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Correlation of effective hepatic blood flow with liver pathology in patients with hepatitis B virus

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liver Research 2021年第4期5卷 243-250页

作者： Xin Shu Haixia Sun Xiaoan Yang Yifan Jia Peiyan Xu Hong Cao ka Zhang Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Infectious Diseases Huadu District People's Hospital of GuangzhouGuangzhouChina

Background and aims:Effective hepatic blood flow(EHBF)decreases with liver disease progression,and identifying liver pathology is critical for patients with liver *** study was designed to elucidate the correlation between EHBF and liver pathology and explore the potential of EHBF for predicting the degree of liver ***:In this study,207 patients with hepatitis B virus(HBV)who underwent liver biopsy and indocyanine green(ICG)clearance tests were *** was measured using the ICG clearance test,and liver tissue was histologically analyzed to determine the pathological stage according to the Scheuer scoring *** data,biochemical indexes,and FibroScan data were collected for statistical ***:EHBF levels decreased as the liver histological stages of inflammation and fibrosis increased(Ply negatively associated with the levels of alanine aminotransferase,aspartate aminotransferase,gamma-glutamyl transpeptidase,alkaline phosphatase,aspartate aminotransferase-to-platelet ratio index,fibrosis index based on the four factors,and liver stiffness measurement(Plevels of patients without liver inflammation(G0)were significantly higher than those of patients with liver inflammation(G1e4)(Plue for discriminating patients without liver inflammation was 0.827,and the optimal cutoff value was 0.936 l/*** EHBF levels of patients with severe liver inflammation(G4)were significantly lower than those of patients with G0e3 liver inflammation(Plue for discriminating patients with severe liver inflammation was 0.792,and the optimal cutoff value was 0.552 l/*** EHBF levels of patients without liver fibrosis(S0)were significantly higher than those of patients with liver fibrosis(S1e4)(Plue for discriminating patients without liver fibrosis was 0.633,and the optimal cutoff val

关键词： Hepatitis B virus(HBV) liver inflammation liver fibrosis Effective hepatic blood flow(EHBF) liver disease

MUlTIFRACTAl STRUCTURE AND PRODUCT OF MATRICES

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Analysis in Theory and Applications 2003年第4期19卷 289-311页

作者： lau ka-sing Department of Mathematics Chinese University of Hong Kong

There is a well established multifractal theory for self-similar measures generated by non-overlapping contractive similutudes. Our report here concerns those with overlaps. In particular we restrict our attention to the important classes of self-similar measures that have matrix representations. The dimension spectra and the l q -spectra are analyzed through the product of matrices. There are abnormal behaviors on the multifractal structure and they will be discussed in detail.

关键词： multifractal self-similar measure iterated function system dimension spectra

lightweight Self Compacting Concrete (lwscc) in the Ready Mix

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Lightweight Self Compacting Concrete (Lwscc) in the Ready Mi...

新疆生产建设兵团不同时期饮水型氟中毒地理分布特征及防治效果评价

The 6th International Symposium on Cement & Concrete and Canmet/Aci International Symposium on Concrete Technology for Sustainable Development

作者： Hela R Hubertová M Bodnárová l Kleka T Brno University of Technology Faculty of Civil Engeneering Veveí 95 62 37 Brno Brno University of Technology Faculty of Civil Engeneering Veveí 95 62 37 Brno Brno University of Technology Faculty of Civil Engeneering Veveí 95 62 37 Brno Prague University of Technology Institut of Klokner Solinova 7 662 37 Brno

The paper describes a new field of development and use of self-compacting concrete (SCC) using artificial light-weight aggregate based on burnt clay for coarse fraction of aggregate for transported re

关键词： lightweight Self Compacting Concrete lwscc in the Ready Mix

来源： cnki会议评论

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环境与健康杂志 2024年第7期41卷 601-603,F0003页

作者：马晓玲葛永梅王文瑾李凡卡新疆生产建设兵团疾病预防控制中心地方病科乌鲁木齐830002 石河子大学医学院预防医学系

目的分析新疆生产建设兵团(以下简称“兵团”)不同时期饮水型氟中毒防治效果及地理分布特征。方法收集2006年兵团开展饮水型氟中毒高氟水源筛查资料及2022年开展饮水型氟中毒病区监测资料,使用ArcGIS10.2软件绘制兵团水氟分布图及空... 详细信息

目的分析新疆生产建设兵团(以下简称“兵团”)不同时期饮水型氟中毒防治效果及地理分布特征。方法收集2006年兵团开展饮水型氟中毒高氟水源筛查资料及2022年开展饮水型氟中毒病区监测资料,使用ArcGIS10.2软件绘制兵团水氟分布图及空间相关性,探讨兵团不同时期水氟的空间分布特征及变化情况。结果 2006年调查了739个监测点,水氟浓度范围为0.01~8.36 mg/l,合格率为66.58%;2022年调查了709个监测点,水氟浓度范围0.01~2.29 mg/l,合格率为99.44%。2022年监测点水氟合格率高于2006年,差异有统计学意义(P<0.001)。水氟空间分布显示,2006年水氟值超标的团场45个,占监测团场的46.88%,主要分布在七师和八师;2022年有2个团场水氟值超标,主要分布在四师、十师。2006年和2022年水氟全局Moran’s I指数分别为0.48和0.23(P值均<0.05),具有空间正相关性。局部空间自相关结果显示,2006年有10个团场水氟空间聚集性呈正相关(均P<0.05),即H-H类型,主要分布在七师、八师;2022年有5个团场水氟空间聚集性呈正相关(均P<0.05),主要分布在第四师。结论兵团饮水型氟中毒防治工作效果显著,特别是既往水氟超标严重的一师、七师、八师;但个别病区监测点仍存在水氟超标情况。

关键词：兵团饮水型氟中毒分布特征防治现状

Measurement of solar pp neutrino flux using electron recoil data from PandaX-4T commissioning run

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Chinese Physics C 2024年第9期48卷 1-7,300页

作者： Xiaoying lu Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Zhaokan Cheng Xiangyi Cui Yingjie Fan Deqing Fang lisheng Geng ka.l giboni Xuyuan Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Junting Huang Zhou Huang Ruquan Hou Yu Hou Xiangdong Ji Yonglin Ju Chenxiang li Jiafu li Mingchuan li Shuaijie li Tao li Qing lin Jianglai liu Congcong lu lingyin luo Yunyang luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Binyu Pang Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed Xiaofeng Shang Xiyuan Shao Guofang Shen Manbin Shen lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Xu Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Yuan Wu Mengjiao Xiao Xiang Xiao kaizhi Xiong Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Ying Yuan Zhe Yuan Youhui Yun Xinning Zeng Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Wei Zhang Yang Zhang Yingxin Zhang Yuanyuan Zhang li Zhao Jifang Zhou Ning Zhou Xiaopeng Zhou Yubo Zhou Zhizhen Zhou Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China New Cornerstone Science laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Jinping Deep Underground Frontier Science and Dark Matter Key laboratory of Sichuan Province Liangshan 615000China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Beijing Key laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Peking UniversityBeijing 100871Ch

The proton-proton(pp)fusion chain dominates the neutrino production in the *** uncertainty of the predicted pp neutrino flux is at the sub-percent level,whereas that of the best measurement is O(10%).In this study,for the first time,we measure solar pp neutrinos in the electron recoil energy range from 24 to 144 keV using the PandaX-4T commissioning data with 0.63 tonne×year *** pp neutrino flux is determined as(8.0±3.9(stat)±10.0(syst))×1010 s^(-1)cm^(-2),which is consistent with the Standard Solar Model and existing measurements,corresponding to an upper flux limit of 23.3×10^(10)s^(-1)cm^(-2)at 90%C.l..

关键词： solar pp neutrino flux PandaX-4T electron recoil spectrum

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四种老龄化理念及其政策蕴意

浙江大学学报（人文社会科学版） 2016年第4期46卷 136-143页

作者：林卡吕浩然浙江大学公共管理学院浙江杭州310058

在老龄化问题研究中,健康老龄化、积极老龄化、成功老龄化和生产性老龄化,这四种理念具有不同的内涵。在结合地方养老服务创新案例分析四种老龄化理念的相互关系及其政策蕴意的基础上,运用"生活质量—社会质量"视角,评估健康老龄化和成... 详细信息

在老龄化问题研究中,健康老龄化、积极老龄化、成功老龄化和生产性老龄化,这四种理念具有不同的内涵。在结合地方养老服务创新案例分析四种老龄化理念的相互关系及其政策蕴意的基础上,运用"生活质量—社会质量"视角,评估健康老龄化和成功老龄化在提升老年群体生活质量方面的效用,探讨生产性老龄化和积极老龄化对提升社会质量的意义,从而深化人们对各种养老理念的理解,将老龄化的问题延展至老年照顾之外的参与和增能方面,丰富养老政策的内容和内涵,为发展老年友好型社会提供政策路径。

关键词：健康老龄化积极老龄化成功老龄化生产性老龄化生活质量社会质量养老政策老年友好型社会

New Sesquiterpene Glycosides from Culture Hairy Roots of Catharanthus roseus

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Chinese Journal of Chemistry 2007年第11期25卷 1695-1699页

作者： CHUNG, Ill-Min All, Mohd CHUN, Se-Chul lEE, Sun-Joo SAN, ka-Yiu CHRISTIE, A. M. Peebles AHMAD, Ateeque Department of Applied life Science Konkuk University Seoul 143-701 South Korea Faculty of Pharmacy Hamdard University New Delhi 110062 India Department of Bioengineering Rice University Houston Texas 77005 USA

Two new compounds cadin-2-en-1β-ol-1β-D-glucuronopyranoside （1）, guaia-l,7-dien-3β,13-diol-13α-D- glucofuranoside （2） along with three known compounds have been isolated from the culture hairy roots of Catharanthus roseus. Their structures have been elucidated with the help of 500 MHz NMR using 1D and 2D spectral methods： viz： ^1H and ^13C NMR, ^1H-^1H COSY, ^1H-^13C HETCOR and DEPT aided by ElMS, FAB-MS, HR-FABMS and IR spectroscopy.

关键词： Catharanthus roseus Apocynaceae culture hairy root new constituent

苯丁酸甘油酯治疗儿童鸟氨酸氨甲酰基转移酶缺乏症1例

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中国当代儿科杂志 2024年第5期26卷 512-517页

作者：杨帆王立瑞李辛胡佳悦应令雯冯碧云李芸芸林卡娜佘佳笑李浩常国营王秀敏上海交通大学医学院附属上海儿童医学中心临床研究病区上海200127 上海交通大学医学院附属上海儿童医学中心内分泌遗传代谢科上海200127 云南省德宏州陇川县人民医院儿科云南德宏678700

苯丁酸甘油酯(glyceryl phenylbutyrate,GPB)是治疗鸟氨酸氨甲酰基转移酶缺乏症(ornithine transcarbamylase deficiency,OTCD)的长期管理药物,可有效控制高氨血症,但国内使用该药的经验匮乏。该文回顾性分析上海交通大学医学院附属上... 详细信息

苯丁酸甘油酯(glyceryl phenylbutyrate,GPB)是治疗鸟氨酸氨甲酰基转移酶缺乏症(ornithine transcarbamylase deficiency,OTCD)的长期管理药物,可有效控制高氨血症,但国内使用该药的经验匮乏。该文回顾性分析上海交通大学医学院附属上海儿童医学中心1例诊断为OTCD的患儿资料,并进行相关文献复习。该患儿确诊后使用GPB治疗,随后进行疗效随访和药学监测。患儿,男,6岁6个月,语言发育差,不听指令,脾气暴躁并伴有攻击性行为。监测血氨最高327μmol/l;尿有机酸分析提示尿嘧啶水平升高;头颅磁共振成像示双侧大脑半球广泛异常信号;基因检测发现OTC基因新生突变(c.241T>C,p.S81P)。予以GPB治疗后1、2、3个月左右的血氨分别为43、80、56μmol/l。患儿治疗期间血氨控制良好,未见与药物相关的不良反应,发育落后情况较前改善,可听指令,脾气好转,无攻击性行为。

关键词：苯丁酸甘油酯鸟氨酸氨甲酰基转移酶缺乏症尿素循环障碍高氨血症药学监测儿童

Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2

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Cellular & Molecular Immunology 2022年第11期19卷 1302-1310页

作者： Qiaoli Peng Runhong Zhou Na liu Hui Wang Haoran Xu Meiqing Zhao Dawei Yang ka-Kit Au Haode Huang li liu Zhiwei Chen AIDS Institute Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionPR China National Clinical Research Center for Infectious Diseases HKU AIDS Institute Shenzhen Research LaboratoryThe Third People’s Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdongPR China Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionPR China Centre for Virology Vaccinology and Therapeutics LimitedThe University of Hong KongHong Kong Special Administrative RegionPR China HKU AIDS Institute Joint laboratory Department of Clinical Microbiology and Infection ControlThe University of Hong Kong-Shenzhen HospitalShenzhenGuangdongPR China State Key laboratory of Emerging Infectious Disease The University of Hong KongHong Kong Special Administrative RegionPR China

Mutations in SARS-CoV-2 variants of concern(VOCs)have enhanced transmissibility and immune evasion with respect to current vaccines and neutralizing antibodies(NAbs).How naturally occurring spike mutations affect the infectivity and antigenicity of VOCs remains to be *** entry efficiency of individual spike mutations was determined in vitro using pseudotyped ***/c mice were immunized with 2-dose DNA vaccines encoding B.1.1.7,B.1.351,B.1.1.529 and their single *** and humoral immune responses were then compared to determine the impact of individual mutations on *** the B.1.1.7 lineage,Del69–70 and Del 144 in NTD,A570D and P681H in SD1 and S982A and D1118H in S2 significantly increased viral entry,whereas T716I resulted in a *** the B.1.351 lineage,l18F and Del 242–244 in the NTD,K417N in the RBD and A701V in S2 also increased viral entry.S982A weakened the generation of binding *** sera showed reduced cross-neutralization activity against B.1.351,B.1.617.2(Delta)and B.1.1.529(Omicron BA.1).S982A,l18F,and Del 242–244 hindered the induction of cross-NAbs,whereas Del 69–70,Del144,R246I,and K417N showed the opposite effects.B.1.351 elicited adequate broad cross-NAbs against both B.1.351 and *** immunogens tested,however,showed low neutralization against circulating *** addition,T-cell responses were unlikely affected by mutations tested in the *** conclude that individual spike mutations influence viral infectivity and vaccine *** VOC-targeted vaccines is likely necessary to overcome immune evasion from current vaccines and neutralizing antibodies.

关键词： SARS-CoV-2 Variants of Concern Single mutation neutralizing antibody T cell responses vaccine immunogenicity