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International Journal of Digital Earth 2016年第4期9卷 325-341页

作者： Tomáš Řezníka Radoslav Chudý Eva Mičietová Department of Geography Masaryk UniversityBrnoThe Czech Republic Department of Cartography Geoinformatics and Remote SensingComenius UniversityBratislavaThe Slovak Republic

Geographic information has a great potential to be re-used when supported by mechanisms for its *** all,the quality of a catalogue service is the key feature supporting users in the discovery *** far,there have been in existence various methodologies dealing with the normalized evaluation of quality with respect to catalogue *** biggest weakness seems to be in the depth of quality testing,*** influences are beyond the scope of evaluation of these methodologies with respect to quality in catalogue *** this study,the quality of 45 catalogue services across Europe was verified with the proposed normalized evaluation methodology originating from documents within the INfrastruture for SPatial InfoRmation in Europe(INSPIRE)*** paper discusses the(statistical)influence of factors that may significantly change the results of catalogue service *** proposals for improving the existing INSPIRE normalized evaluation procedure are applicable for any spatial data infrastructure and/or Digital Earth component using the Open Geospatial Consortium Catalogue Service for the Web as a basis.

关键词： metadata quality evaluation spatial data infrastructures INSPIRE Catalogue Service for the Web

Multi-exponential model to describe pressure-dependent P-and S-wave velocities and its use to estimate the crack aspect ratio

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 385-395页

作者： Mihály Dobróka Norbert Péter Szabó Tünde Edit Dobróka Mátyás Krisztián Baracza Department of Geophysics University of MiskolcMiskolc-Egyetemváros3515Hungary MTA-ME Geoengineering Research Group University of MiskolcMiskolc-Egyetemváros3515Hungary Research Institute of Applied Earth Sciences University of MiskolcMiskolc-Egyetemváros3515Hungary

We present new quantitative model describing the pressure dependence of acoustic P-and S-wave *** that a variety of individual mechanisms or defects(such as cracks,pore collapse and grain crushing)can contribute to the pressure-dependent change of the wave velocity,we order a characteristic pressure to all of them and allow a series of exponential terms in the description of the(Pand S-waves)velocity-pressure *** estimate the parameters of the multi-exponential rock physical model in inversion procedures using laboratory measured P-and S-wave velocity *** is known,the conventional damped least squares method gives acceptable results only when one or two individual mechanisms are *** the number of exponential terms leads to highly nonlinear ill-posed inverse *** to this reason,we develop the spectral inversion method(SIM)in which the velocity amplitudes(the spectral lines in the characteristic pressure spectrum)are only considered as *** characteristic pressures(belonging to the velocity amplitudes)are excluded from the set of inversion unknowns,instead,they are defined in a set of fixed positions equidistantly distributed in the actual interval of the independent variable(pressure).Through this novel linear inversion method,we estimate the parameters of the multi-exponential rock physical model using laboratory measured P-and S-wave velocity *** characteristic pressures are related to the closing pressures of cracks which are described by well-known rock mechanical relationships depending on the aspect ratio of elliptical *** gives the possibility to estimate the aspect ratios in terms of the characteristic pressures.

关键词： Multi-exponential rock physical model Spectral inversion method(SIM) Crack aspect ratio Characteristic pressures

The Relationship Between Orthographic Awareness and Chinese Reading in Hong Kong’s Young CSL Learners

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ECNU Review of Education 2020年第4期3卷 678-693页

作者： Yu ka Wong Department of Curriculum and Instruction The Chinese University of Hong KongShatinHong Kong SARChina

Purpose:This study investigates young Chinese as a second language(CSL)learners’Chinese character reading performance and its relationship with their orthographic *** is a pressing need to gain a better understanding of Hong Kong’s ethnic minority students’CSL acquisition,so that more effective instruction can be ***/Approach/Methods:A total of 157 Hong Kong ethnic minority CSL students in Grade 4 were evaluated using a range of assessments:orthographic awareness in identifying and utilizing character components,listening comprehension for vocabulary terms and short texts,and reading Chinese character lists with single-and two-character ***:The students performed consistently across the two lists but made fewer errors when reading the two-character word list,most of which were *** regression analysis showed that the students’orthographic awareness contributed significantly to their character ***/Value:The findings suggest that orthographic awareness can help ethnic minority CSL learners improve their Chinese character reading *** classes provided for such students,and for CSL learners in general,should place greater focus on literacy training.

关键词： Chinese literacy Chinese as a second language Hong Kong’s ethnic minority students orthographic awareness

Pediatric COVID‑19:what disease is this?

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World Journal of Pediatrics 2020年第4期16卷 323-325页

作者： kam Lun Ellis Hon karen ka Yan Leung Department of Paediatrics and Adolescent Medicine The Hong Kong Children’s HospitalHong Kong SARChina

The coronavirus disease 2019(COVID-19)pandemic spares no nations or cities causing escalating incidence and ***,prime ministers,celebrities and high government officials alike have been affected by the *** peculiar reasons,children and infants have generally been spared in Hong Kong,China until recently,when returning students from affected cities with the virus who largely presented with mild *** fact,several countries have reported on pediatric COVID-19.

关键词： mortality officials Royal

Optimization of nanofiber scaffold properties towards nerve guidance channel design

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Neural Regeneration Research 2018年第7期13卷 1179-1180页

作者： Graham ka-Hon Shea Francis Mok Department of Orthopaedics and Traumatology The University of Hong Kong Li ka Shing Faculty of Medicine The University of Hong Kong

Nerve guidance channels are limited by lack of topographical guidance：Treatment of sizeable nerve gaps remains problematic following peripheral nerve *** outcomes are good when neurorrhaphy,or direct end-to-end suture repair,is *** problem arises when there is significant segmental loss,which can occur following trauma as well as oncological procedures.

关键词： Optimization of nanofiber scaffold properties towards nerve guidance channel design

Bidding Strategy for Coordinated Operation of Wind Power Plants and NGG-P2G Units in Electricity Market

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 212-224页

作者： Xiang Gao ka Wing Chan Shiwei Xia Xian Zhang Guibin Wang Shenzhen Polytechnic ShenzhenChina and also with the Department of Electrical Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina Department of Electrical Engineering The Hong Kong Polytechnic UniversityHung HomHong KongChina School of Electrical and Electronic Engineering North China Electric Power UniversityBeijing 102206China School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen 518055China College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China

The synergies between electricity and other energy resources could promote energy utilization efficiency in electricity *** this context,this paper proposes a bi-level stochastic optimization model for the joint operation of a coordinated wind power plant(WPP)and natural gas generating(NGG)-power to gas(P2G)suppliers participating in the day-ahead(DA)market and real-time(RT)market as well as providing real-time auxiliary *** coordinated supplier’s payoff is maximized in the upper level with consideration of the uncertainties of WPP output capacity and RT electricity price,while the social welfare of the grid is maximized in the lower *** results demonstrate the effectiveness of the proposed bidding model of the coordinated WPPs and NGG-P2G suppliers by examining its bidding behaviors and benefits with comparisons of four other bidding models.

关键词： Bi-level model bidding strategy WPP NGGP2G uncertainties

Structure and sequence analysis of influenza A virus nucleoprotein

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Science China(Life Sciences) 2009年第5期52卷 439-449页

作者： NG Andy ka-Leung SHAW Pang-Chui Molecular Biotechnology Programme Department of Biochemistry and Centre for Protein Science and Crystallography The Chi-nese University of Hong Kong

Influenza A virus nucleoprotein (NP) forms homo-oligomers and multiple copies of NP wrap around genomic RNA, along with a trimeric polymerase making up ribonucleoprotein (RNP) complex. Sequence comparison of more than 2500 influenza A NP showed that this protein contains 30.1 % of polymorphic residues. NP is composed of a head and a body domain and a tail loop/ linker region. The head domain is more conserved than the body domain, as revealed from the structure-based sequence alignment. NP oligomerization is mediated by the insertion of the non-polymorphic and structurally conserved tail loop of one NP molecule to a groove of another NP. The different form of NP oligomers is due to the flexibility of the polymorphic linkers that join the tail loop to the rest of the protein. The RNA binding property of NP is known to involve the protruding element and the flexible basic loop between the head and body domains, both having high degree of primary sequence conservation. To bind RNA, NP may first capture the RNA by the flexible basic loop and then the RNA is clamped by the protruding element.

关键词： Influenza H5N1 nucleoprotein oligomerization RNA binding

Immunomodulation by mesenchymal stem cells:Interplay between mesenchymal stem cells and regulatory lymphocytes

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World Journal of Stem Cells 2016年第9期8卷 268-278页

作者： Oscar ka-Fai Ma Koon Ho Chan Department of Medicine Li Ka Shing Faculty of Medicine the University of Hong Kong

Mesenchymal stem cells(MSCs) possess immunomodulatory properties, which confer enormous potential for clinical application. Considerable evidence revealed their efficacy on various animal models of autoimmune diseases, such as multiple sclerosis, systemic lupus erythematosus and uveitis. MSCs elicit their immunomodulatory effects by inhibiting lymphocyte activation and proliferation, forbidding the secretion of proinflammatory cytokines, limiting the function of antigen presenting cells, and inducing regulatory T(Treg) and B(Breg) cells. The induction of Treg and Breg cells is of particular interest since Treg and Breg cells have significant roles in maintaining immune tolerance. Several mechanisms have been proposed regarding to the MSCs-mediated induction of Treg and Breg cells. Accordingly, MSCs induce regulatory lymphocytes through secretion of multiple pleiotropic cytokines, cell-to-cell contact with target cells and modulation of antigen-presenting cells. Here, we summarized how MSCs induce Treg and Breg cells to provoke immunosuppression.

关键词： Mesenchymal stem cells Regulatory T cells Regulatory B cells Immunomodulation Autoimmunity

Losses Estimation in Transonic Wet Steam Flow through Linear Blade Cascade

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Journal of Thermal Science 2015年第2期24卷 109-116页

作者： Sawomir Dykas Mirosaw Majkut Micha Strozik Krystian Smoka Institute of Power Engineering and Turbomachinery Silesian University of Technology

Experimental investigations of non-equilibrium spontaneous condensation in transonic steam flow were carded out in linear blade cascade. The linear cascade consists of the stator blades of the last stage of low pressure steam turbine. The applied experimental test section is a part of a small scale steam power plant located at Silesian Uni- versity of Technology in Gliwice. The steam parameters at the test section inlet correspond to the real conditions in low pressure part of 200MWe steam turbine. The losses in the cascade were estimated using measured static pressure and temperature behind the cascade and the total parameters at inlet. The static pressure measurements on the blade surface as well as the Schlieren pictures were used to assess the flow field in linear cascade of steam turbine stator blades.

关键词： wet steam condensation transonic flow losses

The role of LIN28B in tumor progression and metastasis in solid tumor entities

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Oncology Research 2023年第2期31卷 101-115页

作者： TABEA GEWALT ka-WON NOH LYDIA MEDER Department I of Internal Medicine Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne University of CologneCologneGermany Institute for Pathology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Mildred Scheel School of Oncology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany

LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and *** normal conditions,LIN28B is exclusively expressed in embryogenic stem cells,blocking differentiation and promoting *** addition,it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 *** malignancies,LIN28B is frequently overexpressed,which is associated with increased tumor aggressiveness and metastatic *** this review,we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.

关键词： Cancer Metastasis LIN28B Let-7 Stemness EMT Resistance