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Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis

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Stroke & Vascular Neurology 2022年第1期7卷 77-85页

作者： Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau kam wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu Hong Kong Chinese Medicine Clinical Study Centre School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Department of Medicine and Therapeutics and Hong Kong Institute of Integrative Medicine Prince of Wales HospitalFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonOntarioCanada Clinical Laboratory Shanghai Traditional Chinese Medicine Integrated Institute of Vascular AbnomaliesShanghaiChina Institute of Medical Research Northwestern Polytechnical UniversityXi'anShanxiChina Evidence Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina School of Chinese medicine Hong Kong Baptist UniversityHong Kong SARChina Brain Center Guangdong Procincial Hospital of Traditional Chinese MedicineGuangdong University of Chinese MedicineGuangzhouChina The Nethersole School of Nuring Faculty of Medicinethe Chinese University of Hong KongHong Kong SARChina Department of Medicine Li Ka Shing Faculty of Medicinethe University of Hong KongHong Kong SARChina Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong SARChina Hong Kong Association for Integration of Chinese-Western Medicine Limited Hong Kong SARChina

Background Stroke is a major cause of death or long-term disability *** patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal ***,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke *** The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM *** The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were ***,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were *** included outcomes were dependency,motor function,depression and swallowing *** analysis was performed,and publication bias was assessed using funnel *** of review 58 studies and 6339 patients were included in the *** analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy *** superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also *** Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy ***,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn ***,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined.

关键词： acupuncture routine alone

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缺氧小鼠肾组织结构的变化

赣南医学院学报 2007年第1期27卷 1-2页

作者：林卡莉钟睿翀袁娲赣南医学院组织胚胎学教研室赣南医学院显微实验室江西赣州341000

目的:通过观测缺氧后小鼠肾组织形态结构、碱性磷酸酶的量的变化,探讨不同缺氧状态下对肾脏结构和功能的影响。方法:用小鼠制作间歇性重复缺氧模型后,在不同时间点取小鼠肾组织分别作HE染色、过碘酸雪夫氏反应(PAS染色)和碱性磷酸酶染... 详细信息

目的:通过观测缺氧后小鼠肾组织形态结构、碱性磷酸酶的量的变化,探讨不同缺氧状态下对肾脏结构和功能的影响。方法:用小鼠制作间歇性重复缺氧模型后,在不同时间点取小鼠肾组织分别作HE染色、过碘酸雪夫氏反应(PAS染色)和碱性磷酸酶染色法操作。结果:缺氧即时处理组肾实质内毛细血管扩张充血,碱性磷酸酶含量增加。但在缺氧延时处理组小鼠由于近曲小管受到损伤,其肾组织切片碱性磷酸酶染色变浅淡。该组近曲小管上皮细胞肿胀,出现颗粒变性。肾小体系膜区增宽,系膜细胞及基质增生。肾实质及肾间质血管扩张充血,间质水肿,中性粒细胞浸润。结论:缺氧时可导致小鼠近曲小管上皮细胞碱性磷酸酶含量增加,但其碱性磷酸酶染色强度随着缺氧时间的延长、近曲小管损伤的加重而成反比变化。

关键词：小鼠肾脏碱性磷酸酶 PAS反应

山西交城断裂北端及中段3个大型探槽全新世断错现象分析

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地震地质 2012年第1期34卷 76-92页

作者：郭慧江娃利谢新生中国地震局地壳应力研究所北京100085

前人在山西交城断裂带上开挖过多个探槽,揭露出全新世3次古地震事件,但其研究结果尚不能确定该断裂带全新世活动段的北部边界。近期在该断裂带北端和中段又开挖了3个大型探槽,其中在阳曲县泥屯盆地西界开挖的龙王沟探槽,是一个由多个探... 详细信息

前人在山西交城断裂带上开挖过多个探槽,揭露出全新世3次古地震事件,但其研究结果尚不能确定该断裂带全新世活动段的北部边界。近期在该断裂带北端和中段又开挖了3个大型探槽,其中在阳曲县泥屯盆地西界开挖的龙王沟探槽,是一个由多个探槽组合成的大探槽,该探槽揭示的地层断错信息,将交城断裂带全新世活动的范围向北延伸了20km。另外2个大型探槽分别为交城断裂带中段瓦窑沟东侧台地前缘的瓦窑探槽与市儿口沟西侧T1阶地前缘的新民探槽。这3个大探槽均揭示出全新世中期(14C测年值为距今5～6ka)的垆土和淤泥层,以及多组平行分布的断面,所揭示的全新世3次古地震事件具有断错事件活动的同步性,可与前人探槽揭示的全新世断层活动事件相对比。3次断错活动时间分别距今3.06～3.53ka、5.32ka左右或6.14ka左右、8.36ka左右;3次事件的时间间隔分别为2.02～2.84ka和2.22～3.04ka。这些断错事件的同震垂直位移为1.5～4.7m,显示了7级以上地表破裂型的强震活动。最后讨论了探槽中14C测年样品的影响因素。

关键词：探槽古地震期次全新世交城断裂带

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重生的光芒

现代装饰（家居） 2011年第10期 73-75页

作者： Chan wan Ki Chen Siu wa Suen ka Hei Transparent House Sarah Turne Jerry Kott Henny Van Nistelrooy Ilsa Parry Alessandro Marelli 王四美

如今的废旧物品大致有两条路可走,一条是真的安息;另一条则是变身为另一样可用的物品,焕发新生。所以,那些弃置的广告牌、录音磁带、废弃光盘、啤酒瓶子等毫不起眼被当作垃圾的东西,如果能遇到设计师的巧思妙想,或许可以"

关键词：录音磁带两条路废旧物品一朵花你我横幅广告节能灯泡手工缝合立体形状磨砂

Cl- is required for HCO3-entry,necessary for sperm capacitation:involvement of a Cl-/HCO3-exchanger(SLC26A3) and CFTR

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Cl- is required for HCO3-entry,necessary for sperm capacitat...

Roles of paroxetine and corticosterone on adult mammalian ciliary body cell proliferation

浙江省生理科学会2008年学术年会

作者： Lai Ling Tsang Yiu wa Chung P.Hglund Hsiao Chang Chan 石其贤 Epithelial Cell Biology Research Center Li Ka Shing Institute of Health SciencesDepartment of PhysiologyFaculty of MedicineThe Chinese University of Hong KongHK Hospital for Children and Adolescents Department of Medical GeneticsUniversity of HelsinkiFinland

Our previous study has demonstrated the involvement of Cystic fibrosis transmembrane conductance regulator(CFTR) in transporting bicarbonate necessary for sperm capacitation,however,whether its involvement is direct or

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Chinese Medical Journal 2010年第10期123卷 1305-1310页

作者： waNG Hua LAU Benson WM YAU Suk-yu LI Suk-yee LEUNG Nelson waNG Ning-li TANG Siu-wa LEE Tatia MC SO Kwok-fai Department of Anatomy Li Ka Shing Faculty of Medicine the University of Hong Kong Hong Kong Special Administrative Region China the State Key Laboratory of Brain and Cognitive Sciences the University of Hong Kong Hong Kong Special Administrative Region China Neuropsychology Laboratory the University of Hong Kong Hong Kong Special Administrative Region China Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Beijing 100730 China Joint Laboratory for Brain Function and Health (BFAH) Jinan University and the University of Hong Kong

Background The neurogenesis in retina of adult mammals is generally abolished, and this renders the retina lack of regenerative capacity. Despite this, there is a small population of nestin-positive cells in the ciliary epithelium which retains neurogenic potential. The present study aimed at investigating the effect of two drugs, corticosterone and paroxetine, on the cell proliferation of the ciliary body. Methods Adult Sprague-Dawley rats were given vehicle, corticosterone, paroxetine, or both corticosterone and paroxetine treatment for 14 days. Cell proliferation in the ciliary body was quantified using 5-bromo-2-deoxyuridine （BrdU） immunohistochemistry. Co-labelling of BrdU and stem cell marker was used to phenotype the BrdU immunoreactive cells. Results Corticosterone treatment suppressed while paroxetine treatment increased the cell proliferation of the ciliary body. Co-labelling with cell markers revealed that the BrdU positive cells also showed nestin expression but not glial fJbrillary acidic protein （GFAP）. Conclusions The results illustrate that proliferation of retinal progenitor cells situated in ciliary body are subjected to regulation by selective serotonin reuptake Jnhibitors （SSRI） and corticosteroJd, which is similar to our previous findings in neurogenic regions in central nervous system （CNS）. Paroxetine treatment could reverse the suppressive effect of corticosterone on ciliary body cell proliferation. This provides information for future investigation of retinal stem cell biology and potential treatment of retinal degenerative diseases.

关键词： paroxetine 5-bromo-2-deoxyuridine corticosterone ciliary body cell proliferation neurogenesis

河流冲沟裂点展布对全新世断层活动事件的响应——以山西交城断裂为例

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地震地质 2012年第2期34卷 254-268页

作者：孙昌斌谢新生江娃利中国地震局地壳应力研究所地壳动力学重点实验室北京100085

交城断裂带位于山西断陷系中部,是晋中盆地西界的控制性断裂。该断裂北端起自阳曲县泥屯镇,南到汾阳西侧,长约125km,总体走向NE,倾向SE。文中通过对山西交城断裂带41条冲沟124个裂点的实测和研究,论述了交城断裂带冲沟裂点的展布特征:1... 详细信息

交城断裂带位于山西断陷系中部,是晋中盆地西界的控制性断裂。该断裂北端起自阳曲县泥屯镇,南到汾阳西侧,长约125km,总体走向NE,倾向SE。文中通过对山西交城断裂带41条冲沟124个裂点的实测和研究,论述了交城断裂带冲沟裂点的展布特征:1)冲沟上游裂点级数的数目与冲沟上游的长度呈正比关系;2)在各级裂点中,裂点距离与冲沟的长度呈正比关系;3)约1/3冲沟不同级别裂点距离接近,这种冲沟裂点的等间距反映了断层垂直位移事件活动的时间等间隔性;4)基岩裂点和松散沉积物中的裂点具有共性,两者之间不存在明显差异;5)在测区124个裂点中,1～5m高的裂点占裂点总数的72%,这种主体裂点高度反映了断裂位移事件的垂直活动量;6)与该断裂带沿线开挖探槽揭示的古地震事件进行对比,调查区内最新的一、二、三级裂点分别对应距今3.06～3.74ka、5.91ka和8.53～8.56ka发生的断层活动事件;7)以古地震事件的时间为参照,得到a～d级冲沟第一级裂点后退速率分别为0.6～0.7cm/a、2.7～3.3cm/a、5.6～6.8cm/a和8.4～10.2cm/a,b～d级冲沟第二级裂点后退速率分别为2.6cm/a、4.6cm/a和8.4cm/a;8)这3次事件的平均高度分别为2.8m、3.0m、2.6m,与前人通过探槽揭示的3次古地震事件位错吻合。最后讨论了可能影响裂点级数及裂点距离的部分因素。

关键词：晋中盆地冲沟裂点交城断裂全新世

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原發性肺動脈肉瘤1例

镜湖医学 2023年第1期23卷 84-84,51,I0002页

作者：林萬雙林俊華李嘉亮澳門鏡湖醫院心胸血管外科中國澳門

原發性肺動脈肉瘤(primary pulmonary artery sarcoma,P-PAS)是一種惡性度極高而又罕見的腫瘤,其發病率為0.001%~0.003%[1],至今全球報導僅500餘例[2],其發病隱匿,預後極差,常被誤診為慢性肺動脈栓塞(pulmonary thromboembolism,PTE)。現報導本院經手術確診的1例PAS如下。患者女性68歲,無基礎病,因“氣促3月餘,下肢浮腫1月”2022年5月經仁伯爵綜合醫院擬“慢性肺動脈栓塞,肺動脈高壓,右心衰”轉介本院評估肺動脈取栓手術。入院前3月餘患者出現乾咳,活動後氣促,2022年4月在內地某醫院行胸部CT示肺動脈栓塞,肺動脈主幹,左、右肺動脈及遠端分支血栓並肺梗死,進一步肺動脈介入治療及血管內溶栓治療,效果不佳,漸出現雙下肢浮腫,予口服NOAC抗凝治療,經治療症狀無改善,2022年5月返澳於仁伯爵綜合醫院跟進,複查CT(圖1見封底)示雙側肺動脈栓塞伴部份肺梗死。

关键词：肺梗死右心衰胸部CT 右肺栓塞 pulmonary 肉瘤 artery

Evolutionary Transients in the Rice Transcriptome

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Genomics, Proteomics & Bioinformatics 2010年第4期8卷 211-228页

作者： Jun wang Jianguo Zhang Ruiqiang Li Hongkun Zheng Jun Li Yong Zhang Heng Li Peixiang Ni Songgang Li Shengting Li Jingqiang wang Dongyuan Liu Jason McDermott Ram Samudrala Siqi Liu Jian wang Huanming Yang Jun Yu Gane ka-Shu Wong Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100029 China Beijing Genomics Institute at Shenzhen Shenzhen 518083 China Department of Biochemistry and Molecular Biology University of Southern Denmark DK-5230 Odense M Denmark Theoretical Life Research Center Fudan University Shanghai 200433 China Computational Genomics Group Department of Microbiology University of Washington Seattle WA 98195 USA Computational Biology and Bioinformatics Pacific Northwest National Laboratory Richland WA 99352 USA Department of Biological Sciences and Department of Medicine University of Alberta Edmonton AB T6G 2E9 Canada

In the canonical version of evolution by gene duplication, one copy is kept unaltered while the other is free to evolve. This process of evolutionary experimentation can persist for millions of years. Since it is so short lived in comparison to the lifetime of the core genes that make up the majority of most genomes, a substantial fraction of the genome and the transcriptome may—in principle—be attributable to what we will refer to as ＂evolutionary transients＂, referring here to both the process and the genes that have gone or are undergoing this process. Using the rice gene set as a test case, we argue that this phenomenon goes a long way towards explaining why there are so many more rice genes than Arabidopsis genes, and why most excess rice genes show low similarity to eudicots.

关键词： evolutionary transients rice gene duplication