团——第巴雅郊巴。第巴雅郊巴的谿卡是雅郊巴的政治、经济和文化的基础。本文在参考大量藏文史籍、教法史、手抄本古籍等文献的基础上,对其下辖杰钦林、伦珠林、班觉若丹林等地进... 详细信息

帕木竹巴时期前藏南部出现了一个强大的地方政治势力集团——第巴雅郊巴。第巴雅郊巴的谿卡是雅郊巴的政治、经济和文化的基础。本文在参考大量藏文史籍、教法史、手抄本古籍等文献的基础上,对其下辖杰钦林、伦珠林、班觉若丹林等地进行考证,并论述与这些谿卡相关的重要史实,考察这些谿卡最终演变为寺庙的过程。

关键词：雅郊巴谿卡杰钦林伦珠林班觉饶丹

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