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Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre maëva Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira Richard Bonnet Nicolas Barnich Frédéric Antonio Carvalho Denis Pezet mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly apparent.The gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstrated with colibactin-producing Escherichia coli(CoPEC).AIM To evaluate the association between CoPEC prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical approaches.METHODS Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric interview.Results were compared according to the CoPEC colonization.In parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC strain.Their behavior was assessed using the Elevated Plus maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC did.This result was confirmed in C57BL6/J wildtype mice and in a CRC susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC strain.CONCLUSION This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Infla.ma.ion Anxiety Depression Behavior

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Association of pla.ma.vitamin A level with type 2 diabetes mellitus:a community aging population-based cross-sectional study

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Food Science and Human Wellness 2024年第4期13卷 2079-2089页

作者： Pengfei Li Jingjing Xu Yujie Guo Xiaojun ma Shaobo Zhou Chi Zhang Huiyan Yu Ying Wang Xixiang Wang Linhong Yuan School of Public Health Beijing Key Laboratory of Environmental ToxicologyChina-British Joint Laboratory of Nutrition Prevention and Control of Chronic DiseasesCapital Medical UniversityBeijing 100069China School of Science Faculty of Engineering and ScienceUniversity of GreenwichChatham ME44TBUK School of Biological Sciences University of Nebraska-LincolnNE 68588-0660USA Suzhou Hospital Affiliated Hospital of Medical SchoolNanjing UniversitySuzhou 215153China

Recent studies indicated that vitamin A(va)might be involved in the pathology of type 2 diabetes mellitus(T2DM).This cross-sectional study was conducted to explore the association between circulating va level and T2DM.A total of 1818 subjects aged 50 years old and above were recruited from the community.Binomial logistic regression and restricted cubic spline(RCS)were applied to analyze the association of pla.ma.va level with the risk of T2DM.Serum va and lipid-adjusted va levels of T2DM patients were significantly higher than that of non-T2DM subjects(Pa.ma.va/total cholesterol(TC),va/high-density lipoprotein cholesterol(HDL-c)and va/low-density lipoprotein cholesterol(LDL-c)were positively associated with the risk of T2DM in the aging population(Pa.ma.va/triglyceride(TG)have decreased risk of T2DM(odds ratio(OR)Q2=0.68,P_(Q2)=0.021;ORQ3=0.59,P_(Q3)lance of circulating lipids and va might affect the relationship between va and T2DM.The middle and aging subjects with higher ratios of pla.ma.va/TC,va/HDL-c,and va/LDL-c displayed increased risk for T2DM,but the moderate ratio of va/TG might protect against risk of T2DM.

关键词： Type 2 diabetes mellitus Vitamin A Lipid Nutrition Disease prevention

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Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 304-310页

作者： Yuan-Zhang Zhu Zhi-Zhi Dou Wen-Ying Wang Qing-Yue ma Wen-Dan Yi Ning-Ning Yao Yi-Chong Liu Xiao-Di Gao Qian Zhang Wen-Juan Luo Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

AIM:To observe the therapeutic effect of conbercept on diabetic macular edema(DME)complicated with diabetic nephropathy(DN).METHODS:In this retrospective study,54 patients(54 eyes)that diagnosed as DME from January 2017 to October 2021 were collected.The patients were divided into two groups:DME patients with DN(25 eyes),and DME patients without DN(29 eyes).General conditions were collected before treatment,laboratory tests include fasting blood glucose,HbA1c,microalbumin/creatinine,serum creatinine.Optical coherence tomography(OCT)was used to check the ellipsoidal zone(ez)and external limiting membrane(ELM)integrity.Central macular thickness(CMT),best corrected visual acuity(BCva),and retinal hyperreflective foci(HF)as well as numbers of injections were recorded.RESULTS:There were significant differences between fasting blood glucose,HbA1c,serum creatinine,urinary microalbumin/creatinine,and estimated glomerular filtration rate(eGFR)between the two groups(all Pez and ELM continuity in the DME+DN group was worse than that in the DME group(Pva(logmaR)in the DME group was significantly better than that in the DME+DN group at the same time points during treatment(all Pvalues were significantly higher in the DME+DN group than that in the DME group at the all time points(all Pva,CMT and the number of HF,treatment efficacy of DME patients without DN is better than that of DME patients with DN.

关键词： conbercept diabetic nephropathy diabetic macular edema optical coherence tomography

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Analyzing Changes in maize Leaves Orientation due to GxExM Using an Automatic Method from RGB Images

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Plant Phenomics 2023年第2期5卷 239-252页

作者： mario Serouart Raul Lopez-Lozano Gaëtan Daubige maëva Baumont Brigitte Escale Benoit De Solan Frédéric Baret Arvalis Institut du végétal228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France INRAE Avignon UniversitéUMR EMMAHUMT CAPTE228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France Arvalis Ecophysiology21 Chemin de Pau64121 MontardonFrance

The sowing pattern has an important impact on light interception efficiency in maize by determining the spatial distribution of leaves within the canopy.Leaves orientation is an important architectural trait determining maize canopies light interception.Previous studies have indicated how maize genotypes may adapt leaves orientation to avoid mutual shading with neighboring plants as a plastic response to intraspecific competition.The goal of the present study is 2-fold:firstly,to propose and validate an automatic algorithm(Automatic Leaf Azimuth Estimation from Midrib detection[AlaEM])based on leaves midrib detection in vertical red green blue(RGB)images to describe leaves orientation at the canopy level;and secondly,to describe genotypic and environmental differences in leaves orientation in a panel of 5 maize hybrids sowing at 2 densities(6 and 12 plants.m^(−2))and 2 row spacing(0.4 and 0.8 m)over 2 different sites in southern France.The AlaEM algorithm was validated against in situ annotations of leaves orientation,showing a satisfactory agreement(root mean square[RMSE]error=0.1,R^(2)=0.35)in the proportion of leaves oriented perpendicular to rows direction across sowing patterns,genotypes,and sites.The results from AlaEM permitted to identify significant differences in leaves orientation associated to leaves intraspecific competition.In both experiments,a progressive increase in the proportion of leaves oriented perpendicular to the row is observed when the rectangularity of the sowing pattern increases from 1(6 plants.m^(−2),0.4 m row spacing)towards 8(12 plants.m^(−2),0.8 m row spacing).Significant differences among the 5 cultivars were found,with 2 hybrids exhibiting,systematically,a more plastic behavior with a significantly higher proportion of leaves oriented perpendicularly to avoid overlapping with neighbor plants at high rectangularity.Differences in leaves orientation were also found between experiments in a squared sowing pattern(6 plants.m^(−2),0.4 m row spacing),indicating a possible contribution

关键词： cultivar spacing pattern

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Reflections on COPD comorbidities

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中华医学杂志(英文版) 2024年第12期137卷 2024 May 16页

作者： He Zhenming Wang Yue Shan Lin Mou Yan Liu Yunhuan ma Guanhua Wu Yanxu Zhu Huili Curtis Jeffrey L. Cui Shilei Ge Haiyan Department of Pulmonary and Critical Care Medicine Huadong Hospital Fudan University Shanghai China Medical Service VA Ann Arbor Healthcare System Ann Arbor MI USA Pulmonary & Critical Care Medicine Division Department of Internal Medicine University of Michigan Ann Arbor MI USA Graduate Program in Immunology University of Michigan Ann Arbor MI USA.

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绩效评价视角下高校国有资产管理内部体系研究

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市场周刊 2024年第10期37卷 21-24页

作者：马玲南京工业职业技术大学江苏南京210023

国有资产为高校育人奠定了物质基础,确保了高校科研、教学等各项工作的稳步推进。是否能够对国有资产进行科学化管理,会直接影响高校内部的运行成效。对国有资产管理状况开展绩效评价,有助于高校国有资产管理体系的优化,帮助相关人员树... 详细信息

国有资产为高校育人奠定了物质基础,确保了高校科研、教学等各项工作的稳步推进。是否能够对国有资产进行科学化管理,会直接影响高校内部的运行成效。对国有资产管理状况开展绩效评价,有助于高校国有资产管理体系的优化,帮助相关人员树立科学的管理观念,提升对国有资产的重视度。文章以江苏省高校国有资产管理现状为例,在分析管理成效的基础上指出存在的不足,并从健全工作管理机制、评价指标体系构建、评价结果利用三个方面提出优化策略。

关键词：绩效评价国有资产价值策略

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primiReference: a reference for analysis of primary-microRNA expression in single-nucleus sequencing data

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Journal of Genetics and Genomics 2023年第2期50卷 108-121页

作者： Amy E.Elias Thomas A.Nuñez Bianca Kun Jill A.Kreiling Roche WilmingtonMA 01887USA. Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRI02903USA Public Health Genetics University of PittsburghPittsburghPA 15260USA

Single-nucleus RNA-sequencing technology has revolutionized understanding of nuanced changes in gene expression between cell types within tissues.Unfortunately,our understanding of regulatory RNAs,such as microRNAs(miRNAs),is limited through both single-cell and single-nucleus techniques due to the short length of miRNAs in the cytoplasm and the incomplete reference of longer primary miRNA(pri-miRNA)transcripts in the nucleus.We build a custom reference to align and count pri-miRNA sequences in singlenucleus data.Using young and aged subventricular zone(SVZ)nuclei,we show differential expression of pri-miRNAs targeting genes involved in neural stem cells(NSC)differentiation in the aged SVZ.Furthermore,using wild-type and 5XFAD mouse model cortex nuclei,to validate the use of primiReference,we find cell-type-specific expression of pri-miRNAs known to be involved in Alzheimer’s disease(AD).pri-miRNAs likely contribute to NSC dysregulation with age and AD pathology.primiReference is paramount in capturing a global profile of gene expression and regulation in single-nucleus data and can provide key insights into cell-type-specific expression of pri-miRNAs,paving the way for future studies of regulation and pathway dysregulation.By looking at pri-miRNA abundance and transcriptional differences,regulation of gene expression by miRNAs in disease and aging can be further explored.

关键词： Primary-microRNA Aging Subventricular zone Alzheimer’s disease Single-nucleus RNA-Seq microRNA Transcriptomics

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基于HS-GC-IMS分析陇南主栽品种初榨橄榄油的风味特征成分

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中国油脂 2024年第3期49卷 21-26页

作者：白万明王菊花马赛买白小勇孔维宝马君义张继陇南田园油橄榄科技开发有限公司甘肃陇南746010 西北师范大学生命科学学院兰州730070

旨在为我国甘肃陇南产区初榨橄榄油(VOO)的快速鉴别以及工业生产过程中的风味品质评价提供数据支撑和理论依据,采用HS-GC-IMS技术对甘肃陇南主栽品种莱星(LX)、佛奥(FO)、科拉蒂(KLD)、皮削利(PXL)、鄂植8号(ez8)以及LX与KLD的混合品种(... 详细信息

旨在为我国甘肃陇南产区初榨橄榄油(VOO)的快速鉴别以及工业生产过程中的风味品质评价提供数据支撑和理论依据,采用HS-GC-IMS技术对甘肃陇南主栽品种莱星(LX)、佛奥(FO)、科拉蒂(KLD)、皮削利(PXL)、鄂植8号(ez8)以及LX与KLD的混合品种(HH)6种VOO中的风味特征成分进行定性和差异分析。结果表明:6种VOO中共检测出39种风味特征物质,定性出22种,其中醛类(9种)、酮类(5种)化合物为主要的风味特征成分,此外还包括酯类(3种)、醇类(3种)、萜烯类(1种)和呋喃类(1种)等物质;6种VOO中含有的风味特征物质均存在不同程度的差异,其中,LX、KLD和HH中的风味特征物质较为相似,其2-甲基丁醛、3-甲基丁醛、(E)-2-戊烯醛、辛醛和2-正戊基呋喃含量较高,FO中的正戊醇、正己醛和3-戊酮含量较高,PXL中的(Z)-3-己烯乙酸酯、α-松油烯、2-己酮的含量较高,ez8中的乙酸乙酯含量最高,HH中的2-丁酮、丙酮、(E)-2-庚烯醛的含量较高。综上,采用HS-GC-IMS可以有效检测VOO中的风味特征物质,定性出的风味特征物质可作为区分6种VOO的依据之一。

关键词：初榨橄榄油风味特征成分 HS-GC-IMS 指纹图谱主成分分析

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A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population

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World Journal of Gastroenterology 2006年第27期12卷 4397-4400页

作者： C Nú■ez B Rueda a.ma.tínez C maluenda I Polanco ma López-Nevot E Ortega E Sierra E Gómez de la Concha E Urcelay J martín Servicio de Inmunología Clínica Hospital Clínico San CarlosMadridSpain Instituto de Parasitología y Biomedicina "López Neyra" CSICGranadaSpain Servicio de Pediatría Hospital Clínico San CarlosMadrid Spain Servicio de Gastroenterología y Nutrición Pediátrica Hospital La PazMadridSpain Servicio de Inmunología Hospital Virgen de las NievesGranadaSpain Servicio de Pediatría Hospital Virgen de las NievesGranadaSpain Centro de Investigaciones Biológicas CISCMadridSpain

瞄准：在乳糜泻(CD ) 探讨 CD209 的角色病人。非人类的白血球抗原(Hla ) 在 CD 倾向的基因因素糟糕被理解，并且象传染病原体一样的环境因素可以起一个作用。CD209 是一树枝状并且涉及病原体识别和有免疫力的激活的巨噬细胞表面分子。... 详细信息

瞄准：在乳糜泻(CD ) 探讨 CD209 的角色病人。非人类的白血球抗原(Hla ) 在 CD 倾向的基因因素糟糕被理解，并且象传染病原体一样的环境因素可以起一个作用。CD209 是一树枝状并且涉及病原体识别和有免疫力的激活的巨噬细胞表面分子。最近，在 CD209 基因的倡导者的功能的变体(-336A/G) 被显示了影响 transcriptional CD209 活动在试管内，它与感染的更高的危险性 to/or 严厉被联系了。方法：学习人口由 103 和 386 个 CD 病人和 312 y 的二个盒子控制队组成象 257 个腹的家庭的一块面板一样的 419 健康控制。为 -336A/G CD209 倡导者多型性的 Genotyping 用 Ta.ma. 5' 被执行突变而产生之遗传的辨别试金。Hla-DQ 被杂交与等位基因 specific 探针决定。结果：开始，盒子控制和家庭研究没与 CD 危险性发现 -336 A/G CD209 基因变体的任何协会。然而，由 Hla-DQ2 的层化确实在 Hla-DQ2 (-) 组揭示了 CD209 倡导者多型性的一个重要协会(在 DQ2 (-) 对 DQ2 (+) 病人的搬运人 A 对 GG (P = 0.026，或 = 3.71 ) 。结论：-336G CD209 等位基因似乎在 Hla-DQ2 (-) 病人涉及 CD 危险性。我们的结果可能在 CD 病人的一个次要的组的发作建议病原体的一个可能的角色。

关键词：腹腔疾病西班牙流行疾病临床

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Novel single-ion conducting polymer electrolytes with high toughness and high resistance against lithium dendrites

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Nano Research 2023年第6期16卷 8457-8468页

作者： David Fraile-Insagurbe Nicola Boaretto Itziar Aldalur Iñigo Raposo Francisco Javier Bonilla Michel a.ma.d maría.ma.tínez-Ibañez Centre for Cooperative Research on Alternative Energies CIC energiGUNEBasque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain

Solid-state polymer electrolytes are considered as an alternative to classic liquid electrolytes,particularly for application in highenergy lithium metal batteries.With respect to common dual-ion conductors,single-ion conducting polymer electrolytes(SICPEs)are less affected by lithium dendrites growth and thus are particularly interesting for application in lithium metal batteries.In this work,novel SIC-PEs are developed,based on an ionomer having poly(ethylene-alt-maleimide)backbone and lithium phenylsulfonyl(trifluoromethanesulfonyl)imide pendant moieties,further blended with poly(ethylene oxide)(PEO)and poly(ethylene glycol)dimethyl ether(PEGDME).These SIC-PEs exhibit ionic conductivity around~7×10^(−6)S·cm^(−1) at 70℃,lithium transference number close to unity,and excellent mechanical properties,with fracture toughness over 30 J·cm^(−3).Additionally,the electrolytes show very high resistance against lithium dendrites growth,by cycling for more than 1200 h in Li°symmetric cells at a current density of 0.1 ma·cm^(−2).LiFePO4||Li°cells with these SIC-PEs were cycled at 70℃ and C/10,showing initial capacity of almost 160 mah·g^(−1)and residual capacity of 45%after 100 cycles.This work shows that single-ion conducting polymer electrolytes based on poly(ethylene-alt-maleimide)backbone are promising materials for application as electrolytes or catholytes in lithium metal polymer batteries.

关键词： single-ion conductors solid-state Li metal batteries polymer electrolytes lithium dendrites transference number mechanical properties

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