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A new series of environment-friendly reddish inorganic pigments based on AFeO_(3)(A=Ln,Y) with high nIR solar reflectance

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Journal of Materiomics 2021年第5期7卷 1061-1073页

作者： Maria Fortuño-Morte Pablo Serna-Gallén Héctor Beltrán-Mir Eloísa Cordoncillo Departamento de Química Inorgánica y Orgánica Universitat Jaume IAv.Sos Baynat s/n12071Castellóde la PlanaSpain

Environment-friendly pigments based on AFeO_(3)(A=La,Pr,nd,Sm,Gd,Tb,Y or Yb)with high nearinfrared(nIR)reflectance were synthesised by a coprecipitation method at 1200℃.The Rietveld refinement analysis showed single-phase orthorhombic perovskite for all *** pigments,which showed reddish hues,offered good colour stability after mixing these pigments in powder form with siloxane transparent paint and two different *** powderepaint mixtures produced with GdFeO_(3),TbFeO_(3) and YFeO_(3) pigments have the highest nIR solar reflectance,reaching values of R=50%.The temperature shielding studies conducted using TbFeO_(3) pigmentepaint mixture for a roof coating yielded a reduction of 3.2℃ in comparison to a commercial ***,the glazes that were pigmented using GdFeO_(3),TbFeO_(3) and YFeO_(3) compositions also presented the most intense reddish colours.A study of the thermal and chemical stability of the pigment with the highest nIR solar reflectance showed good stability in both *** reddish pigments that were prepared can therefore be good candidates for use in different applications such as cool pigments or pigments for ceramic glazes at high temperatures.

关键词： High nIR reflectance Cool pigment Reddish pigment Environment-friendly Coprecipitation

经支气管冷冻肺活检后按需手术肺活检对比即刻手术肺活检诊断间质性肺疾病(COLD研究):一项随机对照临床试验

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中华结核和呼吸杂志 2024年第9期47卷 826-826页

作者： kalverda ka.ninaber MK Wijmans L 阳胜朱娅琳肖奎不详中南大学湘雅二医院呼吸与危重症医学科中南大学呼吸疾病研究所湖南省呼吸与危重症疾病临床医学研究中心中南大学呼吸疾病诊疗中心长沙410000

背景:间质性肺疾病(ILD)的充分诊断对于临床决策和预后非常重要。大多数ILD患者可通过对临床和放射学数据的评估做出准确诊断,但还有相当一部分患者仍需进行肺活检。手术肺活检(SLB)是获取组织的最常用方法,但其发病率甚至死亡率都很高... 详细信息

背景:间质性肺疾病(ILD)的充分诊断对于临床决策和预后非常重要。大多数ILD患者可通过对临床和放射学数据的评估做出准确诊断,但还有相当一部分患者仍需进行肺活检。手术肺活检(SLB)是获取组织的最常用方法,但其发病率甚至死亡率都很高。最近,临床引入了经支气管冷冻肺活检,其不良反应较SLB少,但诊断率低于SLB。本研究旨在比较两种诊断策略:阶梯策略(经支气管冷冻肺活检,如果冷冻活检获得的信息不够,再进行SLB)与即刻SLB策略。方法:COLD研究是一项在荷兰6家医院开展的多中心、随机对照临床试验。该研究纳入了经多学科团队讨论评估有肺活检指征的ILD患者。以1∶1的比例将患者随机分配到阶梯策略或即刻SLB策略中,并从首次手术开始随访12周。本研究的治疗对患者、临床医生和病理学家均未设盲。主要研究终点是非预期的胸管引流,定义为经支气管冷冻肺活检后需要胸管引流,或SLB后胸管引流时间延长(>24 h)。次要研究终点是诊断率、住院时间、术后疼痛评分和严重不良事件,其中,严重不良事件包括研究期间患者出现死亡、危及患者生命、患者需再次入院或患者住院时长增加[经支气管镜检查超过2 d(1个夜晚),SLB超过4 d(3个夜晚)]。研究进行了改良的意向治疗分析。研究已在荷兰试验注册中心(nL7634)注册,现已结束。结果:在2019年4月8日至2021年10月24日期间,122例ILD患者接受了研究评估;55例患者被随机分配至阶梯组(n=28)或即刻SLB组(n=27);即刻SLB组有3例患者被排除。阶梯组的28例患者中有3例发生意外胸管引流(11%,95%CI:4%~27%),而即刻SLB组24例患者中有11例(46%,95%CI:2%~65%)在24 h内无法拔除胸管,绝对风险降低35%(11%~56%,P=0.0058)。在阶梯策略中,仅经支气管冷冻肺活检后的多学科团队诊断率为82%(64%~92%),在经支气管冷冻肺活检不确定后进行后续SLB时,诊断率增至89%(73%~96%)。在即刻SLB策略中,多学科团队的诊断率为88%(69%~97%)。阶梯组的总住院时间为1 d(IQR 1~1),而即刻SLB组为5 d(IQR 4~6)。阶梯组发生了1起(4%)严重不良事件,而即刻SLB组发生了12起(50%)严重不良事件。结论:在ILD诊断中,如果需要对肺组织进行评估,那么诊断策略应从经支气管冷冻肺活检开始,然后在经支气管冷冻肺活检不能得出诊断结论时进行SLB,这样似乎可显著减轻患者负担,缩短住院时间,且诊断率与即刻SLB相似。

关键词：间质性肺疾病支气管镜检查多学科团队患者负担病理学家肺活检临床决策诊断策略

Would behavioral thermoregulation enable pregnant viviparous tropical lizards to cope with a warmer world?

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Integrative Zoology 2017年第5期12卷 379-395页

作者： saúl LÓPEZ-ALCAIDE Miguel nAkaMURA Eric n.SMITH Enrique MARTÍnEZ-MEYER Departament of Zoology Institute of BiologyNational Autonomous University of MexicoMexico CityMexico Center for Research in Mathematics GuanajuatoMexico Amphibian and Reptile Diversity Research Center and Department of Biology University of Texas at ArlingtonArlingtonTexasUSA

Sceloporus lizards depend on external heat to achieve their preferred temperature(Tsel)for performing physiological *** both in the field and laboratory indicates that pregnant females of this Genus select body temperatures(Tb)lower than 34℃ as higher temperatures may be lethal to ***,thermoregulation is crucial for successful embryo *** the increase in global air temperature,it is expected that the first compensatory response of species that inhabit tropical climates will be behavioral *** tested whether viviparous Sceloporus formosus group lizards in the wild exhibited differences in thermoregulatory behavior to achieve the known Tsel for developing embryos regardless of local thermal *** quantified field active body temperature,thermoregulatory behavior mechanisms(time of sighting,microhabitat used and basking time)and available microhabitat thermal conditions(*** temperature)for 10 lizard species during gestation,distributed along an altitudinal *** applied both conventional and phylogenic analyses to explore whether Tb or behavioral thermoregulation could be regulated in response to different thermal *** species showed no significant differences in field Tb during gestation regardless of local thermal *** contrast,they exhibited significant differences in their behavioral thermoregulation associated with local environmental *** on these observations,the differences in thermoregulatory behavior identified are interpreted as compensatory adjustments to local thermal *** conclude that these species may deal with higher temperatures predicted for the tropics by modulating their thermoregulatory behavior.

关键词： altitudinal gradient behavior global warming Sceloporus formosus thermal stress

Coupled quantum molecular cavity optomechanics with surface plasmon enhancement

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Photonics Research 2017年第5期5卷 450-456页

作者： JIAn LIU ka-DI ZHU Key Laboratory of Artificial Structures and Quantum Control (Ministry of Education) School of Physics and Astronomy Shanghai Jiao Tong University

Cavity optomechanics is applied to study the coupling behavior of interacting molecules in surface plasmon systems driven by two-color laser beams. Different from the traditional force–distance measurement, due to a resonant frequency shift or a peak splitting on the probe spectrum, we have proposed a convenient method to measure the van der Waals force strength and interaction energy via nonlinear spectroscopy. The minimum force value can reach approximately 10^(-15) n, which is 3 to 4 orders of magnitude smaller than the widely applied atomic force microscope(AFM). It is also shown that two adjacent molecules with similar chemical structures and nearly equal vibrational frequencies can be easily distinguished by the splitting of the transparency peak. Based on this coupled optomechanical system, we also conceptually design a tunable optical switch by van der Waals interaction. Our results will provide new approaches for understanding the complex and dynamic interactions inmolecule–plasmon systems.

关键词： Coupled quantum molecular cavity optomechanics with surface plasmon enhancement THz

胎儿心脏定量分析技术评估小于胎龄儿和生长受限儿心室功能

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中华超声影像学杂志 2024年第7期33卷 580-588页

作者：王漫琪冯帆吴娟刘云王新霞陈飒栗河舟郑州大学第三附属医院超声科郑州450052

目的探讨胎儿心脏定量分析(fetal HQ)技术在评估小于胎龄儿(SGA)及生长受限(FGR)胎儿心室收缩功能中的应用价值。方法前瞻性选取2022年8月至2023年9月郑州大学第三附属医院胎儿预估体重(EFW)或腹围小于第10百分位数的单胎胎儿152例,其... 详细信息

目的探讨胎儿心脏定量分析(fetal HQ)技术在评估小于胎龄儿(SGA)及生长受限(FGR)胎儿心室收缩功能中的应用价值。方法前瞻性选取2022年8月至2023年9月郑州大学第三附属医院胎儿预估体重(EFW)或腹围小于第10百分位数的单胎胎儿152例,其中胎儿EFW或腹围位于第3~10百分位数且不伴有血流动力学异常为SGA组(n=79),其余为FGR组(n=73);匹配同期正常单胎胎儿161例作为对照组。依据FGR发生孕周,将FGR组分为早发组(n=11),其余为轻度FGR(n=62)。应用fetal HQ软件获取胎儿心室面积变化分数(FAC)、整体纵向应变(GLS)、纵向缩短率(LFS)及24节段短轴缩短率(FS),比较各组间心室收缩功能差异,分析各参数与孕周的相关性,进行观察者间及观察者内重复性检验。结果与对照组相比,SGA组及FGR组心室FAC、LFS及GLS均减低,SGA组右心室9~24节段FS减低、FGR组左心室10~19、21~24节段及右心室18~24节段FS减低,差异有统计学意义(均P0.6(均P0.05)。心室收缩功能参数观察者间及观察者内ICC均>0.75,具有较好的重复性。结论Fetal HQ可定量评估SGA及FGR胎儿心室收缩功能,SGA及FGR胎儿心室整体、纵向及局部横向收缩功能均减低,心室收缩功能异常与不良围产期结局相关。

关键词：超声检查胎儿心脏定量分析小于胎龄儿胎儿生长受限心室功能

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具有蜂窝薄片状高比表面积氢氧化镁的制备

盐科学与化工 2024年第4期53卷 30-34页

作者：郭彦彦赵飒唐山三友新材料股份有限公司河北唐山063600 生特瑞(河北)工程设计有限公司河北石家庄050000

文章以普通氢氧化镁为原料,采用溶剂热法,考察了水溶剂和非水溶剂对氢氧化镁热处理结果的影响。采用扫描电子显微镜(SEM)、X射线衍射仪(XRD)和低温氮气吸附比表面积测定仪对氢氧化镁的形貌和晶体结构进行了表征。结果表明,以15 mL正丁... 详细信息

文章以普通氢氧化镁为原料,采用溶剂热法,考察了水溶剂和非水溶剂对氢氧化镁热处理结果的影响。采用扫描电子显微镜(SEM)、X射线衍射仪(XRD)和低温氮气吸附比表面积测定仪对氢氧化镁的形貌和晶体结构进行了表征。结果表明,以15 mL正丁醇为溶剂,4 g氢氧化钠为矿化剂,加1 g氢氧化镁干粉,在150℃下维持5 h,制备出了蜂窝状有序排列的薄片氢氧化镁,比表面积高达108.13 m^(2)/g。以正丙醇和异丙醇为溶剂也可得到同样的氢氧化镁产品,所得产品比表面积分别为140.65 m^(2)/g和139.04 m^(2)/g。

关键词：氢氧化镁高比表面积正丁醇

Synthesis,Structures,and Fluorescence Property of a novel Heterometallic Complex Constructed by Imidazole

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Chinese Journal of Structural Chemistry 2020年第5期39卷 942-948页

作者： LI sa-Ying Department of Chemistry Chemical Engineering Shaanxi Xueqian Normal UniversityXi'an 710100China

A novel heterometallic complex constructed by imidazole ligand,CoZn(C3n2H3)4(1),has been synthesized under hydrothermal *** 1 was characterized by IR spectra,thermal analysis,powder X-ray diffraction and single-crystal X-ray ***-crystal X-ray diffraction studies reveals that compound 1 is in the tetragonal system,space group I41cd with a=23.4371(5),b=23.4371(5),c=12.4430(7)?,V=6834.9(4)?3,Z=16,C12H12Con8Zn,Mr=392.60,Dc=1.526 g/cm^3,F(000)=3152,μ=2.381 mm–1,R=0.0323 and w R=*** CoZn(C3n2H3)4 is one-dimensional heterometallic molecular chains,which are further extended into a 3D open ***,the solid-state fluorescence property of the complex has also been investigated at room temperature.

关键词： heterometallic complex crystal structure fluorescence property

Identification of novel small-molecule inhibitors of saRS-CoV-2 by chemical genetics

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo Jasper Fuk-Woo Chan kaiming Tang Jian-Piao Cai Kenn ka-Heng Chik Yixin Huang Mei Dai Bo Qin Chon Phin Ong Allen Wing-Ho Chu Wan-Mui Chan Jonathan Daniel Ip Lei Wen Jessica Oi-Ling Tsang Tong-Yun Wang Yubin Xie Zhenzhi Qin Jianli Cao Zi-Wei Ye Hin Chu Kelvin kai-Wang To Xing-Yi Ge Tao ni Dong-Yan Jin Sheng Cui Kwok-Yung Yuen Shuofeng Yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan Province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China nHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-saRS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different saRS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the saRS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： saRS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics

Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore national Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi